TWAS
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Usage
Models
Genes
Traits
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Traits
:
Blood White Count
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chr9:112,938,178-114,585,634
Best TWAS P=2.36e-44 · Best GWAS P=2.98e-38 conditioned to 0.582
113M
113.2M
113.4M
113.6M
113.8M
114M
114.2M
114.4M
114.6M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
NTR
Blood
LPAR1
0.19
0.07
lasso
10
0.14
2.1e-43
12.9
14.0
2.4e-44
0.75
0.00
1.00
TRUE
2
METSIM
Adipose
LPAR1
0.10
0.02
enet
26
0.06
7.4e-09
12.3
13.3
3.8e-40
0.64
0.01
0.99
TRUE
4
The Cancer Genome Atlas
Liver Hepatocellular Carcinoma
ZNF483
0.11
0.00
blup
60
0.03
1.3e-02
-2.5
-5.3
8.8e-08
-0.21
0.01
0.50
TRUE
1
GTEx
Whole Blood
LPAR1
0.10
0.00
enet
23
0.00
2.3e-01
12.9
11.0
5.4e-28
0.71
0.01
0.97
FALSE