Best TWAS P=8.72e-11 · Best GWAS P=3.09e-16 conditioned to 3.71e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | LUZP1 | 0.15 | 0.08 | lasso | 7 | 0.09 | 1.8e-05 | -5.9 | -5.6 | 2.1e-08 | -0.25 | 0.28 | 0.03 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | TCEA3 | 0.35 | 0.24 | lasso | 6 | 0.25 | 2.5e-07 | 4.2 | -6.5 | 8.7e-11 | -0.45 | 0.08 | 0.78 | TRUE |
| 3 | GTEx | Heart Left Ventricle | TCEA3 | 0.26 | 0.06 | enet | 30 | 0.18 | 5.6e-10 | -4.8 | -5.2 | 1.9e-07 | -0.18 | 0.89 | 0.02 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | ASAP3 | 0.17 | 0.07 | bslmm | 307 | 0.09 | 5.7e-12 | 4.4 | -5.8 | 8.9e-09 | -0.36 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ASAP3 | 0.03 | 0.02 | blup | 49 | 0.01 | 7.9e-03 | 7.0 | -6.0 | 1.7e-09 | -0.69 | 0.01 | 0.70 | FALSE |