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chr11:198,510-1,309,956

Best TWAS P=4.16e-55 · Best GWAS P=1.14e-55 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	IFITM2	0.07	0.01	enet	12	0.04	2.1e-05	13.89	-10.9	1.5e-27	-0.40	0.24	0.14	TRUE
2	GTEx	Adipose Subcutaneous	IFITM2	0.16	0.14	lasso	5	0.16	1.1e-12	15.72	-14.2	6.4e-46	-0.95	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	RP11-326C3.11	0.40	0.17	lasso	7	0.17	1.1e-13	11.37	12.5	7.7e-36	0.28	1.00	0.00	FALSE
4	GTEx	Artery Aorta	RP11-326C3.12	0.34	0.12	lasso	7	0.15	1.1e-08	-10.71	-10.0	9.5e-24	-0.28	0.92	0.04	FALSE
5	GTEx	Artery Tibial	IFITM2	0.10	0.08	enet	42	0.05	8.5e-05	15.72	-10.5	1.1e-25	-0.65	0.00	1.00	FALSE
6	GTEx	Artery Tibial	RP11-326C3.11	0.36	0.04	lasso	9	0.06	2.3e-05	11.37	12.1	1.3e-33	0.31	0.56	0.06	FALSE
7	GTEx	Artery Tibial	RP11-326C3.12	0.30	0.06	lasso	7	0.04	3.2e-04	-10.40	-9.3	1.8e-20	-0.26	0.84	0.01	FALSE
8	GTEx	Brain Cortex	RP11-326C3.12	0.28	0.19	lasso	2	0.16	3.0e-05	-12.56	-12.4	3.2e-35	-0.33	0.16	0.26	FALSE
9	GTEx	Brain Hypothalamus	ATHL1	0.52	0.25	enet	20	0.32	3.7e-08	-3.62	-9.0	2.3e-19	-0.30	0.12	0.12	FALSE
10	GTEx	Brain Hypothalamus	RP11-326C3.12	0.39	0.26	lasso	4	0.26	7.7e-07	-10.40	-12.5	7.1e-36	-0.35	0.22	0.46	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	IFITM2	0.23	0.22	lasso	3	0.20	4.5e-07	-12.56	-13.1	3.4e-39	-0.44	0.07	0.81	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	RP11-326C3.7	0.34	0.08	enet	25	0.15	1.7e-05	-12.56	-6.3	2.5e-10	-0.07	0.10	0.05	FALSE
13	GTEx	Cells Transformed fibroblasts	IFITM2	0.24	0.04	enet	36	0.18	1.0e-13	-12.56	-11.1	1.5e-28	-0.48	0.00	0.99	FALSE
14	GTEx	Colon Sigmoid	RP11-326C3.12	0.31	0.04	enet	22	0.06	4.1e-03	-12.56	-9.1	1.2e-19	-0.30	0.13	0.31	FALSE
15	GTEx	Colon Transverse	RP11-326C3.11	0.20	0.04	enet	32	0.06	1.0e-03	-10.40	5.3	1.5e-07	0.21	0.16	0.04	FALSE
16	GTEx	Esophagus Mucosa	IFITM2	0.23	0.03	enet	28	0.13	2.9e-09	15.72	-9.5	1.8e-21	-0.59	0.00	1.00	FALSE
17	GTEx	Esophagus Muscularis	BET1L	0.15	0.07	enet	10	0.04	1.8e-03	3.98	6.7	2.5e-11	0.23	0.10	0.14	FALSE
18	GTEx	Esophagus Muscularis	IFITM2	0.11	0.01	enet	29	0.04	1.4e-03	13.86	-10.8	4.1e-27	-0.61	0.00	0.95	FALSE
19	GTEx	Esophagus Muscularis	RP11-326C3.12	0.29	0.24	lasso	4	0.24	1.3e-14	-12.56	-11.2	3.2e-29	-0.30	1.00	0.00	FALSE
20	GTEx	Heart Atrial Appendage	IFITM2	0.33	0.05	lasso	7	0.04	7.8e-03	15.72	-15.3	3.8e-53	-0.90	0.00	0.89	TRUE
21	GTEx	Heart Left Ventricle	PTDSS2	0.18	0.02	enet	42	0.04	2.4e-03	-2.79	5.3	1.4e-07	0.32	0.27	0.27	FALSE
22	GTEx	Lung	RP11-326C3.11	0.22	0.00	enet	3	0.01	3.2e-02	-10.40	11.3	2.1e-29	0.29	0.19	0.03	FALSE
23	GTEx	Nerve Tibial	B4GALNT4	0.17	0.06	enet	43	0.11	1.9e-08	-1.51	6.8	7.2e-12	0.22	0.52	0.07	FALSE
24	GTEx	Nerve Tibial	IFITM2	0.20	0.07	lasso	4	0.10	8.5e-08	15.72	-13.6	3.8e-42	-0.92	0.00	1.00	FALSE
25	GTEx	Nerve Tibial	RP11-326C3.12	0.25	0.15	enet	30	0.18	9.7e-13	-0.35	-7.5	5.1e-14	-0.27	0.99	0.01	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	B4GALNT4	0.21	0.00	lasso	6	0.00	4.5e-01	-1.06	7.5	5.5e-14	0.29	0.05	0.04	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	RP11-326C3.11	0.22	0.10	enet	13	0.11	2.1e-06	11.37	10.1	6.3e-24	0.26	0.44	0.04	FALSE
28	GTEx	Skin Sun Exposed Lower leg	PHRF1	0.09	0.00	enet	21	0.03	1.7e-03	-2.50	5.3	1.4e-07	0.16	0.18	0.04	TRUE
29	GTEx	Skin Sun Exposed Lower leg	RP11-326C3.11	0.33	0.08	lasso	6	0.07	1.4e-06	-10.40	12.2	2.9e-34	0.32	0.99	0.00	FALSE
30	GTEx	Skin Sun Exposed Lower leg	RP11-326C3.12	0.09	0.02	enet	9	0.05	7.1e-05	-12.56	-9.8	1.4e-22	-0.27	0.44	0.20	FALSE
31	GTEx	Thyroid	IFITM2	0.16	0.09	lasso	3	0.07	4.0e-06	15.72	-14.4	3.9e-47	-0.96	0.00	1.00	FALSE
32	GTEx	Whole Blood	IFITM3	0.09	0.02	enet	12	0.07	5.2e-07	15.72	15.6	4.2e-55	0.68	0.00	1.00	TRUE
33	GTEx	Whole Blood	IFITM2	0.17	0.08	lasso	8	0.09	6.2e-09	15.72	-13.9	5.8e-44	-0.82	0.00	1.00	FALSE
34	GTEx	Whole Blood	RP11-326C3.11	0.21	0.12	lasso	3	0.11	5.2e-10	11.37	10.7	1.2e-26	0.17	1.00	0.00	TRUE
35	METSIM	Adipose	IFITM3	0.15	0.09	lasso	2	0.08	1.3e-12	-12.56	12.7	3.4e-37	0.33	1.00	0.00	FALSE
36	METSIM	Adipose	RP11-326C3.12	0.08	0.03	enet	21	0.05	1.3e-08	-0.35	-6.1	1.1e-09	-0.21	0.99	0.00	FALSE
37	METSIM	Adipose	RP11-326C3.13	0.03	0.04	lasso	3	0.05	1.6e-07	-10.40	-10.1	3.4e-24	-0.30	0.85	0.00	FALSE
38	NTR	Blood	IFITM3	0.19	0.10	bslmm	303	0.12	9.4e-38	13.86	12.9	4.1e-38	0.36	1.00	0.00	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	IFITM3	0.10	0.06	lasso	5	0.08	1.1e-10	-12.56	12.2	3.2e-34	0.29	0.99	0.01	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	ATHL1	0.29	0.10	enet	21	0.14	5.0e-18	3.06	-9.8	1.4e-22	-0.45	1.00	0.00	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	RP11-326C3.7	0.07	0.06	lasso	2	0.04	2.9e-06	11.37	-11.3	8.6e-30	-0.20	0.98	0.00	FALSE
42	YFS	Blood	IFITM3	0.70	0.26	enet	78	0.43	2.0e-158	13.86	11.4	4.7e-30	0.32	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	IFITM3	0.10	0.10	lasso	3	0.11	1.6e-21	-12.56	13.3	2.1e-40	0.30	1.00	0.00	TRUE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	IFITM3	0.10	0.03	blup	57	0.02	1.8e-02	6.16	10.2	2.0e-24	0.19	0.03	0.04	FALSE
45	The Cancer Genome Atlas	Esophageal Carcinoma	IFITM3	0.15	0.07	lasso	4	0.09	1.0e-03	-3.17	6.1	1.1e-09	0.20	0.07	0.08	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IFITM3	0.04	0.02	blup	57	0.02	4.7e-03	-10.71	13.4	4.1e-41	0.50	0.01	0.59	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATHL1	0.05	0.02	blup	79	0.02	1.3e-03	1.78	-9.8	1.6e-22	-0.31	0.04	0.15	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	IFITM1	0.05	0.05	lasso	6	0.05	1.8e-06	-10.71	-12.8	1.3e-37	-0.39	0.90	0.05	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	IFITM3	0.06	0.01	blup	57	0.03	1.2e-04	11.37	11.6	5.6e-31	0.42	0.06	0.79	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATHL1	0.08	0.00	blup	80	0.04	6.0e-05	8.72	-8.5	2.7e-17	-0.24	0.05	0.07	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IFITM3	0.04	0.01	lasso	4	0.01	1.2e-02	11.37	11.3	1.2e-29	0.33	0.02	0.30	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	IFITM3	0.14	0.09	enet	21	0.12	1.7e-12	11.37	11.8	4.0e-32	0.33	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	IFITM3	0.08	0.01	enet	16	0.03	3.8e-04	5.99	11.9	1.5e-32	0.54	0.01	0.78	FALSE