Hub : Genes

WDFY2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.2356 0.0553 3.2e-07 0.128 NA 0.113 NA 0.113 2.5e-09 NA 2.4e-08 NA 2.2e-08
2 GTEx Pancreas 0.2120 0.0740 1.1e-03 0.010 NA 0.013 NA 0.072 1.2e-01 NA 9.3e-02 NA 5.6e-04
3 METSIM Adipose 0.0883 0.0259 8.6e-07 0.080 0.066 0.067 0.079 0.076 5.4e-12 3.6e-10 2.6e-10 7.2e-12 1.7e-11
4 NTR Blood 0.0413 0.0115 2.2e-07 0.035 0.021 0.035 0.031 0.034 1.9e-11 2.1e-07 1.7e-11 2.0e-10 2.9e-11
5 TCGA Breast Invasive Carcinoma 0.0197 0.0127 2.6e-03 0.019 0.005 0.010 NA 0.015 6.2e-05 2.2e-02 3.6e-03 NA 3.4e-04
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0328 0.0180 2.7e-03 0.027 0.014 0.020 NA 0.017 4.4e-04 9.6e-03 2.3e-03 NA 4.9e-03
7 TCGA Prostate Adenocarcinoma 0.0620 0.0339 1.8e-03 0.013 0.025 0.019 NA 0.016 1.4e-02 1.0e-03 4.1e-03 NA 7.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.1 0.1 0.6 0.0 0.8 0.3 -0.2 -0.2 -0.5 -0.1
Bipolar Disorder or Schizophrenia 0.9 2.1 3.6 1.1 1.3 1.6 -1.9 -1.5 -1.9 -0.3
Depressed Affect (Nagel 2018) 1.2 2.4 3.5 -1.9 -0.8 -1.9 1.8 1.8 1.3 1.1
Depression (Nagel 2018) 5.1 7.7 11.9 -2.6 -0.8 -3.1 3.5 3.2 3.0 2.4
Intelligence (Savage-Jansen 2018) 0.3 1.0 3.5 0.5 -1.9 -0.2 -0.9 -0.5 -0.3 -1.4
Neuroticism (Nagel 2018) 0.4 0.8 1.3 -0.8 -0.6 -0.9 1.1 1.1 1.1 0.6
Schizophrenia (2018) 1.3 2.7 5.2 1.4 1.1 1.8 -2.3 -1.7 -2.0 -0.3
Schizophrenia vs Biploar Disorder 1.2 1.5 3.1 1.3 -0.4 1.5 -1.5 -1.7 -1.2 -0.3
Worry (Nagel 2018) 0.1 0.2 0.5 0.1 0.6 0.4 0.3 0.0 0.6 0.7
Alzheimer’s Disease (in mother) 0.6 0.8 1.6 1.2 -0.8 1.0 -1.1 -0.3 -0.8 -0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.5 -0.3 -0.2 -0.1 0.4 0.1 -0.2 -0.7
Alzheimer’s Disease (including proxy) 1.2 1.7 2.2 1.5 -1.2 1.3 -1.5 -0.8 -1.4 -1.4
Crohns Disease (2017) 0.1 0.2 0.5 0.4 0.3 0.7 -0.4 -0.6 -0.6 -0.3
Irritable Bowel Disease (IBD) 0.6 1.3 3.0 1.3 -0.1 1.3 -1.2 -1.2 -1.7 -0.1
Ulcerative Colitis (UC) 0.9 1.6 3.0 1.5 0.6 1.5 -1.4 -1.3 -1.7 0.2
Major Depression (MDD) 0.4 0.4 1.2 -0.6 1.1 -0.3 0.5 0.5 0.7 0.6
Reaction Time 1.0 1.9 3.7 1.4 0.9 1.8 -1.3 -1.1 -1.9 -0.8
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.3 -0.2 -0.8 -0.6 -0.2 0.3 0.5 -1.5
Breast Cancer 0.4 0.9 2.4 -1.3 -1.6 -0.9 1.0 0.3 0.8 0.2
Ovarian Cancer 1.3 1.7 3.2 1.2 -1.0 0.9 -1.8 -1.6 -1.1 -1.3
Prostate Cancer 2.1 2.9 4.5 -1.6 1.7 -1.6 1.5 2.0 1.3 2.1
Age at First Birth 0.0 0.1 0.1 0.2 -0.2 -0.3 -0.0 -0.4 0.0 -0.2
Bipolar Disorder (2011) 0.5 0.4 2.1 0.0 1.4 0.4 -0.2 -0.5 -0.0 -0.8
Body Mass Index (BMI) (2010) 0.1 0.1 0.4 0.3 0.0 -0.1 -0.0 -0.4 0.0 -0.6
Coronary Artery Disease (CAD) 1.2 1.5 2.2 0.9 -0.7 1.4 -1.2 -1.5 -1.3 -1.3
Crohns Disease (2012) 0.5 0.9 1.1 0.9 1.1 1.0 -1.0 -0.8 -0.8 0.9
Mean Putamen Volume 0.2 0.2 0.6 -0.1 0.8 0.1 0.5 0.3 -0.6 0.5
Fasting Glucose 0.5 0.6 2.7 0.9 -1.6 0.2 -0.5 0.3 -0.1 -0.6
HbA1C 0.5 0.5 1.8 0.8 -0.8 0.4 -0.3 -0.4 -0.3 -1.3
HDL Cholesterol 0.9 1.4 2.2 -1.5 0.8 -1.3 1.2 1.2 0.9 1.5
LDL Cholesterol 3.1 5.0 8.9 2.3 0.8 2.5 -2.6 -2.6 -3.0 -0.5
Lupus 4.1 6.2 9.0 2.6 1.4 2.8 -2.8 -3.0 -2.4 -2.0
Neuroticism (2016) 0.9 1.3 2.0 -1.2 -1.4 -1.2 1.4 1.4 0.4 -0.6
Primary Biliary Cirrhosis 2.1 2.9 6.6 2.1 -0.6 1.7 -1.4 -1.4 -1.5 -2.6
Rheumatoid Arthritis 0.1 0.2 0.8 -0.1 0.1 0.1 -0.5 -0.4 -0.4 0.9
Schizophrenia (2014) 1.6 3.5 6.4 1.5 1.3 2.2 -2.3 -2.0 -2.5 -0.4
Triglycerides 0.1 0.2 0.8 0.1 -0.1 -0.1 0.3 0.6 0.1 -0.9
Type 2 Diabetes (T2D) (2012) 1.7 1.9 3.8 1.6 -0.5 1.7 -1.5 -2.0 -1.2 -0.6
Ulcerative Colitis 1.6 2.4 4.2 1.4 1.1 1.9 -1.6 -1.3 -2.1 1.3
Blood Eosinophil Count 0.9 7.2 9.4 -3.1 -1.9 -2.7 3.0 2.5 2.6 2.9
Blood Platelet Count 0.8 9.5 13.8 -3.4 -1.0 -3.4 3.7 3.7 2.8 2.7
Blood Red Count 0.1 1.3 2.4 -0.9 -0.5 -0.9 1.4 1.1 1.2 1.6
Blood White Count 5.4 40.0 57.3 -7.3 -1.4 -7.2 7.6 6.9 6.8 4.6
Heel T-Score 3.5 27.8 43.7 -6.0 -1.0 -5.9 6.6 5.6 5.5 4.2
BMI 0.1 0.3 1.3 -0.3 -0.3 -0.7 0.1 -0.1 0.6 -1.1
Height 0.2 4.3 6.2 1.5 -1.8 2.0 -2.5 -2.3 -2.0 -2.2
Waist Hip Ratio (WHR) 0.0 0.2 0.6 -0.6 -0.8 -0.2 0.2 0.3 0.4 0.3
Systolic Blood Pressure 0.3 1.3 2.6 1.4 0.4 1.1 -1.1 -1.3 -1.6 -0.5
Smoking Status 2.9 7.0 10.6 -2.8 0.3 -2.8 3.3 3.2 2.5 2.6
Allergy or Eczema 0.3 0.8 2.4 0.5 -1.5 0.6 -1.1 -0.9 -0.4 -0.4
Cardiovascular Disease 0.2 0.7 1.4 0.9 -1.2 0.0 -0.9 -0.8 -0.6 -1.0
Hypothyroidism (self reported) 0.1 0.3 1.8 -0.1 1.3 0.0 -0.3 -0.5 -0.1 -0.1
Respiratory disease 0.6 1.4 5.1 -1.0 -0.4 -0.7 0.9 1.1 1.1 2.2
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.1 0.2 -1.5 0.3 -0.5 -0.7 -0.1 -1.3
Lung FEV1/FVC ratio 0.1 0.8 3.0 -0.6 0.5 -0.6 1.1 0.1 -0.5 -1.7
Lung FVC 0.1 0.7 1.6 0.9 1.2 0.9 -1.0 -0.7 -0.0 0.5
Neuroticism 1.4 3.3 5.7 -1.8 -0.5 -1.9 2.4 2.1 2.2 1.0
Chronotype (morning person) 0.4 0.8 3.5 0.5 1.9 0.8 -0.3 -0.6 -0.7 -0.6
Hair Pigment 0.0 1.4 2.1 -1.2 -1.3 -1.1 1.2 1.2 0.7 1.5
Tanning 0.1 1.4 2.6 -1.2 1.0 -1.4 1.0 1.1 0.9 1.6
Hand grip strength (left) 0.4 1.0 1.8 1.0 -1.3 0.8 -0.4 -1.1 -1.1 -1.1
Number of treatments/medications taken 1.1 1.9 3.9 -1.9 -0.1 -2.0 1.4 1.4 1.5 0.6
Average weekly spirits intake 0.3 0.4 0.9 -0.2 0.3 -0.5 0.6 0.8 0.9 0.8
Sensitivity / hurt feelings 0.1 0.2 0.8 -0.1 -0.5 -0.2 0.4 0.2 0.0 -0.9
Frequency of depressed mood in last 2 weeks 4.1 5.7 9.1 -2.0 0.3 -2.7 3.0 2.6 2.5 2.7
Hearing difficulty/problems: Yes 1.4 2.1 4.1 -1.4 -1.3 -1.3 1.5 1.6 2.0 0.8
Relative age of first facial hair 0.9 1.8 2.5 1.5 1.4 1.5 -1.1 -1.3 -1.6 -1.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.2 -0.4 1.5 -0.2 0.1 -0.1 0.4 0.7
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.5 -1.0 0.1 -1.2 1.0 0.8 0.9 0.3
Ever had hysterectomy (womb removed) 0.3 0.4 1.0 -0.5 -0.5 -0.8 1.0 0.5 0.3 0.5
Systolic blood pressure, automated reading 0.1 0.4 1.1 0.6 1.0 0.2 -0.7 -0.5 -0.4 -0.4
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.5 -0.4 0.2 -0.2 -0.0 0.1 0.4 1.2
Angina 1.0 1.3 2.0 1.3 1.2 1.4 -1.2 -1.1 -1.0 0.6
Medication for hormone replacement therapy 1.3 1.4 3.5 -0.6 1.9 -0.6 1.2 1.4 1.1 1.0
Vitamin and mineral supplements 0.9 1.2 2.4 1.0 1.5 1.0 -1.5 -1.0 -0.6 -0.5
Supplements: Zinc 0.7 0.7 2.8 0.2 -1.3 0.2 -0.2 -0.5 -0.1 -1.7
Medication: Co-codamol 0.7 0.9 3.1 -0.8 0.1 -0.9 0.6 0.7 0.7 1.8
Medication: Metformin 1.4 1.9 6.0 1.0 -1.3 1.1 -1.3 -1.4 -0.3 -2.5
Diabetes (father) 2.1 2.6 6.0 1.7 -0.3 1.8 -1.6 -1.9 -2.4 -0.4
Diabetes (mother) 0.7 0.9 1.4 -1.1 0.3 -1.2 1.0 0.7 0.9 1.2
Severe depression (siblings) 2.1 2.3 3.6 -1.6 -1.0 -1.5 1.9 1.8 1.7 0.7
Pack years adult smoking proportion 2.0 3.0 5.0 -2.1 -0.4 -1.8 1.9 2.2 1.5 1.6
Impedance of leg (right) 0.5 2.6 6.4 1.6 -0.4 2.4 -1.1 -1.6 -2.5 0.1
Leg fat-free mass (left) 0.2 1.2 2.4 -0.9 -1.2 -1.5 0.5 0.4 1.3 -1.3
Trunk fat percentage 0.0 0.1 0.2 -0.5 -0.0 -0.3 -0.1 -0.4 0.3 -0.3
Hand grip strength (right) 0.3 0.9 4.4 0.2 -2.1 0.1 0.2 -0.7 -0.4 -1.0
Townsend deprivation index at recruitment 0.6 0.8 1.8 -0.6 -1.3 -0.4 1.3 0.7 0.8 0.9
Current tobacco smoking 5.0 8.2 14.7 -2.8 -0.1 -3.0 3.8 3.5 2.2 3.0
Average weekly fortified wine intake 1.4 1.6 3.2 1.8 0.3 1.5 -1.8 -0.9 -1.1 0.7
Maternal smoking around birth 0.3 0.4 1.4 0.2 1.2 0.4 0.1 0.1 -0.4 1.0
Fed-up feelings 0.2 0.3 0.6 -0.2 0.4 -0.5 0.5 0.8 0.4 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 3.4 4.6 11.3 -1.7 0.4 -2.1 2.3 2.2 1.6 3.4
Relative age voice broke 0.5 0.8 1.7 1.2 0.9 0.8 -0.5 -0.7 -1.3 -0.3
Taking other prescription medications 2.2 3.5 6.0 -2.2 0.0 -2.4 1.6 2.1 2.3 1.1
Age when periods started (menarche) 1.0 2.4 5.3 1.2 -2.1 1.1 -1.3 -1.3 -1.0 -2.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 0.2 0.0 -0.2 -0.2 -0.2 -0.9 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 4.4 -1.7 -0.6 -2.0 1.6 1.4 2.1 0.5
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 4.6 -0.6 2.1 -0.2 0.6 0.6 0.4 0.0
Qualifications: CSEs or equivalent 1.1 1.4 4.1 0.5 -0.5 1.2 -0.7 -1.1 -1.5 -2.0
Serious illness, injury or assault to yourself 0.4 0.5 1.8 0.5 -0.9 0.4 -0.2 -0.4 -0.4 -1.3
High blood pressure 0.7 2.1 4.1 -1.2 0.1 -2.0 1.1 1.7 1.6 1.4
Hayfever, allergic rhinitis or eczema 0.5 1.1 6.9 -0.3 -2.6 -0.5 0.0 0.2 0.4 -0.0
Multivitamins +/- minerals 1.1 1.4 5.3 -0.9 -2.3 -1.0 1.3 0.8 0.5 0.5
Stomach or abdominal pain in last month 0.9 1.1 2.3 -0.8 -1.5 -0.7 1.5 1.1 1.1 -0.1
Supplements: Glucosamine 0.4 0.5 0.9 -0.9 0.2 -0.7 0.8 0.6 0.2 0.9
Diverticular disease/diverticulitis (self-reported) 2.4 2.9 5.0 -1.8 -1.8 -2.0 2.2 1.7 1.4 -0.3
Medication: Atenolol 1.0 1.2 5.2 -0.5 2.3 -0.1 -0.1 0.2 0.4 1.7
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.6 0.5 -0.5 0.2 0.4 0.3 0.5
Sitting height 0.8 5.5 8.6 2.6 -1.1 2.3 -2.9 -2.8 -2.2 -1.9
Chronic bronchitis/emphysema (father) 0.2 0.3 0.9 -0.4 -0.9 -0.1 -0.0 -0.2 -0.3 -0.9
High blood pressure (mother) 0.1 0.2 0.4 0.2 0.6 -0.3 -0.6 -0.4 0.2 -0.1
Body mass index (BMI) 0.3 1.2 2.4 -1.3 0.5 -1.5 1.1 0.8 1.4 -0.3
Impedance of leg (left) 0.7 3.2 8.1 1.7 -0.2 2.5 -1.3 -1.8 -2.8 0.4
Leg predicted mass (left) 0.2 1.2 2.4 -0.8 -1.2 -1.6 0.5 0.4 1.3 -1.3
Trunk fat mass 0.0 0.2 0.4 -0.6 -0.1 -0.5 0.0 -0.3 0.6 -0.5
Waist circumference 0.5 2.0 3.5 -1.8 -0.1 -1.7 1.6 1.2 1.9 0.6
Number of incorrect matches in round 0.1 0.1 0.5 -0.2 0.4 -0.0 0.2 -0.2 -0.3 -0.7
Past tobacco smoking 1.4 2.5 3.5 1.9 0.4 1.9 -1.8 -1.7 -1.7 -1.2
Alcohol usually taken with meals 0.3 0.4 1.0 0.7 0.0 0.3 -1.0 -0.7 -0.3 -0.8
Nervous feelings 1.0 1.9 3.8 1.8 0.1 1.9 -1.5 -1.7 -1.2 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.5 -0.5 -0.5 -1.1 1.1 1.2 1.0 0.3
Hearing difficulty/problems with background noise 1.1 1.8 8.8 -0.9 -3.0 -0.7 0.4 0.7 1.3 0.5
Hair/balding pattern: Pattern 2 0.5 0.6 3.1 0.5 -0.8 0.3 -0.1 0.2 0.3 1.7
Had menopause 0.7 0.8 2.6 -0.5 1.0 -0.4 0.8 0.8 0.8 1.6
Had other major operations 3.6 4.3 8.4 -2.4 -0.9 -2.1 2.4 2.1 2.9 0.8
Forced vital capacity (FVC) 1.0 3.9 5.9 1.8 -0.4 2.1 -2.4 -2.3 -1.7 -2.4
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 5.1 -1.8 -1.1 -1.9 1.7 1.6 2.3 0.9
Ever unenthusiastic/disinterested for a whole week 1.4 1.8 5.5 1.0 2.3 1.4 -1.0 -1.1 -1.2 0.1
Qualifications: None of the above 0.5 1.1 2.3 -1.2 0.6 -1.1 1.5 1.3 0.4 0.4
Financial difficulties in last 2 years 0.6 0.8 2.1 -0.7 -0.3 -1.0 1.5 1.3 0.7 -0.0
Mouth/teeth dental problems 1.5 2.3 3.8 1.7 0.1 1.5 -1.6 -2.0 -1.3 -1.6
Heart attack 0.2 0.3 0.6 0.3 -0.8 0.4 -0.4 -0.7 -0.4 -0.4
Allergy 0.5 1.2 4.2 1.0 2.0 1.1 -0.5 -0.9 -1.1 -0.4
Pain all over the body in last month 0.9 0.9 1.7 0.6 1.3 0.8 -1.1 -1.1 -0.6 -1.1
Diabetes (self-reported) 0.4 0.6 1.8 -0.2 -1.1 -0.2 -0.5 -0.5 0.9 -1.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.1 0.5 -1.5 0.6 -1.1 -0.9 -0.8 -0.2
Medication: Ramipril 1.0 1.3 4.3 0.2 -2.1 -0.6 -0.5 -0.4 -0.6 -1.9
Medication: Simvastatin 0.1 0.2 0.6 0.2 -0.2 0.0 -0.3 -0.8 -0.2 -0.5
Fluid intelligence score 0.5 1.0 5.0 -0.2 -2.2 -0.6 -0.0 0.5 0.2 -1.0
Illnesses of siblings 0.3 0.5 0.7 -0.8 0.1 -0.6 0.9 0.6 0.7 0.8
Neuroticism score 0.9 1.8 3.5 -1.3 -0.6 -1.5 1.9 1.6 1.5 0.6
Weight 0.1 0.7 1.5 -1.1 -0.2 -1.2 0.6 0.3 1.1 -0.5
Impedance of arm (right) 0.4 1.9 3.6 1.4 -0.7 1.9 -1.5 -1.3 -1.8 0.5
Arm fat percentage (right) 0.1 0.3 0.7 -0.8 0.7 -0.7 0.4 0.2 0.8 0.1
Trunk fat-free mass 0.1 0.7 1.6 -0.7 -0.4 -1.2 0.6 0.3 1.1 -1.0
Hip circumference 0.1 0.5 0.9 -0.8 -0.0 -0.9 0.9 0.4 0.9 0.5
Time employed in main current job 4.8 5.6 7.9 2.8 0.2 2.5 -2.5 -2.7 -2.5 -2.2
Alcohol intake versus 10 years previously 0.3 0.5 1.1 -1.0 -0.6 -0.8 0.9 0.6 0.5 0.4
Father’s age at death 0.4 0.5 2.1 0.6 1.4 0.4 -0.3 0.1 0.3 0.8
Worrier / anxious feelings 0.7 1.3 3.6 1.2 1.9 1.0 -1.2 -0.9 -0.4 -0.7
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 3.9 -1.6 0.8 -1.4 1.5 1.4 2.0 1.3
Falls in the last year 0.3 0.4 0.9 -0.2 1.0 0.3 -0.1 -0.5 -0.8 -0.9
Hair/balding pattern: Pattern 3 0.5 0.8 1.7 -1.1 -0.2 -1.3 1.2 0.9 0.6 0.2
Number of live births 1.3 1.8 3.7 1.3 0.1 1.9 -1.9 -1.7 -0.7 -0.9
Forced expiratory volume in 1-second (FEV1) 1.2 3.9 6.1 1.8 -0.1 2.0 -2.1 -2.4 -1.9 -2.5
Pulse rate 0.3 0.5 1.1 0.9 -0.6 0.9 -0.5 -0.3 -0.3 -1.0
Happiness 0.6 0.8 3.6 0.0 0.7 0.0 0.8 0.5 0.7 1.9
Noisy workplace 1.3 1.5 5.7 0.9 -2.4 0.8 -0.5 -0.4 -0.5 -1.7
Qualifications: A levels/AS levels or equivalent 0.5 1.2 6.6 -0.1 -2.6 -0.4 0.0 0.6 1.1 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.2 0.8 1.5 0.5 -0.6 -0.5 -1.2 -0.2
Mouth/teeth dental problems: Dentures 0.6 1.1 5.0 -0.5 1.1 -0.1 0.4 0.7 0.5 2.2
Asthma 0.4 0.8 3.4 -0.7 -0.6 -0.3 0.1 0.5 0.9 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 0.2 -0.0 -0.0 -0.0 0.4 -0.2 -0.5
Medication: Cholesterol lowering 1.2 1.9 3.4 1.0 0.3 0.9 -1.8 -1.7 -1.4 -1.8
Depression (self-reported) 0.9 1.1 2.0 -1.2 -0.5 -1.1 1.4 0.9 1.3 0.8
Medication: Lansoprazole 0.8 0.9 2.7 -0.6 -0.7 -0.5 0.2 0.8 1.6 1.3
Prospective memory result 0.6 0.8 1.1 -0.9 -0.9 -1.0 0.9 0.9 0.9 -0.4
Lung cancer (father) 0.1 0.1 0.3 -0.5 0.0 -0.3 0.4 0.2 0.4 0.5
Illnesses of mother 0.3 0.4 2.0 -0.1 -1.4 0.2 0.0 -0.1 -0.5 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 7.6 1.4 -0.4 1.8 -1.8 -1.9 -1.5 -2.8
Pulse wave Arterial Stiffness index 0.9 1.0 2.1 0.8 -1.4 1.2 -1.1 -1.0 -0.7 0.4
Impedance of arm (left) 0.5 2.1 4.2 1.4 -0.8 2.0 -1.6 -1.4 -1.8 0.8
Arm fat mass (right) 0.1 0.3 0.8 -0.8 0.3 -0.8 0.4 0.1 0.9 -0.3
Trunk predicted mass 0.1 0.7 1.6 -0.7 -0.4 -1.3 0.6 0.3 1.1 -1.0
Standing height 0.1 1.0 2.5 0.7 -1.6 0.7 -1.1 -1.1 -0.5 -0.7
Length of working week for main job 0.5 0.5 1.8 0.2 -1.4 -0.3 0.3 0.2 0.0 -1.2
Exposure to tobacco smoke at home 4.0 4.5 7.1 -2.3 -1.1 -2.3 2.7 2.6 2.3 -0.5
Breastfed as a baby 0.3 0.3 1.3 0.1 0.9 -0.1 -0.0 0.2 -0.4 1.2
Tense / ‘highly strung’ 1.5 2.4 3.2 -1.3 -1.5 -1.8 1.8 1.8 1.5 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 4.6 7.1 12.2 -2.9 -1.2 -3.0 3.5 2.9 2.6 1.8
Hair/balding pattern: Pattern 4 0.6 1.4 3.9 -1.6 2.0 -1.0 0.7 0.9 1.0 -0.2
Birth weight of first child 0.9 1.6 3.3 -1.5 -1.8 -1.2 1.0 1.2 0.9 -0.9
Peak expiratory flow (PEF) 2.5 5.9 8.7 2.6 -0.3 2.8 -2.7 -2.9 -2.9 -1.5
Pulse wave reflection index 1.3 1.6 5.2 0.7 -2.3 0.9 -1.3 -1.1 -1.3 -0.3
Ever highly irritable/argumentative for 2 days 2.9 3.5 5.2 -2.3 2.1 -1.7 2.1 1.7 0.8 2.0
Loud music exposure frequency 3.5 3.9 5.9 -2.2 -1.1 -1.7 2.2 2.4 1.9 1.9
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 2.0 -0.7 -1.4 -0.9 0.9 0.8 1.3 0.4
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 4.0 -1.7 -1.6 -1.7 1.9 2.0 1.6 0.2
Blood clot in the leg (DVT) 0.6 0.7 1.9 -0.7 -0.6 -0.8 0.8 1.0 1.4 0.1
Medication: Paracetamol 1.3 2.1 4.1 -1.7 0.5 -1.8 2.0 1.7 0.9 0.7
Headache pain in last month 0.1 0.2 0.6 -0.2 -0.2 -0.3 0.5 0.8 0.2 -0.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.6 -0.4 -0.2 0.1 1.0 0.6 0.5 1.6
Glaucoma (self-reported) 0.7 0.8 1.6 -1.2 -0.7 -1.1 0.8 1.0 0.7 -0.4
Gout (self-reported) 2.1 2.9 5.2 1.7 1.5 1.6 -2.3 -2.3 -1.4 -0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.8 0.3 0.9 0.4 -0.7 -0.5 -0.2 -0.3
Medication: Amlodipine 0.7 1.0 3.2 -0.2 1.8 -0.9 0.7 0.8 0.7 1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.3 -1.2 -0.7 -0.6 0.5 0.4 0.4 0.2
Birth weight 0.3 0.7 1.9 -1.1 -0.4 -1.4 0.6 0.6 1.1 -0.2
Chronic bronchitis/emphysema (mother) 1.3 1.5 2.7 -1.3 -0.8 -1.3 1.7 1.0 1.5 -0.5
High blood pressure (siblings) 0.8 1.2 1.9 1.3 1.4 0.7 -1.4 -0.8 -1.0 -0.8
Forced vital capacity (FVC), Best measure 0.7 2.7 6.2 1.3 -0.3 1.8 -1.9 -1.8 -1.1 -2.5
Body fat percentage 0.1 0.2 0.6 -0.8 0.4 -0.6 0.4 0.1 0.7 0.1
Leg fat percentage (right) 0.2 0.6 1.0 -1.0 0.9 -0.8 0.9 0.4 0.5 0.4
Arm fat-free mass (right) 0.2 1.2 2.2 -0.9 -1.0 -1.5 0.8 0.5 1.4 -1.3
Exposure to tobacco smoke outside home 3.5 4.6 9.2 -2.2 -0.9 -2.3 3.0 2.2 1.6 2.1
Comparative body size at age 10 0.4 1.0 1.8 -1.0 0.3 -1.3 1.3 1.1 1.0 0.8
Number of full brothers 0.6 0.8 1.6 0.4 -1.3 1.0 -1.1 -0.6 -0.5 -1.0
Worry too long after embarrassment 0.3 0.4 0.9 -0.2 0.3 -0.4 0.8 0.9 0.9 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 3.8 4.9 8.2 -2.0 -0.1 -2.4 2.8 2.9 1.7 2.5
Wheeze or whistling in the chest in last year 1.6 2.8 5.8 -1.3 -2.4 -1.3 1.8 1.0 1.2 2.2
Number of children fathered 1.8 2.0 3.2 -1.8 1.4 -1.6 1.4 1.6 1.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 -0.3 -0.0 -0.2 -0.1 0.2 0.2 -0.3
Age at first live birth 1.4 2.5 3.7 1.8 -1.0 1.8 -1.8 -1.9 -1.4 -1.0
Pulse wave peak to peak time 0.9 1.1 1.7 -0.9 1.3 -1.3 1.3 1.1 0.9 -0.3
Health satisfaction 0.4 0.5 1.0 -0.9 0.6 -1.0 1.0 0.5 0.6 0.0
Shortness of breath walking on level ground 0.5 0.6 1.0 0.8 0.6 0.9 -0.5 -0.9 -1.0 0.8
Qualifications: College or University degree 0.3 0.9 2.0 1.4 -1.3 0.8 -1.0 -0.7 -0.5 -0.4
Eye problems/disorders: None of the above 0.6 0.7 1.6 0.9 -1.2 0.8 -0.5 -0.0 -0.1 -1.2
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.4 -0.8 -1.2 -1.1 1.1 1.1 1.2 -0.2
Emphysema/chronic bronchitis 0.1 0.1 0.6 0.2 0.0 0.0 0.2 0.3 0.0 0.8
Medication for pain relief, constipation, heartburn 1.0 1.7 2.7 1.5 -0.1 1.6 -1.5 -1.6 -1.5 -0.4
Neck or shoulder pain in last month 0.7 1.0 3.1 0.7 1.8 0.5 -0.5 -0.5 -1.5 -0.9
Medication: Blood pressure 0.1 0.3 0.9 -0.3 0.5 -0.7 -0.2 0.2 0.2 -0.9
Angina (self-reported) 0.6 0.7 1.3 1.0 0.8 1.1 -0.9 -0.9 -0.7 0.4
Migraine (self-reported) 0.2 0.2 0.6 -0.3 -0.0 -0.3 0.5 0.5 0.2 0.8
Medication: Ibuprofen 0.2 0.2 0.7 -0.2 0.2 -0.3 0.2 0.7 0.1 -0.8
Medication: Allopurinol 0.8 1.1 1.9 1.1 0.5 1.1 -1.3 -1.4 -1.0 -0.3
Medication: Omeprazole 0.7 0.8 1.6 -1.0 -0.8 -1.2 0.8 0.7 1.3 -0.4
Medication: Seretide 50 evohaler 0.5 0.6 2.1 -0.4 -1.4 -0.6 0.4 0.8 0.1 0.7
Mean time to correctly identify matches 0.2 0.3 1.3 0.2 1.2 0.7 -0.3 -0.2 -0.5 -0.3
Heart disease (mother) 0.3 0.4 1.6 0.1 1.3 0.8 -0.5 -0.5 0.2 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.3 0.7 0.1 1.4 -1.5 -1.5 -1.5 0.2
Whole body fat mass 0.1 0.5 1.0 -0.9 -0.0 -1.0 0.5 0.2 1.0 -0.4
Leg fat mass (right) 0.2 0.6 1.4 -1.1 -0.1 -1.2 0.9 0.4 0.9 -0.3
Arm predicted mass (right) 0.2 1.1 2.1 -0.9 -0.8 -1.4 0.9 0.4 1.3 -1.3
Pulse rate, automated reading 0.1 0.3 1.0 0.7 0.4 -0.0 0.1 0.3 0.4 -1.0
Alcohol intake frequency. 0.4 1.0 1.7 -0.7 0.3 -0.8 0.9 1.2 1.2 1.3
Comparative height size at age 10 0.1 0.3 0.6 -0.6 -0.7 -0.4 0.3 0.3 0.5 0.8
Number of full sisters 1.4 1.7 3.1 -1.2 -1.2 -1.4 1.3 1.7 1.5 0.1
Suffer from ‘nerves’ 0.2 0.2 0.7 -0.3 -0.8 0.3 0.6 0.1 0.1 0.7
Overall health rating 2.5 5.4 8.5 -2.7 -0.6 -2.9 2.8 2.6 2.5 0.9
Chest pain or discomfort 5.2 7.5 12.7 -3.0 0.2 -3.2 3.0 3.3 3.6 0.8
Had major operations 1.8 2.1 4.3 -1.3 -2.1 -1.8 0.6 1.1 2.0 0.2
Age at last live birth 1.2 1.8 2.6 1.5 -0.9 1.5 -1.5 -1.6 -1.1 -1.0
Family relationship satisfaction 0.4 0.5 1.7 0.9 1.3 0.8 -0.1 -0.3 -0.0 0.6
Leg pain on walking 0.2 0.3 1.5 -0.1 1.2 -0.2 0.4 0.2 -0.1 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.4 0.9 -0.4 1.1 -1.2 -1.2 -1.1 -1.2
Commuting to job workplace: Car/motor vehicle 1.8 2.1 3.5 1.1 0.2 1.3 -1.6 -1.7 -1.6 -1.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 1.0 -0.1 -1.0 -0.0 -0.2 -0.1 0.5 -0.0
Medication: Aspirin 0.3 0.4 2.2 -0.6 0.1 -0.3 -0.4 -0.2 0.3 -1.5
Supplements: Vitamin C 0.5 0.6 0.9 -0.8 -0.6 -1.0 0.9 0.4 0.3 -0.9
Knee pain experienced in last month 0.3 0.4 1.1 -0.4 1.1 -0.5 0.7 0.6 0.0 0.5
Hypertension (Self-reported) 0.9 2.4 5.2 -1.6 0.1 -2.3 1.3 1.8 1.7 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.4 0.3 -0.0 0.6 -0.4 -0.3 0.4 0.2
Illnesses of father: Heart disease 0.3 0.4 0.8 -0.6 0.6 -0.7 0.8 0.9 0.6 -0.3
Illnesses of siblings: Diabetes 1.2 1.5 2.8 1.7 -0.7 1.1 -1.2 -1.1 -0.7 -1.7
Smoking status: Previous 0.2 0.2 0.9 -0.4 1.0 -0.4 -0.1 0.1 0.6 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 2.7 1.5 0.1 1.1 -1.7 -1.6 -1.6 -0.5
Whole body fat-free mass 0.2 1.1 2.3 -0.9 -0.8 -1.5 0.6 0.4 1.3 -1.2
Leg fat-free mass (right) 0.2 1.0 2.1 -0.7 -1.2 -1.5 0.4 0.3 1.2 -1.0
Arm fat percentage (left) 0.1 0.3 0.8 -0.8 0.5 -0.7 0.4 0.2 0.9 0.1
Average weekly red wine intake 0.8 1.2 2.6 -1.0 1.5 -1.2 0.2 0.9 1.6 0.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.7 -0.4 0.6 -0.5 -0.0 0.5 0.4 1.7
Mood swings 0.4 0.7 1.2 -0.9 -0.4 -1.1 1.0 1.1 0.1 0.5
Loneliness, isolation 1.3 1.8 2.8 -1.2 -0.6 -1.7 1.6 1.5 1.5 0.9
Long-standing illness, disability or infirmity 1.7 2.7 4.1 -2.0 -0.2 -1.8 1.7 1.5 1.6 1.8
Ever had bowel cancer screening 2.4 2.8 4.2 -1.9 -2.0 -1.7 1.8 1.8 1.5 -0.2
Diabetes diagnosed by doctor 0.5 0.9 3.0 -0.2 -1.7 -0.2 -0.4 -0.4 0.7 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.4 0.1 -1.2 0.3 -0.4 -0.8 -0.5 0.5
Friendships satisfaction 0.2 0.2 0.8 -0.6 0.4 -0.2 0.9 0.3 0.4 0.3
Qualifications: nursing, teaching 0.0 0.1 0.2 0.2 -0.2 0.2 -0.1 -0.3 -0.4 0.1
Commuting to job workplace: Walk 0.5 0.6 1.4 -0.7 -0.1 -0.5 0.8 0.8 1.2 0.7
Eye problems/disorders: Cataract 2.3 2.6 8.3 0.7 2.8 0.5 -0.4 -0.4 -1.1 2.9
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.2 -0.8 1.0 -0.8 0.9 0.8 0.2 1.1
Medication for cholesterol 0.9 1.3 2.1 1.1 -0.1 1.4 -1.3 -1.2 -1.3 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 3.9 0.7 2.0 0.9 -0.5 -0.3 -0.9 1.3
Back pain experienced in last month 2.0 2.9 5.1 -1.9 -1.3 -1.8 2.3 1.6 2.1 0.3
Mineral and other dietary supplements 0.3 0.4 0.6 0.8 -0.8 0.7 -0.7 -0.5 -0.4 -0.1
Breast cancer (self-reported) 0.2 0.2 0.6 0.3 0.2 0.3 -0.1 -0.8 -0.3 0.5
Asthma (self-reported) 0.5 1.0 4.6 -0.8 -0.6 -0.5 0.2 0.6 0.9 2.2
Osteoporosis (self-reported) 0.3 0.4 1.2 0.4 -0.4 0.8 -0.1 -0.7 -1.1 -0.4
Osteoarthritis (self-reported) 0.1 0.2 0.7 -0.2 0.5 -0.4 0.2 0.1 -0.1 -0.8
Medication: Aspirin 0.3 0.4 1.9 -0.5 0.4 -0.0 -0.6 -0.3 0.2 -1.4
Medication: Gliclazide 0.9 1.0 5.1 -0.5 -0.8 -0.2 -0.4 -0.0 0.9 -2.3
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 -0.1 -0.5 0.2 -0.6 -0.1 0.5 0.7
Smoking status: Current 6.2 9.8 17.1 -3.1 -0.7 -3.3 4.1 3.7 2.5 3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.3 4.9 7.7 2.2 0.2 2.8 -2.4 -2.6 -2.1 -2.1
Whole body water mass 0.2 0.9 1.8 -0.7 -0.7 -1.4 0.5 0.3 1.2 -1.3
Leg predicted mass (right) 0.2 1.1 2.3 -0.8 -1.2 -1.5 0.4 0.4 1.3 -1.1
Arm fat mass (left) 0.1 0.3 0.7 -0.7 0.3 -0.7 0.3 0.0 0.9 -0.5
Number of self-reported non-cancer illnesses 0.6 1.0 1.9 -1.1 0.5 -1.4 1.1 1.1 1.1 0.6
Average weekly champagne plus white wine intake 1.0 1.4 3.1 1.8 -0.1 1.4 -1.3 -0.8 -1.6 -0.6
Miserableness 0.9 1.6 4.6 -0.9 1.1 -1.1 1.2 1.2 0.6 2.1
Guilty feelings 0.6 0.9 3.5 -0.8 -1.9 -0.9 0.6 0.3 0.3 -0.7
Wears glasses or contact lenses 1.6 1.8 6.9 -1.3 -0.4 -1.2 0.9 1.1 0.8 2.6
Ever taken oral contraceptive pill 0.4 0.5 1.8 -0.6 -1.3 -0.3 0.6 0.6 0.6 -0.2
Hearing aid user 0.9 1.1 2.1 -0.8 -0.2 -1.0 1.3 1.5 1.3 0.5
Mother’s age at death 0.4 0.4 2.6 -0.0 0.6 0.2 0.2 -0.2 -0.3 1.6
Financial situation satisfaction 0.5 0.6 1.5 -0.9 -0.8 -0.3 1.2 0.6 0.3 0.9
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.4 0.2 0.5 -0.5 -0.1 0.0 -0.5
Commuting to job workplace: Public transport 0.4 0.5 1.3 0.9 1.1 0.7 -0.3 -0.3 -0.7 -0.1
Eye problems/disorders: Glaucoma 0.7 0.9 1.9 -1.4 -0.9 -1.3 0.9 0.7 0.6 0.4
Medication: Blood pressure 1.1 2.2 3.8 -1.4 0.6 -1.9 1.2 1.4 1.8 1.6
Pain type(s) experienced in last month: Hip pain 1.9 2.3 4.1 -1.7 -0.1 -1.8 1.6 1.7 2.0 0.7
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.6 -0.7 0.8 -0.7 0.5 0.4 0.5 0.5
High cholesterol (Self-reported) 1.0 1.8 3.1 1.1 -0.2 1.1 -1.6 -1.7 -1.4 -1.8
Medication: Bendroflumethiazide 0.8 1.2 2.4 -1.1 0.3 -1.6 1.1 1.5 1.2 -0.4
Medication: Paracetamol 1.1 1.7 3.3 -1.8 0.7 -1.6 1.6 1.5 0.9 0.2
Medication: Lisinopril 3.0 3.9 6.6 -1.6 1.4 -1.9 1.6 1.9 2.5 2.6
Medication: Atorvastatin 0.4 0.5 1.1 0.6 -0.7 0.9 -1.1 -0.6 -0.7 -0.3
Illnesses of father: High blood pressure 0.6 0.7 1.9 0.8 1.4 0.8 -0.2 -0.5 -1.2 0.3
Alcohol drinker status: Never 2.0 2.4 4.3 -1.6 1.0 -1.6 1.7 1.8 2.1 0.3
Ever smoked 3.4 6.0 8.2 -2.7 -0.8 -2.7 2.8 2.9 2.6 2.0
Basal metabolic rate 0.1 0.8 1.7 -0.8 -0.7 -1.3 0.5 0.2 1.1 -1.1
Leg fat percentage (left) 0.1 0.5 1.5 -0.8 1.2 -0.6 0.6 0.2 0.2 0.7
Arm fat-free mass (left) 0.1 0.8 1.9 -0.6 -0.2 -1.2 0.6 0.3 1.1 -1.4
Number of operations (self-reported) 4.0 5.9 9.6 -2.9 -1.8 -2.9 2.3 2.4 3.1 -0.2
Average weekly beer plus cider intake 0.2 0.3 1.5 -0.3 -0.0 0.1 0.2 0.2 -0.9 1.2
Irritability 0.2 0.3 0.6 -0.2 -0.5 -0.8 0.5 0.4 0.6 -0.3
Risk taking 2.4 3.5 10.9 -2.0 -3.3 -2.1 1.4 1.5 0.9 -0.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.9 0.8 1.4 0.4 -0.5 -0.8 -0.8 -0.5
Fractured/broken bones in last 5 years 2.6 3.3 6.3 2.1 0.3 1.7 -1.9 -2.1 -1.3 -2.5
Age started oral contraceptive pill 1.9 2.3 3.7 -0.9 0.6 -1.6 1.9 1.8 1.9 1.5
Diastolic blood pressure, automated reading 0.3 0.8 2.1 1.2 -0.1 0.6 -1.0 -0.4 -0.8 -1.4
Ever depressed for a whole week 0.2 0.2 0.5 -0.3 0.7 -0.1 0.7 0.5 0.0 -0.3
Unable to work because of sickness or disability 0.1 0.1 0.5 0.2 -0.7 0.2 0.4 -0.1 -0.2 -0.5
Commuting to job workplace: Cycle 0.1 0.1 0.5 0.2 0.2 0.7 -0.3 -0.4 -0.4 0.1
Myopia 1.6 2.4 3.9 -2.0 -0.2 -1.8 1.9 1.8 1.3 1.0
Vascular/heart problems diagnosed by doctor 0.7 1.9 3.3 1.3 -0.4 1.8 -1.2 -1.6 -1.3 -1.6
Cholesterol lowering medication 0.1 0.2 1.2 0.2 -1.1 -0.1 -0.0 -0.4 0.2 0.1
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 3.1 -1.5 -1.4 -1.7 1.4 1.2 1.8 0.1
Pain experienced in last month 0.3 0.5 1.6 0.7 0.4 0.6 -0.9 -0.6 -0.1 1.3
Supplements: Calcium 2.7 3.0 4.7 1.7 -1.1 1.7 -2.2 -2.1 -1.8 -1.3
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 0.5 0.8 0.4 -0.4 -0.2 -0.1 0.2
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.5 0.3 -0.4 0.4 -0.5 -0.7 -0.3 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.4 -0.5 -0.3 -0.6 0.6 0.7 1.2 0.1
Heart disease (siblings) 2.5 3.1 6.5 1.4 -0.6 1.7 -1.8 -2.1 -1.5 -2.6
Alcohol drinker status: Previous 0.9 1.0 3.2 1.2 -0.0 0.9 -0.7 -1.1 -1.8 -0.3
Pack years of smoking 3.2 4.7 6.9 -2.6 -0.3 -2.3 2.4 2.6 2.1 2.0
Impedance of whole body 0.6 3.1 6.3 1.7 -0.8 2.5 -1.8 -1.7 -2.4 0.3
Leg fat mass (left) 0.1 0.4 0.9 -0.9 0.1 -1.0 0.7 0.1 0.6 -0.2
Arm predicted mass (left) 0.1 0.6 2.4 -0.3 -0.1 -0.9 0.2 -0.1 0.8 -1.5