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chr11:117,368,982-119,218,648

Best TWAS P=4.4e-13 · Best GWAS P=6.55e-15 conditioned to 7.5e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	MPZL3	0.08	0.08	blup	71	0.07	1.5e-07	-7.0	7.2	4.4e-13	-0.88	0.24	0.76	TRUE
6	GTEx	Thyroid	MPZL3	0.18	0.16	lasso	5	0.16	3.7e-12	-7.0	6.4	2.0e-10	-0.91	0.02	0.98	TRUE
2	GTEx	Adrenal Gland	AMICA1	0.32	0.14	lasso	8	0.16	2.0e-06	-4.1	6.0	2.3e-09	-0.79	0.06	0.92	TRUE
8	ROSMAP	Brain Pre-frontal Cortex	PHLDB1	0.05	0.00	bslmm	279	0.01	3.0e-02	2.2	5.5	4.3e-08	-0.33	0.03	0.06	TRUE
4	GTEx	Nerve Tibial	AMICA1	0.19	0.14	lasso	7	0.16	2.5e-11	-7.4	7.0	1.9e-12	-0.95	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	MPZL3	0.06	0.07	blup	72	0.05	6.2e-06	-7.0	6.9	5.5e-12	-0.90	0.03	0.97	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	MPZL3	0.02	0.02	blup	71	0.01	5.7e-04	-6.3	6.6	3.1e-11	-0.87	0.08	0.74	FALSE
5	GTEx	Skin Sun Exposed Lower leg	MPZL2	0.08	0.05	lasso	3	0.06	1.4e-05	-6.3	-6.5	7.2e-11	0.87	0.06	0.92	FALSE
11	The Cancer Genome Atlas	Glioblastoma Multiforme	MPZL2	0.12	0.04	enet	14	0.06	5.9e-03	-7.0	-6.4	1.7e-10	0.83	0.02	0.66	FALSE
3	GTEx	Artery Tibial	AMICA1	0.10	0.01	enet	15	0.02	8.3e-03	-7.4	6.2	7.8e-10	-0.81	0.01	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MPZL2	0.05	0.02	lasso	4	0.03	3.1e-04	-7.4	-6.0	1.5e-09	0.83	0.02	0.88	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMICA1	0.04	0.03	blup	88	0.05	4.6e-10	-3.5	5.9	3.8e-09	-0.85	0.12	0.88	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AMICA1	0.10	0.09	blup	89	0.12	1.6e-13	3.3	5.8	8.4e-09	-0.85	0.39	0.61	FALSE
15	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AMICA1	0.07	0.02	blup	89	0.05	3.7e-04	-3.5	5.7	9.8e-09	-0.81	0.06	0.92	FALSE
13	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AMICA1	0.09	0.03	blup	89	0.07	5.3e-05	-4.7	5.7	1.6e-08	-0.84	0.29	0.40	FALSE
7	METSIM	Adipose	AMICA1	0.04	0.00	blup	559	0.02	4.2e-04	1.1	5.5	5.0e-08	-0.71	0.01	0.96	FALSE
14	The Cancer Genome Atlas	Lung Adenocarcinoma	MPZL3	0.06	0.01	enet	9	0.02	1.2e-03	-4.7	5.3	1.1e-07	-0.69	0.08	0.67	FALSE