Best TWAS P=2.58e-13 · Best GWAS P=1.08e-15 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PHF11 | 0.06 | 0.00 | enet | 19 | 0.01 | 4.4e-02 | -3.9 | 7.3 | 3.8e-13 | 0.05 | 0.02 | 0.67 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | EBPL | 0.41 | 0.06 | lasso | 7 | 0.12 | 2.1e-04 | -5.8 | 5.9 | 4.8e-09 | -0.10 | 0.13 | 0.05 | FALSE |
3 | GTEx | Brain Cerebellum | RCBTB1 | 0.28 | 0.04 | enet | 11 | 0.16 | 1.6e-05 | 3.1 | -5.4 | 7.2e-08 | 0.09 | 0.17 | 0.10 | TRUE |
4 | GTEx | Brain Cortex | EBPL | 0.36 | 0.08 | enet | 24 | 0.14 | 1.5e-04 | -6.0 | 5.8 | 5.0e-09 | -0.14 | 0.20 | 0.05 | TRUE |
5 | GTEx | Esophagus Gastroesophageal Junction | EBPL | 0.27 | 0.24 | enet | 14 | 0.26 | 4.6e-10 | -5.8 | 5.6 | 2.2e-08 | -0.08 | 0.99 | 0.00 | TRUE |
6 | GTEx | Esophagus Mucosa | EBPL | 0.44 | 0.16 | enet | 35 | 0.24 | 2.6e-16 | 2.0 | 7.3 | 2.6e-13 | -0.06 | 1.00 | 0.00 | TRUE |
7 | GTEx | Heart Atrial Appendage | EBPL | 0.17 | 0.04 | lasso | 5 | 0.05 | 2.2e-03 | -6.0 | 5.5 | 4.8e-08 | -0.11 | 0.26 | 0.04 | FALSE |
8 | GTEx | Heart Left Ventricle | RCBTB1 | 0.16 | 0.13 | enet | 19 | 0.14 | 8.8e-08 | -5.1 | -5.6 | 1.9e-08 | -0.05 | 0.94 | 0.06 | TRUE |
9 | GTEx | Muscle Skeletal | CDADC1 | 0.10 | 0.04 | enet | 10 | 0.02 | 1.6e-03 | -2.7 | -5.5 | 3.4e-08 | -0.01 | 0.81 | 0.01 | TRUE |
10 | GTEx | Muscle Skeletal | PHF11 | 0.11 | 0.14 | lasso | 6 | 0.13 | 9.4e-13 | -5.3 | 5.3 | 1.1e-07 | -0.09 | 1.00 | 0.00 | FALSE |
11 | GTEx | Pancreas | EBPL | 0.18 | 0.10 | enet | 5 | 0.09 | 1.6e-04 | -6.0 | 5.4 | 7.2e-08 | -0.10 | 0.38 | 0.04 | FALSE |
12 | GTEx | Skin Not Sun Exposed Suprapubic | EBPL | 0.34 | 0.26 | enet | 12 | 0.30 | 4.0e-17 | -5.7 | 5.6 | 2.5e-08 | -0.02 | 1.00 | 0.00 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | RCBTB1 | 0.17 | 0.03 | lasso | 8 | 0.02 | 1.9e-02 | -7.0 | 6.6 | 5.3e-11 | 0.08 | 0.06 | 0.82 | TRUE |
14 | GTEx | Skin Sun Exposed Lower leg | EBPL | 0.28 | 0.21 | lasso | 5 | 0.20 | 2.5e-16 | -5.6 | 5.6 | 2.2e-08 | -0.11 | 1.00 | 0.00 | FALSE |
15 | GTEx | Spleen | EBPL | 0.58 | 0.33 | enet | 28 | 0.35 | 7.1e-10 | 0.6 | 5.6 | 1.8e-08 | -0.04 | 0.72 | 0.02 | FALSE |
16 | GTEx | Testis | EBPL | 0.33 | 0.17 | lasso | 6 | 0.24 | 8.4e-11 | -5.9 | 5.9 | 3.5e-09 | -0.08 | 1.00 | 0.00 | TRUE |
17 | METSIM | Adipose | PHF11 | 0.16 | 0.14 | lasso | 9 | 0.14 | 8.7e-20 | -5.3 | 5.7 | 1.3e-08 | -0.09 | 1.00 | 0.00 | FALSE |
18 | METSIM | Adipose | SETDB2 | 0.06 | 0.03 | enet | 17 | 0.05 | 5.1e-08 | -6.7 | -5.1 | 3.1e-07 | 0.02 | 0.02 | 0.98 | TRUE |
19 | NTR | Blood | PHF11 | 0.04 | 0.03 | bslmm | 406 | 0.04 | 3.1e-12 | -5.6 | 6.2 | 6.8e-10 | -0.06 | 1.00 | 0.00 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | EBPL | 0.43 | 0.28 | lasso | 8 | 0.43 | 7.3e-60 | -5.8 | 5.8 | 5.6e-09 | -0.06 | 1.00 | 0.00 | FALSE |
21 | YFS | Blood | PHF11 | 0.16 | 0.16 | lasso | 19 | 0.16 | 5.0e-49 | -5.6 | 5.4 | 5.4e-08 | -0.07 | 1.00 | 0.00 | FALSE |
22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EBPL | 0.07 | 0.03 | enet | 11 | 0.06 | 2.1e-12 | -5.8 | 5.2 | 1.5e-07 | -0.06 | 0.01 | 0.99 | FALSE |
23 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PHF11 | 0.13 | 0.13 | blup | 92 | 0.12 | 4.3e-06 | -5.6 | -5.8 | 8.6e-09 | 0.06 | 0.24 | 0.76 | FALSE |
24 | The Cancer Genome Atlas | Lung Adenocarcinoma | EBPL | 0.07 | 0.02 | blup | 59 | 0.03 | 8.9e-05 | -2.2 | 5.3 | 1.3e-07 | -0.14 | 0.01 | 0.92 | FALSE |
25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EBPL | 0.21 | 0.09 | enet | 10 | 0.13 | 4.9e-06 | -6.0 | 6.5 | 6.2e-11 | -0.13 | 0.00 | 1.00 | FALSE |
26 | The Cancer Genome Atlas | Stomach Adenocarcinoma | EBPL | 0.10 | 0.07 | enet | 7 | 0.08 | 2.8e-06 | -6.0 | 5.2 | 1.7e-07 | -0.12 | 0.00 | 0.99 | TRUE |
27 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RCBTB1 | 0.13 | 0.07 | lasso | 4 | 0.08 | 1.2e-03 | -5.8 | -6.7 | 2.6e-11 | -0.08 | 0.01 | 0.93 | FALSE |
28 | The Cancer Genome Atlas | Thyroid Carcinoma | RCBTB1 | 0.10 | 0.09 | lasso | 10 | 0.12 | 8.9e-12 | -5.8 | -6.3 | 3.3e-10 | -0.01 | 0.53 | 0.47 | TRUE |