Best TWAS P=2.02e-09 · Best GWAS P=1.04e-09 conditioned to 0.0257
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | PHLDA2 | 0.09 | 0.06 | lasso | 4 | 0.05 | 1.2e-04 | -5.4 | -5.5 | 4.2e-08 | 0.04 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Heart Left Ventricle | C11orf21 | 0.18 | 0.02 | lasso | 4 | 0.04 | 2.6e-03 | -6.1 | -5.9 | 3.3e-09 | 0.89 | 0.00 | 0.99 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | NAP1L4 | 0.13 | 0.05 | lasso | 6 | 0.03 | 1.4e-03 | 5.1 | 5.3 | 1.0e-07 | 0.02 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Testis | NAP1L4 | 0.24 | 0.12 | lasso | 8 | 0.13 | 2.4e-06 | 5.4 | 6.0 | 2.0e-09 | 0.00 | 0.01 | 0.98 | TRUE |
| 5 | METSIM | Adipose | NAP1L4 | 0.09 | 0.09 | lasso | 5 | 0.08 | 1.4e-12 | 5.3 | 5.2 | 2.2e-07 | 0.00 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | TH | 0.05 | 0.03 | blup | 60 | 0.01 | 1.9e-02 | 4.6 | -5.3 | 1.4e-07 | -0.04 | 0.00 | 0.57 | TRUE |