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chr11:119,496,472-121,057,430

Best TWAS P=5.99e-13 · Best GWAS P=4.24e-13 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM136	0.05	0.06	enet	7	0.06	1.8e-07	7.1	7.2	6.0e-13	0.99	0.01	0.99	TRUE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARHGEF12	0.01	0.02	lasso	1	0.01	6.6e-04	7.1	-7.1	1.1e-12	-0.93	0.02	0.88	FALSE
3	GTEx	Artery Tibial	TMEM136	0.09	0.02	lasso	2	0.01	2.2e-02	7.2	6.9	3.8e-12	0.99	0.02	0.97	FALSE
9	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM136	0.03	0.03	enet	8	0.02	3.5e-03	7.1	6.6	4.8e-11	0.91	0.01	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM136	0.04	0.03	lasso	2	0.02	2.4e-03	7.2	6.5	7.9e-11	0.98	0.02	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ARHGEF12	0.05	0.04	lasso	2	0.04	5.9e-06	-4.6	-5.8	7.1e-09	-0.86	0.04	0.96	FALSE
5	GTEx	Skin Not Sun Exposed Suprapubic	TMEM136	0.25	0.04	enet	19	0.09	1.3e-05	7.1	5.6	1.7e-08	0.74	0.03	0.95	FALSE
4	GTEx	Nerve Tibial	TMEM136	0.23	0.19	lasso	6	0.23	1.4e-16	7.2	5.6	2.5e-08	0.91	0.02	0.98	FALSE
8	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM136	0.14	0.00	blup	45	0.10	2.2e-04	7.2	5.5	3.9e-08	0.71	0.01	0.68	FALSE