Hub : Genes

ARHGEF12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0480	0.0170	0.00069	0.042	0.026	0.038	0.032	0.043	6.8e-06	0.00035	1.7e-05	8.4e-05	5.9e-06
2	GTEx	Brain Caudate basal ganglia	0.4150	0.1410	0.00610	-0.004	NA	0.002	NA	-0.008	4.2e-01	NA	2.8e-01	NA	6.3e-01
3	GTEx	Brain Nucleus accumbens basal ganglia	0.5860	0.1410	0.00200	0.081	NA	0.051	NA	0.045	3.5e-03	NA	1.7e-02	NA	2.4e-02
4	TCGA	Breast Invasive Carcinoma	0.0123	0.0077	0.00520	0.017	0.008	0.004	NA	0.014	1.8e-04	0.00780	4.1e-02	NA	6.6e-04
5	TCGA	Colon Adenocarcinoma	0.0770	0.0400	0.00037	0.052	0.058	0.024	NA	0.048	5.5e-04	0.00029	1.4e-02	NA	9.6e-04
6	TCGA	Pheochromocytoma and Paraganglioma	0.1440	0.0900	0.00810	-0.006	0.025	0.017	NA	-0.005	7.2e-01	0.03600	6.5e-02	NA	5.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.7	1.3	-0.7	-1.1	-1.1	-0.9	0.6	-0.2
Bipolar Disorder or Schizophrenia	0.6	1.5	3.5	-1.2	0.3	1.9	-1.4	-0.2	-1.4
Depressed Affect (Nagel 2018)	0.9	1.9	3.8	-1.6	-0.6	-0.9	-2.0	1.7	0.8
Depression (Nagel 2018)	1.9	2.9	6.7	-2.4	-0.9	-0.8	-2.6	1.8	0.4
Intelligence (Savage-Jansen 2018)	1.8	5.5	10.4	1.8	-0.2	-1.8	3.0	-3.2	-2.6
Neuroticism (Nagel 2018)	0.4	1.0	4.6	-0.2	-0.7	-2.1	-0.8	0.4	-0.3
Schizophrenia (2018)	1.3	2.8	10.6	-0.9	1.3	3.3	-1.0	-0.7	-1.4
Schizophrenia vs Biploar Disorder	1.0	1.4	5.9	0.4	1.2	2.4	0.8	-0.2	0.0
Worry (Nagel 2018)	0.3	0.7	3.7	0.1	-0.4	-1.9	-0.2	0.0	-0.6
Alzheimer’s Disease (in mother)	0.9	1.1	3.0	-0.5	-1.6	-1.7	-0.1	-0.7	-0.4
Alzheimer’s Disease (in father)	1.1	1.2	2.2	-1.0	-1.5	-0.9	-1.1	0.6	1.2
Alzheimer’s Disease (including proxy)	1.7	2.4	6.7	-1.0	-2.6	-1.6	-1.4	0.8	1.4
Crohns Disease (2017)	0.7	1.6	3.0	1.6	-0.6	-1.3	1.2	-1.7	-0.8
Irritable Bowel Disease (IBD)	1.8	4.3	10.9	1.8	-0.2	-0.0	2.2	-3.3	-2.7
Ulcerative Colitis (UC)	2.3	4.4	10.9	1.3	-0.2	0.6	2.1	-3.3	-3.0
Major Depression (MDD)	0.2	0.2	0.5	-0.1	-0.4	0.7	-0.4	0.3	-0.7
Reaction Time	2.9	5.5	9.1	1.4	0.7	-3.0	2.1	-3.0	-2.9
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.3	0.7	-0.8	-0.7	1.7	-1.8	-1.8
Breast Cancer	2.1	5.1	11.8	3.0	1.2	-0.4	3.4	-2.4	-1.5
Ovarian Cancer	1.7	2.3	5.9	2.4	0.3	-0.4	2.4	-1.4	-0.3
Prostate Cancer	1.2	1.6	3.6	1.1	0.6	0.1	1.2	-1.9	-1.8
Age at First Birth	0.4	0.5	1.1	0.9	0.3	-1.1	1.0	0.1	0.4
Bipolar Disorder (2011)	1.3	1.2	2.9	-1.4	-1.0	0.6	-1.7	0.8	0.6
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	1.5	0.6	1.2	0.7	-0.3	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	1.3	1.1	-0.7	-0.9	1.0	0.3	1.2
Crohns Disease (2012)	1.4	2.3	5.2	2.3	0.3	-0.8	2.0	-1.7	-0.9
Mean Putamen Volume	0.4	0.5	0.8	-0.0	-0.5	0.9	0.3	-0.9	-0.9
Fasting Glucose	0.2	0.2	0.6	-0.4	0.3	-0.8	-0.6	0.0	-0.0
HbA1C	0.9	1.0	3.5	-1.2	-0.5	-0.1	-1.9	0.6	0.3
HDL Cholesterol	0.6	0.9	3.4	-0.1	0.6	-0.3	0.3	-1.3	-1.9
LDL Cholesterol	0.4	0.6	1.1	0.8	-1.0	0.7	1.0	-0.2	-0.6
Lupus	1.1	1.6	6.1	-0.6	-0.2	-0.2	-0.4	-1.7	-2.5
Neuroticism (2016)	0.3	0.4	1.3	-0.1	0.6	-0.2	0.2	-0.8	-1.1
Primary Biliary Cirrhosis	0.3	0.5	1.1	0.7	-0.4	-0.3	0.2	-1.0	-1.0
Rheumatoid Arthritis	1.8	2.5	6.8	-0.8	-1.5	0.2	-0.4	-2.6	-2.2
Schizophrenia (2014)	0.8	1.7	5.3	-1.3	-0.1	2.3	-1.6	0.8	-0.4
Triglycerides	0.7	1.1	2.6	-1.1	-1.0	0.5	-1.0	1.6	0.9
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.9	-0.8	-2.0	0.7	-1.2	1.1	0.4
Ulcerative Colitis	4.3	6.3	16.0	1.4	0.4	1.5	2.3	-3.4	-4.0
Blood Eosinophil Count	0.6	5.0	9.8	-2.3	-1.5	0.9	-3.1	2.6	2.2
Blood Platelet Count	2.9	33.4	81.5	-7.3	-5.7	1.4	-9.0	4.6	3.2
Blood Red Count	0.2	1.6	5.2	-1.7	-0.2	1.2	-2.3	0.4	0.1
Blood White Count	3.0	22.2	50.7	-5.8	-3.9	0.7	-7.1	4.2	4.1
Heel T-Score	1.8	14.1	36.6	2.4	-0.5	1.1	2.4	-6.0	-6.0
BMI	0.8	4.5	16.2	1.7	-1.4	-1.2	-0.1	2.1	4.0
Height	0.2	3.8	12.0	-0.4	1.8	-0.1	3.5	2.2	1.5
Waist Hip Ratio (WHR)	0.3	1.5	3.7	-1.9	-0.8	0.9	-1.4	1.4	0.1
Systolic Blood Pressure	1.6	7.8	15.1	-1.3	-3.3	2.4	-3.9	2.5	2.6
Smoking Status	3.7	9.0	19.3	-4.4	-1.7	0.7	-3.5	3.6	2.4
Allergy or Eczema	0.7	1.9	5.5	2.3	0.1	-0.2	1.7	-1.5	-0.7
Cardiovascular Disease	1.8	6.0	9.3	-1.9	-2.8	2.3	-3.0	2.2	2.2
Hypothyroidism (self reported)	2.7	6.1	9.0	-2.0	-3.0	-0.5	-3.0	2.8	2.6
Respiratory disease	0.2	0.3	1.1	0.4	-0.3	-0.3	0.0	0.7	1.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	6.3	0.2	0.3	0.1	-0.5	1.8	2.5
Lung FEV1/FVC ratio	1.8	9.3	15.1	3.5	3.9	0.8	2.8	-3.4	-3.0
Lung FVC	0.4	1.9	6.0	0.4	-1.3	-0.3	0.8	-1.6	-2.5
Neuroticism	0.7	1.7	3.2	-1.4	-1.4	-1.7	-1.8	0.8	-0.0
Chronotype (morning person)	1.5	3.5	10.3	1.5	-1.2	-0.2	1.5	-3.2	-2.3
Hair Pigment	0.1	1.4	3.0	-1.7	-0.6	-1.1	-1.1	1.2	1.1
Tanning	0.2	2.7	8.5	-0.2	1.1	1.2	0.3	-2.2	-2.9
Hand grip strength (left)	0.3	0.9	2.8	0.0	0.6	-0.1	0.4	1.5	1.7
Number of treatments/medications taken	4.3	7.8	15.4	-3.0	-2.6	1.9	-3.9	2.9	1.9
Average weekly spirits intake	0.7	0.9	1.7	-1.2	-0.4	0.2	-0.8	-1.1	-1.3
Sensitivity / hurt feelings	0.7	1.1	2.6	-1.6	0.6	-0.9	-1.5	0.2	-0.9
Frequency of depressed mood in last 2 weeks	2.1	2.9	4.6	-1.9	-0.9	-1.4	-2.1	2.1	1.3
Hearing difficulty/problems: Yes	1.1	1.7	2.7	-1.1	-1.7	-0.5	-1.1	1.5	1.6
Relative age of first facial hair	0.7	1.5	2.8	-1.2	-1.1	1.7	-1.2	1.0	0.8
Other serious medical condition/disability diagnosed by doctor	2.0	2.5	3.7	-1.8	-1.5	-1.1	-1.9	1.9	1.0
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.1	-1.6	-1.8	0.1	-1.4	1.4	0.7
Ever had hysterectomy (womb removed)	0.2	0.3	0.9	-0.2	0.2	0.9	0.1	0.5	0.6
Systolic blood pressure, automated reading	1.8	5.2	9.1	-0.8	-1.7	2.5	-3.0	2.2	2.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.5	1.9	-0.6	-0.1	1.2	-0.2	0.4
Angina	7.5	9.9	19.5	-2.0	-2.0	0.8	-3.9	4.4	4.0
Medication for hormone replacement therapy	1.4	1.6	5.1	-1.0	-1.2	-2.3	-1.0	-0.0	-0.9
Vitamin and mineral supplements	0.7	1.0	2.8	1.7	0.1	-0.5	0.7	-1.5	-0.2
Supplements: Zinc	0.8	0.9	2.4	-0.9	-1.5	-1.0	-0.7	0.8	-0.1
Medication: Co-codamol	0.8	1.0	2.9	-0.9	-0.8	0.3	-1.7	0.7	0.9
Medication: Metformin	2.0	2.8	9.7	0.2	-0.8	-0.1	-0.7	2.4	3.1
Diabetes (father)	0.5	0.7	1.1	0.9	0.7	-1.1	0.7	-0.8	-0.6
Diabetes (mother)	1.3	1.7	5.0	2.2	1.6	-0.1	0.9	-0.7	1.0
Severe depression (siblings)	3.2	3.6	8.2	-2.9	-2.3	-0.3	-2.5	1.1	0.5
Pack years adult smoking proportion	2.1	3.2	4.9	-1.9	-0.6	2.1	-2.2	1.9	1.6
Impedance of leg (right)	1.0	5.0	10.6	-1.0	1.2	3.3	-0.6	-2.6	-3.1
Leg fat-free mass (left)	0.9	5.0	12.4	1.3	0.5	-2.2	1.8	2.8	3.5
Trunk fat percentage	0.7	3.0	10.3	2.2	-0.0	-0.5	1.1	0.9	3.2
Hand grip strength (right)	0.4	1.1	3.0	0.6	1.7	-0.4	1.7	0.2	0.4
Townsend deprivation index at recruitment	2.3	3.2	7.1	-2.7	-2.1	-1.3	-1.9	1.5	0.2
Current tobacco smoking	2.6	4.2	11.6	-3.4	-2.1	0.5	-2.4	1.7	0.7
Average weekly fortified wine intake	0.5	0.5	1.3	-1.1	0.7	-0.2	-0.7	-0.1	-1.0
Maternal smoking around birth	0.2	0.2	0.7	0.8	0.1	-0.1	0.8	0.3	-0.2
Fed-up feelings	0.6	1.1	2.4	-0.9	-0.8	-0.6	-1.1	1.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	6.3	-2.5	-0.1	-0.3	-1.9	2.0	0.7
Relative age voice broke	0.4	0.5	1.9	0.0	-0.1	0.9	-0.1	0.6	1.4
Taking other prescription medications	1.2	1.8	4.3	-1.4	-0.9	0.1	-2.1	1.6	0.9
Age when periods started (menarche)	0.6	1.5	3.7	-1.8	1.9	1.0	-1.0	-0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	3.3	-1.2	-1.7	0.9	-1.1	1.8	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.2	1.4	-1.0	-0.1	0.6	-2.0	-1.1
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	2.2	-0.7	-1.1	0.6	-1.2	1.5	1.5
Qualifications: CSEs or equivalent	0.6	0.8	2.5	-1.6	-0.6	-0.1	-1.3	0.5	0.1
Serious illness, injury or assault to yourself	2.9	3.5	7.8	-2.1	-0.5	0.9	-2.0	2.8	2.0
High blood pressure	2.9	8.0	13.5	-2.6	-3.3	1.7	-3.7	2.9	2.3
Hayfever, allergic rhinitis or eczema	2.3	4.9	12.7	3.6	0.5	-0.2	2.8	-2.6	-1.5
Multivitamins +/- minerals	0.2	0.3	0.5	-0.6	0.7	0.2	-0.2	0.7	-0.3
Stomach or abdominal pain in last month	0.2	0.2	0.4	0.0	0.6	-0.7	-0.2	0.5	0.5
Supplements: Glucosamine	0.6	0.8	2.0	-0.3	-1.4	1.2	-0.4	-0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	0.4	0.1	-0.9	0.0	0.9	1.0
Medication: Atenolol	1.5	1.9	7.9	0.1	0.1	0.3	-0.6	1.7	2.8
Medication: Levothyroxine sodium	2.7	4.6	8.5	-1.6	-2.9	-0.0	-2.3	2.4	2.4
Sitting height	0.3	2.2	6.8	-0.6	0.2	-0.5	1.1	2.6	2.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.2	-1.0	1.0	0.5	-0.9	0.7	1.1
High blood pressure (mother)	1.7	2.4	5.2	-1.1	-1.3	-0.8	-1.7	2.3	1.7
Body mass index (BMI)	1.1	4.9	17.9	1.5	-1.1	-1.6	-0.2	2.3	4.2
Impedance of leg (left)	1.0	4.8	10.0	-1.0	1.1	3.2	-0.5	-2.7	-3.0
Leg predicted mass (left)	0.9	5.0	12.2	1.3	0.5	-2.2	1.9	2.7	3.5
Trunk fat mass	0.9	3.8	13.8	1.9	-0.0	-0.9	1.1	1.8	3.7
Waist circumference	1.2	4.3	16.3	1.2	0.0	-0.8	0.3	2.7	4.0
Number of incorrect matches in round	0.8	1.4	2.9	-0.7	-0.8	0.4	-1.4	1.7	1.5
Past tobacco smoking	1.1	2.0	4.3	1.9	0.0	-0.2	1.7	-2.1	-1.0
Alcohol usually taken with meals	6.4	10.3	21.7	4.7	1.7	-0.7	4.2	-3.6	-2.5
Nervous feelings	0.5	0.9	3.0	1.2	-0.5	-1.7	0.2	-0.7	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.9	-0.9	0.6	-1.7	-0.4	0.3	-0.3
Hearing difficulty/problems with background noise	1.2	2.0	6.3	-0.8	-2.5	-0.2	-0.9	1.5	1.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.2	-0.6	-0.1	-0.1	1.1	0.9
Had menopause	0.3	0.4	1.3	0.4	-0.1	-0.9	1.1	-0.3	-0.3
Had other major operations	0.6	0.7	2.9	-0.4	0.8	-1.7	0.2	0.5	0.4
Forced vital capacity (FVC)	0.6	2.3	4.9	-0.2	-1.4	-1.5	1.7	-1.2	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.8	1.7	-0.7	0.1	0.8	-2.4	-1.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.3	0.2	0.4	0.1	-0.4	-0.3	-1.1
Qualifications: None of the above	0.3	0.7	1.4	-1.2	-0.7	-0.2	-1.1	-0.3	-0.9
Financial difficulties in last 2 years	1.9	2.5	7.2	-0.7	0.5	-1.0	-0.6	2.4	2.7
Mouth/teeth dental problems	0.5	0.8	2.1	1.4	0.8	0.1	1.4	-0.1	0.4
Heart attack	3.8	4.9	8.8	-1.8	-1.7	1.5	-3.0	2.6	2.3
Allergy	2.5	5.8	13.0	-3.6	-0.9	1.7	-3.4	2.4	1.0
Pain all over the body in last month	1.4	1.4	3.6	-1.1	-0.9	-1.6	-1.9	0.3	-0.6
Diabetes (self-reported)	1.1	1.7	5.0	-0.2	-0.9	-0.0	-0.7	1.9	2.2
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	6.7	1.8	0.2	-0.0	1.7	-2.6	-1.7
Medication: Ramipril	5.0	6.4	11.5	-2.4	-2.7	2.0	-3.4	2.5	1.9
Medication: Simvastatin	1.9	2.7	5.2	-1.2	-0.8	1.2	-1.9	2.3	1.9
Fluid intelligence score	1.0	2.2	4.5	1.4	-0.3	-0.4	2.1	-2.0	-1.5
Illnesses of siblings	1.2	1.6	4.0	1.3	2.0	0.1	1.7	-0.9	-0.6
Neuroticism score	0.5	1.0	3.5	-0.9	-0.4	-1.9	-1.1	0.4	-0.3
Weight	1.1	5.2	18.0	1.3	-0.3	-1.5	1.1	2.8	4.2
Impedance of arm (right)	0.7	3.2	6.4	1.1	0.7	1.1	2.0	-2.5	-2.5
Arm fat percentage (right)	1.0	3.9	15.0	2.0	-0.3	-1.1	0.4	1.8	3.9
Trunk fat-free mass	0.4	2.4	5.8	0.0	0.6	-1.2	1.2	2.4	2.2
Hip circumference	1.1	4.8	17.4	2.2	0.5	-0.9	1.1	2.1	4.2
Time employed in main current job	0.8	0.9	3.3	-0.3	1.4	1.8	-0.3	-0.0	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	1.2	0.2	-1.1	0.2	-0.3	0.7	0.8
Father’s age at death	0.9	1.2	3.3	0.4	1.6	-1.8	1.0	-0.0	-0.6
Worrier / anxious feelings	0.4	0.8	3.7	0.5	0.1	-1.9	0.7	0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	7.5	-1.5	-2.7	-2.1	-1.6	2.3	1.1
Falls in the last year	0.4	0.5	0.9	0.9	0.7	-0.3	0.9	-0.7	-0.6
Hair/balding pattern: Pattern 3	1.2	1.7	2.4	1.4	1.4	0.6	1.3	-1.6	-1.5
Number of live births	0.7	1.0	2.2	-0.8	1.1	0.3	-0.7	1.5	1.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	8.6	1.0	0.3	-0.5	2.2	-2.3	-2.9
Pulse rate	1.5	2.6	5.4	-0.5	-0.5	1.8	-1.4	2.0	2.3
Happiness	1.0	1.2	3.5	-1.3	0.2	-0.1	-0.7	1.9	1.1
Noisy workplace	2.7	3.3	5.2	-1.8	-2.3	1.2	-2.0	2.0	1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.2	1.2	0.8	-0.4	1.5	-1.1	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.4	1.0	0.3	-1.2	0.8	0.3	1.0
Mouth/teeth dental problems: Dentures	0.9	1.5	2.4	-1.2	-1.0	1.2	-1.6	1.3	1.0
Asthma	0.4	0.7	2.1	1.2	0.2	-0.3	0.6	0.6	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.3	-2.0	-0.1	0.4	-2.1	1.7	0.9
Medication: Cholesterol lowering	1.9	3.0	6.3	-1.2	-1.5	0.4	-2.5	2.1	1.8
Depression (self-reported)	1.1	1.3	6.7	-0.3	-0.4	-2.6	-0.4	-0.0	-0.6
Medication: Lansoprazole	2.4	2.8	4.7	-1.8	-1.6	-1.1	-2.2	1.5	1.5
Prospective memory result	0.9	1.1	1.6	-1.2	-1.3	1.1	-1.3	0.6	0.8
Lung cancer (father)	0.6	0.7	1.9	-0.3	1.4	1.2	-0.5	0.7	0.6
Illnesses of mother	0.3	0.4	0.9	0.4	1.0	-0.1	0.6	0.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	6.3	1.2	1.1	-0.8	2.5	-2.1	-2.5
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.4	-0.7	-0.2	-0.1	0.7	1.0
Impedance of arm (left)	0.9	4.3	8.5	1.5	1.4	0.9	2.3	-2.9	-2.7
Arm fat mass (right)	1.1	4.7	18.3	1.6	-0.3	-1.1	0.5	2.4	4.3
Trunk predicted mass	0.4	2.3	5.4	0.1	0.6	-1.3	1.3	2.3	2.1
Standing height	0.2	2.4	8.9	-0.2	1.9	0.5	3.0	1.3	0.3
Length of working week for main job	1.2	1.3	3.6	1.9	1.1	-0.1	1.3	0.3	1.1
Exposure to tobacco smoke at home	0.7	0.8	4.2	0.3	0.2	-2.0	0.4	0.2	0.5
Breastfed as a baby	9.0	11.2	19.8	3.0	2.3	-1.1	3.9	-4.5	-4.1
Tense / ‘highly strung’	1.1	1.9	7.5	-1.0	-1.1	-2.7	-0.5	-0.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	8.1	-0.9	-0.2	-2.8	-0.5	0.8	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	-0.1	-0.8	0.2	0.1	-0.9	-0.2
Birth weight of first child	1.2	2.2	4.7	-0.2	1.9	1.4	1.2	-1.3	-2.2
Peak expiratory flow (PEF)	1.0	2.3	4.2	2.1	-0.2	-1.6	1.6	-1.5	-1.4
Pulse wave reflection index	0.4	0.5	1.2	-0.3	-0.6	-0.5	-0.1	-0.9	-1.1
Ever highly irritable/argumentative for 2 days	0.5	0.7	2.2	0.4	-0.0	0.1	-0.5	1.2	1.5
Loud music exposure frequency	0.2	0.2	0.9	-0.4	0.3	1.0	-0.4	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.4	1.1	0.9	-0.4	1.5	-1.0	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	-0.2	0.9	-0.0	0.0	-1.0	-1.3
Blood clot in the leg (DVT)	1.7	2.1	8.2	1.1	0.3	-2.9	1.7	-0.5	-0.1
Medication: Paracetamol	0.7	1.2	2.7	-1.2	-0.5	1.7	-1.4	0.4	-0.6
Headache pain in last month	1.8	3.1	7.6	-1.6	-0.7	-0.7	-1.9	2.8	2.0
Medication for cholesterol, blood pressure or diabetes	3.2	5.3	9.8	2.1	2.4	-0.6	3.1	-2.6	-2.2
Glaucoma (self-reported)	8.7	10.2	18.7	-3.4	-3.1	1.2	-4.3	3.6	2.7
Gout (self-reported)	0.3	0.4	1.5	1.2	-0.3	0.1	0.4	0.7	0.4
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	8.4	-1.5	-2.9	-0.4	-2.6	2.6	2.4
Medication: Amlodipine	3.0	4.2	8.0	-2.0	-2.8	1.8	-2.6	1.5	0.8
Medication: Ventolin 100micrograms inhaler	1.8	2.3	9.1	1.0	3.0	-1.4	1.1	-0.7	-0.3
Birth weight	0.4	1.0	3.3	1.2	0.9	0.1	1.8	0.0	0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.9	-0.5	-1.4	-0.1	-0.9	0.1	0.3
High blood pressure (siblings)	1.5	2.2	4.8	-1.3	-2.0	0.9	-2.2	1.0	0.6
Forced vital capacity (FVC), Best measure	0.6	2.3	5.8	0.3	0.2	-1.2	2.4	-1.4	-2.1
Body fat percentage	0.8	3.0	11.2	2.2	-0.2	-0.7	0.7	1.1	3.4
Leg fat percentage (right)	0.7	2.6	11.2	1.2	-0.6	-0.5	-0.6	1.4	3.4
Arm fat-free mass (right)	0.5	2.7	7.5	0.4	0.7	-1.0	1.2	2.4	2.7
Exposure to tobacco smoke outside home	0.3	0.4	1.2	0.1	1.1	-0.9	0.2	0.1	-0.2
Comparative body size at age 10	0.4	1.1	2.5	1.3	0.3	0.0	1.6	-1.1	-1.0
Number of full brothers	0.9	1.1	3.9	-2.0	-1.0	0.2	-1.3	0.1	-0.4
Worry too long after embarrassment	0.7	1.1	4.7	0.9	0.3	-2.2	1.0	-0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.5	-1.1	-1.0	-1.2	-0.7	-0.1	-0.9
Wheeze or whistling in the chest in last year	0.5	1.0	2.1	-0.4	-0.2	-1.5	-0.3	1.3	1.3
Number of children fathered	0.5	0.6	1.4	-0.8	-0.1	-0.1	-1.2	-0.9	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.4	-0.2	-1.3	-0.2	-1.6	0.2	-0.1
Age at first live birth	0.7	1.2	3.2	1.8	1.5	-0.4	1.2	-0.3	0.4
Pulse wave peak to peak time	0.4	0.5	1.1	-0.3	1.0	0.2	0.4	-0.7	-1.0
Health satisfaction	3.1	4.0	7.4	-2.3	-1.6	-0.3	-2.7	2.5	1.5
Shortness of breath walking on level ground	0.5	0.6	2.2	-0.4	-0.2	0.4	-0.4	1.0	1.5
Qualifications: College or University degree	0.5	1.4	3.9	1.9	0.1	-1.0	2.0	-0.4	-0.1
Eye problems/disorders: None of the above	0.2	0.3	0.5	-0.6	-0.5	0.7	-0.2	0.2	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	0.2	0.7	0.9	0.6	-0.5	-0.3
Emphysema/chronic bronchitis	0.2	0.3	0.7	-0.8	0.8	-0.4	0.3	-0.1	-0.3
Medication for pain relief, constipation, heartburn	3.7	6.3	11.0	2.6	2.5	-1.8	3.3	-3.0	-1.4
Neck or shoulder pain in last month	0.8	1.2	4.1	-1.6	-0.0	-2.0	-0.6	0.5	-0.0
Medication: Blood pressure	5.0	8.8	15.3	-2.9	-3.0	0.9	-3.9	3.5	2.6
Angina (self-reported)	6.5	8.6	17.1	-1.9	-1.8	1.1	-3.6	4.1	3.7
Migraine (self-reported)	1.0	1.2	1.9	-0.9	-1.0	-1.1	-1.2	1.0	1.4
Medication: Ibuprofen	0.9	1.1	1.8	-1.1	-0.5	0.9	-1.2	1.4	1.0
Medication: Allopurinol	0.4	0.5	1.8	1.3	-0.7	-0.4	0.7	0.2	0.2
Medication: Omeprazole	1.0	1.2	3.0	0.8	1.6	1.7	0.6	-0.0	0.7
Medication: Seretide 50 evohaler	0.7	0.8	1.3	0.9	1.1	-1.1	1.0	-0.6	0.1
Mean time to correctly identify matches	2.3	4.3	6.7	1.4	0.6	-2.5	2.1	-2.6	-2.5
Heart disease (mother)	0.4	0.5	1.1	-0.6	0.8	0.6	-0.6	-0.7	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.3	-0.6	-0.3	0.8	-1.8	1.6	1.8
Whole body fat mass	0.9	3.7	13.5	1.8	-0.0	-0.9	1.0	1.8	3.7
Leg fat mass (right)	1.0	3.9	16.0	1.2	-0.2	-0.9	-0.0	2.3	4.0
Arm predicted mass (right)	0.7	3.5	10.6	0.4	0.7	-1.1	0.9	2.8	3.3
Pulse rate, automated reading	1.1	3.5	7.9	-2.3	-0.6	0.4	-2.1	2.8	1.8
Alcohol intake frequency.	0.4	1.0	2.6	1.4	-0.4	-0.3	1.6	-1.0	-0.4
Comparative height size at age 10	0.2	1.2	4.1	0.6	1.3	0.5	2.0	0.8	0.3
Number of full sisters	0.7	0.9	2.9	-0.9	-0.7	-0.8	-1.7	0.1	0.4
Suffer from ‘nerves’	0.3	0.4	2.0	-0.2	-0.1	0.3	-0.4	-0.3	-1.4
Overall health rating	3.3	7.2	12.3	-2.6	-2.2	-0.7	-3.4	3.5	2.7
Chest pain or discomfort	0.7	1.1	4.4	0.7	0.7	-0.3	0.5	0.9	2.1
Had major operations	1.3	1.5	3.9	0.5	0.7	0.5	1.0	-1.8	-2.0
Age at last live birth	0.9	1.4	4.3	2.1	0.6	-0.9	1.6	-0.5	0.1
Family relationship satisfaction	0.2	0.2	0.8	-0.0	0.0	0.9	0.2	-0.2	-0.6
Leg pain on walking	1.0	1.2	3.7	0.3	-1.7	-1.9	-0.4	0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.0	0.4	0.4	-0.2	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	4.1	-0.2	2.0	0.3	-0.2	0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.6	0.4	-1.2	1.6	0.1	-1.0	-0.9
Medication: Aspirin	3.0	3.9	7.3	-0.7	-2.7	-0.3	-2.1	2.6	2.0
Supplements: Vitamin C	1.2	1.4	3.0	-1.2	-0.3	-0.5	-1.5	1.7	1.2
Knee pain experienced in last month	0.3	0.5	1.9	0.2	-1.4	-0.1	-0.1	0.8	0.7
Hypertension (Self-reported)	2.5	6.9	12.4	-2.5	-3.0	1.5	-3.5	2.7	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	5.7	-2.1	-1.5	0.6	-2.4	1.6	1.3
Illnesses of father: Heart disease	2.3	3.1	9.7	-1.0	-3.1	0.2	-1.9	1.6	1.5
Illnesses of siblings: Diabetes	0.2	0.3	1.1	0.1	-0.2	-0.2	0.1	0.7	1.1
Smoking status: Previous	0.9	1.4	2.9	-1.4	0.7	0.8	-1.2	1.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.0	-1.0	0.4	-0.9	-0.1	1.4	0.8
Whole body fat-free mass	0.6	3.5	8.1	0.6	0.6	-1.7	1.5	2.6	2.9
Leg fat-free mass (right)	0.9	4.7	11.1	1.3	0.4	-2.2	2.0	2.6	3.3
Arm fat percentage (left)	1.0	4.1	15.1	2.3	0.0	-1.2	0.7	1.5	3.9
Average weekly red wine intake	0.6	0.8	1.8	1.3	-0.3	-1.3	0.6	0.0	1.0
Handedness (chirality/laterality): Left-handed	1.3	1.6	5.4	1.0	0.2	-2.3	0.8	1.1	1.0
Mood swings	1.5	2.8	6.7	-2.1	-0.6	-1.0	-2.6	1.8	1.0
Loneliness, isolation	0.5	0.7	1.8	-0.6	-0.8	1.0	-0.5	1.3	0.7
Long-standing illness, disability or infirmity	1.0	1.6	3.5	-1.9	-1.7	-0.0	-1.5	0.9	0.1
Ever had bowel cancer screening	2.3	2.7	6.6	1.0	-0.7	-1.0	1.3	-2.4	-2.6
Diabetes diagnosed by doctor	1.1	1.7	6.4	0.4	-0.2	0.4	-0.3	1.9	2.5
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.6	1.4	-1.9	-1.3	1.1	-1.1	-1.3
Friendships satisfaction	0.7	0.9	1.8	-0.4	-1.4	-1.1	-0.5	1.1	0.7
Qualifications: nursing, teaching	0.5	0.8	2.3	1.5	0.5	-1.0	0.9	-0.3	0.3
Commuting to job workplace: Walk	0.5	0.5	2.1	-0.3	-1.5	-0.0	-0.6	0.6	0.3
Eye problems/disorders: Cataract	1.8	2.1	3.1	1.1	1.1	-1.6	1.3	-1.7	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.9	1.5	0.9	0.1	2.0	-0.7	-0.4
Medication for cholesterol	2.6	3.9	9.1	2.0	1.7	-0.7	3.0	-2.5	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.6	-0.9	0.3	-0.9	-1.2	1.9	1.4
Back pain experienced in last month	1.8	2.6	7.7	-2.8	-1.2	-0.0	-2.2	1.3	0.2
Mineral and other dietary supplements	0.9	1.2	3.2	1.1	1.8	-1.1	1.0	-0.2	0.6
Breast cancer (self-reported)	0.5	0.6	1.7	-1.3	0.8	0.4	-0.6	0.8	-0.1
Asthma (self-reported)	0.3	0.6	1.5	1.1	0.2	-0.2	0.7	0.4	1.2
Osteoporosis (self-reported)	0.6	0.7	2.8	-0.2	0.5	-0.4	0.4	-1.0	-1.7
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.3	-0.6	0.3	-0.7	0.4	0.6
Medication: Aspirin	3.3	4.3	8.8	-0.8	-2.4	0.1	-2.0	3.0	2.5
Medication: Gliclazide	3.0	3.4	12.3	1.3	-0.1	0.5	-0.2	2.5	3.5
Illnesses of father: None of the above (group 1)	2.3	2.9	6.0	1.6	2.4	0.9	2.3	-1.5	-0.8
Smoking status: Current	2.1	3.3	8.8	-3.0	-1.8	0.4	-2.0	1.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	7.1	1.9	0.7	-0.5	1.9	-2.7	-2.3
Whole body water mass	0.6	3.5	8.6	0.7	0.6	-1.4	1.6	2.6	2.9
Leg predicted mass (right)	0.9	4.8	11.4	1.3	0.4	-2.1	2.0	2.6	3.4
Arm fat mass (left)	1.2	5.0	19.0	1.9	0.2	-1.1	1.0	2.2	4.4
Number of self-reported non-cancer illnesses	1.8	3.1	5.4	-1.3	-2.3	-0.1	-2.2	2.1	1.5
Average weekly champagne plus white wine intake	0.3	0.4	1.5	-0.7	-0.2	-0.1	0.3	-0.6	-1.2
Miserableness	0.9	1.6	3.4	-1.8	-0.2	-1.6	-1.4	1.2	0.5
Guilty feelings	1.2	1.8	7.8	0.8	-1.4	-2.8	0.5	0.5	-0.1
Wears glasses or contact lenses	0.5	0.6	2.0	-0.8	-0.4	1.4	-0.7	0.1	-0.4
Ever taken oral contraceptive pill	1.9	2.2	3.9	-1.5	-0.8	-0.1	-1.8	2.0	1.7
Hearing aid user	2.9	3.3	5.7	-2.2	-2.4	-1.4	-1.9	1.8	0.6
Mother’s age at death	0.6	0.7	2.0	0.9	-0.6	1.4	0.4	0.5	0.8
Financial situation satisfaction	0.4	0.5	1.1	-0.8	-0.6	-1.0	-0.4	0.9	0.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.4	-0.5	-0.0	0.7	-0.6	1.5	1.2
Commuting to job workplace: Public transport	0.7	0.8	2.1	0.1	-1.5	0.6	0.1	0.7	1.4
Eye problems/disorders: Glaucoma	8.0	9.5	19.9	-3.6	-1.3	1.5	-4.5	3.5	2.8
Medication: Blood pressure	1.3	2.5	5.1	-0.7	-2.3	1.2	-1.9	1.7	1.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.2	0.4	1.1	0.1	0.3	-1.0	-1.1
Supplements: Fish oil (including cod liver oil)	1.5	1.9	2.9	-1.7	-1.6	0.4	-1.7	1.5	0.7
High cholesterol (Self-reported)	1.3	2.4	4.0	-1.1	-1.2	1.2	-1.9	2.0	1.6
Medication: Bendroflumethiazide	2.3	3.5	7.5	-0.9	-1.7	1.3	-1.5	2.7	2.4
Medication: Paracetamol	1.2	1.8	7.4	-1.3	-0.3	2.7	-1.3	0.2	-0.2
Medication: Lisinopril	0.3	0.4	1.6	1.3	-0.3	-0.5	0.5	0.3	0.4
Medication: Atorvastatin	0.2	0.2	0.5	0.7	-0.7	-0.3	-0.2	0.0	0.2
Illnesses of father: High blood pressure	0.6	0.7	2.6	-0.5	0.0	-0.2	-1.2	1.6	0.3
Alcohol drinker status: Never	1.4	1.7	2.8	1.2	-1.6	-1.2	1.1	0.5	1.7
Ever smoked	0.5	0.9	2.2	-1.3	-0.6	-0.5	-1.0	1.5	0.2
Basal metabolic rate	0.7	4.1	11.7	0.8	0.5	-1.5	1.4	2.8	3.4
Leg fat percentage (left)	0.8	2.9	12.6	1.2	-0.7	-0.8	-0.6	1.4	3.5
Arm fat-free mass (left)	0.6	2.9	8.9	0.6	0.4	-0.7	1.2	2.4	3.0
Number of operations (self-reported)	0.6	0.9	1.1	0.9	0.2	-1.0	1.0	-1.0	-1.0
Average weekly beer plus cider intake	1.2	1.7	3.8	-1.9	0.7	1.6	-0.5	1.5	0.9
Irritability	0.7	1.3	3.6	-1.6	-0.5	-0.1	-1.9	0.9	0.3
Risk taking	0.9	1.3	3.0	-1.1	1.4	1.7	-0.5	0.9	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.2	-0.1	-1.5	-0.2	-0.4	0.5	0.6
Fractured/broken bones in last 5 years	0.7	0.8	1.8	0.9	1.3	-0.1	1.4	0.7	0.5
Age started oral contraceptive pill	0.5	0.6	2.6	-0.1	0.4	1.6	-0.3	0.1	0.8
Diastolic blood pressure, automated reading	1.5	4.6	7.6	-2.0	-1.6	1.6	-2.8	2.4	2.4
Ever depressed for a whole week	0.3	0.3	0.6	-0.5	0.3	0.7	-0.7	-0.3	-0.7
Unable to work because of sickness or disability	1.0	1.3	1.7	-1.0	-1.3	-0.8	-1.3	1.2	1.1
Commuting to job workplace: Cycle	0.4	0.5	0.9	1.0	0.6	0.4	0.6	-0.8	-0.6
Myopia	1.8	2.6	5.0	1.8	-0.1	-1.5	1.3	-2.2	-1.8
Vascular/heart problems diagnosed by doctor	3.8	10.4	18.5	2.8	3.5	-1.7	4.3	-3.6	-2.9
Cholesterol lowering medication	1.4	2.0	4.0	-0.6	-0.9	1.5	-1.4	2.0	1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	0.5	1.2	1.5	0.6	0.1	0.7
Pain experienced in last month	1.1	1.9	3.3	1.5	1.3	1.4	1.8	-1.3	-0.6
Supplements: Calcium	1.0	1.1	3.6	-1.4	0.6	0.5	-0.1	-0.5	-1.9
Basal cell carcinoma (self-reported)	0.1	0.2	0.6	-0.2	0.1	0.8	-0.3	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	4.1	5.3	9.4	-2.0	-1.9	1.3	-3.1	2.8	2.3
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	10.1	1.1	0.3	-3.2	1.7	-0.6	-0.3
Heart disease (siblings)	0.6	0.8	2.8	0.6	-1.7	-1.0	0.3	-0.1	-0.4
Alcohol drinker status: Previous	2.3	2.6	9.8	-0.8	1.3	0.5	0.2	-1.8	-3.1
Pack years of smoking	1.9	2.8	4.5	-1.8	-0.9	1.7	-2.1	1.7	1.4
Impedance of whole body	1.0	4.8	10.6	0.3	1.2	2.3	1.2	-3.2	-3.3
Leg fat mass (left)	1.0	4.0	16.3	1.1	-0.2	-0.9	-0.1	2.3	4.0
Arm predicted mass (left)	0.7	3.7	12.0	0.4	0.4	-1.0	0.9	2.9	3.5