TWAS hub - WDFY2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.2356	0.0553	3.2e-07	0.128	NA	0.113	NA	0.113	2.5e-09	NA	2.4e-08	NA	2.2e-08
2	GTEx	Pancreas	0.2120	0.0740	1.1e-03	0.010	NA	0.013	NA	0.072	1.2e-01	NA	9.3e-02	NA	5.6e-04
3	METSIM	Adipose	0.0883	0.0259	8.6e-07	0.080	0.066	0.067	0.079	0.076	5.4e-12	3.6e-10	2.6e-10	7.2e-12	1.7e-11
4	NTR	Blood	0.0413	0.0115	2.2e-07	0.035	0.021	0.035	0.031	0.034	1.9e-11	2.1e-07	1.7e-11	2.0e-10	2.9e-11
5	TCGA	Breast Invasive Carcinoma	0.0197	0.0127	2.6e-03	0.019	0.005	0.010	NA	0.015	6.2e-05	2.2e-02	3.6e-03	NA	3.4e-04
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0328	0.0180	2.7e-03	0.027	0.014	0.020	NA	0.017	4.4e-04	9.6e-03	2.3e-03	NA	4.9e-03
7	TCGA	Prostate Adenocarcinoma	0.0620	0.0339	1.8e-03	0.013	0.025	0.019	NA	0.016	1.4e-02	1.0e-03	4.1e-03	NA	7.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Smoking status: Current	6.2	9.8	17.1	-3.1	-0.7	-3.3	4.1	3.7	2.5	3.2
Blood White Count	5.4	40.0	57.3	-7.3	-1.4	-7.2	7.6	6.9	6.8	4.6
Chest pain or discomfort	5.2	7.5	12.7	-3.0	0.2	-3.2	3.0	3.3	3.6	0.8
Depression (Nagel 2018)	5.1	7.7	11.9	-2.6	-0.8	-3.1	3.5	3.2	3.0	2.4
Current tobacco smoking	5.0	8.2	14.7	-2.8	-0.1	-3.0	3.8	3.5	2.2	3.0
Time employed in main current job	4.8	5.6	7.9	2.8	0.2	2.5	-2.5	-2.7	-2.5	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	4.6	7.1	12.2	-2.9	-1.2	-3.0	3.5	2.9	2.6	1.8
Lupus	4.1	6.2	9.0	2.6	1.4	2.8	-2.8	-3.0	-2.4	-2.0
Frequency of depressed mood in last 2 weeks	4.1	5.7	9.1	-2.0	0.3	-2.7	3.0	2.6	2.5	2.7
Exposure to tobacco smoke at home	4.0	4.5	7.1	-2.3	-1.1	-2.3	2.7	2.6	2.3	-0.5
Number of operations (self-reported)	4.0	5.9	9.6	-2.9	-1.8	-2.9	2.3	2.4	3.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.8	4.9	8.2	-2.0	-0.1	-2.4	2.8	2.9	1.7	2.5
Had other major operations	3.6	4.3	8.4	-2.4	-0.9	-2.1	2.4	2.1	2.9	0.8
Heel T-Score	3.5	27.8	43.7	-6.0	-1.0	-5.9	6.6	5.6	5.5	4.2
Loud music exposure frequency	3.5	3.9	5.9	-2.2	-1.1	-1.7	2.2	2.4	1.9	1.9
Exposure to tobacco smoke outside home	3.5	4.6	9.2	-2.2	-0.9	-2.3	3.0	2.2	1.6	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.6	11.3	-1.7	0.4	-2.1	2.3	2.2	1.6	3.4
Ever smoked	3.4	6.0	8.2	-2.7	-0.8	-2.7	2.8	2.9	2.6	2.0
Pack years of smoking	3.2	4.7	6.9	-2.6	-0.3	-2.3	2.4	2.6	2.1	2.0
LDL Cholesterol	3.1	5.0	8.9	2.3	0.8	2.5	-2.6	-2.6	-3.0	-0.5
Medication: Lisinopril	3.0	3.9	6.6	-1.6	1.4	-1.9	1.6	1.9	2.5	2.6
Smoking Status	2.9	7.0	10.6	-2.8	0.3	-2.8	3.3	3.2	2.5	2.6
Ever highly irritable/argumentative for 2 days	2.9	3.5	5.2	-2.3	2.1	-1.7	2.1	1.7	0.8	2.0
Supplements: Calcium	2.7	3.0	4.7	1.7	-1.1	1.7	-2.2	-2.1	-1.8	-1.3
Fractured/broken bones in last 5 years	2.6	3.3	6.3	2.1	0.3	1.7	-1.9	-2.1	-1.3	-2.5
Peak expiratory flow (PEF)	2.5	5.9	8.7	2.6	-0.3	2.8	-2.7	-2.9	-2.9	-1.5
Overall health rating	2.5	5.4	8.5	-2.7	-0.6	-2.9	2.8	2.6	2.5	0.9
Heart disease (siblings)	2.5	3.1	6.5	1.4	-0.6	1.7	-1.8	-2.1	-1.5	-2.6
Diverticular disease/diverticulitis (self-reported)	2.4	2.9	5.0	-1.8	-1.8	-2.0	2.2	1.7	1.4	-0.3
Ever had bowel cancer screening	2.4	2.8	4.2	-1.9	-2.0	-1.7	1.8	1.8	1.5	-0.2
Risk taking	2.4	3.5	10.9	-2.0	-3.3	-2.1	1.4	1.5	0.9	-0.3
Eye problems/disorders: Cataract	2.3	2.6	8.3	0.7	2.8	0.5	-0.4	-0.4	-1.1	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	7.7	2.2	0.2	2.8	-2.4	-2.6	-2.1	-2.1
Taking other prescription medications	2.2	3.5	6.0	-2.2	0.0	-2.4	1.6	2.1	2.3	1.1
Prostate Cancer	2.1	2.9	4.5	-1.6	1.7	-1.6	1.5	2.0	1.3	2.1
Primary Biliary Cirrhosis	2.1	2.9	6.6	2.1	-0.6	1.7	-1.4	-1.4	-1.5	-2.6
Diabetes (father)	2.1	2.6	6.0	1.7	-0.3	1.8	-1.6	-1.9	-2.4	-0.4
Severe depression (siblings)	2.1	2.3	3.6	-1.6	-1.0	-1.5	1.9	1.8	1.7	0.7
Gout (self-reported)	2.1	2.9	5.2	1.7	1.5	1.6	-2.3	-2.3	-1.4	-0.4
Pack years adult smoking proportion	2.0	3.0	5.0	-2.1	-0.4	-1.8	1.9	2.2	1.5	1.6
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	4.0	-1.7	-1.6	-1.7	1.9	2.0	1.6	0.2
Back pain experienced in last month	2.0	2.9	5.1	-1.9	-1.3	-1.8	2.3	1.6	2.1	0.3
Alcohol drinker status: Never	2.0	2.4	4.3	-1.6	1.0	-1.6	1.7	1.8	2.1	0.3
Pain type(s) experienced in last month: Hip pain	1.9	2.3	4.1	-1.7	-0.1	-1.8	1.6	1.7	2.0	0.7
Age started oral contraceptive pill	1.9	2.3	3.7	-0.9	0.6	-1.6	1.9	1.8	1.9	1.5
Number of children fathered	1.8	2.0	3.2	-1.8	1.4	-1.6	1.4	1.6	1.2	0.6
Had major operations	1.8	2.1	4.3	-1.3	-2.1	-1.8	0.6	1.1	2.0	0.2
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.5	1.1	0.2	1.3	-1.6	-1.7	-1.6	-1.9
Type 2 Diabetes (T2D) (2012)	1.7	1.9	3.8	1.6	-0.5	1.7	-1.5	-2.0	-1.2	-0.6
Long-standing illness, disability or infirmity	1.7	2.7	4.1	-2.0	-0.2	-1.8	1.7	1.5	1.6	1.8
Schizophrenia (2014)	1.6	3.5	6.4	1.5	1.3	2.2	-2.3	-2.0	-2.5	-0.4
Ulcerative Colitis	1.6	2.4	4.2	1.4	1.1	1.9	-1.6	-1.3	-2.1	1.3
Wheeze or whistling in the chest in last year	1.6	2.8	5.8	-1.3	-2.4	-1.3	1.8	1.0	1.2	2.2
Wears glasses or contact lenses	1.6	1.8	6.9	-1.3	-0.4	-1.2	0.9	1.1	0.8	2.6
Myopia	1.6	2.4	3.9	-2.0	-0.2	-1.8	1.9	1.8	1.3	1.0
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.1	-1.5	-1.4	-1.7	1.4	1.2	1.8	0.1
Mouth/teeth dental problems	1.5	2.3	3.8	1.7	0.1	1.5	-1.6	-2.0	-1.3	-1.6
Tense / ‘highly strung’	1.5	2.4	3.2	-1.3	-1.5	-1.8	1.8	1.8	1.5	1.3
Neuroticism	1.4	3.3	5.7	-1.8	-0.5	-1.9	2.4	2.1	2.2	1.0
Hearing difficulty/problems: Yes	1.4	2.1	4.1	-1.4	-1.3	-1.3	1.5	1.6	2.0	0.8
Medication: Metformin	1.4	1.9	6.0	1.0	-1.3	1.1	-1.3	-1.4	-0.3	-2.5
Average weekly fortified wine intake	1.4	1.6	3.2	1.8	0.3	1.5	-1.8	-0.9	-1.1	0.7
Past tobacco smoking	1.4	2.5	3.5	1.9	0.4	1.9	-1.8	-1.7	-1.7	-1.2
Ever unenthusiastic/disinterested for a whole week	1.4	1.8	5.5	1.0	2.3	1.4	-1.0	-1.1	-1.2	0.1
Age at first live birth	1.4	2.5	3.7	1.8	-1.0	1.8	-1.8	-1.9	-1.4	-1.0
Number of full sisters	1.4	1.7	3.1	-1.2	-1.2	-1.4	1.3	1.7	1.5	0.1
Schizophrenia (2018)	1.3	2.7	5.2	1.4	1.1	1.8	-2.3	-1.7	-2.0	-0.3
Ovarian Cancer	1.3	1.7	3.2	1.2	-1.0	0.9	-1.8	-1.6	-1.1	-1.3
Medication for hormone replacement therapy	1.3	1.4	3.5	-0.6	1.9	-0.6	1.2	1.4	1.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.9	-1.6	0.8	-1.4	1.5	1.4	2.0	1.3
Number of live births	1.3	1.8	3.7	1.3	0.1	1.9	-1.9	-1.7	-0.7	-0.9
Noisy workplace	1.3	1.5	5.7	0.9	-2.4	0.8	-0.5	-0.4	-0.5	-1.7
Pulse wave reflection index	1.3	1.6	5.2	0.7	-2.3	0.9	-1.3	-1.1	-1.3	-0.3
Medication: Paracetamol	1.3	2.1	4.1	-1.7	0.5	-1.8	2.0	1.7	0.9	0.7
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.7	-1.3	-0.8	-1.3	1.7	1.0	1.5	-0.5
Loneliness, isolation	1.3	1.8	2.8	-1.2	-0.6	-1.7	1.6	1.5	1.5	0.9
Depressed Affect (Nagel 2018)	1.2	2.4	3.5	-1.9	-0.8	-1.9	1.8	1.8	1.3	1.1
Schizophrenia vs Biploar Disorder	1.2	1.5	3.1	1.3	-0.4	1.5	-1.5	-1.7	-1.2	-0.3
Alzheimer’s Disease (including proxy)	1.2	1.7	2.2	1.5	-1.2	1.3	-1.5	-0.8	-1.4	-1.4
Coronary Artery Disease (CAD)	1.2	1.5	2.2	0.9	-0.7	1.4	-1.2	-1.5	-1.3	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	5.1	-1.8	-1.1	-1.9	1.7	1.6	2.3	0.9
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	6.1	1.8	-0.1	2.0	-2.1	-2.4	-1.9	-2.5
Medication: Cholesterol lowering	1.2	1.9	3.4	1.0	0.3	0.9	-1.8	-1.7	-1.4	-1.8
Age at last live birth	1.2	1.8	2.6	1.5	-0.9	1.5	-1.5	-1.6	-1.1	-1.0
Illnesses of siblings: Diabetes	1.2	1.5	2.8	1.7	-0.7	1.1	-1.2	-1.1	-0.7	-1.7
Number of treatments/medications taken	1.1	1.9	3.9	-1.9	-0.1	-2.0	1.4	1.4	1.5	0.6
Qualifications: CSEs or equivalent	1.1	1.4	4.1	0.5	-0.5	1.2	-0.7	-1.1	-1.5	-2.0
Multivitamins +/- minerals	1.1	1.4	5.3	-0.9	-2.3	-1.0	1.3	0.8	0.5	0.5
Hearing difficulty/problems with background noise	1.1	1.8	8.8	-0.9	-3.0	-0.7	0.4	0.7	1.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.3	0.7	0.1	1.4	-1.5	-1.5	-1.5	0.2
Medication: Blood pressure	1.1	2.2	3.8	-1.4	0.6	-1.9	1.2	1.4	1.8	1.6
Medication: Paracetamol	1.1	1.7	3.3	-1.8	0.7	-1.6	1.6	1.5	0.9	0.2
Reaction Time	1.0	1.9	3.7	1.4	0.9	1.8	-1.3	-1.1	-1.9	-0.8
Angina	1.0	1.3	2.0	1.3	1.2	1.4	-1.2	-1.1	-1.0	0.6
Age when periods started (menarche)	1.0	2.4	5.3	1.2	-2.1	1.1	-1.3	-1.3	-1.0	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	4.4	-1.7	-0.6	-2.0	1.6	1.4	2.1	0.5
Medication: Atenolol	1.0	1.2	5.2	-0.5	2.3	-0.1	-0.1	0.2	0.4	1.7
Nervous feelings	1.0	1.9	3.8	1.8	0.1	1.9	-1.5	-1.7	-1.2	0.6
Forced vital capacity (FVC)	1.0	3.9	5.9	1.8	-0.4	2.1	-2.4	-2.3	-1.7	-2.4
Medication: Ramipril	1.0	1.3	4.3	0.2	-2.1	-0.6	-0.5	-0.4	-0.6	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	7.6	1.4	-0.4	1.8	-1.8	-1.9	-1.5	-2.8
Medication for pain relief, constipation, heartburn	1.0	1.7	2.7	1.5	-0.1	1.6	-1.5	-1.6	-1.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.9	0.7	2.0	0.9	-0.5	-0.3	-0.9	1.3
Average weekly champagne plus white wine intake	1.0	1.4	3.1	1.8	-0.1	1.4	-1.3	-0.8	-1.6	-0.6
High cholesterol (Self-reported)	1.0	1.8	3.1	1.1	-0.2	1.1	-1.6	-1.7	-1.4	-1.8
Bipolar Disorder or Schizophrenia	0.9	2.1	3.6	1.1	1.3	1.6	-1.9	-1.5	-1.9	-0.3
Ulcerative Colitis (UC)	0.9	1.6	3.0	1.5	0.6	1.5	-1.4	-1.3	-1.7	0.2
HDL Cholesterol	0.9	1.4	2.2	-1.5	0.8	-1.3	1.2	1.2	0.9	1.5
Neuroticism (2016)	0.9	1.3	2.0	-1.2	-1.4	-1.2	1.4	1.4	0.4	-0.6
Blood Eosinophil Count	0.9	7.2	9.4	-3.1	-1.9	-2.7	3.0	2.5	2.6	2.9
Relative age of first facial hair	0.9	1.8	2.5	1.5	1.4	1.5	-1.1	-1.3	-1.6	-1.1
Vitamin and mineral supplements	0.9	1.2	2.4	1.0	1.5	1.0	-1.5	-1.0	-0.6	-0.5
Stomach or abdominal pain in last month	0.9	1.1	2.3	-0.8	-1.5	-0.7	1.5	1.1	1.1	-0.1
Pain all over the body in last month	0.9	0.9	1.7	0.6	1.3	0.8	-1.1	-1.1	-0.6	-1.1
Neuroticism score	0.9	1.8	3.5	-1.3	-0.6	-1.5	1.9	1.6	1.5	0.6
Depression (self-reported)	0.9	1.1	2.0	-1.2	-0.5	-1.1	1.4	0.9	1.3	0.8
Pulse wave Arterial Stiffness index	0.9	1.0	2.1	0.8	-1.4	1.2	-1.1	-1.0	-0.7	0.4
Birth weight of first child	0.9	1.6	3.3	-1.5	-1.8	-1.2	1.0	1.2	0.9	-0.9
Pulse wave peak to peak time	0.9	1.1	1.7	-0.9	1.3	-1.3	1.3	1.1	0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.4	0.9	-0.4	1.1	-1.2	-1.2	-1.1	-1.2
Hypertension (Self-reported)	0.9	2.4	5.2	-1.6	0.1	-2.3	1.3	1.8	1.7	1.3
Medication for cholesterol	0.9	1.3	2.1	1.1	-0.1	1.4	-1.3	-1.2	-1.3	-1.1
Medication: Gliclazide	0.9	1.0	5.1	-0.5	-0.8	-0.2	-0.4	-0.0	0.9	-2.3
Miserableness	0.9	1.6	4.6	-0.9	1.1	-1.1	1.2	1.2	0.6	2.1
Hearing aid user	0.9	1.1	2.1	-0.8	-0.2	-1.0	1.3	1.5	1.3	0.5
Alcohol drinker status: Previous	0.9	1.0	3.2	1.2	-0.0	0.9	-0.7	-1.1	-1.8	-0.3
Blood Platelet Count	0.8	9.5	13.8	-3.4	-1.0	-3.4	3.7	3.7	2.8	2.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	4.6	-0.6	2.1	-0.2	0.6	0.6	0.4	0.0
Sitting height	0.8	5.5	8.6	2.6	-1.1	2.3	-2.9	-2.8	-2.2	-1.9
Medication: Lansoprazole	0.8	0.9	2.7	-0.6	-0.7	-0.5	0.2	0.8	1.6	1.3
High blood pressure (siblings)	0.8	1.2	1.9	1.3	1.4	0.7	-1.4	-0.8	-1.0	-0.8
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.4	-0.8	-1.2	-1.1	1.1	1.1	1.2	-0.2
Medication: Allopurinol	0.8	1.1	1.9	1.1	0.5	1.1	-1.3	-1.4	-1.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.7	1.5	0.1	1.1	-1.7	-1.6	-1.6	-0.5
Average weekly red wine intake	0.8	1.2	2.6	-1.0	1.5	-1.2	0.2	0.9	1.6	0.2
Medication: Bendroflumethiazide	0.8	1.2	2.4	-1.1	0.3	-1.6	1.1	1.5	1.2	-0.4
Supplements: Zinc	0.7	0.7	2.8	0.2	-1.3	0.2	-0.2	-0.5	-0.1	-1.7
Medication: Co-codamol	0.7	0.9	3.1	-0.8	0.1	-0.9	0.6	0.7	0.7	1.8
Diabetes (mother)	0.7	0.9	1.4	-1.1	0.3	-1.2	1.0	0.7	0.9	1.2
High blood pressure	0.7	2.1	4.1	-1.2	0.1	-2.0	1.1	1.7	1.6	1.4
Impedance of leg (left)	0.7	3.2	8.1	1.7	-0.2	2.5	-1.3	-1.8	-2.8	0.4
Had menopause	0.7	0.8	2.6	-0.5	1.0	-0.4	0.8	0.8	0.8	1.6
Worrier / anxious feelings	0.7	1.3	3.6	1.2	1.9	1.0	-1.2	-0.9	-0.4	-0.7
Glaucoma (self-reported)	0.7	0.8	1.6	-1.2	-0.7	-1.1	0.8	1.0	0.7	-0.4
Medication: Amlodipine	0.7	1.0	3.2	-0.2	1.8	-0.9	0.7	0.8	0.7	1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	6.2	1.3	-0.3	1.8	-1.9	-1.8	-1.1	-2.5
Neck or shoulder pain in last month	0.7	1.0	3.1	0.7	1.8	0.5	-0.5	-0.5	-1.5	-0.9
Medication: Omeprazole	0.7	0.8	1.6	-1.0	-0.8	-1.2	0.8	0.7	1.3	-0.4
Eye problems/disorders: Glaucoma	0.7	0.9	1.9	-1.4	-0.9	-1.3	0.9	0.7	0.6	0.4
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.3	1.3	-0.4	1.8	-1.2	-1.6	-1.3	-1.6
Alzheimer’s Disease (in mother)	0.6	0.8	1.6	1.2	-0.8	1.0	-1.1	-0.3	-0.8	-0.2
Irritable Bowel Disease (IBD)	0.6	1.3	3.0	1.3	-0.1	1.3	-1.2	-1.2	-1.7	-0.1
Respiratory disease	0.6	1.4	5.1	-1.0	-0.4	-0.7	0.9	1.1	1.1	2.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.5	-1.0	0.1	-1.2	1.0	0.8	0.9	0.3
Townsend deprivation index at recruitment	0.6	0.8	1.8	-0.6	-1.3	-0.4	1.3	0.7	0.8	0.9
Financial difficulties in last 2 years	0.6	0.8	2.1	-0.7	-0.3	-1.0	1.5	1.3	0.7	-0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	0.5	-1.5	0.6	-1.1	-0.9	-0.8	-0.2
Happiness	0.6	0.8	3.6	0.0	0.7	0.0	0.8	0.5	0.7	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.2	0.8	1.5	0.5	-0.6	-0.5	-1.2	-0.2
Mouth/teeth dental problems: Dentures	0.6	1.1	5.0	-0.5	1.1	-0.1	0.4	0.7	0.5	2.2
Prospective memory result	0.6	0.8	1.1	-0.9	-0.9	-1.0	0.9	0.9	0.9	-0.4
Hair/balding pattern: Pattern 4	0.6	1.4	3.9	-1.6	2.0	-1.0	0.7	0.9	1.0	-0.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.0	-0.7	-1.4	-0.9	0.9	0.8	1.3	0.4
Blood clot in the leg (DVT)	0.6	0.7	1.9	-0.7	-0.6	-0.8	0.8	1.0	1.4	0.1
Number of full brothers	0.6	0.8	1.6	0.4	-1.3	1.0	-1.1	-0.6	-0.5	-1.0
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.9	-1.2	0.8	-0.5	-0.0	-0.1	-1.2
Angina (self-reported)	0.6	0.7	1.3	1.0	0.8	1.1	-0.9	-0.9	-0.7	0.4
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	-1.1	0.5	-1.4	1.1	1.1	1.1	0.6
Guilty feelings	0.6	0.9	3.5	-0.8	-1.9	-0.9	0.6	0.3	0.3	-0.7
Illnesses of father: High blood pressure	0.6	0.7	1.9	0.8	1.4	0.8	-0.2	-0.5	-1.2	0.3
Impedance of whole body	0.6	3.1	6.3	1.7	-0.8	2.5	-1.8	-1.7	-2.4	0.3
Bipolar Disorder (2011)	0.5	0.4	2.1	0.0	1.4	0.4	-0.2	-0.5	-0.0	-0.8
Crohns Disease (2012)	0.5	0.9	1.1	0.9	1.1	1.0	-1.0	-0.8	-0.8	0.9
Fasting Glucose	0.5	0.6	2.7	0.9	-1.6	0.2	-0.5	0.3	-0.1	-0.6
HbA1C	0.5	0.5	1.8	0.8	-0.8	0.4	-0.3	-0.4	-0.3	-1.3
Impedance of leg (right)	0.5	2.6	6.4	1.6	-0.4	2.4	-1.1	-1.6	-2.5	0.1
Relative age voice broke	0.5	0.8	1.7	1.2	0.9	0.8	-0.5	-0.7	-1.3	-0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	6.9	-0.3	-2.6	-0.5	0.0	0.2	0.4	-0.0
Waist circumference	0.5	2.0	3.5	-1.8	-0.1	-1.7	1.6	1.2	1.9	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.5	-0.5	-0.5	-1.1	1.1	1.2	1.0	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	3.1	0.5	-0.8	0.3	-0.1	0.2	0.3	1.7
Qualifications: None of the above	0.5	1.1	2.3	-1.2	0.6	-1.1	1.5	1.3	0.4	0.4
Allergy	0.5	1.2	4.2	1.0	2.0	1.1	-0.5	-0.9	-1.1	-0.4
Fluid intelligence score	0.5	1.0	5.0	-0.2	-2.2	-0.6	-0.0	0.5	0.2	-1.0
Hair/balding pattern: Pattern 3	0.5	0.8	1.7	-1.1	-0.2	-1.3	1.2	0.9	0.6	0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.2	6.6	-0.1	-2.6	-0.4	0.0	0.6	1.1	0.1
Impedance of arm (left)	0.5	2.1	4.2	1.4	-0.8	2.0	-1.6	-1.4	-1.8	0.8
Length of working week for main job	0.5	0.5	1.8	0.2	-1.4	-0.3	0.3	0.2	0.0	-1.2
Shortness of breath walking on level ground	0.5	0.6	1.0	0.8	0.6	0.9	-0.5	-0.9	-1.0	0.8
Medication: Seretide 50 evohaler	0.5	0.6	2.1	-0.4	-1.4	-0.6	0.4	0.8	0.1	0.7
Supplements: Vitamin C	0.5	0.6	0.9	-0.8	-0.6	-1.0	0.9	0.4	0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.7	-0.4	0.6	-0.5	-0.0	0.5	0.4	1.7
Diabetes diagnosed by doctor	0.5	0.9	3.0	-0.2	-1.7	-0.2	-0.4	-0.4	0.7	-1.5
Commuting to job workplace: Walk	0.5	0.6	1.4	-0.7	-0.1	-0.5	0.8	0.8	1.2	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.2	-0.8	1.0	-0.8	0.9	0.8	0.2	1.1
Asthma (self-reported)	0.5	1.0	4.6	-0.8	-0.6	-0.5	0.2	0.6	0.9	2.2
Financial situation satisfaction	0.5	0.6	1.5	-0.9	-0.8	-0.3	1.2	0.6	0.3	0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.9	0.8	1.4	0.4	-0.5	-0.8	-0.8	-0.5
Neuroticism (Nagel 2018)	0.4	0.8	1.3	-0.8	-0.6	-0.9	1.1	1.1	1.1	0.6
Major Depression (MDD)	0.4	0.4	1.2	-0.6	1.1	-0.3	0.5	0.5	0.7	0.6
Breast Cancer	0.4	0.9	2.4	-1.3	-1.6	-0.9	1.0	0.3	0.8	0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.1	0.2	-1.5	0.3	-0.5	-0.7	-0.1	-1.3
Chronotype (morning person)	0.4	0.8	3.5	0.5	1.9	0.8	-0.3	-0.6	-0.7	-0.6
Hand grip strength (left)	0.4	1.0	1.8	1.0	-1.3	0.8	-0.4	-1.1	-1.1	-1.1
Serious illness, injury or assault to yourself	0.4	0.5	1.8	0.5	-0.9	0.4	-0.2	-0.4	-0.4	-1.3
Supplements: Glucosamine	0.4	0.5	0.9	-0.9	0.2	-0.7	0.8	0.6	0.2	0.9
Diabetes (self-reported)	0.4	0.6	1.8	-0.2	-1.1	-0.2	-0.5	-0.5	0.9	-1.3
Impedance of arm (right)	0.4	1.9	3.6	1.4	-0.7	1.9	-1.5	-1.3	-1.8	0.5
Father’s age at death	0.4	0.5	2.1	0.6	1.4	0.4	-0.3	0.1	0.3	0.8
Asthma	0.4	0.8	3.4	-0.7	-0.6	-0.3	0.1	0.5	0.9	1.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.6	-0.4	-0.2	0.1	1.0	0.6	0.5	1.6
Comparative body size at age 10	0.4	1.0	1.8	-1.0	0.3	-1.3	1.3	1.1	1.0	0.8
Health satisfaction	0.4	0.5	1.0	-0.9	0.6	-1.0	1.0	0.5	0.6	0.0
Alcohol intake frequency.	0.4	1.0	1.7	-0.7	0.3	-0.8	0.9	1.2	1.2	1.3
Family relationship satisfaction	0.4	0.5	1.7	0.9	1.3	0.8	-0.1	-0.3	-0.0	0.6
Mood swings	0.4	0.7	1.2	-0.9	-0.4	-1.1	1.0	1.1	0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	0.1	-1.2	0.3	-0.4	-0.8	-0.5	0.5
Ever taken oral contraceptive pill	0.4	0.5	1.8	-0.6	-1.3	-0.3	0.6	0.6	0.6	-0.2
Mother’s age at death	0.4	0.4	2.6	-0.0	0.6	0.2	0.2	-0.2	-0.3	1.6
Commuting to job workplace: Public transport	0.4	0.5	1.3	0.9	1.1	0.7	-0.3	-0.3	-0.7	-0.1
Medication: Atorvastatin	0.4	0.5	1.1	0.6	-0.7	0.9	-1.1	-0.6	-0.7	-0.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.5	0.5	-1.9	-0.2	-0.9	-0.5	-0.3	-1.4
Systolic Blood Pressure	0.3	1.3	2.6	1.4	0.4	1.1	-1.1	-1.3	-1.6	-0.5
Allergy or Eczema	0.3	0.8	2.4	0.5	-1.5	0.6	-1.1	-0.9	-0.4	-0.4
Average weekly spirits intake	0.3	0.4	0.9	-0.2	0.3	-0.5	0.6	0.8	0.9	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.2	-0.4	1.5	-0.2	0.1	-0.1	0.4	0.7
Ever had hysterectomy (womb removed)	0.3	0.4	1.0	-0.5	-0.5	-0.8	1.0	0.5	0.3	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.5	-0.4	0.2	-0.2	-0.0	0.1	0.4	1.2
Hand grip strength (right)	0.3	0.9	4.4	0.2	-2.1	0.1	0.2	-0.7	-0.4	-1.0
Maternal smoking around birth	0.3	0.4	1.4	0.2	1.2	0.4	0.1	0.1	-0.4	1.0
Body mass index (BMI)	0.3	1.2	2.4	-1.3	0.5	-1.5	1.1	0.8	1.4	-0.3
Alcohol usually taken with meals	0.3	0.4	1.0	0.7	0.0	0.3	-1.0	-0.7	-0.3	-0.8
Illnesses of siblings	0.3	0.5	0.7	-0.8	0.1	-0.6	0.9	0.6	0.7	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.1	-1.0	-0.6	-0.8	0.9	0.6	0.5	0.4
Falls in the last year	0.3	0.4	0.9	-0.2	1.0	0.3	-0.1	-0.5	-0.8	-0.9
Pulse rate	0.3	0.5	1.1	0.9	-0.6	0.9	-0.5	-0.3	-0.3	-1.0
Illnesses of mother	0.3	0.4	2.0	-0.1	-1.4	0.2	0.0	-0.1	-0.5	-0.6
Breastfed as a baby	0.3	0.3	1.3	0.1	0.9	-0.1	-0.0	0.2	-0.4	1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	-1.2	-0.7	-0.6	0.5	0.4	0.4	0.2
Birth weight	0.3	0.7	1.9	-1.1	-0.4	-1.4	0.6	0.6	1.1	-0.2
Worry too long after embarrassment	0.3	0.4	0.9	-0.2	0.3	-0.4	0.8	0.9	0.9	0.6
Qualifications: College or University degree	0.3	0.9	2.0	1.4	-1.3	0.8	-1.0	-0.7	-0.5	-0.4
Heart disease (mother)	0.3	0.4	1.6	0.1	1.3	0.8	-0.5	-0.5	0.2	0.1
Medication: Aspirin	0.3	0.4	2.2	-0.6	0.1	-0.3	-0.4	-0.2	0.3	-1.5
Knee pain experienced in last month	0.3	0.4	1.1	-0.4	1.1	-0.5	0.7	0.6	0.0	0.5
Illnesses of father: Heart disease	0.3	0.4	0.8	-0.6	0.6	-0.7	0.8	0.9	0.6	-0.3
Mineral and other dietary supplements	0.3	0.4	0.6	0.8	-0.8	0.7	-0.7	-0.5	-0.4	-0.1
Osteoporosis (self-reported)	0.3	0.4	1.2	0.4	-0.4	0.8	-0.1	-0.7	-1.1	-0.4
Medication: Aspirin	0.3	0.4	1.9	-0.5	0.4	-0.0	-0.6	-0.3	0.2	-1.4
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.6	-0.7	0.8	-0.7	0.5	0.4	0.5	0.5
Diastolic blood pressure, automated reading	0.3	0.8	2.1	1.2	-0.1	0.6	-1.0	-0.4	-0.8	-1.4
Pain experienced in last month	0.3	0.5	1.6	0.7	0.4	0.6	-0.9	-0.6	-0.1	1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.4	-0.5	-0.3	-0.6	0.6	0.7	1.2	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.3	-0.2	-0.8	-0.6	-0.2	0.3	0.5	-1.5
Mean Putamen Volume	0.2	0.2	0.6	-0.1	0.8	0.1	0.5	0.3	-0.6	0.5
Height	0.2	4.3	6.2	1.5	-1.8	2.0	-2.5	-2.3	-2.0	-2.2
Cardiovascular Disease	0.2	0.7	1.4	0.9	-1.2	0.0	-0.9	-0.8	-0.6	-1.0
Leg fat-free mass (left)	0.2	1.2	2.4	-0.9	-1.2	-1.5	0.5	0.4	1.3	-1.3
Fed-up feelings	0.2	0.3	0.6	-0.2	0.4	-0.5	0.5	0.8	0.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	0.2	0.0	-0.2	-0.2	-0.2	-0.9	-0.9
Chronic bronchitis/emphysema (father)	0.2	0.3	0.9	-0.4	-0.9	-0.1	-0.0	-0.2	-0.3	-0.9
Leg predicted mass (left)	0.2	1.2	2.4	-0.8	-1.2	-1.6	0.5	0.4	1.3	-1.3
Heart attack	0.2	0.3	0.6	0.3	-0.8	0.4	-0.4	-0.7	-0.4	-0.4
Leg fat percentage (right)	0.2	0.6	1.0	-1.0	0.9	-0.8	0.9	0.4	0.5	0.4
Arm fat-free mass (right)	0.2	1.2	2.2	-0.9	-1.0	-1.5	0.8	0.5	1.4	-1.3
Migraine (self-reported)	0.2	0.2	0.6	-0.3	-0.0	-0.3	0.5	0.5	0.2	0.8
Medication: Ibuprofen	0.2	0.2	0.7	-0.2	0.2	-0.3	0.2	0.7	0.1	-0.8
Mean time to correctly identify matches	0.2	0.3	1.3	0.2	1.2	0.7	-0.3	-0.2	-0.5	-0.3
Leg fat mass (right)	0.2	0.6	1.4	-1.1	-0.1	-1.2	0.9	0.4	0.9	-0.3
Arm predicted mass (right)	0.2	1.1	2.1	-0.9	-0.8	-1.4	0.9	0.4	1.3	-1.3
Suffer from ‘nerves’	0.2	0.2	0.7	-0.3	-0.8	0.3	0.6	0.1	0.1	0.7
Leg pain on walking	0.2	0.3	1.5	-0.1	1.2	-0.2	0.4	0.2	-0.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.0	-0.1	-1.0	-0.0	-0.2	-0.1	0.5	-0.0
Smoking status: Previous	0.2	0.2	0.9	-0.4	1.0	-0.4	-0.1	0.1	0.6	0.1
Whole body fat-free mass	0.2	1.1	2.3	-0.9	-0.8	-1.5	0.6	0.4	1.3	-1.2
Leg fat-free mass (right)	0.2	1.0	2.1	-0.7	-1.2	-1.5	0.4	0.3	1.2	-1.0
Friendships satisfaction	0.2	0.2	0.8	-0.6	0.4	-0.2	0.9	0.3	0.4	0.3
Breast cancer (self-reported)	0.2	0.2	0.6	0.3	0.2	0.3	-0.1	-0.8	-0.3	0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.1	-0.5	0.2	-0.6	-0.1	0.5	0.7
Whole body water mass	0.2	0.9	1.8	-0.7	-0.7	-1.4	0.5	0.3	1.2	-1.3
Leg predicted mass (right)	0.2	1.1	2.3	-0.8	-1.2	-1.5	0.4	0.4	1.3	-1.1
Average weekly beer plus cider intake	0.2	0.3	1.5	-0.3	-0.0	0.1	0.2	0.2	-0.9	1.2
Irritability	0.2	0.3	0.6	-0.2	-0.5	-0.8	0.5	0.4	0.6	-0.3
Ever depressed for a whole week	0.2	0.2	0.5	-0.3	0.7	-0.1	0.7	0.5	0.0	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.5	0.8	0.4	-0.4	-0.2	-0.1	0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	0.3	-0.4	0.4	-0.5	-0.7	-0.3	-0.4
Bipolar Disorder (2018)	0.1	0.1	0.6	0.0	0.8	0.3	-0.2	-0.2	-0.5	-0.1
Worry (Nagel 2018)	0.1	0.2	0.5	0.1	0.6	0.4	0.3	0.0	0.6	0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.5	-0.3	-0.2	-0.1	0.4	0.1	-0.2	-0.7
Crohns Disease (2017)	0.1	0.2	0.5	0.4	0.3	0.7	-0.4	-0.6	-0.6	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	0.3	0.0	-0.1	-0.0	-0.4	0.0	-0.6
Rheumatoid Arthritis	0.1	0.2	0.8	-0.1	0.1	0.1	-0.5	-0.4	-0.4	0.9
Triglycerides	0.1	0.2	0.8	0.1	-0.1	-0.1	0.3	0.6	0.1	-0.9
Blood Red Count	0.1	1.3	2.4	-0.9	-0.5	-0.9	1.4	1.1	1.2	1.6
BMI	0.1	0.3	1.3	-0.3	-0.3	-0.7	0.1	-0.1	0.6	-1.1
Hypothyroidism (self reported)	0.1	0.3	1.8	-0.1	1.3	0.0	-0.3	-0.5	-0.1	-0.1
Lung FEV1/FVC ratio	0.1	0.8	3.0	-0.6	0.5	-0.6	1.1	0.1	-0.5	-1.7
Lung FVC	0.1	0.7	1.6	0.9	1.2	0.9	-1.0	-0.7	-0.0	0.5
Tanning	0.1	1.4	2.6	-1.2	1.0	-1.4	1.0	1.1	0.9	1.6
Sensitivity / hurt feelings	0.1	0.2	0.8	-0.1	-0.5	-0.2	0.4	0.2	0.0	-0.9
Systolic blood pressure, automated reading	0.1	0.4	1.1	0.6	1.0	0.2	-0.7	-0.5	-0.4	-0.4
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.6	0.5	-0.5	0.2	0.4	0.3	0.5
High blood pressure (mother)	0.1	0.2	0.4	0.2	0.6	-0.3	-0.6	-0.4	0.2	-0.1
Number of incorrect matches in round	0.1	0.1	0.5	-0.2	0.4	-0.0	0.2	-0.2	-0.3	-0.7
Medication: Simvastatin	0.1	0.2	0.6	0.2	-0.2	0.0	-0.3	-0.8	-0.2	-0.5
Weight	0.1	0.7	1.5	-1.1	-0.2	-1.2	0.6	0.3	1.1	-0.5
Arm fat percentage (right)	0.1	0.3	0.7	-0.8	0.7	-0.7	0.4	0.2	0.8	0.1
Trunk fat-free mass	0.1	0.7	1.6	-0.7	-0.4	-1.2	0.6	0.3	1.1	-1.0
Hip circumference	0.1	0.5	0.9	-0.8	-0.0	-0.9	0.9	0.4	0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.2	-0.0	-0.0	-0.0	0.4	-0.2	-0.5
Lung cancer (father)	0.1	0.1	0.3	-0.5	0.0	-0.3	0.4	0.2	0.4	0.5
Arm fat mass (right)	0.1	0.3	0.8	-0.8	0.3	-0.8	0.4	0.1	0.9	-0.3
Trunk predicted mass	0.1	0.7	1.6	-0.7	-0.4	-1.3	0.6	0.3	1.1	-1.0
Standing height	0.1	1.0	2.5	0.7	-1.6	0.7	-1.1	-1.1	-0.5	-0.7
Headache pain in last month	0.1	0.2	0.6	-0.2	-0.2	-0.3	0.5	0.8	0.2	-0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	0.3	0.9	0.4	-0.7	-0.5	-0.2	-0.3
Body fat percentage	0.1	0.2	0.6	-0.8	0.4	-0.6	0.4	0.1	0.7	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.6	0.2	0.0	0.0	0.2	0.3	0.0	0.8
Medication: Blood pressure	0.1	0.3	0.9	-0.3	0.5	-0.7	-0.2	0.2	0.2	-0.9
Whole body fat mass	0.1	0.5	1.0	-0.9	-0.0	-1.0	0.5	0.2	1.0	-0.4
Pulse rate, automated reading	0.1	0.3	1.0	0.7	0.4	-0.0	0.1	0.3	0.4	-1.0
Comparative height size at age 10	0.1	0.3	0.6	-0.6	-0.7	-0.4	0.3	0.3	0.5	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	0.3	-0.0	0.6	-0.4	-0.3	0.4	0.2
Arm fat percentage (left)	0.1	0.3	0.8	-0.8	0.5	-0.7	0.4	0.2	0.9	0.1
Osteoarthritis (self-reported)	0.1	0.2	0.7	-0.2	0.5	-0.4	0.2	0.1	-0.1	-0.8
Arm fat mass (left)	0.1	0.3	0.7	-0.7	0.3	-0.7	0.3	0.0	0.9	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.4	0.2	0.5	-0.5	-0.1	0.0	-0.5
Basal metabolic rate	0.1	0.8	1.7	-0.8	-0.7	-1.3	0.5	0.2	1.1	-1.1
Leg fat percentage (left)	0.1	0.5	1.5	-0.8	1.2	-0.6	0.6	0.2	0.2	0.7
Arm fat-free mass (left)	0.1	0.8	1.9	-0.6	-0.2	-1.2	0.6	0.3	1.1	-1.4
Unable to work because of sickness or disability	0.1	0.1	0.5	0.2	-0.7	0.2	0.4	-0.1	-0.2	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.5	0.2	0.2	0.7	-0.3	-0.4	-0.4	0.1
Cholesterol lowering medication	0.1	0.2	1.2	0.2	-1.1	-0.1	-0.0	-0.4	0.2	0.1
Leg fat mass (left)	0.1	0.4	0.9	-0.9	0.1	-1.0	0.7	0.1	0.6	-0.2
Arm predicted mass (left)	0.1	0.6	2.4	-0.3	-0.1	-0.9	0.2	-0.1	0.8	-1.5
Age at First Birth	0.0	0.1	0.1	0.2	-0.2	-0.3	-0.0	-0.4	0.0	-0.2
Waist Hip Ratio (WHR)	0.0	0.2	0.6	-0.6	-0.8	-0.2	0.2	0.3	0.4	0.3
Hair Pigment	0.0	1.4	2.1	-1.2	-1.3	-1.1	1.2	1.2	0.7	1.5
Trunk fat percentage	0.0	0.1	0.2	-0.5	-0.0	-0.3	-0.1	-0.4	0.3	-0.3
Trunk fat mass	0.0	0.2	0.4	-0.6	-0.1	-0.5	0.0	-0.3	0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.3	-0.0	-0.2	-0.1	0.2	0.2	-0.3
Qualifications: nursing, teaching	0.0	0.1	0.2	0.2	-0.2	0.2	-0.1	-0.3	-0.4	0.1

Hub : Genes

WDFY2

Models

Trait associations