Best TWAS P=1.74e-17 · Best GWAS P=4.14e-16 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCDC92 | 0.09 | 0.01 | bslmm | 438 | 0.03 | 3.1e-04 | -7.4 | 8.5 | 1.8e-17 | -0.72 | 0.06 | 0.93 | TRUE |
2 | GTEx | Adipose Subcutaneous | CCDC92 | 0.23 | 0.04 | enet | 27 | 0.16 | 6.9e-13 | 4.8 | -5.7 | 1.3e-08 | 0.46 | 0.37 | 0.63 | FALSE |
3 | GTEx | Adipose Subcutaneous | RP11-380L11.3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.4e-03 | -7.0 | -7.9 | 2.4e-15 | 0.82 | 0.02 | 0.98 | FALSE |
4 | GTEx | Adipose Subcutaneous | RP11-380L11.4 | 0.08 | 0.06 | lasso | 4 | 0.04 | 1.9e-04 | -5.1 | -5.2 | 2.6e-07 | 0.54 | 0.78 | 0.11 | FALSE |
5 | GTEx | Adipose Visceral Omentum | CCDC92 | 0.19 | 0.02 | lasso | 8 | 0.09 | 3.3e-05 | -7.1 | -7.1 | 1.2e-12 | 0.57 | 0.13 | 0.83 | FALSE |
6 | GTEx | Adipose Visceral Omentum | RP11-380L11.3 | 0.15 | 0.03 | lasso | 5 | 0.01 | 1.4e-01 | -4.3 | -7.5 | 4.9e-14 | 0.58 | 0.11 | 0.32 | TRUE |
7 | GTEx | Artery Tibial | TMED2 | 0.09 | 0.04 | enet | 18 | 0.06 | 8.7e-06 | 5.6 | 6.4 | 1.3e-10 | -0.20 | 0.86 | 0.03 | TRUE |
8 | GTEx | Artery Tibial | RP11-380L11.3 | 0.08 | 0.02 | lasso | 2 | 0.01 | 4.5e-02 | -2.1 | -5.3 | 1.4e-07 | 0.72 | 0.01 | 0.92 | FALSE |
9 | GTEx | Artery Tibial | RP11-380L11.4 | 0.14 | 0.12 | lasso | 4 | 0.12 | 2.2e-09 | -7.0 | -7.2 | 5.0e-13 | 0.90 | 0.57 | 0.43 | FALSE |
10 | GTEx | Brain Cerebellum | GTF2H3 | 0.13 | 0.18 | lasso | 2 | 0.14 | 6.9e-05 | 5.6 | -5.6 | 1.8e-08 | 0.09 | 0.16 | 0.11 | TRUE |
11 | GTEx | Brain Hypothalamus | DDX55 | 0.37 | 0.05 | enet | 20 | 0.03 | 7.4e-02 | 3.4 | -5.6 | 2.4e-08 | 0.35 | 0.09 | 0.14 | FALSE |
12 | GTEx | Breast Mammary Tissue (Male) | CCDC92 | 0.06 | -0.01 | lasso | 3 | 0.00 | 4.3e-01 | -7.3 | -6.6 | 3.6e-11 | 0.87 | 0.03 | 0.32 | FALSE |
13 | GTEx | Breast Mammary Tissue (Female) | CCDC92 | 0.05 | -0.01 | enet | 2 | -0.01 | 6.2e-01 | -7.4 | -7.4 | 1.4e-13 | 0.95 | 0.03 | 0.39 | FALSE |
14 | GTEx | Colon Sigmoid | RP11-380L11.4 | 0.21 | 0.12 | lasso | 3 | 0.08 | 1.1e-03 | -7.2 | -6.9 | 4.8e-12 | 0.88 | 0.04 | 0.89 | FALSE |
15 | GTEx | Esophagus Mucosa | CCDC92 | 0.11 | 0.02 | lasso | 4 | 0.02 | 1.9e-02 | -7.3 | -7.3 | 3.5e-13 | 0.94 | 0.02 | 0.96 | FALSE |
16 | GTEx | Esophagus Muscularis | RP11-380L11.4 | 0.27 | 0.29 | lasso | 8 | 0.27 | 1.0e-16 | -7.1 | -7.1 | 1.1e-12 | 0.91 | 0.62 | 0.38 | FALSE |
17 | GTEx | Heart Atrial Appendage | CCDC92 | 0.12 | 0.11 | enet | 9 | 0.11 | 1.1e-05 | -3.7 | -6.2 | 6.1e-10 | 0.84 | 0.03 | 0.96 | FALSE |
18 | GTEx | Heart Atrial Appendage | RP11-380L11.4 | 0.18 | 0.11 | lasso | 7 | 0.12 | 6.5e-06 | -7.1 | -7.0 | 2.1e-12 | 0.89 | 0.17 | 0.79 | FALSE |
19 | GTEx | Heart Left Ventricle | CCDC92 | 0.26 | 0.19 | lasso | 4 | 0.21 | 1.9e-11 | -7.3 | -7.8 | 7.0e-15 | 0.91 | 0.33 | 0.67 | FALSE |
20 | GTEx | Lung | CCDC92 | 0.14 | 0.00 | enet | 10 | 0.01 | 1.1e-01 | -4.3 | -5.4 | 6.8e-08 | 0.17 | 0.12 | 0.39 | FALSE |
21 | GTEx | Lung | RP11-380L11.4 | 0.07 | 0.07 | lasso | 3 | 0.07 | 8.2e-06 | -7.0 | -7.4 | 1.5e-13 | 0.95 | 0.01 | 0.99 | FALSE |
22 | GTEx | Muscle Skeletal | RP11-380L11.4 | 0.14 | 0.03 | lasso | 8 | 0.03 | 4.0e-04 | -7.0 | -6.7 | 2.3e-11 | 0.85 | 0.43 | 0.51 | FALSE |
23 | GTEx | Nerve Tibial | CCDC92 | 0.16 | 0.01 | enet | 6 | 0.04 | 6.7e-04 | -8.1 | -6.2 | 6.3e-10 | 0.73 | 0.01 | 0.96 | FALSE |
24 | GTEx | Prostate | CCDC92 | 0.31 | 0.10 | enet | 42 | 0.11 | 9.0e-04 | -7.4 | -6.3 | 2.9e-10 | 0.47 | 0.14 | 0.38 | FALSE |
25 | GTEx | Skin Sun Exposed Lower leg | RP11-380L11.4 | 0.04 | 0.02 | enet | 15 | 0.02 | 1.9e-02 | -7.1 | -7.5 | 8.5e-14 | 0.77 | 0.04 | 0.91 | FALSE |
26 | GTEx | Testis | RP11-380L11.3 | 0.14 | 0.05 | enet | 29 | 0.06 | 1.4e-03 | -7.3 | -5.6 | 2.0e-08 | 0.54 | 0.06 | 0.63 | TRUE |
27 | GTEx | Thyroid | CCDC92 | 0.06 | 0.03 | lasso | 3 | 0.02 | 1.1e-02 | -7.1 | -6.8 | 1.2e-11 | 0.86 | 0.01 | 0.98 | FALSE |
28 | GTEx | Thyroid | ZNF664 | 0.13 | 0.06 | lasso | 11 | 0.08 | 6.7e-07 | -7.4 | 7.9 | 2.5e-15 | -0.93 | 0.19 | 0.81 | FALSE |
29 | GTEx | Thyroid | ATP6V0A2 | 0.07 | 0.02 | enet | 9 | 0.02 | 9.8e-03 | 4.1 | 5.2 | 1.7e-07 | -0.24 | 0.28 | 0.14 | FALSE |
30 | GTEx | Whole Blood | CDK2AP1 | 0.24 | 0.18 | lasso | 5 | 0.18 | 1.1e-16 | 5.5 | 6.6 | 3.4e-11 | -0.13 | 0.25 | 0.75 | TRUE |
31 | GTEx | Whole Blood | RP11-282O18.3 | 0.20 | 0.15 | lasso | 4 | 0.15 | 1.7e-13 | 5.5 | 6.3 | 2.9e-10 | -0.11 | 0.26 | 0.74 | FALSE |
32 | METSIM | Adipose | CCDC92 | 0.10 | 0.01 | bslmm | 435 | 0.06 | 5.5e-10 | 6.0 | -6.8 | 8.4e-12 | 0.56 | 0.09 | 0.91 | FALSE |
33 | METSIM | Adipose | DNAH10 | 0.03 | 0.00 | bslmm | 475 | 0.01 | 3.2e-03 | -6.8 | -8.1 | 7.4e-16 | 0.65 | 0.07 | 0.64 | FALSE |
34 | METSIM | Adipose | RP11-214K3.24 | 0.05 | 0.03 | bslmm | 444 | 0.02 | 2.7e-04 | -7.3 | -7.0 | 1.9e-12 | 0.74 | 0.05 | 0.92 | TRUE |
35 | YFS | Blood | CDK2AP1 | 0.26 | 0.27 | enet | 30 | 0.29 | 1.8e-96 | 5.5 | 5.2 | 1.7e-07 | -0.06 | 0.27 | 0.73 | FALSE |
36 | YFS | Blood | EIF2B1 | 0.13 | 0.12 | bslmm | 333 | 0.12 | 4.8e-38 | 5.6 | 5.3 | 1.3e-07 | -0.04 | 1.00 | 0.00 | FALSE |
37 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC92 | 0.07 | 0.02 | blup | 52 | 0.04 | 1.8e-02 | -7.4 | -7.2 | 8.5e-13 | 0.94 | 0.02 | 0.70 | FALSE |
38 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC92 | 0.06 | 0.04 | enet | 8 | 0.05 | 1.7e-06 | -7.3 | -6.4 | 1.6e-10 | 0.78 | 0.14 | 0.80 | FALSE |
39 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DNAH10 | 0.07 | 0.03 | lasso | 3 | 0.05 | 7.4e-06 | -7.0 | -5.7 | 1.6e-08 | 0.82 | 0.06 | 0.93 | FALSE |
40 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CCDC92 | 0.05 | 0.03 | blup | 52 | 0.03 | 5.8e-03 | -6.3 | -7.0 | 3.3e-12 | 0.87 | 0.06 | 0.51 | TRUE |
41 | The Cancer Genome Atlas | Thyroid Carcinoma | DNAH10 | 0.04 | 0.03 | lasso | 5 | 0.02 | 4.6e-03 | -8.1 | -8.5 | 1.7e-17 | 0.96 | 0.00 | 0.95 | FALSE |
42 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF664 | 0.06 | 0.05 | enet | 9 | 0.05 | 2.8e-05 | -7.0 | 6.3 | 3.5e-10 | -0.87 | 0.25 | 0.73 | FALSE |