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chr15:90,233,553-92,135,418

Best TWAS P=1.36e-13 · Best GWAS P=8.88e-12 conditioned to 0.875

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FURIN	0.12	0.14	lasso	2	0.13	1.2e-15	-5.7	5.7	1.5e-08	0.82	0.77	0.23	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IQGAP1	0.19	0.21	lasso	5	0.20	1.7e-24	4.5	5.2	1.9e-07	0.02	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	FES	0.21	0.09	lasso	5	0.05	1.3e-03	5.8	-5.8	7.1e-09	-0.70	0.34	0.34	FALSE
4	GTEx	Artery Aorta	IQGAP1	0.44	0.51	enet	27	0.51	5.3e-32	5.7	5.6	2.7e-08	0.06	0.79	0.21	FALSE
5	GTEx	Artery Coronary	IQGAP1	0.33	0.42	enet	19	0.44	2.6e-16	5.7	5.9	3.2e-09	0.02	0.81	0.19	TRUE
6	GTEx	Artery Tibial	FES	0.16	0.04	lasso	5	0.05	4.8e-05	5.9	-6.3	2.2e-10	-0.73	0.19	0.80	FALSE
7	GTEx	Cells Transformed fibroblasts	FES	0.28	0.17	enet	21	0.20	2.8e-15	5.8	-7.4	1.4e-13	-0.90	0.01	0.99	TRUE
8	GTEx	Colon Sigmoid	IQGAP1	0.18	0.16	lasso	7	0.15	6.6e-06	5.6	5.7	1.1e-08	0.02	0.79	0.17	FALSE
9	GTEx	Colon Transverse	IQGAP1	0.23	0.15	lasso	2	0.10	1.4e-05	5.7	5.7	1.2e-08	0.02	0.73	0.20	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	IQGAP1	0.11	0.15	lasso	3	0.14	7.9e-06	5.6	5.7	1.4e-08	0.01	0.62	0.15	FALSE
11	GTEx	Esophagus Muscularis	IQGAP1	0.24	0.14	enet	18	0.14	5.7e-09	5.7	5.6	1.8e-08	0.04	0.79	0.21	FALSE
12	GTEx	Lung	FES	0.24	0.07	lasso	6	0.05	5.1e-05	5.9	-6.8	7.6e-12	-0.79	0.11	0.87	FALSE
13	GTEx	Ovary	IQGAP1	0.43	0.53	lasso	3	0.53	2.3e-15	5.7	5.8	8.8e-09	0.02	0.77	0.23	FALSE
14	GTEx	Skin Sun Exposed Lower leg	FES	0.09	0.04	lasso	5	0.04	1.4e-04	5.8	-5.3	1.4e-07	-0.66	0.10	0.59	FALSE
15	GTEx	Small Intestine Terminal Ileum	IQGAP1	0.27	0.26	lasso	4	0.20	2.7e-05	5.7	5.7	1.2e-08	0.02	0.30	0.10	FALSE
16	GTEx	Spleen	IQGAP1	0.45	0.34	lasso	7	0.41	9.1e-12	5.7	5.2	2.6e-07	0.03	0.84	0.15	FALSE
17	GTEx	Testis	IQGAP1	0.25	0.37	lasso	4	0.36	1.2e-16	5.6	5.7	9.6e-09	0.02	0.81	0.19	FALSE
18	GTEx	Thyroid	FES	0.33	0.19	lasso	6	0.18	4.3e-14	5.8	-5.9	4.0e-09	-0.70	0.59	0.41	FALSE
19	GTEx	Uterus	IQGAP1	0.29	0.16	lasso	5	0.13	1.3e-03	5.7	5.7	9.9e-09	0.02	0.25	0.08	FALSE
20	METSIM	Adipose	FES	0.08	0.06	lasso	3	0.05	6.8e-08	5.8	-5.9	2.8e-09	-0.63	0.60	0.40	FALSE
21	YFS	Blood	FES	0.31	0.11	enet	77	0.22	1.2e-68	5.8	-7.2	6.0e-13	-0.68	0.02	0.98	FALSE
22	YFS	Blood	FURIN	0.11	0.03	enet	37	0.06	8.3e-19	-5.7	-5.3	1.5e-07	-0.67	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FES	0.06	0.05	blup	46	0.06	1.9e-05	6.7	-5.4	7.1e-08	-0.83	0.00	0.99	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	FES	0.06	0.05	blup	46	0.07	7.4e-14	5.8	-6.5	1.1e-10	-0.89	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQGAP1	0.03	0.02	blup	94	0.02	6.5e-05	4.7	5.5	5.1e-08	0.02	0.11	0.86	FALSE
26	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FES	0.06	0.02	blup	46	0.02	2.4e-02	5.8	-6.1	8.3e-10	-0.77	0.01	0.81	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	FES	0.08	0.07	blup	46	0.06	3.4e-04	6.5	-7.3	2.7e-13	-0.91	0.01	0.98	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	FES	0.12	0.06	enet	6	0.06	5.7e-03	6.8	-7.1	1.6e-12	-0.94	0.00	0.94	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	6.8	-5.2	1.7e-07	-0.81	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FES	0.10	0.07	enet	5	0.05	2.8e-06	6.8	-6.8	1.0e-11	-0.99	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IQGAP1	0.06	0.05	blup	94	0.04	2.6e-03	4.4	5.2	2.7e-07	0.03	0.06	0.78	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQGAP1	0.05	0.04	enet	12	0.03	1.1e-04	5.2	5.2	1.6e-07	-0.03	0.04	0.94	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	FES	0.05	0.04	lasso	2	0.04	2.2e-05	5.8	-6.7	1.9e-11	-0.90	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FES	0.08	0.07	enet	7	0.08	4.2e-09	5.8	-6.4	2.0e-10	-0.82	0.06	0.94	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQGAP1	0.02	0.02	blup	94	0.02	6.2e-03	4.6	5.5	4.5e-08	0.02	0.04	0.67	FALSE
36	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FES	0.13	0.16	lasso	2	0.14	6.1e-10	5.8	-5.9	2.9e-09	-0.71	0.49	0.51	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	FES	0.12	0.09	lasso	5	0.08	4.1e-09	5.8	-6.5	1.0e-10	-0.80	0.14	0.86	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	6.7	-6.0	2.3e-09	-0.78	0.01	0.69	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FES	0.32	0.26	lasso	2	0.25	2.0e-09	5.8	-5.9	3.0e-09	-0.72	0.30	0.69	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	FES	0.30	0.30	lasso	7	0.32	1.3e-31	5.8	-6.7	2.4e-11	-0.84	0.58	0.42	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	IQGAP1	0.06	0.04	blup	95	0.08	3.0e-08	4.6	5.4	6.5e-08	0.02	0.07	0.93	FALSE