Best TWAS P=1.02e-11 · Best GWAS P=1.16e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ST5 | 0.10 | 0.08 | lasso | 4 | 0.09 | 8.6e-11 | 6.8 | -6.8 | 1.0e-11 | -0.98 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | AMPD3 | 0.14 | 0.11 | lasso | 3 | 0.09 | 1.7e-07 | -5.7 | 5.6 | 1.7e-08 | -0.09 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | AMPD3 | 0.15 | 0.00 | enet | 28 | 0.02 | 2.2e-02 | -2.8 | 5.4 | 8.0e-08 | -0.02 | 0.05 | 0.45 | FALSE |
| 4 | GTEx | Esophagus Muscularis | AMPD3 | 0.35 | 0.30 | lasso | 4 | 0.30 | 1.3e-18 | -5.2 | 5.5 | 3.1e-08 | -0.09 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Lung | AKIP1 | 0.11 | 0.06 | lasso | 7 | 0.09 | 2.0e-07 | -4.6 | -6.2 | 4.6e-10 | -0.70 | 0.09 | 0.91 | FALSE |
| 6 | GTEx | Muscle Skeletal | AMPD3 | 0.12 | 0.03 | lasso | 4 | 0.03 | 6.7e-04 | -5.2 | 5.3 | 1.3e-07 | -0.09 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Nerve Tibial | AMPD3 | 0.16 | 0.13 | lasso | 3 | 0.11 | 5.1e-08 | -5.6 | 5.7 | 1.1e-08 | -0.09 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Pancreas | AMPD3 | 0.19 | 0.12 | lasso | 5 | 0.13 | 5.1e-06 | -5.6 | 5.5 | 4.9e-08 | -0.08 | 0.00 | 0.99 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | AKIP1 | 0.05 | 0.05 | enet | 8 | 0.04 | 1.7e-04 | -4.8 | -5.2 | 2.3e-07 | -0.60 | 0.21 | 0.63 | FALSE |
| 10 | GTEx | Whole Blood | ST5 | 0.07 | 0.08 | enet | 18 | 0.05 | 3.3e-05 | -5.2 | -5.5 | 4.6e-08 | -0.52 | 0.83 | 0.15 | FALSE |
| 11 | GTEx | Whole Blood | RP11-152H18.3 | 0.04 | 0.02 | lasso | 4 | 0.01 | 2.0e-02 | -5.3 | -5.3 | 9.6e-08 | -0.51 | 0.57 | 0.18 | FALSE |
| 12 | NTR | Blood | SBF2 | 0.02 | 0.00 | bslmm | 671 | 0.01 | 1.8e-03 | -4.3 | -5.3 | 1.4e-07 | -0.05 | 0.27 | 0.06 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | ST5 | 0.08 | 0.06 | lasso | 5 | 0.06 | 4.4e-08 | 6.8 | -6.4 | 1.8e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ST5 | 0.03 | 0.05 | lasso | 3 | 0.04 | 8.0e-06 | -5.4 | -5.4 | 5.8e-08 | -0.50 | 0.57 | 0.26 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C11orf17 | 0.03 | 0.02 | lasso | 2 | 0.02 | 3.4e-03 | -5.0 | -5.1 | 3.0e-07 | -0.48 | 0.02 | 0.57 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM9B | 0.06 | 0.00 | blup | 52 | 0.00 | 8.0e-02 | 3.4 | -5.2 | 2.5e-07 | -0.83 | 0.01 | 0.38 | FALSE |