TWAS
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Models
Genes
Traits
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Traits
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Blood White Count
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chr16:69,062,879-70,473,934
Best TWAS P=2.2e-09 · Best GWAS P=9.6e-09 conditioned to 0.349
69M
69.2M
69.4M
69.6M
69.8M
70M
70.2M
70.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Thyroid
CTD-2033A16.3
0.03
0.02
enet
7
0.02
0.0067
5.4
-6.0
2.2e-09
-0.89
0.03
0.90
TRUE
1
GTEx
Thyroid
NOB1
0.03
0.01
enet
6
0.02
0.0077
4.2
-5.8
5.2e-09
-0.77
0.08
0.74
FALSE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
NQO1
0.02
0.01
blup
39
0.01
0.0043
5.5
5.5
3.3e-08
0.86
0.01
0.86
FALSE
4
The Cancer Genome Atlas
Colon Adenocarcinoma
NQO1
0.06
0.04
lasso
3
0.01
0.0527
5.5
5.5
4.4e-08
0.99
0.01
0.74
FALSE