TWAS hub - PRUNE2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.3180	0.1010	1.3e-03	0.135	NA	0.042	NA	0.086	3.8e-05	NA	1.7e-02	NA	9.4e-04
2	GTEx	Spleen	0.3370	0.1030	3.4e-03	0.123	NA	0.133	NA	0.126	4.8e-04	NA	2.8e-04	NA	4.0e-04
3	GTEx	Whole Blood	0.5090	0.0440	0.0e+00	0.473	NA	0.462	NA	0.469	9.0e-49	NA	3.4e-47	NA	3.8e-48
4	METSIM	Adipose	0.1658	0.0322	6.3e-13	0.111	0.107	0.092	0.111	0.109	3.0e-16	1.0e-15	1.2e-13	2.9e-16	4.9e-16
5	NTR	Blood	0.1673	0.0214	0.0e+00	0.191	0.182	0.199	0.202	0.200	2.5e-59	2.3e-56	4.5e-62	4.7e-63	1.4e-62
6	TCGA	Breast Invasive Carcinoma	0.0558	0.0200	2.0e-06	0.043	0.035	0.030	NA	0.037	3.6e-09	9.4e-08	7.0e-07	NA	4.1e-08
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.1027	0.0316	1.6e-06	0.072	0.068	0.060	NA	0.065	1.6e-08	4.0e-08	2.4e-07	NA	7.6e-08
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.1452	0.0382	3.0e-06	0.083	0.047	0.077	NA	0.080	1.4e-09	5.3e-06	4.6e-09	NA	2.5e-09
9	TCGA	Brain Lower Grade Glioma	0.0759	0.0276	5.3e-04	0.019	0.011	0.018	NA	0.013	2.6e-03	1.6e-02	3.4e-03	NA	1.1e-02
10	TCGA	Liver Hepatocellular Carcinoma	0.1010	0.0420	4.7e-03	0.055	0.031	0.027	NA	0.046	1.3e-03	1.4e-02	1.8e-02	NA	3.2e-03
11	TCGA	Lung Squamous Cell Carcinoma	0.0834	0.0255	8.9e-08	0.093	0.076	0.081	NA	0.082	1.0e-10	5.5e-09	1.8e-09	NA	1.4e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Cholesterol lowering medication	8.4	12.3	17.5	-4.2	-3.8	-3.8	-4.1	-3.6	-4.1	-3.2	-1.0	-1.2	-3.9	-3.8
Alzheimer’s Disease (in father)	6.0	6.5	9.1	2.5	2.9	2.8	2.7	3.0	2.4	2.2	-2.3	-1.4	2.8	2.8
Average weekly spirits intake	5.1	6.3	8.9	-3.0	-2.6	-2.8	-2.7	-2.5	-2.4	-3.0	0.6	0.1	-2.9	-3.0
Alzheimer’s Disease (including proxy)	5.0	7.2	12.3	2.6	2.7	3.0	3.3	3.5	2.5	2.8	-0.2	0.3	3.1	3.0
Time employed in main current job	4.9	5.7	8.2	-2.9	-2.4	-2.8	-2.4	-2.3	-2.8	-1.8	1.1	1.5	-2.8	-2.7
Hypothyroidism/myxoedema (self-reported)	4.5	8.8	14.1	-3.1	-3.5	-3.2	-3.2	-2.9	-3.8	-3.0	-0.6	-1.3	-3.2	-3.2
Blood White Count	4.1	30.1	41.9	6.5	6.0	6.3	6.4	5.7	5.6	4.3	-2.5	-1.4	6.3	6.5
Ever had prostate specific antigen (PSA) test	4.1	4.7	7.0	2.1	1.9	2.2	2.3	2.5	2.7	2.3	1.4	1.5	2.3	2.4
Breastfed as a baby	3.8	4.7	7.8	-2.6	-2.1	-2.5	-2.2	-2.8	-1.7	-1.8	-0.9	-0.3	-2.6	-2.7
Hair/balding pattern: Pattern 2	3.6	4.6	7.7	-2.1	-2.3	-2.2	-2.4	-2.2	-2.7	-2.8	0.5	0.3	-2.2	-2.4
Major Depression (MDD)	3.5	4.3	7.3	-1.7	-1.8	-1.9	-1.6	-2.1	-2.7	-2.5	-2.2	-1.9	-1.9	-2.0
Frequency of depressed mood in last 2 weeks	3.2	4.5	6.6	-2.4	-2.0	-2.3	-2.3	-2.1	-2.3	-2.6	0.4	-0.0	-2.4	-2.6
Had menopause	3.2	4.0	4.8	-2.1	-1.9	-2.2	-2.1	-2.1	-2.0	-2.1	1.7	1.4	-2.1	-2.1
Ever taken oral contraceptive pill	3.1	3.5	9.2	-1.8	-2.1	-1.9	-1.9	-2.1	-1.3	-3.0	0.5	-0.7	-1.9	-1.9
Severe depression (siblings)	2.9	3.2	4.9	-2.2	-1.6	-2.1	-2.0	-1.5	-1.6	-2.2	1.0	0.3	-2.2	-2.1
Stomach or abdominal pain in last month	2.9	3.6	5.6	2.4	2.2	2.2	1.9	1.9	1.8	1.6	-1.3	-1.1	2.2	1.9
Body mass index (BMI)	2.9	12.3	16.3	-3.5	-3.7	-4.0	-3.8	-4.0	-4.0	-3.6	-1.5	-1.7	-3.8	-3.9
Medication: Simvastatin	2.8	4.1	6.8	-2.5	-2.1	-2.0	-2.0	-1.9	-2.6	-2.5	0.2	-0.4	-2.2	-2.2
Father’s age at death	2.8	3.8	6.7	2.2	2.6	2.2	2.0	2.3	1.7	2.0	-0.2	-0.0	2.2	2.2
Mouth/teeth dental problems: Dentures	2.8	4.8	9.3	-2.6	-2.2	-2.4	-3.1	-1.7	-2.0	-2.3	1.3	-0.3	-2.4	-2.6
Primary Biliary Cirrhosis	2.7	3.9	7.0	-2.0	-2.1	-2.2	-1.7	-2.6	-1.8	-2.3	-0.3	-0.7	-2.3	-2.3
Leg fat mass (right)	2.7	10.4	14.3	-3.4	-3.6	-3.7	-3.4	-3.5	-3.8	-3.0	-0.8	-0.8	-3.6	-3.8
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	4.3	-1.9	-1.4	-1.8	-1.7	-2.1	-2.0	-0.5	1.3	2.0	-1.8	-1.7
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	6.8	1.8	1.8	2.0	2.0	2.6	0.9	1.5	0.3	1.6	2.1	1.9
Medication: Levothyroxine sodium	2.5	4.3	6.9	-2.0	-2.6	-2.2	-2.2	-2.4	-2.3	-2.0	-0.5	-1.1	-2.2	-2.2
Qualifications: A levels/AS levels or equivalent	2.5	5.5	9.5	2.2	2.6	2.5	3.0	2.6	3.1	2.0	-0.1	0.3	2.6	2.5
Depression (self-reported)	2.5	3.0	7.0	-1.8	-1.6	-1.6	-1.3	-1.3	-1.4	-2.6	-0.9	-2.2	-1.7	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.5	1.9	1.3	2.0	2.1	1.8	1.8	1.9	-1.2	0.2	2.0	1.7
Back pain experienced in last month	2.5	3.6	5.6	-1.7	-2.4	-1.9	-2.2	-2.0	-2.1	-2.2	-0.8	-1.2	-2.0	-2.0
Leg fat mass (left)	2.5	9.9	13.5	-3.3	-3.5	-3.6	-3.4	-3.4	-3.7	-3.0	-0.8	-0.9	-3.5	-3.7
Heart attack	2.4	3.0	9.3	-1.5	-1.2	-1.3	-1.6	-0.7	-2.3	-3.1	-1.3	-2.2	-1.4	-1.6
Impedance of arm (left)	2.4	11.0	14.4	3.3	2.9	3.6	3.8	3.6	3.4	3.1	3.0	2.9	3.5	3.5
Leg fat percentage (right)	2.3	8.5	12.6	-2.9	-3.3	-3.4	-3.0	-3.3	-3.5	-2.8	0.3	0.1	-3.3	-3.4
Risk taking	2.3	3.4	4.9	-2.2	-1.8	-2.1	-2.2	-2.0	-1.5	-2.0	0.1	-0.4	-2.2	-2.1
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.9	1.8	1.6	1.7	2.1	1.5	2.2	1.4	-0.1	0.6	1.7	1.7
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	4.6	-1.9	-2.1	-1.9	-1.9	-1.7	-2.1	-2.1	-0.2	-0.5	-1.9	-2.0
Financial difficulties in last 2 years	2.1	2.8	5.9	-1.5	-2.3	-1.7	-1.7	-1.6	-1.7	-2.4	-0.9	-1.1	-1.6	-1.6
Hip circumference	2.1	8.9	12.3	-3.1	-3.4	-3.5	-3.1	-3.4	-3.1	-3.2	-0.8	-0.6	-3.3	-3.4
Arm fat mass (left)	2.1	8.7	11.4	-2.9	-3.3	-3.4	-3.0	-3.3	-3.3	-2.8	-1.4	-1.3	-3.2	-3.3
Leg fat percentage (left)	2.1	7.6	11.0	-2.7	-3.1	-3.2	-3.0	-3.1	-3.3	-2.7	0.1	-0.1	-3.1	-3.2
Impedance of whole body	2.1	10.7	13.3	3.2	2.7	3.4	3.6	3.6	3.1	3.5	2.9	3.2	3.4	3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	4.0	-2.0	-1.8	-1.9	-1.5	-1.6	-1.9	-1.6	0.2	0.7	-1.8	-1.9
Weight	2.0	10.1	13.1	-3.4	-3.4	-3.6	-3.3	-3.5	-3.3	-3.2	-1.5	-1.6	-3.5	-3.6
Impedance of arm (right)	2.0	9.2	14.0	3.1	2.4	3.3	3.7	3.2	3.3	2.8	2.3	2.4	3.3	3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	5.3	-2.0	-2.3	-1.9	-1.8	-2.0	-1.6	-1.7	0.9	0.5	-1.9	-2.0
Heart attack/myocardial infarction (self-reported)	2.0	2.5	7.7	-1.2	-1.1	-1.2	-1.4	-0.5	-2.2	-2.8	-1.3	-2.0	-1.2	-1.4
BMI	1.9	11.0	14.0	-3.1	-3.4	-3.6	-3.5	-3.7	-3.7	-3.3	-2.4	-2.2	-3.5	-3.6
Hypothyroidism (self reported)	1.9	4.4	7.7	-2.1	-2.5	-2.2	-2.5	-2.0	-2.8	-2.0	-0.2	-1.1	-2.2	-2.2
Happiness	1.9	2.3	4.7	1.6	2.2	1.6	1.7	1.7	1.4	1.5	-0.3	0.3	1.5	1.6
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.9	-1.0	-1.4	-1.4	-1.5	-1.6	-1.8	-2.2	-0.2	-1.3	-1.4	-1.4
Neuroticism (2016)	1.8	2.6	4.5	2.1	1.7	1.7	1.6	1.6	2.0	1.1	-0.6	-1.0	1.8	1.8
Arm fat mass (right)	1.8	7.6	10.1	-2.7	-3.1	-3.2	-2.7	-3.2	-3.0	-2.7	-1.3	-1.2	-3.0	-3.1
Arm predicted mass (right)	1.8	9.2	12.0	-3.3	-3.1	-3.4	-3.5	-3.2	-3.0	-2.8	-1.9	-1.8	-3.4	-3.5
Long-standing illness, disability or infirmity	1.8	2.8	5.1	-1.9	-2.0	-1.7	-1.3	-1.7	-2.2	-1.7	-0.5	-0.4	-1.8	-1.9
Arm fat-free mass (left)	1.8	9.3	11.7	-3.3	-3.1	-3.4	-3.2	-3.2	-2.8	-2.9	-2.5	-2.2	-3.3	-3.4
Ulcerative Colitis	1.7	2.5	4.1	-1.7	-2.0	-2.0	-1.6	-2.0	-1.0	-1.4	0.3	-0.1	-2.0	-1.8
Lung cancer (father)	1.7	2.0	3.0	-1.4	-1.7	-1.6	-1.6	-1.2	-1.3	-1.3	-0.6	-0.9	-1.6	-1.7
Trunk predicted mass	1.7	9.5	11.7	-3.4	-3.0	-3.3	-3.2	-3.1	-2.6	-3.1	-2.6	-2.7	-3.3	-3.4
Whole body fat mass	1.7	7.3	9.9	-2.8	-3.1	-3.1	-2.7	-3.0	-3.0	-2.5	-1.0	-0.9	-3.0	-3.1
Family relationship satisfaction	1.7	2.1	4.2	1.5	1.5	1.5	1.7	2.1	1.7	0.8	-0.2	0.3	1.6	1.6
Arm predicted mass (left)	1.7	8.5	11.1	-3.2	-2.9	-3.3	-3.1	-3.2	-2.8	-2.6	-2.1	-1.9	-3.3	-3.3
Current tobacco smoking	1.6	2.7	4.1	-1.4	-1.7	-1.9	-1.9	-1.7	-1.6	-1.6	-0.7	-0.9	-1.9	-2.0
Waist circumference	1.6	5.8	8.3	-2.4	-2.5	-2.6	-2.5	-2.6	-2.9	-2.5	-1.2	-1.4	-2.5	-2.6
Trunk fat-free mass	1.6	9.3	11.2	-3.4	-3.0	-3.2	-3.1	-3.0	-2.6	-3.1	-2.7	-2.8	-3.2	-3.3
Arm fat-free mass (right)	1.6	8.1	10.7	-3.2	-2.8	-3.2	-3.3	-3.0	-2.8	-2.4	-1.8	-1.7	-3.2	-3.3
Smoking status: Current	1.6	2.6	4.0	-1.4	-1.8	-1.8	-1.9	-1.9	-1.5	-1.6	-0.3	-0.6	-1.9	-2.0
Body Mass Index (BMI) (2010)	1.5	2.0	3.4	-1.3	-1.6	-1.3	-1.1	-1.8	-1.5	-1.0	1.4	1.7	-1.3	-1.2
Heel T-Score	1.5	12.0	15.9	3.8	3.8	4.0	3.5	3.8	3.5	3.7	0.5	1.6	3.9	4.0
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.2	-1.4	-1.6	-1.7	-1.1	-1.4	-1.8	-1.3	1.0	0.4	-1.6	-1.6
Chronic bronchitis/emphysema (father)	1.5	1.7	4.0	-1.7	-1.2	-1.4	-2.0	-1.0	-1.7	-0.5	0.3	-0.1	-1.5	-1.4
Exposure to tobacco smoke outside home	1.5	2.0	3.4	-1.1	-1.2	-1.6	-1.4	-1.6	-1.8	-1.6	-0.7	-1.1	-1.6	-1.5
Whole body water mass	1.5	8.6	10.0	-3.1	-2.9	-3.1	-3.1	-3.0	-2.5	-2.9	-2.6	-2.6	-3.1	-3.2
Basal metabolic rate	1.5	8.3	9.8	-3.0	-2.9	-3.1	-3.0	-3.0	-2.5	-2.9	-2.5	-2.5	-3.1	-3.1
Irritable Bowel Disease (IBD)	1.4	3.3	5.5	-2.1	-2.1	-2.3	-2.1	-2.2	-1.6	-0.7	0.2	-0.0	-2.4	-2.2
Type 2 Diabetes (T2D) (2018)	1.4	2.7	4.2	-1.9	-2.0	-1.8	-1.5	-1.9	-2.0	-1.2	-0.7	-0.6	-1.9	-1.9
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	6.8	-0.6	-1.1	-0.8	-0.5	-0.4	-0.3	-0.9	-2.5	-2.6	-0.8	-0.6
Glaucoma (self-reported)	1.4	1.6	3.0	-1.2	-1.4	-1.4	-1.2	-1.0	-1.4	-1.7	0.6	0.2	-1.4	-1.5
Whole body fat-free mass	1.4	8.3	9.5	-3.1	-2.8	-3.1	-3.0	-2.9	-2.5	-2.9	-2.7	-2.7	-3.0	-3.1
Myopia	1.4	2.1	3.0	1.3	1.6	1.7	1.7	1.5	1.6	1.4	-0.2	-0.8	1.7	1.7
Ulcerative Colitis (UC)	1.3	2.5	4.1	-1.7	-1.9	-2.0	-1.8	-2.0	-1.3	-0.3	-0.2	0.0	-2.0	-1.9
Medication: Metformin	1.3	1.8	3.5	-1.5	-1.9	-1.5	-1.4	-1.0	-1.2	-1.4	0.1	-0.8	-1.5	-1.5
Illnesses of siblings	1.3	1.8	3.6	1.6	1.3	1.6	1.4	1.5	1.9	0.3	0.3	-0.5	1.6	1.6
Falls in the last year	1.3	1.7	8.4	0.4	0.4	0.5	0.7	0.5	-0.0	0.9	2.8	2.9	0.5	0.5
Had major operations	1.3	1.5	2.2	1.5	1.4	1.2	1.3	1.5	1.0	1.5	0.5	0.9	1.3	1.3
Illnesses of father: None of the above (group 1)	1.3	1.6	2.3	-1.4	-1.4	-1.4	-1.5	-1.4	-0.5	-0.8	1.5	0.8	-1.4	-1.5
High cholesterol (Self-reported)	1.3	2.4	4.7	-1.8	-1.2	-1.3	-1.8	-1.0	-1.8	-2.2	-0.9	-1.6	-1.4	-1.6
Ever smoked	1.3	2.2	3.6	-1.9	-1.6	-1.5	-1.3	-1.6	-1.5	-1.9	-0.5	-0.7	-1.7	-1.6
Depression (Nagel 2018)	1.2	1.8	2.8	-1.6	-1.3	-1.5	-1.1	-1.4	-1.4	-1.3	0.7	0.7	-1.5	-1.7
Alzheimer’s Disease (in mother)	1.2	1.4	2.7	0.8	0.9	1.2	1.4	1.3	0.6	1.6	0.9	1.4	1.3	1.2
Diabetes (father)	1.2	1.4	7.7	0.2	0.1	0.0	-0.1	0.3	-0.3	-1.1	-2.8	-2.6	0.0	-0.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.0	-1.1	-0.8	-1.0	-1.2	-1.3	-1.6	-0.1	1.0	1.7	-1.1	-1.2
Diabetes (self-reported)	1.2	1.8	3.6	-1.5	-1.1	-1.2	-1.1	-0.9	-1.3	-1.4	-1.5	-1.9	-1.3	-1.3
Prospective memory result	1.2	1.4	5.4	0.5	0.6	0.9	0.5	1.1	1.2	-0.3	-2.3	-2.3	0.8	0.6
Wheeze or whistling in the chest in last year	1.2	2.1	3.3	-1.2	-1.8	-1.6	-1.5	-1.6	-1.7	-1.7	0.0	-0.2	-1.6	-1.7
Migraine (self-reported)	1.2	1.5	2.7	1.0	1.3	1.3	1.6	0.8	1.4	1.6	-1.1	0.5	1.3	1.2
Medication: Allopurinol	1.2	1.6	3.3	-1.8	-0.9	-1.4	-1.2	-1.0	-1.7	-1.3	0.2	-0.1	-1.6	-1.3
Medication: Omeprazole	1.2	1.4	2.4	1.1	1.0	1.3	1.4	1.6	0.6	1.1	0.4	1.5	1.3	1.1
Illnesses of siblings: Diabetes	1.2	1.4	2.9	-1.4	-1.5	-1.3	-1.5	-0.7	-1.7	-0.8	-0.4	-0.6	-1.3	-1.1
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.4	1.2	0.9	0.9	0.6	1.1	1.1	1.0	-2.1	-1.6	0.9	0.9
Schizophrenia (2018)	1.1	2.3	4.2	1.3	1.8	1.8	1.4	2.0	1.6	1.4	-0.6	-0.6	1.7	1.6
Triglycerides	1.1	1.8	2.7	-1.2	-1.4	-1.4	-1.6	-1.2	-1.4	-1.1	-1.4	-1.3	-1.3	-1.4
Impedance of leg (right)	1.1	5.5	7.9	2.1	1.6	2.4	2.6	2.8	1.9	2.5	2.5	2.7	2.3	2.2
Supplements: Glucosamine	1.1	1.4	4.4	-0.1	0.9	0.7	0.8	0.9	1.2	2.1	1.5	2.0	0.7	0.7
Impedance of leg (left)	1.1	5.5	8.0	2.2	1.8	2.3	2.4	2.8	1.9	2.5	2.4	2.7	2.3	2.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.9	1.0	1.3	1.4	1.2	0.8	1.0	1.2	0.7	1.0	1.3	1.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.8	-0.9	-1.7	-1.2	-1.3	-1.2	-1.2	-1.3	-0.1	-0.0	-1.2	-1.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.2	1.2	0.8	1.1	1.7	1.6	2.1	0.4	-1.1	-0.7	1.3	1.3
Gout (self-reported)	1.1	1.5	3.4	-1.8	-0.9	-1.3	-1.0	-0.9	-1.6	-1.6	-0.1	-0.3	-1.4	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.2	-1.4	-1.4	-1.4	-1.3	-0.7	-1.0	-1.4	0.4	-0.6	-1.4	-1.5
Number of children fathered	1.1	1.2	4.4	-1.0	-0.9	-0.9	-0.9	-0.7	-0.2	-0.6	2.1	1.6	-1.0	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	7.0	0.3	0.1	0.2	0.4	0.1	0.2	0.6	2.6	2.6	0.1	0.1
Number of self-reported non-cancer illnesses	1.1	1.8	3.9	-1.3	-1.5	-1.4	-1.2	-1.6	-2.0	-1.2	-0.4	-0.2	-1.4	-1.6
Ever depressed for a whole week	1.1	1.4	6.1	0.8	1.0	1.1	1.4	0.9	0.6	-0.1	-2.5	-1.3	1.0	0.8
LDL Cholesterol	1.0	1.5	2.4	-1.5	-1.3	-1.5	-1.3	-1.4	-1.0	-1.4	0.0	-0.2	-1.6	-1.4
Leg fat-free mass (left)	1.0	5.3	6.2	-2.4	-2.2	-2.5	-2.3	-2.5	-1.9	-2.2	-2.2	-2.2	-2.4	-2.5
Medication: Atenolol	1.0	1.2	2.1	-1.3	-1.4	-1.3	-0.9	-1.2	-1.1	-0.8	-0.8	-0.6	-1.3	-1.2
Leg predicted mass (left)	1.0	5.1	5.9	-2.3	-2.1	-2.4	-2.3	-2.4	-1.8	-2.2	-2.2	-2.2	-2.4	-2.4
Arm fat percentage (right)	1.0	4.0	5.9	-1.8	-2.4	-2.3	-1.8	-2.4	-2.2	-2.0	-1.1	-1.0	-2.2	-2.2
Pulse rate, automated reading	1.0	3.2	5.7	2.0	2.4	2.2	2.0	2.1	1.2	1.4	-0.6	-0.2	2.1	1.9
Chest pain or discomfort	1.0	1.4	3.1	-0.6	-1.2	-1.2	-1.0	-1.6	-1.5	-1.8	-0.7	-0.1	-1.1	-1.2
Leg fat-free mass (right)	1.0	5.4	6.1	-2.3	-2.1	-2.4	-2.4	-2.5	-1.8	-2.3	-2.3	-2.4	-2.4	-2.4
Arm fat percentage (left)	1.0	4.2	6.1	-1.8	-2.4	-2.4	-2.0	-2.5	-2.3	-2.1	-0.7	-0.8	-2.2	-2.3
Diabetes diagnosed by doctor	1.0	1.6	2.7	-1.7	-1.3	-1.3	-1.0	-1.0	-1.4	-1.2	-0.8	-1.3	-1.4	-1.4
Eye problems/disorders: Cataract	1.0	1.1	2.7	1.1	1.0	1.4	1.0	1.6	0.9	0.4	-0.1	-0.5	1.4	1.3
Leg predicted mass (right)	1.0	5.4	6.2	-2.3	-2.1	-2.5	-2.5	-2.5	-1.8	-2.3	-2.3	-2.4	-2.4	-2.4
Average weekly beer plus cider intake	1.0	1.4	2.9	1.4	1.0	1.3	0.7	0.9	1.3	0.9	-1.2	-1.7	1.3	1.3
Unable to work because of sickness or disability	1.0	1.2	3.3	-1.3	-0.9	-1.0	-0.8	-1.0	-1.8	-1.6	0.0	-0.6	-1.0	-1.1
Coronary Artery Disease (CAD)	0.9	1.1	3.2	0.7	1.6	1.0	1.0	0.8	1.2	1.8	0.1	0.5	0.9	0.9
Schizophrenia (2014)	0.9	1.9	3.4	1.4	1.7	1.5	1.2	1.9	1.4	1.5	-0.5	-0.2	1.5	1.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	6.1	-0.3	-0.3	-0.2	-0.4	-0.1	-0.7	0.5	2.5	2.3	-0.1	-0.0
Systolic blood pressure, automated reading	0.9	2.5	3.8	-1.9	-1.8	-1.8	-1.8	-1.8	-1.9	-0.9	-0.1	0.0	-2.0	-1.8
Medication for hormone replacement therapy	0.9	1.0	2.0	1.4	0.4	1.0	1.3	0.3	1.1	0.5	0.7	1.3	1.1	1.2
Diabetes (mother)	0.9	1.2	2.5	-1.1	-1.2	-1.1	-1.2	-0.6	-1.6	-0.9	-0.6	-1.1	-1.1	-1.1
Trunk fat mass	0.9	4.0	5.8	-2.0	-2.4	-2.4	-2.0	-2.3	-2.2	-1.9	-0.5	-0.4	-2.3	-2.4
Mouth/teeth dental problems	0.9	1.3	2.1	1.4	1.2	1.2	1.4	1.1	1.1	0.9	-1.2	-0.5	1.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	6.0	-1.0	-1.1	-1.1	-0.9	-1.3	-1.2	-2.5	-0.9	-0.9	-1.0	-1.1
Pulse rate	0.9	1.5	2.4	1.6	1.3	1.5	1.6	1.1	0.5	0.9	-1.1	-0.7	1.4	1.1
Body fat percentage	0.9	3.6	5.6	-1.7	-2.4	-2.2	-1.8	-2.2	-2.3	-1.7	-0.0	0.0	-2.1	-2.2
Eye problems/disorders: None of the above	0.9	1.1	4.5	-0.8	-0.9	-1.0	-0.6	-2.1	-1.0	-0.0	0.2	1.3	-1.0	-1.0
Overall health rating	0.9	1.9	4.3	-1.2	-1.2	-1.4	-0.9	-1.8	-1.9	-2.1	-0.4	-0.5	-1.4	-1.5
Illnesses of father: Heart disease	0.9	1.2	2.5	1.0	1.0	1.0	1.2	0.8	0.3	0.9	1.5	1.6	1.1	1.1
Ovarian Cancer	0.8	1.0	3.1	1.0	1.2	0.9	1.0	0.7	1.8	1.0	-0.3	-0.8	0.9	1.0
HbA1C	0.8	0.9	1.5	0.8	1.2	1.1	0.8	0.6	0.6	0.9	1.2	1.1	1.1	1.1
Hand grip strength (left)	0.8	2.0	5.4	-1.3	-1.3	-1.2	-1.2	-1.4	-0.7	-0.6	-2.3	-1.9	-1.2	-1.5
Number of incorrect matches in round	0.8	1.4	3.2	-1.3	-0.6	-1.1	-1.8	-0.7	-1.8	-1.1	0.6	-0.3	-1.2	-1.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.2	-1.0	-1.4	-0.9	-0.8	-0.8	-0.5	-1.3	-1.5	-0.8	-0.9	-1.0
Number of live births	0.8	1.1	3.9	0.3	0.6	1.0	0.4	2.0	0.7	1.1	1.6	1.0	1.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	-1.0	-1.5	-1.1	-0.9	-1.0	-0.6	-0.9	-1.1	-0.6	-1.1	-1.2
Illnesses of mother	0.8	0.9	2.5	0.9	0.5	0.9	0.3	1.0	1.0	0.4	-1.5	-1.6	0.9	0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.0	-0.6	-1.4	-0.7	-1.0	-0.7	-0.7	-1.2	-1.4	-1.4	-0.6	-0.7
Medication: Bendroflumethiazide	0.8	1.3	2.3	-1.2	-0.9	-1.2	-1.0	-1.4	-1.5	-1.3	0.1	0.4	-1.2	-1.2
Medication: Lisinopril	0.8	1.0	2.2	-1.1	-0.7	-1.0	-1.0	-1.3	-1.5	-0.7	-0.0	0.6	-1.0	-1.2
Diastolic blood pressure, automated reading	0.8	2.6	4.6	-1.7	-1.8	-1.9	-1.6	-2.0	-2.2	-0.5	-0.7	0.5	-1.9	-1.8
Smoking Status	0.7	1.7	4.5	-1.2	-1.2	-1.2	-1.2	-1.1	-1.3	-2.1	-0.7	-1.6	-1.3	-1.3
Fed-up feelings	0.7	1.3	4.1	-0.7	-0.8	-1.0	-1.4	-1.4	-2.0	-1.1	0.7	0.8	-1.0	-1.1
Taking other prescription medications	0.7	1.0	4.5	-0.6	-0.7	-0.5	-0.0	-0.7	-0.7	0.2	2.1	2.1	-0.5	-0.7
Nervous feelings	0.7	1.4	3.8	1.1	2.0	1.1	1.6	0.9	0.7	0.5	-1.5	-0.8	1.0	1.0
Had other major operations	0.7	0.8	5.2	-0.1	-0.0	0.1	0.2	-0.2	0.3	1.2	1.4	2.3	0.2	0.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.2	-0.5	-1.5	-0.8	-0.7	-0.9	-0.6	-0.9	1.2	1.3	-0.8	-1.0
Worrier / anxious feelings	0.7	1.4	3.6	1.3	1.9	1.3	1.1	0.8	1.2	1.4	-0.2	0.0	1.2	1.2
High blood pressure (siblings)	0.7	1.0	1.9	-1.4	-0.8	-1.1	-0.8	-1.4	-1.0	0.1	0.1	0.9	-1.2	-1.2
Medication: Seretide 50 evohaler	0.7	0.8	2.5	-0.9	-1.0	-0.9	-0.9	-0.3	-0.2	-1.6	-0.4	-1.3	-0.8	-0.7
Ever had bowel cancer screening	0.7	0.8	2.3	0.4	0.6	0.7	0.9	0.0	0.6	1.1	1.5	1.3	0.7	0.8
Commuting to job workplace: Public transport	0.7	0.9	1.8	1.0	1.1	0.9	1.0	0.6	1.1	1.3	-0.5	0.2	1.0	1.0
Depressed Affect (Nagel 2018)	0.6	1.4	2.5	-0.8	-1.1	-1.2	-1.0	-1.6	-1.5	-0.9	1.1	1.1	-1.1	-1.2
Prostate Cancer	0.6	0.9	1.8	-0.9	-1.0	-1.0	-0.8	-1.3	-0.8	-0.2	1.2	0.6	-1.0	-1.0
Cardiovascular Disease	0.6	2.0	9.8	-0.3	-0.5	-0.5	-0.6	-1.4	-1.1	-1.2	-3.1	-2.4	-0.6	-0.7
Hand grip strength (right)	0.6	1.8	2.7	-1.2	-1.5	-1.2	-1.5	-1.5	-0.9	-0.7	-1.7	-1.6	-1.2	-1.4
Townsend deprivation index at recruitment	0.6	0.8	3.5	-0.0	-0.7	-0.5	-0.9	-0.3	-1.1	-0.4	-1.4	-1.9	-0.4	-0.4
Loud music exposure frequency	0.6	0.6	1.3	0.9	0.3	0.9	1.0	1.1	0.7	0.5	-0.8	-0.4	0.9	0.9
Heart disease (mother)	0.6	0.7	1.3	0.8	0.8	0.9	0.8	0.5	0.0	1.1	0.9	0.9	0.9	0.8
Friendships satisfaction	0.6	0.8	1.5	0.8	0.9	0.6	0.9	1.0	0.5	-0.8	-1.2	-1.1	0.7	0.8
Asthma (self-reported)	0.6	1.2	3.6	1.2	0.8	1.1	1.5	0.9	1.9	1.0	-0.5	0.0	1.2	1.1
Eye problems/disorders: Glaucoma	0.6	0.7	3.6	0.3	0.1	0.0	0.2	0.3	0.1	0.8	1.9	1.9	0.0	-0.1
Breast Cancer	0.5	1.3	2.3	-0.9	-1.5	-1.5	-1.0	-1.5	-1.4	-0.3	0.2	0.1	-1.5	-1.3
Ever had hysterectomy (womb removed)	0.5	0.6	4.1	0.1	0.3	0.3	0.3	-0.1	0.1	0.3	2.0	1.3	0.3	0.1
Trunk fat percentage	0.5	1.9	3.2	-1.2	-1.8	-1.6	-1.2	-1.6	-1.6	-1.1	0.4	0.4	-1.5	-1.6
Relative age voice broke	0.5	0.7	1.8	-1.0	-0.7	-0.8	-0.8	-0.8	-1.3	-1.2	0.4	0.2	-0.8	-0.8
Qualifications: CSEs or equivalent	0.5	0.7	2.1	-0.6	-1.0	-0.9	-0.7	-1.4	-0.5	0.0	-0.3	-0.4	-1.1	-1.1
Headache pain in last month	0.5	0.9	1.8	1.3	0.8	1.1	1.0	0.6	0.9	0.8	-1.1	-0.4	1.2	1.0
Knee pain experienced in last month	0.5	0.8	2.2	0.8	0.8	1.0	0.4	1.5	1.1	-0.2	-0.4	-0.7	1.0	1.0
Mood swings	0.5	0.8	1.7	-0.3	-1.1	-0.8	-1.1	-1.1	-1.3	-1.2	0.5	-0.1	-0.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.3	-1.0	-1.5	-1.0	-0.9	-0.6	-1.0	-0.7	-0.1	-0.4	-0.9	-1.0
Medication: Atorvastatin	0.5	0.6	1.0	0.5	0.9	0.8	0.7	0.9	1.0	0.6	-0.6	-0.8	0.8	0.9
Bipolar Disorder (2018)	0.4	0.6	0.9	-0.9	-0.9	-0.9	-0.5	-0.8	-0.5	-0.9	0.1	0.6	-0.9	-0.8
Reaction Time	0.4	0.8	4.1	0.4	0.2	0.2	0.3	0.2	0.5	-0.4	-2.0	-2.0	0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	3.0	0.2	-0.3	-0.3	-0.8	-0.5	-0.3	-0.7	1.7	0.8	-0.2	-0.1
Waist Hip Ratio (WHR)	0.4	2.0	3.1	1.4	1.6	1.8	1.6	1.4	0.8	1.8	-0.4	-0.5	1.7	1.6
Lung FEV1/FVC ratio	0.4	1.9	4.1	-1.3	-1.8	-1.1	-1.7	-0.7	-1.4	-2.0	1.2	0.3	-1.2	-1.5
Relative age of first facial hair	0.4	0.9	2.1	-1.2	-1.0	-1.0	-1.1	-0.7	-1.4	-0.8	-0.3	-0.0	-1.0	-0.9
Supplements: Zinc	0.4	0.5	2.3	0.2	1.1	0.5	-0.0	0.2	0.3	0.5	-1.5	-0.9	0.3	0.4
Average weekly fortified wine intake	0.4	0.5	0.9	-0.5	-0.9	-0.7	-0.8	-0.6	-0.6	-0.9	0.9	0.4	-0.6	-0.7
Maternal smoking around birth	0.4	0.6	3.5	0.1	-0.4	-0.2	-0.6	-0.7	-0.5	0.2	1.9	1.2	-0.3	-0.5
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-0.9	-0.5	-0.6	-1.0	-0.5	-0.8	-0.7	0.8	0.2	-0.6	-0.7
Alcohol usually taken with meals	0.4	0.6	1.3	0.1	0.2	0.6	1.1	0.9	0.5	1.0	-1.2	-0.6	0.6	0.7
Qualifications: None of the above	0.4	0.8	2.6	-0.8	-0.8	-0.7	-1.6	-0.6	-1.4	-0.6	0.3	0.1	-0.7	-0.9
Asthma	0.4	0.7	2.2	1.0	0.5	0.7	1.2	0.6	1.5	0.7	-0.1	0.3	0.8	0.8
Length of working week for main job	0.4	0.4	1.8	-0.2	-0.8	-0.4	-0.8	-0.3	0.4	-0.3	-0.8	-1.3	-0.5	-0.4
Birth weight of first child	0.4	0.6	1.6	1.0	1.3	0.9	0.7	0.9	0.7	-0.0	-0.1	-0.0	0.9	1.0
Pulse wave reflection index	0.4	0.5	2.0	-0.9	-0.9	-0.6	-0.7	-0.5	-0.6	-1.4	-0.1	-0.0	-0.6	-0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	-0.5	-1.3	-1.1	-1.3	-0.9	-0.4	0.4	0.4	0.3	-0.9	-0.7
Medication: Amlodipine	0.4	0.6	1.1	0.8	0.6	1.0	0.9	0.8	0.5	0.7	0.7	0.4	1.0	0.7
Age at first live birth	0.4	0.7	5.1	-0.0	0.5	-0.0	0.5	-0.2	0.3	-0.1	-2.3	-1.4	-0.1	0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	0.8	0.7	0.7	0.8	1.0	0.8	0.7	0.0	-0.2	0.8	0.8
Medication: Blood pressure	0.4	0.7	2.6	0.0	0.6	0.5	1.1	0.4	-0.2	-1.1	-1.6	-1.2	0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.8	0.5	0.9	0.7	1.1	0.6	0.5	-0.1	-0.3	0.8	0.9
Average weekly red wine intake	0.4	0.6	1.5	-1.2	-1.0	-1.0	-0.3	-0.4	-0.7	-0.9	-0.5	-0.2	-1.0	-1.0
Medication for cholesterol	0.4	0.6	1.6	0.6	1.3	0.7	0.9	1.0	0.8	0.7	0.5	0.3	0.7	0.6
Mineral and other dietary supplements	0.4	0.6	2.0	0.1	-0.7	-0.4	-0.2	-0.6	-0.8	-1.4	-1.3	-0.7	-0.3	-0.4
Breast cancer (self-reported)	0.4	0.5	1.5	-0.6	-0.6	-0.7	-0.4	-1.0	-0.3	-1.2	-0.8	-0.5	-0.7	-0.6
Average weekly champagne plus white wine intake	0.4	0.5	1.7	-0.5	-0.6	-0.4	-0.1	-0.8	-0.8	0.9	0.9	1.3	-0.5	-0.3
Mother’s age at death	0.4	0.5	2.7	-0.2	0.3	-0.3	0.1	-0.5	-0.2	-0.1	1.6	1.6	-0.4	-0.2
Medication: Blood pressure	0.4	0.7	1.3	-0.6	-0.9	-0.7	-1.1	-0.9	-1.2	-0.9	-0.6	-0.5	-0.7	-0.7
Age started oral contraceptive pill	0.4	0.5	2.7	-0.1	0.6	0.1	-0.1	-0.2	0.2	0.6	1.5	1.6	0.2	0.1
Basal cell carcinoma (self-reported)	0.4	0.4	2.4	0.5	0.5	0.2	-0.2	0.1	-0.1	-0.8	-1.0	-1.5	0.2	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	0.4	1.0	0.5	0.2	0.3	0.6	0.7	-0.8	-0.9	0.4	0.4
Bipolar Disorder (2011)	0.3	0.3	1.7	-0.0	-0.4	-0.3	-0.2	-0.6	-0.5	0.1	0.4	1.3	-0.2	-0.1
Rheumatoid Arthritis	0.3	0.4	1.1	0.5	0.8	0.6	0.5	0.6	0.8	0.5	0.6	1.1	0.5	0.5
Blood Platelet Count	0.3	4.0	6.2	2.5	2.0	2.4	2.3	2.5	1.7	1.9	0.6	0.4	2.3	2.3
Blood Red Count	0.3	2.5	6.9	1.6	1.4	1.6	1.7	1.2	0.5	1.8	1.0	2.6	1.5	1.4
Allergy or Eczema	0.3	0.9	2.2	-0.9	-1.2	-0.8	-1.0	-1.0	-0.8	-1.5	0.9	-0.3	-0.8	-0.7
Hearing difficulty/problems: Yes	0.3	0.5	1.1	-0.5	-0.8	-0.7	-0.5	-1.0	-0.4	-0.9	1.0	0.4	-0.7	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.0	-0.7	-0.3	-0.8	-0.4	-0.5	-0.2	-1.0	0.6	0.1	-0.7	-0.7
Past tobacco smoking	0.3	0.6	3.2	0.8	0.7	0.6	0.4	0.7	0.4	1.8	0.2	0.6	0.7	0.6
Noisy workplace	0.3	0.3	0.8	-0.1	-0.4	-0.6	-0.6	-0.8	-0.9	-0.3	0.6	0.6	-0.6	-0.6
Medication: Cholesterol lowering	0.3	0.5	1.1	0.2	1.0	0.8	1.0	0.8	0.3	-0.0	1.1	0.6	0.6	0.5
Pulse wave Arterial Stiffness index	0.3	0.3	2.0	-0.3	-0.3	-0.0	-0.3	0.3	-0.1	-0.6	1.4	0.9	0.1	-0.1
Peak expiratory flow (PEF)	0.3	0.7	1.7	1.0	0.5	0.9	0.8	0.9	0.9	1.3	0.1	0.1	1.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.2	-0.4	-0.0	-0.2	0.7	-0.2	-0.7	0.8	0.1	1.5	-0.2	-0.1
Pulse wave peak to peak time	0.3	0.3	2.1	0.1	0.2	-0.1	0.2	-0.4	0.0	0.5	-1.4	-0.9	-0.2	-0.0
Leg pain on walking	0.3	0.3	0.8	0.5	0.5	0.6	0.4	0.9	0.2	-0.6	0.9	-0.0	0.6	0.7
Smoking status: Previous	0.3	0.4	2.2	-0.2	0.2	0.3	0.6	0.5	0.2	-1.5	-0.5	-1.0	0.3	0.3
Commuting to job workplace: Walk	0.3	0.3	1.3	-0.6	0.1	-0.3	-0.6	-0.1	-0.8	0.3	-1.1	-0.8	-0.4	-0.2
Medication: Aspirin	0.3	0.4	1.6	0.0	0.4	0.4	0.5	0.6	-0.4	-0.5	-1.3	-1.2	0.4	0.3
Medication: Gliclazide	0.3	0.4	1.9	-0.0	0.4	0.3	0.4	0.6	0.1	0.3	-1.4	-1.2	0.3	0.2
Number of operations (self-reported)	0.3	0.4	0.7	-0.6	-0.8	-0.6	-0.5	-0.6	-0.8	-0.7	-0.2	0.2	-0.6	-0.8
Commuting to job workplace: Cycle	0.3	0.3	1.5	-0.0	0.1	0.2	-0.1	0.1	0.6	-0.1	-1.2	-1.2	0.2	0.3
Pain experienced in last month	0.3	0.6	1.9	-0.8	-0.1	-0.5	-0.2	-0.3	-0.6	0.8	1.4	1.4	-0.5	-0.4
Heart disease (siblings)	0.3	0.3	1.5	0.0	0.1	-0.1	-0.6	0.1	-0.7	0.4	-1.2	-1.0	-0.1	0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	0.5	0.8	0.8	0.8	1.1	0.9	0.5	-0.4	-0.1	0.8	0.8
Worry (Nagel 2018)	0.2	0.4	1.5	0.4	1.2	0.5	0.7	0.3	0.5	0.7	-0.8	-0.3	0.4	0.4
Crohns Disease (2017)	0.2	0.5	0.9	-0.8	-0.8	-0.9	-0.9	-0.7	-0.6	0.1	0.1	-0.2	-1.0	-1.0
Age at First Birth	0.2	0.3	0.9	-0.1	0.2	0.5	0.3	0.8	0.4	0.2	-0.9	-0.8	0.4	0.7
Crohns Disease (2012)	0.2	0.3	0.7	-0.4	-0.4	-0.6	-0.5	-0.9	-0.2	0.5	0.8	0.5	-0.7	-0.7
Chronotype (morning person)	0.2	0.4	1.9	-0.2	-1.1	-0.2	-1.0	-0.4	-0.5	-0.3	1.4	-0.1	-0.1	-0.2
Hair Pigment	0.2	5.4	15.2	-1.6	-1.3	-1.9	-2.4	-1.4	-2.4	-2.2	-3.9	-2.9	-2.0	-2.2
Number of treatments/medications taken	0.2	0.4	1.3	-0.5	-0.6	-0.3	-0.1	-0.3	-0.8	-1.1	-0.1	-0.9	-0.4	-0.5
Vitamin and mineral supplements	0.2	0.2	1.6	-0.2	-0.1	-0.2	-0.1	-0.0	-0.5	-0.1	-1.3	-0.5	-0.2	-0.1
Pack years adult smoking proportion	0.2	0.2	1.0	-0.4	-0.2	-0.5	-0.4	-0.1	-1.0	-0.6	-0.1	-0.6	-0.5	-0.4
High blood pressure	0.2	0.6	2.4	-0.4	-0.1	-0.4	-0.3	-1.0	-0.9	-0.8	-1.5	-0.8	-0.4	-0.4
Multivitamins +/- minerals	0.2	0.2	1.9	0.2	-0.0	-0.1	0.1	-0.3	0.3	-0.1	1.4	0.6	-0.0	-0.1
Sitting height	0.2	1.6	2.8	-1.6	-1.7	-1.6	-1.2	-0.9	-0.6	-1.4	-1.0	-0.5	-1.5	-1.5
Forced vital capacity (FVC)	0.2	0.7	1.5	0.4	0.7	0.8	1.0	0.7	1.2	0.4	-1.1	-0.7	0.8	0.8
Pain all over the body in last month	0.2	0.2	1.0	-0.1	-0.3	-0.3	-0.2	-0.3	0.0	-0.7	1.0	0.7	-0.2	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.6	-0.6	-0.4	-0.2	-0.4	-0.2	-0.1	-0.9	-0.8	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.6	0.5	0.6	0.8	0.9	0.8	1.2	0.5	-0.3	-0.2	0.8	0.8
Exposure to tobacco smoke at home	0.2	0.3	1.7	-0.4	-0.3	-0.3	-0.3	-0.3	-0.1	-1.3	-0.2	-0.4	-0.4	-0.5
Tense / ‘highly strung’	0.2	0.4	3.2	-0.0	0.1	0.1	-0.1	-0.0	-0.1	-0.2	-1.8	-1.0	0.1	-0.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	0.8	1.3	0.8	0.6	0.7	0.9	0.7	0.4	0.1	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.6	0.0	0.3	-0.0	0.0	-0.6	0.2	0.4	0.4	1.3	-0.1	0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.6	0.5	0.5	0.6	0.3	0.6	0.2	-0.5	-0.3	0.5	0.5
Birth weight	0.2	0.4	1.5	-1.2	-0.3	-0.7	-0.1	0.0	-0.1	-0.5	-0.7	-1.1	-0.7	-0.6
Forced vital capacity (FVC), Best measure	0.2	0.7	3.2	-0.0	0.1	0.3	0.2	0.2	0.5	-0.8	-1.8	-1.7	0.3	0.2
Comparative body size at age 10	0.2	0.6	1.9	0.8	0.5	0.6	0.5	0.4	0.7	0.4	-1.4	-1.3	0.6	0.5
Shortness of breath walking on level ground	0.2	0.3	0.6	0.6	0.4	0.7	0.5	0.4	0.4	0.2	-0.1	-0.5	0.7	0.7
Emphysema/chronic bronchitis	0.2	0.2	1.2	-0.0	-0.0	0.1	-0.1	0.2	-0.9	0.2	1.1	0.4	0.1	-0.0
Medication: Ibuprofen	0.2	0.2	0.9	-0.1	-0.6	-0.3	-0.1	-0.3	0.4	-0.1	-0.9	-0.6	-0.2	-0.3
Mean time to correctly identify matches	0.2	0.4	1.7	-0.3	-0.2	-0.2	-0.1	-0.2	-0.2	-0.5	-1.2	-1.3	-0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	-0.9	-0.3	-0.5	-0.4	0.1	-0.5	0.1	0.6	0.7	-0.5	-0.4
Alcohol intake frequency.	0.2	0.4	2.7	-0.2	-0.1	-0.0	-0.1	-0.0	0.4	-0.4	-1.1	-1.6	0.1	0.1
Age at last live birth	0.2	0.4	2.4	-0.3	-0.2	-0.4	0.1	-0.5	-0.0	-0.3	-1.5	-0.8	-0.3	-0.3
Medication: Aspirin	0.2	0.2	0.9	0.0	0.2	0.3	0.4	0.4	-0.4	-0.5	-0.9	-0.9	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.2	-0.1	-0.3	-0.0	0.6	-0.1	1.0	-0.6	-1.5	-1.2	-0.0	-0.0
Loneliness, isolation	0.2	0.3	1.6	-0.4	0.1	-0.3	-0.0	-0.6	-0.4	0.1	0.7	1.2	-0.4	-0.3
Osteoporosis (self-reported)	0.2	0.3	0.7	0.5	0.8	0.6	0.6	0.7	0.2	0.3	-0.3	-0.7	0.5	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.5	-0.4	-0.1	-0.4	-0.7	-0.3	-0.3	0.4	0.5	0.4	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	0.5	0.7	0.7	0.7	1.0	0.6	0.2	-0.6	0.3	0.8	0.7
Miserableness	0.2	0.3	1.9	0.2	-0.0	0.2	0.2	0.1	-0.3	-0.3	-1.2	-1.4	0.3	0.2
Wears glasses or contact lenses	0.2	0.2	0.8	-0.4	-0.3	-0.1	0.3	0.5	-0.3	-0.8	-0.4	-0.9	-0.1	-0.3
Hearing aid user	0.2	0.3	0.9	0.0	-0.5	-0.3	-0.9	-0.7	-0.1	-0.0	0.9	0.5	-0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.1	-0.3	0.2	0.0	-0.2	0.2	0.4	1.1	0.9	0.4	0.0	0.1
Illnesses of father: High blood pressure	0.2	0.3	1.5	0.2	-0.3	-0.3	0.5	-1.2	0.2	-0.2	-0.9	0.1	-0.2	-0.3
Alcohol drinker status: Never	0.2	0.3	2.3	-0.0	-0.0	0.0	-0.4	0.2	-0.4	-0.2	-0.6	-1.5	-0.0	-0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.6	-0.2	-0.4	-0.5	-0.6	-0.5	0.3	0.6	0.4	-0.5	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	3.5	0.1	-0.0	0.1	0.1	0.5	0.9	0.9	1.9	1.2	0.2	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.1	-0.3	-0.2	0.8	-0.3	0.1	-0.4	0.7	0.8	-0.1	-0.1
Neuroticism (Nagel 2018)	0.1	0.1	0.6	0.1	0.5	0.0	0.2	-0.2	-0.2	0.3	0.8	0.7	-0.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.8	0.3	-0.0	0.0	0.6	0.0	0.2	0.0	0.6	0.9	0.1	0.2
Mean Putamen Volume	0.1	0.2	0.5	0.7	0.4	0.2	0.0	0.0	0.5	-0.2	0.6	0.7	0.1	0.3
Fasting Glucose	0.1	0.1	0.4	0.6	0.2	0.3	0.3	-0.1	0.1	-0.1	-0.1	0.2	0.3	0.1
Lupus	0.1	0.1	0.6	0.3	0.3	0.1	-0.6	0.2	-0.7	-0.3	-0.2	-0.2	0.1	0.1
Systolic Blood Pressure	0.1	0.7	1.4	0.8	0.6	1.0	1.1	0.4	0.8	1.2	-0.8	-0.1	0.9	1.0
Respiratory disease	0.1	0.2	0.8	0.1	-0.4	-0.1	0.2	-0.2	0.8	-0.2	-0.9	-0.9	-0.0	-0.0
Lung FVC	0.1	0.5	2.3	0.3	0.6	0.7	0.8	0.3	0.6	0.6	-1.5	-0.3	0.7	0.7
Neuroticism	0.1	0.2	0.6	0.7	0.8	0.4	0.5	0.2	0.2	0.2	0.7	0.5	0.4	0.5
Tanning	0.1	0.9	2.4	0.7	1.6	1.1	0.9	0.9	0.7	0.8	0.2	-0.2	1.1	1.3
Sensitivity / hurt feelings	0.1	0.2	1.0	-0.1	0.1	-0.2	-0.5	-0.2	-0.7	-0.4	1.0	0.4	-0.2	-0.2
Angina	0.1	0.1	0.4	0.3	-0.2	0.1	0.3	0.2	-0.2	-0.2	-0.4	-0.6	0.2	0.2
Medication: Co-codamol	0.1	0.2	0.3	0.1	0.4	0.5	0.1	0.5	0.4	-0.4	0.5	-0.3	0.5	0.6
Age when periods started (menarche)	0.1	0.2	0.8	0.6	0.3	0.4	0.2	-0.1	0.8	0.9	0.2	0.2	0.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.2	-0.1	0.7	0.3	0.3	0.5	0.8	1.1	-0.3	0.1	0.2	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	-0.4	-0.7	-0.3	-0.4	-0.5	-0.1	-0.6	0.9	0.1	-0.3	-0.2
High blood pressure (mother)	0.1	0.1	0.4	-0.4	0.5	-0.2	0.4	0.2	0.3	-0.0	-0.6	-0.0	-0.2	-0.0
Hearing difficulty/problems with background noise	0.1	0.1	0.6	0.1	-0.1	-0.1	0.1	-0.2	0.1	-0.6	0.8	0.0	-0.1	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.2	-0.3	0.4	-0.1	0.1	-0.2	0.4	1.0	0.6	1.1	-0.2	-0.1
Allergy	0.1	0.3	1.7	-0.5	0.1	-0.3	-0.3	0.1	-0.6	0.1	-1.3	-0.5	-0.4	-0.4
Fluid intelligence score	0.1	0.2	0.8	0.4	0.3	0.1	0.9	0.2	0.4	0.4	0.2	0.8	0.2	0.4
Neuroticism score	0.1	0.3	1.1	0.6	1.1	0.6	0.4	0.5	0.3	0.1	0.4	0.2	0.5	0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.8	-0.1	-0.1	-0.1	0.1	-0.0	0.9	-0.3	0.9	-0.3	-0.0	0.1
Medication: Lansoprazole	0.1	0.1	0.3	0.4	-0.2	0.4	0.2	0.3	-0.5	0.5	-0.6	0.1	0.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.5	0.0	-0.1	0.3	0.2	0.3	0.4	-0.6	-1.0	-1.2	0.3	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.2	0.1	0.5	-0.1	0.1	0.4	-0.4	0.3	-0.2	0.5	0.4
Medication: Paracetamol	0.1	0.2	0.5	0.6	0.4	0.6	0.6	0.7	0.2	0.4	0.1	-0.1	0.5	0.5
Number of full brothers	0.1	0.1	0.3	-0.3	0.0	-0.1	-0.5	0.1	-0.5	-0.0	0.4	-0.3	-0.2	-0.1
Worry too long after embarrassment	0.1	0.2	0.5	0.3	0.7	0.4	0.1	0.6	-0.1	0.3	0.3	-0.3	0.4	0.5
Health satisfaction	0.1	0.1	0.4	0.3	0.0	0.3	0.6	0.3	-0.3	0.0	0.0	0.4	0.3	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.0	0.3	-0.2	-0.5	-0.6	0.2	-0.0	0.3	0.2	-0.2	-0.0
Angina (self-reported)	0.1	0.1	0.2	0.3	-0.2	0.2	0.3	0.3	-0.2	-0.1	-0.3	-0.5	0.2	0.2
Comparative height size at age 10	0.1	0.5	1.7	-0.1	0.5	0.5	0.6	0.7	1.1	0.8	1.3	0.8	0.4	0.2
Number of full sisters	0.1	0.1	0.2	0.5	0.0	0.2	0.1	0.1	0.4	0.4	-0.4	0.3	0.3	0.4
Suffer from ‘nerves’	0.1	0.1	0.5	0.1	0.7	0.0	0.3	0.4	0.6	0.4	0.1	-0.1	-0.0	0.2
Supplements: Vitamin C	0.1	0.2	0.6	-0.1	0.3	0.0	0.1	0.2	-0.0	0.6	0.8	0.8	-0.0	-0.2
Hypertension (Self-reported)	0.1	0.4	2.2	-0.2	0.1	-0.2	-0.0	-1.0	-0.8	-0.4	-1.5	-0.6	-0.3	-0.3
Qualifications: nursing, teaching	0.1	0.2	1.0	0.0	0.1	-0.2	0.3	-1.0	0.2	0.4	-0.7	0.2	-0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	-0.4	-0.1	-0.0	-0.1	0.2	0.7	0.1	0.4	-0.6	-0.0	-0.1
Guilty feelings	0.1	0.1	0.4	-0.0	0.3	0.3	0.5	0.5	0.6	-0.4	0.2	-0.1	0.2	0.3
Financial situation satisfaction	0.1	0.2	0.6	0.1	-0.5	0.0	-0.0	0.8	-0.6	-0.7	-0.1	0.1	0.1	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.2	-0.4	-0.3	0.1	-0.2	-0.4	0.4	-0.7	-0.3	-0.2	-0.0
Medication: Paracetamol	0.1	0.2	0.5	0.5	-0.0	0.4	0.5	0.3	-0.1	0.7	0.6	0.4	0.3	0.3
Irritability	0.1	0.1	0.3	-0.3	-0.4	-0.4	-0.3	-0.2	0.1	-0.6	0.4	0.2	-0.4	-0.4
Supplements: Calcium	0.1	0.1	0.3	-0.4	0.2	-0.4	0.1	-0.5	-0.5	-0.0	-0.1	0.3	-0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.2	0.0	0.4	-0.2	-0.1	0.3	-0.5	0.2	-0.3	0.3	0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.3	-0.6	-0.1	-0.0	-0.3	0.2	0.2	-0.4	-0.1	-0.1	-0.1
Pack years of smoking	0.1	0.1	0.5	-0.2	-0.0	-0.3	-0.4	0.1	-0.7	-0.4	0.4	-0.4	-0.3	-0.2
HDL Cholesterol	0.0	0.1	0.4	-0.1	-0.2	-0.2	-0.2	-0.6	-0.0	0.2	0.1	-0.1	-0.3	-0.2
Blood Eosinophil Count	0.0	0.4	2.6	0.0	-0.3	-0.0	-0.2	-0.1	0.2	-0.8	-0.9	-1.6	-0.0	-0.1
Height	0.0	0.8	3.6	-0.4	0.4	0.5	1.2	0.5	0.7	0.7	1.0	1.9	0.4	0.4
Medication: Ramipril	0.0	0.0	0.2	0.3	0.2	0.2	0.3	-0.1	-0.4	-0.0	0.2	-0.2	0.1	-0.0
Standing height	0.0	0.3	1.2	-0.4	0.0	0.3	0.6	0.8	1.1	0.6	0.0	0.2	0.2	0.1
Qualifications: College or University degree	0.0	0.1	0.3	-0.2	0.0	-0.4	0.4	-0.6	0.6	-0.3	0.0	0.6	-0.3	-0.2
Neck or shoulder pain in last month	0.0	0.1	0.2	0.3	0.0	0.2	0.2	0.2	0.2	0.4	0.1	0.5	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.1	0.3	-0.1	-0.0	-0.3	0.1	-0.1	-0.0	0.2	-0.5	-0.4	-0.2	-0.2

Hub : Genes

PRUNE2

Models

Trait associations