Best TWAS P=7.48e-15 · Best GWAS P=2.23e-14 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | PIGV | 0.05 | 0.00 | enet | 10 | 0.03 | 4.3e-03 | -4.8 | 5.3 | 9.1e-08 | -0.03 | 0.71 | 0.01 | FALSE |
2 | GTEx | Esophagus Muscularis | THEMIS2 | 0.10 | 0.02 | lasso | 4 | 0.03 | 7.1e-03 | 4.9 | 6.5 | 7.0e-11 | -0.85 | 0.02 | 0.94 | FALSE |
3 | GTEx | Testis | NUDC | 0.10 | 0.01 | enet | 16 | 0.06 | 1.4e-03 | 3.1 | -6.3 | 3.9e-10 | 0.03 | 0.06 | 0.10 | TRUE |
4 | GTEx | Whole Blood | RPA2 | 0.16 | 0.10 | enet | 13 | 0.08 | 1.2e-07 | -3.8 | -5.3 | 1.3e-07 | 0.83 | 0.20 | 0.80 | FALSE |
5 | METSIM | Adipose | THEMIS2 | 0.08 | 0.02 | blup | 210 | 0.04 | 1.8e-06 | 4.9 | 6.7 | 2.0e-11 | -0.74 | 0.07 | 0.93 | FALSE |
6 | NTR | Blood | C1orf38 | 0.08 | 0.06 | enet | 11 | 0.07 | 2.1e-21 | 4.9 | 6.6 | 4.0e-11 | -0.79 | 0.99 | 0.01 | FALSE |
7 | NTR | Blood | RPA2 | 0.09 | 0.09 | lasso | 4 | 0.09 | 9.0e-27 | -7.5 | 7.5 | 6.8e-14 | -0.99 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C1orf38 | 0.05 | 0.03 | lasso | 5 | 0.04 | 4.5e-08 | 3.3 | 5.9 | 4.7e-09 | -0.63 | 0.12 | 0.87 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C1orf38 | 0.03 | 0.01 | blup | 35 | 0.02 | 1.7e-03 | -7.5 | 7.8 | 7.5e-15 | -0.98 | 0.02 | 0.97 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C1orf38 | 0.04 | 0.02 | blup | 35 | 0.03 | 4.2e-04 | 4.9 | 5.4 | 6.9e-08 | -0.74 | 0.06 | 0.43 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPA2 | 0.07 | 0.07 | enet | 8 | 0.07 | 4.2e-08 | -4.5 | -5.2 | 2.5e-07 | 0.78 | 0.35 | 0.65 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1orf38 | 0.04 | 0.02 | blup | 35 | 0.03 | 1.0e-04 | -7.5 | 6.9 | 7.0e-12 | -0.87 | 0.02 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RPA2 | 0.11 | 0.03 | blup | 46 | 0.07 | 1.3e-03 | -3.7 | -6.2 | 6.1e-10 | 0.80 | 0.01 | 0.63 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | RPA2 | 0.16 | 0.15 | lasso | 3 | 0.15 | 2.1e-14 | -4.8 | -5.2 | 2.6e-07 | 0.74 | 0.99 | 0.01 | FALSE |