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chr9:115,320,787-116,859,769

Best TWAS P=5.29e-11 · Best GWAS P=4.39e-09 conditioned to 0.41

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Heart Atrial Appendage	HDHD3	0.21	0.15	enet	18	0.08	1.6e-04	-5.5	-6.6	5.3e-11	-0.82	0.01	0.99	TRUE
14	GTEx	Heart Atrial Appendage	BSPRY	0.35	0.26	lasso	5	0.36	5.0e-17	-5.1	-6.3	3.0e-10	-0.87	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	HDHD3	0.21	0.06	lasso	4	0.11	3.4e-04	5.9	-6.2	6.2e-10	-0.94	0.01	0.88	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDC26	0.10	0.07	enet	16	0.08	1.9e-07	-5.1	6.0	2.0e-09	0.67	0.02	0.97	FALSE
4	GTEx	Artery Aorta	CDC26	0.27	0.20	lasso	6	0.24	2.5e-13	-5.1	6.0	2.2e-09	0.81	0.14	0.86	FALSE
16	GTEx	Heart Atrial Appendage	WDR31	0.17	0.08	enet	16	0.10	3.9e-05	-5.5	-6.0	2.4e-09	-0.70	0.02	0.96	FALSE
7	GTEx	Brain Cortex	BSPRY	0.33	0.26	lasso	3	0.34	2.8e-10	5.9	-5.9	2.8e-09	-0.96	0.00	0.99	FALSE
18	GTEx	Heart Left Ventricle	BSPRY	0.34	0.28	enet	8	0.28	4.1e-15	5.9	-5.9	3.0e-09	-0.99	0.00	1.00	FALSE
22	GTEx	Lung	BSPRY	0.18	0.17	enet	8	0.17	9.7e-13	5.9	-5.9	3.7e-09	-0.97	0.00	1.00	FALSE
31	GTEx	Thyroid	BSPRY	0.16	0.14	lasso	5	0.13	3.6e-10	5.9	-5.9	3.9e-09	-0.99	0.00	1.00	FALSE
20	GTEx	Heart Left Ventricle	ALAD	0.18	0.17	lasso	1	0.14	4.6e-08	5.9	-5.9	4.4e-09	-1.00	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BSPRY	0.37	0.36	lasso	9	0.43	5.4e-57	5.9	-5.8	5.3e-09	-0.93	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Glioblastoma Multiforme	CDC26	0.20	0.20	blup	58	0.17	6.6e-06	-5.1	5.8	5.6e-09	0.67	0.04	0.94	FALSE
21	GTEx	Heart Left Ventricle	CDC26	0.33	0.12	enet	22	0.19	1.8e-10	-4.9	5.8	6.7e-09	0.67	0.38	0.62	FALSE
23	GTEx	Pancreas	BSPRY	0.38	0.41	lasso	2	0.40	3.8e-18	-5.6	5.7	1.1e-08	0.73	0.02	0.98	FALSE
6	GTEx	Artery Tibial	WDR31	0.18	0.07	enet	10	0.10	3.3e-08	-5.6	-5.6	2.4e-08	-0.63	0.02	0.97	FALSE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	BSPRY	0.19	0.01	lasso	5	0.01	1.1e-01	5.9	-5.5	3.1e-08	-0.97	0.01	0.77	FALSE
25	GTEx	Pituitary	CDC26	0.24	0.09	lasso	3	0.02	1.1e-01	-4.9	5.5	3.2e-08	0.60	0.07	0.23	FALSE
19	GTEx	Heart Left Ventricle	HDHD3	0.24	0.18	lasso	3	0.16	5.4e-09	5.9	-5.5	3.5e-08	-0.93	0.00	1.00	FALSE
8	GTEx	Brain Frontal Cortex BA9	BSPRY	0.37	0.32	lasso	8	0.30	1.5e-08	5.9	-5.5	4.2e-08	-0.98	0.00	0.99	FALSE
2	GTEx	Adipose Subcutaneous	PRPF4	0.17	0.13	lasso	3	0.11	2.1e-09	-5.0	-5.4	7.0e-08	-0.51	0.34	0.66	FALSE
3	GTEx	Adipose Visceral Omentum	CDC26	0.37	0.33	lasso	5	0.32	3.3e-17	-5.1	5.4	7.6e-08	0.65	0.28	0.72	FALSE
32	GTEx	Thyroid	CDC26	0.24	0.19	lasso	7	0.22	7.3e-17	-4.9	5.4	7.7e-08	0.57	0.45	0.54	FALSE
29	GTEx	Small Intestine Terminal Ileum	CDC26	0.41	0.20	lasso	5	0.14	5.5e-04	-5.1	5.4	8.1e-08	0.58	0.21	0.51	FALSE
10	GTEx	Breast Mammary Tissue (Female)	CDC26	0.12	0.01	lasso	9	0.05	1.7e-02	-4.9	5.4	8.3e-08	0.43	0.11	0.24	FALSE
30	GTEx	Testis	CDC26	0.18	0.11	enet	9	0.14	8.7e-07	-5.1	5.3	1.0e-07	0.56	0.31	0.68	FALSE
24	GTEx	Pancreas	CDC26	0.24	0.26	lasso	3	0.22	1.1e-09	-4.7	5.3	1.1e-07	0.69	0.23	0.77	FALSE
28	GTEx	Small Intestine Terminal Ileum	PRPF4	0.50	0.30	enet	14	0.33	2.9e-08	-4.8	-5.3	1.1e-07	-0.45	0.29	0.60	FALSE
42	The Cancer Genome Atlas	Soft Tissue Sarcoma	HDHD3	0.11	0.00	enet	11	0.04	1.9e-03	-5.2	-5.3	1.1e-07	-0.57	0.01	0.57	FALSE
13	GTEx	Colon Sigmoid	CDC26	0.22	0.08	lasso	4	0.05	8.5e-03	-5.1	5.3	1.4e-07	0.58	0.17	0.40	FALSE
33	METSIM	Adipose	CDC26	0.08	0.08	lasso	5	0.08	2.2e-12	-5.0	5.3	1.4e-07	0.58	0.31	0.69	FALSE
34	METSIM	Adipose	PRPF4	0.10	0.10	lasso	8	0.08	1.4e-12	-5.1	-5.3	1.4e-07	-0.51	0.22	0.77	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CDC26	0.12	0.16	lasso	6	0.14	1.5e-07	-5.1	5.3	1.4e-07	0.44	0.04	0.96	FALSE
12	GTEx	Cells Transformed fibroblasts	CDC26	0.40	0.34	enet	44	0.41	4.2e-33	-5.1	5.2	1.5e-07	0.54	0.30	0.70	FALSE
5	GTEx	Artery Tibial	HDHD3	0.50	0.25	enet	35	0.44	3.5e-38	-5.2	-5.2	1.9e-07	-0.68	0.13	0.87	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	PRPF4	0.23	0.24	lasso	2	0.20	5.7e-07	-5.0	-5.2	2.0e-07	-0.50	0.32	0.62	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	CDC26	0.24	0.14	lasso	4	0.12	6.0e-07	-5.1	5.2	2.1e-07	0.59	0.25	0.75	FALSE
9	GTEx	Breast Mammary Tissue	CDC26	0.20	0.10	lasso	6	0.10	8.7e-06	-5.1	5.2	2.3e-07	0.54	0.30	0.69	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRPF4	0.04	0.01	enet	11	0.02	2.4e-03	2.0	-5.2	2.3e-07	-0.71	0.02	0.72	FALSE
17	GTEx	Heart Atrial Appendage	CDC26	0.24	0.20	enet	13	0.22	3.6e-10	-5.1	5.2	2.5e-07	0.59	0.28	0.72	FALSE
27	GTEx	Skin Sun Exposed Lower leg	CDC26	0.24	0.20	enet	13	0.25	6.8e-21	-5.1	5.2	2.6e-07	0.55	0.30	0.69	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDC26	0.11	0.16	lasso	5	0.15	1.4e-15	-5.0	5.1	2.9e-07	0.58	0.03	0.96	FALSE