Best TWAS P=3.76e-14 · Best GWAS P=8.68e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | DHRS12 | 0.40 | 0.11 | lasso | 10 | 0.09 | 2.0e-03 | -6.9 | 6.5 | 6.4e-11 | -0.74 | 0.15 | 0.21 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | DHRS12 | 0.25 | 0.11 | lasso | 4 | 0.04 | 3.5e-02 | -6.8 | 6.7 | 2.1e-11 | -0.81 | 0.05 | 0.27 | FALSE |
| 3 | GTEx | Nerve Tibial | WDFY2 | 0.24 | 0.13 | lasso | 11 | 0.11 | 2.2e-08 | -7.7 | -7.3 | 2.9e-13 | 0.97 | 0.01 | 0.99 | FALSE |
| 4 | METSIM | Adipose | WDFY2 | 0.09 | 0.08 | bslmm | 500 | 0.08 | 7.2e-12 | -7.2 | -7.2 | 6.4e-13 | 0.97 | 0.01 | 0.99 | FALSE |
| 5 | NTR | Blood | WDFY2 | 0.04 | 0.03 | enet | 11 | 0.04 | 1.7e-11 | -7.8 | 7.6 | 3.8e-14 | -0.97 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WDFY2 | 0.02 | 0.02 | lasso | 3 | 0.02 | 3.4e-04 | -7.2 | 6.9 | 4.1e-12 | -0.94 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DLEU7 | 0.11 | 0.00 | enet | 36 | 0.03 | 1.8e-04 | -2.9 | 5.8 | 8.7e-09 | -0.01 | 0.01 | 0.18 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | WDFY2 | 0.03 | 0.03 | enet | 8 | 0.02 | 2.3e-03 | -7.7 | 6.8 | 1.2e-11 | -0.92 | 0.01 | 0.97 | FALSE |