Best TWAS P=6.21e-15 · Best GWAS P=4.19e-19 conditioned to 1.29e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PIK3CD | 0.23 | 0.19 | enet | 7 | 0.18 | 1.3e-21 | -4.1 | -5.4 | 7.4e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RERE | 0.20 | 0.23 | lasso | 2 | 0.24 | 1.7e-19 | -6.0 | -6.2 | 6.3e-10 | 0.22 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | RP5-1115A15.1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 7.0e-03 | -6.0 | -6.0 | 1.9e-09 | 0.27 | 0.63 | 0.03 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | RP5-1115A15.1 | 0.18 | 0.07 | lasso | 3 | 0.06 | 1.7e-02 | 3.6 | -5.7 | 1.4e-08 | 0.28 | 0.06 | 0.07 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RERE | 0.12 | 0.08 | lasso | 4 | 0.05 | 6.0e-05 | -6.2 | -5.9 | 3.1e-09 | 0.23 | 0.94 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Mucosa | RERE | 0.13 | 0.16 | lasso | 3 | 0.16 | 7.2e-11 | 5.5 | -5.5 | 3.0e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RP5-1115A15.1 | 0.06 | 0.06 | lasso | 4 | 0.05 | 3.0e-04 | 5.5 | -7.1 | 1.6e-12 | 0.16 | 0.14 | 0.66 | TRUE |
| 8 | GTEx | Lung | RERE | 0.07 | 0.05 | lasso | 4 | 0.05 | 2.0e-04 | 5.0 | -5.2 | 1.8e-07 | 0.09 | 0.87 | 0.03 | FALSE |
| 9 | GTEx | Lung | RP5-1115A15.1 | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.0e-05 | 5.2 | -5.2 | 2.5e-07 | 0.00 | 0.59 | 0.04 | FALSE |
| 10 | GTEx | Nerve Tibial | RERE | 0.12 | 0.09 | enet | 16 | 0.11 | 5.6e-08 | -6.5 | -5.2 | 2.3e-07 | 0.16 | 0.99 | 0.00 | FALSE |
| 11 | GTEx | Pancreas | RERE | 0.11 | 0.12 | lasso | 4 | 0.07 | 5.9e-04 | -6.3 | -7.2 | 7.1e-13 | 0.37 | 0.30 | 0.15 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | RP5-1115A15.1 | 0.08 | 0.04 | enet | 8 | 0.04 | 3.0e-03 | 5.5 | -5.5 | 3.6e-08 | 0.06 | 0.40 | 0.06 | TRUE |
| 13 | GTEx | Skin Sun Exposed Lower leg | RP5-1115A15.1 | 0.07 | 0.03 | enet | 13 | 0.03 | 1.5e-03 | 5.5 | -5.1 | 2.9e-07 | 0.13 | 0.38 | 0.38 | FALSE |
| 14 | GTEx | Thyroid | RP5-1115A15.1 | 0.09 | 0.12 | lasso | 2 | 0.09 | 1.5e-07 | 5.2 | -5.4 | 6.8e-08 | 0.02 | 0.98 | 0.01 | FALSE |
| 15 | GTEx | Whole Blood | RERE | 0.19 | 0.15 | lasso | 4 | 0.13 | 2.7e-12 | 5.5 | -5.7 | 1.1e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 16 | METSIM | Adipose | APITD1 | 0.04 | 0.05 | lasso | 3 | 0.03 | 5.1e-06 | -5.4 | -5.5 | 2.9e-08 | 0.02 | 0.04 | 0.96 | FALSE |
| 17 | METSIM | Adipose | RERE | 0.08 | 0.12 | lasso | 17 | 0.13 | 1.8e-19 | -5.9 | -7.1 | 1.4e-12 | 0.29 | 1.00 | 0.00 | FALSE |
| 18 | NTR | Blood | RBP7 | 0.02 | 0.02 | lasso | 2 | 0.02 | 4.7e-07 | -5.3 | 5.2 | 2.2e-07 | 0.00 | 0.96 | 0.01 | FALSE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | RERE | 0.15 | 0.15 | lasso | 7 | 0.15 | 1.5e-18 | -6.0 | -5.4 | 8.0e-08 | 0.18 | 1.00 | 0.00 | FALSE |
| 20 | YFS | Blood | ENO1 | 0.07 | 0.06 | lasso | 7 | 0.06 | 5.1e-19 | -7.4 | 7.8 | 6.2e-15 | -0.64 | 1.00 | 0.00 | TRUE |
| 21 | YFS | Blood | RBP7 | 0.08 | 0.09 | lasso | 8 | 0.09 | 5.0e-27 | -5.5 | 5.7 | 1.5e-08 | 0.02 | 0.99 | 0.01 | FALSE |
| 22 | YFS | Blood | RERE | 0.09 | 0.15 | lasso | 4 | 0.16 | 5.7e-49 | 5.3 | -5.4 | 7.0e-08 | 0.02 | 1.00 | 0.00 | FALSE |
| 23 | YFS | Blood | UBE4B | 0.03 | 0.01 | bslmm | 373 | 0.02 | 3.1e-06 | -6.1 | 6.1 | 1.4e-09 | 0.00 | 0.93 | 0.06 | TRUE |
| 24 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CORT | 0.04 | 0.05 | lasso | 6 | 0.04 | 1.7e-04 | -5.6 | 5.6 | 1.7e-08 | -0.05 | 0.01 | 0.98 | FALSE |
| 25 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C1orf200 | 0.13 | 0.00 | blup | 30 | 0.00 | 1.8e-01 | -6.9 | 5.2 | 2.1e-07 | 0.05 | 0.00 | 0.43 | FALSE |
| 26 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | APITD1 | 0.05 | 0.02 | blup | 51 | 0.05 | 3.1e-06 | -5.7 | -6.0 | 2.4e-09 | 0.00 | 0.01 | 0.98 | FALSE |
| 27 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PIK3CD | 0.06 | 0.00 | enet | 5 | 0.02 | 2.4e-02 | -5.9 | -6.5 | 6.0e-11 | -0.03 | 0.01 | 0.52 | TRUE |
| 28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | APITD1 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | -5.4 | -5.5 | 3.6e-08 | 0.02 | 0.01 | 0.95 | FALSE |
| 29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CORT | 0.12 | 0.07 | lasso | 6 | 0.06 | 9.3e-05 | -5.6 | 5.7 | 1.5e-08 | -0.04 | 0.01 | 0.99 | FALSE |
| 30 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RERE | 0.22 | 0.04 | lasso | 10 | 0.08 | 4.1e-04 | 5.5 | -5.1 | 3.0e-07 | 0.05 | 0.34 | 0.04 | FALSE |
| 31 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CORT | 0.06 | 0.03 | enet | 5 | 0.04 | 7.1e-04 | -5.7 | 6.6 | 4.7e-11 | -0.01 | 0.01 | 0.96 | TRUE |
| 32 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RERE | 0.12 | 0.01 | enet | 10 | 0.03 | 4.6e-02 | 4.6 | -5.4 | 7.8e-08 | 0.07 | 0.07 | 0.13 | FALSE |