TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
:
Blood White Count
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chr1:22,712,328-24,446,128
Best TWAS P=8.72e-11 · Best GWAS P=3.09e-16 conditioned to 3.71e-09
22.8M
23M
23.2M
23.4M
23.6M
23.8M
24M
24.2M
24.4M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Frontal Cortex BA9
TCEA3
0.35
0.24
lasso
6
0.25
2.5e-07
4.2
-6.5
8.7e-11
-0.45
0.08
0.78
TRUE
5
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
ASAP3
0.03
0.02
blup
49
0.01
7.9e-03
7.0
-6.0
1.7e-09
-0.69
0.01
0.70
FALSE
4
ROSMAP
Brain Pre-frontal Cortex
ASAP3
0.17
0.07
bslmm
307
0.09
5.7e-12
4.4
-5.8
8.9e-09
-0.36
1.00
0.00
FALSE
1
GTEx
Adipose Visceral Omentum
LUZP1
0.15
0.08
lasso
7
0.09
1.8e-05
-5.9
-5.6
2.1e-08
-0.25
0.28
0.03
FALSE
3
GTEx
Heart Left Ventricle
TCEA3
0.26
0.06
enet
30
0.18
5.6e-10
-4.8
-5.2
1.9e-07
-0.18
0.89
0.02
FALSE