Best TWAS P=4.4e-13 · Best GWAS P=6.55e-15 conditioned to 7.5e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MPZL2 | 0.05 | 0.02 | lasso | 4 | 0.03 | 3.1e-04 | -7.4 | -6.0 | 1.5e-09 | 0.83 | 0.02 | 0.88 | FALSE |
| 2 | GTEx | Adrenal Gland | AMICA1 | 0.32 | 0.14 | lasso | 8 | 0.16 | 2.0e-06 | -4.1 | 6.0 | 2.3e-09 | -0.79 | 0.06 | 0.92 | TRUE |
| 3 | GTEx | Artery Tibial | AMICA1 | 0.10 | 0.01 | enet | 15 | 0.02 | 8.3e-03 | -7.4 | 6.2 | 7.8e-10 | -0.81 | 0.01 | 0.97 | FALSE |
| 4 | GTEx | Nerve Tibial | AMICA1 | 0.19 | 0.14 | lasso | 7 | 0.16 | 2.5e-11 | -7.4 | 7.0 | 1.9e-12 | -0.95 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | MPZL2 | 0.08 | 0.05 | lasso | 3 | 0.06 | 1.4e-05 | -6.3 | -6.5 | 7.2e-11 | 0.87 | 0.06 | 0.92 | FALSE |
| 6 | GTEx | Thyroid | MPZL3 | 0.18 | 0.16 | lasso | 5 | 0.16 | 3.7e-12 | -7.0 | 6.4 | 2.0e-10 | -0.91 | 0.02 | 0.98 | TRUE |
| 7 | METSIM | Adipose | AMICA1 | 0.04 | 0.00 | blup | 559 | 0.02 | 4.2e-04 | 1.1 | 5.5 | 5.0e-08 | -0.71 | 0.01 | 0.96 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | PHLDB1 | 0.05 | 0.00 | bslmm | 279 | 0.01 | 3.0e-02 | 2.2 | 5.5 | 4.3e-08 | -0.33 | 0.03 | 0.06 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AMICA1 | 0.04 | 0.03 | blup | 88 | 0.05 | 4.6e-10 | -3.5 | 5.9 | 3.8e-09 | -0.85 | 0.12 | 0.88 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MPZL3 | 0.02 | 0.02 | blup | 71 | 0.01 | 5.7e-04 | -6.3 | 6.6 | 3.1e-11 | -0.87 | 0.08 | 0.74 | FALSE |
| 11 | The Cancer Genome Atlas | Glioblastoma Multiforme | MPZL2 | 0.12 | 0.04 | enet | 14 | 0.06 | 5.9e-03 | -7.0 | -6.4 | 1.7e-10 | 0.83 | 0.02 | 0.66 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AMICA1 | 0.10 | 0.09 | blup | 89 | 0.12 | 1.6e-13 | 3.3 | 5.8 | 8.4e-09 | -0.85 | 0.39 | 0.61 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AMICA1 | 0.09 | 0.03 | blup | 89 | 0.07 | 5.3e-05 | -4.7 | 5.7 | 1.6e-08 | -0.84 | 0.29 | 0.40 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | MPZL3 | 0.06 | 0.01 | enet | 9 | 0.02 | 1.2e-03 | -4.7 | 5.3 | 1.1e-07 | -0.69 | 0.08 | 0.67 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AMICA1 | 0.07 | 0.02 | blup | 89 | 0.05 | 3.7e-04 | -3.5 | 5.7 | 9.8e-09 | -0.81 | 0.06 | 0.92 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MPZL3 | 0.08 | 0.08 | blup | 71 | 0.07 | 1.5e-07 | -7.0 | 7.2 | 4.4e-13 | -0.88 | 0.24 | 0.76 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | MPZL3 | 0.06 | 0.07 | blup | 72 | 0.05 | 6.2e-06 | -7.0 | 6.9 | 5.5e-12 | -0.90 | 0.03 | 0.97 | FALSE |