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chr12:119,410,233-122,931,150

Best TWAS P=1.8e-15 · Best GWAS P=2.66e-13 conditioned to 0.797

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
45	YFS	Blood	PRKAB1	0.40	0.17	lasso	6	0.23	3.9e-75	-7.31	-8.0	1.8e-15	0.89	0.00	1.00	TRUE
32	GTEx	Skin Not Sun Exposed Suprapubic	AC084018.1	0.17	0.09	lasso	5	0.05	6.8e-04	7.03	-7.8	7.6e-15	-0.01	0.01	0.99	TRUE
31	GTEx	Skin Not Sun Exposed Suprapubic	P2RX4	0.17	0.05	lasso	8	0.06	3.6e-04	4.59	-6.1	1.2e-09	0.07	0.03	0.89	TRUE
61	The Cancer Genome Atlas	Thyroid Carcinoma	RHOF	0.05	0.06	lasso	3	0.06	3.6e-06	7.03	7.5	8.5e-14	0.04	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC338799	0.04	0.04	enet	7	0.03	4.2e-03	7.12	-7.5	8.9e-14	-0.05	0.01	0.95	FALSE
42	METSIM	Adipose	PRKAB1	0.11	0.09	bslmm	464	0.09	2.7e-13	-7.31	-7.4	1.3e-13	0.99	0.00	1.00	FALSE
13	GTEx	Cells Transformed fibroblasts	PRKAB1	0.24	0.28	lasso	2	0.31	6.0e-24	-7.31	-7.4	1.4e-13	0.97	0.00	1.00	FALSE
26	GTEx	Muscle Skeletal	RP11-347I19.8	0.08	0.06	lasso	4	0.06	2.4e-06	7.18	-7.3	2.7e-13	-0.03	0.01	0.99	FALSE
41	METSIM	Adipose	AC084018.1	0.27	0.25	enet	19	0.26	1.3e-38	7.12	-7.3	3.7e-13	-0.04	0.01	0.99	FALSE
6	GTEx	Artery Aorta	RP11-347I19.8	0.11	0.08	lasso	3	0.06	4.4e-04	7.07	-7.3	3.8e-13	-0.03	0.01	0.98	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-347I19.8	0.24	0.15	lasso	5	0.12	6.1e-07	7.01	-7.2	5.8e-13	-0.05	0.01	0.99	FALSE
35	GTEx	Skin Sun Exposed Lower leg	RP11-347I19.8	0.22	0.16	lasso	6	0.17	4.3e-14	7.10	-7.2	7.2e-13	-0.04	0.01	0.99	FALSE
10	GTEx	Brain Cortex	AC084018.1	0.40	0.32	enet	7	0.30	6.4e-09	7.10	-7.2	8.4e-13	-0.04	0.01	0.99	FALSE
24	GTEx	Lung	AC084018.1	0.12	0.13	lasso	2	0.13	5.0e-10	7.10	-7.2	8.8e-13	-0.04	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC338799	0.07	0.07	enet	10	0.05	4.3e-03	7.10	-7.2	9.0e-13	-0.04	0.01	0.84	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC338799	0.03	0.04	lasso	3	0.03	1.8e-07	7.18	-7.1	9.6e-13	-0.04	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LOC338799	0.04	0.03	blup	29	0.03	2.7e-04	6.98	-7.1	1.2e-12	-0.02	0.01	0.96	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	AC084018.1	0.24	0.15	lasso	2	0.09	9.3e-04	7.01	-7.1	1.3e-12	-0.04	0.01	0.98	FALSE
19	GTEx	Esophagus Mucosa	RP11-347I19.8	0.10	0.11	lasso	2	0.12	4.6e-08	7.07	-7.1	1.5e-12	-0.04	0.01	0.99	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	RP11-347I19.8	0.15	0.16	lasso	4	0.14	3.2e-08	7.07	-7.1	1.5e-12	-0.04	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC338799	0.04	0.04	lasso	2	0.04	4.2e-05	6.98	-7.1	1.7e-12	-0.04	0.01	0.98	FALSE
17	GTEx	Esophagus Mucosa	PRKAB1	0.38	0.32	lasso	5	0.32	5.4e-22	-7.31	-7.0	1.8e-12	0.99	0.00	1.00	FALSE
22	GTEx	Heart Left Ventricle	RHOF	0.10	0.05	lasso	3	0.08	6.4e-05	6.98	7.0	1.8e-12	0.03	0.01	0.97	FALSE
16	GTEx	Colon Transverse	RP11-347I19.8	0.11	0.12	lasso	2	0.10	2.1e-05	6.98	-7.0	2.0e-12	-0.04	0.01	0.98	FALSE
25	GTEx	Lung	RP11-347I19.8	0.15	0.15	enet	9	0.15	7.7e-12	7.01	-7.0	2.8e-12	-0.04	0.01	0.99	FALSE
28	GTEx	Nerve Tibial	RP11-347I19.8	0.11	0.10	lasso	3	0.10	1.6e-07	6.98	-7.0	2.8e-12	-0.04	0.02	0.98	FALSE
37	GTEx	Testis	AC084018.1	0.26	0.28	lasso	2	0.27	2.6e-12	6.98	-7.0	2.9e-12	-0.04	0.02	0.98	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	RP11-347I19.8	0.20	0.17	lasso	3	0.10	4.7e-04	7.01	-7.0	3.1e-12	-0.04	0.01	0.98	FALSE
18	GTEx	Esophagus Mucosa	AC084018.1	0.09	0.12	lasso	4	0.11	5.7e-08	7.01	-7.0	3.2e-12	-0.04	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC338799	0.06	0.09	lasso	6	0.10	2.1e-11	7.03	-6.9	4.4e-12	-0.04	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	AC084018.1	0.17	0.14	lasso	5	0.16	4.2e-13	6.98	-6.9	4.7e-12	-0.03	0.02	0.98	FALSE
43	METSIM	Adipose	RP11-347I19.8	0.10	0.10	lasso	9	0.09	2.7e-13	6.98	-6.9	4.8e-12	-0.04	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM120B	0.05	0.00	blup	44	0.02	1.1e-03	-2.24	-6.9	5.5e-12	0.00	0.01	0.28	FALSE
21	GTEx	Heart Atrial Appendage	AC084018.1	0.34	0.19	enet	9	0.20	3.7e-09	7.18	-6.9	5.9e-12	-0.02	0.01	0.99	FALSE
40	GTEx	Thyroid	RP11-347I19.8	0.23	0.22	lasso	14	0.22	7.3e-17	7.01	-6.8	9.1e-12	-0.04	0.01	0.99	FALSE
44	NTR	Blood	PRKAB1	0.02	0.02	lasso	2	0.02	4.0e-07	-7.31	-6.8	9.3e-12	0.96	0.00	1.00	FALSE
8	GTEx	Artery Tibial	AC084018.1	0.15	0.09	lasso	6	0.10	1.8e-08	7.10	-6.8	1.1e-11	-0.03	0.01	0.99	FALSE
29	GTEx	Pituitary	AC084018.1	0.25	0.13	lasso	4	0.11	1.0e-03	7.01	-6.8	1.5e-11	-0.03	0.02	0.87	FALSE
2	GTEx	Adipose Subcutaneous	RP11-347I19.8	0.18	0.17	lasso	5	0.16	2.6e-13	6.98	-6.6	3.6e-11	-0.04	0.02	0.98	FALSE
27	GTEx	Nerve Tibial	AC084018.1	0.18	0.09	lasso	3	0.11	4.8e-08	6.98	-6.5	9.6e-11	-0.06	0.01	0.99	FALSE
34	GTEx	Skin Sun Exposed Lower leg	AC084018.1	0.29	0.15	enet	22	0.21	3.5e-17	7.10	-6.5	1.0e-10	-0.05	0.01	0.99	FALSE
36	GTEx	Stomach	RP11-347I19.8	0.22	0.09	lasso	7	0.11	4.2e-06	7.03	-6.5	1.0e-10	-0.05	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	LOC338799	0.09	0.08	blup	29	0.08	1.5e-08	7.12	-6.2	4.4e-10	-0.03	0.01	0.99	FALSE
15	GTEx	Cells Transformed fibroblasts	RP11-347I19.8	0.12	0.11	lasso	5	0.11	2.1e-08	7.03	-6.1	1.3e-09	-0.03	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Esophageal Carcinoma	LOC338799	0.10	0.02	blup	30	0.06	6.9e-03	2.96	-6.0	2.2e-09	-0.04	0.01	0.61	FALSE
5	GTEx	Artery Aorta	P2RX4	0.20	0.03	enet	28	0.05	1.6e-03	-2.67	-5.9	2.8e-09	0.06	0.07	0.75	FALSE
23	GTEx	Lung	SPPL3	0.15	0.05	enet	27	0.06	1.1e-05	5.82	5.8	5.3e-09	-0.06	0.02	0.98	FALSE
39	GTEx	Thyroid	AC084018.1	0.15	0.12	enet	12	0.13	2.5e-10	7.01	-5.7	1.5e-08	-0.05	0.01	0.99	FALSE
14	GTEx	Cells Transformed fibroblasts	AC084018.1	0.15	0.12	enet	16	0.10	9.4e-08	7.03	-5.7	1.6e-08	-0.03	0.01	0.99	FALSE
20	GTEx	Esophagus Muscularis	AC084018.1	0.11	0.04	enet	14	0.05	7.5e-04	7.07	-5.6	1.8e-08	-0.06	0.01	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	AC084018.1	0.22	0.10	lasso	2	0.18	8.7e-10	7.01	-5.6	2.6e-08	-0.06	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACADS	0.05	0.01	blup	50	0.04	7.4e-05	5.79	5.5	2.9e-08	0.06	0.00	0.94	FALSE
7	GTEx	Artery Tibial	P2RX4	0.18	0.15	enet	7	0.16	9.1e-13	4.59	-5.5	3.0e-08	0.05	0.56	0.43	FALSE
9	GTEx	Artery Tibial	RP11-347I19.8	0.16	0.09	enet	26	0.10	1.7e-08	7.10	-5.5	4.2e-08	-0.04	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC338799	0.04	0.01	blup	29	0.03	6.4e-04	-0.54	-5.3	1.1e-07	-0.04	0.01	0.77	FALSE
38	GTEx	Testis	RP11-347I19.8	0.19	0.08	enet	10	0.13	3.1e-06	6.98	-5.3	1.2e-07	-0.04	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	LOC338799	0.06	0.03	blup	31	0.05	5.2e-04	-0.84	-5.3	1.3e-07	-0.05	0.01	0.85	FALSE
46	YFS	Blood	SPPL3	0.02	0.00	blup	460	0.01	2.1e-03	-2.53	5.2	1.5e-07	-0.01	0.12	0.33	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	P2RX4	0.18	0.04	blup	71	0.08	1.3e-05	-2.67	-5.2	1.9e-07	0.09	0.01	0.73	FALSE
30	GTEx	Pituitary	RP11-347I19.8	0.32	0.23	lasso	2	0.30	3.5e-08	7.01	-5.2	2.0e-07	-0.02	0.02	0.96	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SPPL3	0.18	0.10	enet	11	0.15	9.1e-07	4.44	5.2	2.4e-07	0.00	0.01	0.99	FALSE