Best TWAS P=1.99e-13 · Best GWAS P=1.99e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | PSMD5 | 0.40 | 0.22 | enet | 37 | 0.23 | 7.2e-09 | -4.5 | -6.2 | 7.0e-10 | 0.75 | 0.06 | 0.93 | FALSE |
2 | GTEx | Artery Tibial | TRAF1 | 0.04 | 0.05 | lasso | 2 | 0.03 | 1.2e-03 | -7.3 | -7.3 | 2.0e-13 | 1.00 | 0.01 | 0.99 | TRUE |
3 | GTEx | Brain Putamen basal ganglia | TRAF1 | 0.26 | 0.21 | lasso | 6 | 0.19 | 2.3e-05 | -5.1 | 6.2 | 7.2e-10 | -0.93 | 0.04 | 0.93 | FALSE |
4 | GTEx | Esophagus Mucosa | TRAF1 | 0.08 | 0.00 | lasso | 4 | 0.01 | 8.5e-02 | -7.3 | -6.1 | 8.6e-10 | 0.66 | 0.02 | 0.95 | FALSE |
5 | GTEx | Esophagus Muscularis | PHF19 | 0.16 | 0.06 | lasso | 8 | 0.07 | 3.1e-05 | -7.3 | 6.6 | 3.5e-11 | -0.82 | 0.02 | 0.97 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | TRAF1 | 0.25 | 0.17 | lasso | 12 | 0.16 | 4.4e-09 | -7.3 | -6.5 | 1.0e-10 | 0.97 | 0.01 | 0.99 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | TRAF1 | 0.11 | 0.09 | lasso | 5 | 0.09 | 1.4e-07 | -7.3 | -7.2 | 4.4e-13 | 0.97 | 0.01 | 0.99 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | PSMD5 | 0.04 | 0.04 | lasso | 6 | 0.03 | 3.1e-03 | -4.7 | -5.5 | 2.8e-08 | 0.67 | 0.16 | 0.72 | FALSE |
9 | METSIM | Adipose | PHF19 | 0.07 | 0.01 | bslmm | 374 | 0.01 | 2.3e-02 | -4.4 | 7.0 | 3.3e-12 | -0.63 | 0.26 | 0.49 | FALSE |
10 | YFS | Blood | PHF19 | 0.05 | 0.03 | enet | 21 | 0.04 | 2.9e-14 | -7.3 | 6.3 | 3.1e-10 | -0.85 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRAF1 | 0.04 | 0.04 | lasso | 3 | 0.05 | 7.2e-10 | -5.0 | 5.4 | 5.4e-08 | -0.90 | 0.20 | 0.80 | FALSE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TRAF1 | 0.05 | 0.00 | blup | 56 | 0.02 | 1.9e-02 | -7.3 | 5.7 | 1.4e-08 | -0.89 | 0.02 | 0.65 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PHF19 | 0.03 | 0.03 | lasso | 2 | 0.02 | 3.6e-03 | -7.3 | 7.3 | 2.6e-13 | -0.96 | 0.01 | 0.92 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRAF1 | 0.07 | 0.06 | blup | 53 | 0.08 | 1.7e-08 | -5.0 | 5.8 | 6.3e-09 | -0.87 | 0.04 | 0.96 | FALSE |