Hub : Genes

NOB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0180	0.00023	0.046	0.028	0.042	0.030	0.039	2.4e-06	0.00020	7.2e-06	0.00014	1.3e-05
2	GTEx	Brain Cerebellum	0.1470	0.0640	0.00180	0.081	NA	0.026	NA	0.072	2.2e-03	NA	5.8e-02	NA	3.7e-03
3	GTEx	Nerve Tibial	0.0999	0.0402	0.00048	0.077	NA	0.082	NA	0.043	4.2e-06	NA	1.9e-06	NA	4.9e-04
4	GTEx	Thyroid	0.0340	0.0170	0.00520	0.008	NA	0.022	NA	0.013	6.8e-02	NA	7.7e-03	NA	3.2e-02
5	METSIM	Adipose	0.0251	0.0117	0.00045	0.026	0.025	0.022	0.023	0.029	6.9e-05	0.00009	2.4e-04	0.00016	2.8e-05
6	TCGA	Pancreatic Adenocarcinoma	0.1270	0.0710	0.00610	0.013	0.032	0.006	NA	0.006	8.9e-02	0.01700	1.7e-01	NA	1.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.7	2.2	0.0	0.9	-0.6	-0.7	-0.1	-1.5
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.4	0.6	-0.2	-0.2	-0.2	-0.2
Depressed Affect (Nagel 2018)	1.1	2.3	3.9	1.9	1.6	2.0	0.7	1.7	-0.8
Depression (Nagel 2018)	1.1	1.7	2.3	1.5	1.3	1.3	0.6	1.5	-1.3
Intelligence (Savage-Jansen 2018)	1.0	3.1	7.3	-2.7	-1.4	-1.1	-2.3	-1.7	0.0
Neuroticism (Nagel 2018)	1.1	2.7	5.8	2.4	1.3	1.8	1.1	1.7	-1.1
Schizophrenia (2018)	0.1	0.2	0.9	-0.4	-0.0	0.3	0.3	-0.1	0.9
Schizophrenia vs Biploar Disorder	0.8	1.0	1.8	-0.8	-1.4	-0.5	-0.8	-1.2	1.1
Worry (Nagel 2018)	1.2	2.6	5.1	2.3	1.1	1.2	1.8	1.7	-1.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.3	-0.0	-0.2	-0.1	0.4	0.1
Alzheimer’s Disease (in father)	1.6	1.7	5.7	-0.3	0.5	-1.1	1.7	0.7	-2.4
Alzheimer’s Disease (including proxy)	0.7	1.0	3.6	-0.2	0.4	-0.3	1.9	1.3	-0.7
Crohns Disease (2017)	0.9	1.9	3.4	-1.2	-1.9	-1.8	-1.0	-1.7	-0.1
Irritable Bowel Disease (IBD)	2.3	5.6	9.4	-2.0	-2.3	-2.6	-2.7	-3.1	0.3
Ulcerative Colitis (UC)	2.9	5.4	9.8	-2.1	-1.7	-2.5	-3.0	-3.1	0.7
Major Depression (MDD)	2.6	3.1	5.8	-1.4	-1.9	-0.3	-1.5	-2.4	2.3
Reaction Time	0.1	0.2	0.5	0.2	-0.6	0.1	0.4	0.0	0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	8.3	-1.6	-0.6	0.4	-2.9	-1.0	0.5
Breast Cancer	0.8	1.9	8.0	0.5	0.6	0.7	2.8	1.4	-0.5
Ovarian Cancer	0.4	0.6	3.0	-0.0	0.0	0.6	-0.2	0.0	1.7
Prostate Cancer	0.2	0.3	0.9	0.9	0.4	0.2	-1.0	0.2	-0.1
Age at First Birth	0.6	0.8	1.7	0.0	1.2	1.3	0.9	1.0	0.0
Bipolar Disorder (2011)	1.0	1.0	2.1	1.0	0.9	0.2	0.7	1.1	-1.5
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.6	-0.3	0.7	-0.7	-0.6	0.8
Coronary Artery Disease (CAD)	1.0	1.2	3.2	0.7	0.3	1.8	1.0	1.3	0.9
Crohns Disease (2012)	2.6	4.1	6.7	-2.0	-2.3	-2.1	-2.0	-2.6	0.1
Mean Putamen Volume	0.5	0.6	2.0	0.4	0.6	-0.8	0.3	0.4	-1.4
Fasting Glucose	2.2	2.6	8.4	-1.4	-0.7	0.1	-2.9	-2.1	0.6
HbA1C	0.8	0.9	1.8	-1.3	-0.7	-1.0	-1.2	0.3	0.8
HDL Cholesterol	0.6	1.1	2.6	-0.4	-0.4	-0.9	1.4	0.9	-1.6
LDL Cholesterol	0.1	0.2	0.6	-0.1	0.2	-0.6	-0.8	-0.5	0.0
Lupus	1.5	2.2	6.2	1.2	1.6	2.5	0.5	1.6	0.3
Neuroticism (2016)	0.4	0.5	2.2	0.3	-0.4	1.5	-0.2	0.0	0.8
Primary Biliary Cirrhosis	0.8	1.2	3.4	-1.1	-0.2	-0.3	-1.9	-1.4	0.6
Rheumatoid Arthritis	0.4	0.6	1.0	0.4	1.0	0.7	0.9	0.9	-0.7
Schizophrenia (2014)	0.3	0.7	1.7	-1.0	-0.3	0.1	-0.8	-0.6	1.3
Triglycerides	1.3	2.2	6.9	-0.6	-0.3	-0.1	-2.6	-2.0	1.2
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.2	0.5	0.4	1.7	-0.4	0.2	1.8
Ulcerative Colitis	5.0	7.2	12.5	-3.1	-2.1	-2.5	-3.2	-3.5	0.1
Blood Eosinophil Count	1.0	7.5	33.6	-1.4	-0.1	0.7	-5.8	-2.2	2.0
Blood Platelet Count	1.2	14.1	37.9	-2.6	-3.8	-6.2	-0.2	-2.0	-4.6
Blood Red Count	1.1	10.6	27.9	-1.7	-1.1	2.5	-4.5	-2.3	5.3
Blood White Count	1.7	12.5	34.1	-3.0	-2.4	-3.2	-5.8	-4.0	-0.0
Heel T-Score	1.7	13.8	19.2	3.0	4.0	4.4	3.1	4.2	3.3
BMI	6.6	38.1	85.0	-5.9	-4.9	-2.0	-9.2	-7.6	4.9
Height	2.9	54.9	112.4	9.0	4.4	7.1	10.6	8.2	0.8
Waist Hip Ratio (WHR)	0.7	3.3	5.6	-2.2	-2.2	-0.4	-1.2	-1.8	2.4
Systolic Blood Pressure	1.9	9.3	17.6	3.1	3.9	4.2	1.5	3.3	-0.6
Smoking Status	10.6	25.5	41.2	-6.4	-5.9	-4.6	-4.4	-5.9	1.4
Allergy or Eczema	1.1	2.9	5.5	1.9	2.3	1.1	1.2	2.3	-0.4
Cardiovascular Disease	0.2	0.6	2.4	0.7	0.5	1.6	-0.6	0.1	-0.1
Hypothyroidism (self reported)	3.1	7.2	13.0	-2.0	-2.2	-0.2	-3.4	-3.6	3.1
Respiratory disease	2.9	6.4	10.7	-3.3	-2.6	-1.3	-3.0	-2.9	1.4
Type 2 Diabetes (T2D) (2018)	5.4	10.1	21.6	-3.1	-2.0	0.4	-4.7	-2.8	4.2
Lung FEV1/FVC ratio	0.6	3.0	7.6	2.3	1.5	-0.4	1.2	1.2	-2.8
Lung FVC	7.7	39.4	73.6	6.3	5.3	2.8	8.6	7.5	-5.6
Neuroticism	1.6	3.9	6.7	2.6	1.7	2.0	1.9	2.0	-1.3
Chronotype (morning person)	1.6	3.8	6.7	1.7	1.3	0.6	2.6	2.5	-2.2
Hair Pigment	0.1	3.7	8.2	-2.0	-2.4	-2.9	-1.1	-1.9	0.4
Tanning	0.2	2.6	4.5	-1.8	-2.1	-1.9	0.1	-1.5	1.4
Hand grip strength (left)	9.3	24.5	53.1	5.2	4.1	2.8	7.3	5.6	-3.3
Number of treatments/medications taken	2.2	3.9	7.3	-1.9	-2.1	-2.0	-1.9	-2.7	-0.6
Average weekly spirits intake	1.2	1.5	4.3	-1.0	-0.6	0.0	-2.1	-1.1	1.5
Sensitivity / hurt feelings	1.7	3.0	6.2	2.5	1.3	1.7	1.3	1.9	-1.4
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	0.3	-0.1	0.0	0.1	-0.0	-0.3
Hearing difficulty/problems: Yes	1.0	1.6	4.3	-0.6	0.1	1.1	-1.4	-1.3	2.1
Relative age of first facial hair	1.4	2.9	9.2	1.1	1.2	-0.9	1.6	1.4	-3.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.7	-0.3	-0.4	0.2	-1.6	-0.9	0.0
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	1.8	0.2	-0.4	1.9	1.0	-0.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	0.1	0.0	0.6	-1.0	-0.6	1.4
Systolic blood pressure, automated reading	1.4	4.0	10.3	1.8	2.4	3.2	0.3	2.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	-0.5	-0.5	0.4	-1.3	-0.7	-0.2
Angina	7.7	10.1	18.6	-3.1	-4.3	-2.2	-3.1	-3.8	1.8
Medication for hormone replacement therapy	2.4	2.7	7.2	1.9	0.6	-0.1	1.6	1.6	-2.7
Vitamin and mineral supplements	0.5	0.7	2.0	-0.4	0.1	0.4	-1.4	-0.4	1.2
Supplements: Zinc	0.7	0.8	3.0	0.4	-0.7	-1.7	0.5	0.0	-0.8
Medication: Co-codamol	0.3	0.3	0.9	-0.6	-0.4	-0.1	-0.9	-0.3	-0.7
Medication: Metformin	1.9	2.6	6.6	-1.8	-1.2	0.4	-1.9	-0.8	2.6
Diabetes (father)	0.8	1.0	2.2	0.7	0.5	1.2	-1.5	0.2	1.3
Diabetes (mother)	0.8	1.0	3.4	-1.8	-1.0	0.0	-0.9	-0.9	0.1
Severe depression (siblings)	3.4	3.8	7.5	2.1	2.7	2.4	0.2	2.1	-0.6
Pack years adult smoking proportion	2.9	4.4	11.2	-2.2	-1.0	0.1	-3.4	-2.1	2.2
Impedance of leg (right)	3.2	15.4	28.5	3.8	4.0	2.9	3.8	5.3	-3.2
Leg fat-free mass (left)	0.8	4.0	7.6	-0.8	-2.4	0.5	-1.9	-2.4	2.8
Trunk fat percentage	5.2	21.0	62.6	-3.9	-3.7	-1.3	-7.9	-5.2	2.3
Hand grip strength (right)	6.7	18.3	43.1	4.1	3.7	2.8	6.6	4.6	-2.6
Townsend deprivation index at recruitment	1.5	2.1	4.5	-2.1	-1.0	-1.6	-1.2	-1.7	0.3
Current tobacco smoking	4.4	7.1	11.8	-3.2	-2.5	-1.5	-3.4	-3.2	1.2
Average weekly fortified wine intake	0.8	0.9	2.0	-1.4	-0.3	-1.1	-0.7	-0.7	-1.0
Maternal smoking around birth	5.1	7.4	13.2	-2.7	-2.8	-1.3	-3.6	-3.1	2.2
Fed-up feelings	1.1	1.9	2.9	1.6	1.0	1.6	1.3	1.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	3.1	0.4	0.2	0.2	0.4	0.5	-1.8
Relative age voice broke	4.4	6.7	11.6	1.9	2.2	0.4	3.3	3.0	-3.4
Taking other prescription medications	2.1	3.2	6.2	-1.7	-1.8	-0.4	-2.4	-2.5	0.9
Age when periods started (menarche)	14.3	34.4	59.0	6.1	4.3	1.0	6.8	6.7	-7.7
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.1	1.4	0.5	0.4	1.8	1.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	9.0	1.6	2.1	3.0	0.7	2.1	2.0
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.2	1.7	1.8	1.6	0.4	1.2	1.2
Qualifications: CSEs or equivalent	1.0	1.3	4.0	0.2	-0.4	-1.2	1.4	0.2	-2.0
Serious illness, injury or assault to yourself	4.2	5.0	13.4	-1.5	-1.7	-0.7	-3.7	-2.7	2.0
High blood pressure	0.1	0.2	1.0	0.2	-0.4	1.0	0.3	0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.3	1.7	1.8	0.9	1.0	1.8	-0.9
Multivitamins +/- minerals	0.7	0.9	3.0	0.5	0.2	-0.4	1.7	0.6	-1.3
Stomach or abdominal pain in last month	0.5	0.6	1.9	-1.4	-1.1	-0.3	0.7	-0.3	0.1
Supplements: Glucosamine	0.4	0.6	1.8	-0.3	0.3	-1.1	-0.4	-0.2	-1.4
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	6.7	1.7	1.9	1.8	1.1	2.6	-2.5
Medication: Atenolol	4.1	5.1	7.3	-2.5	-2.7	-1.9	-2.3	-2.7	1.0
Medication: Levothyroxine sodium	2.0	3.4	11.3	-1.0	-0.6	1.4	-1.6	-1.8	3.4
Sitting height	3.3	23.3	54.5	5.9	2.2	4.1	7.4	5.2	1.0
Chronic bronchitis/emphysema (father)	1.0	1.2	3.1	0.4	0.8	0.8	-1.7	-0.4	1.5
High blood pressure (mother)	0.1	0.2	0.5	-0.7	-0.2	0.1	-0.2	-0.4	-0.4
Body mass index (BMI)	6.0	25.5	58.8	-5.0	-4.4	-2.0	-7.7	-6.1	3.0
Impedance of leg (left)	3.2	15.4	27.6	3.7	3.8	2.0	4.1	5.2	-3.9
Leg predicted mass (left)	0.7	3.9	7.7	-0.8	-2.3	0.6	-1.9	-2.4	2.8
Trunk fat mass	3.8	16.4	45.6	-3.2	-3.6	-0.7	-6.8	-4.7	2.7
Waist circumference	4.9	17.8	41.2	-3.8	-3.9	-1.0	-6.4	-5.0	3.2
Number of incorrect matches in round	0.7	1.1	5.3	-0.8	-0.4	0.6	0.6	-0.1	2.3
Past tobacco smoking	14.1	26.0	38.7	5.8	6.2	4.9	4.5	6.1	-1.6
Alcohol usually taken with meals	1.2	1.9	3.6	1.9	1.0	0.1	1.9	1.8	-0.5
Nervous feelings	0.3	0.5	1.2	1.1	-0.3	0.9	0.9	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.4	7.6	2.8	2.4	2.4	1.5	2.2	-0.1
Hearing difficulty/problems with background noise	0.4	0.6	1.9	-1.0	-0.8	-0.1	-0.4	-1.4	-0.1
Hair/balding pattern: Pattern 2	0.7	0.8	2.3	0.8	1.5	0.6	0.4	0.8	-0.9
Had menopause	1.1	1.4	2.5	1.1	0.9	1.3	1.4	1.6	0.1
Had other major operations	0.4	0.4	1.0	-0.7	-0.7	-0.4	-0.4	-1.0	-0.6
Forced vital capacity (FVC)	8.6	33.3	65.9	6.0	4.5	3.4	8.1	6.8	-4.4
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.4	11.9	1.8	2.3	3.5	1.2	2.4	2.1
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.1	-1.4	-2.0	-0.4	-1.0	-1.5	2.0
Qualifications: None of the above	0.5	1.1	3.5	0.3	0.9	1.9	0.5	1.4	-0.1
Financial difficulties in last 2 years	0.5	0.7	1.9	0.6	1.0	1.4	-0.9	0.2	0.3
Mouth/teeth dental problems	0.1	0.2	0.6	-0.4	0.8	0.2	0.1	0.1	0.6
Heart attack	8.1	10.4	17.6	-4.1	-4.2	-2.6	-2.3	-3.8	1.4
Allergy	0.1	0.2	1.0	-0.1	-0.1	-0.2	1.0	0.2	-0.5
Pain all over the body in last month	1.9	2.0	4.6	2.1	1.2	1.9	0.6	1.3	0.5
Diabetes (self-reported)	6.2	9.6	14.0	-3.3	-3.2	-0.3	-3.7	-3.1	3.5
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	6.8	2.5	2.6	1.4	1.0	2.5	-0.4
Medication: Ramipril	0.1	0.1	0.4	0.2	0.2	-0.4	-0.4	0.2	-0.6
Medication: Simvastatin	4.2	6.2	9.1	-2.7	-2.4	-1.5	-2.9	-3.0	2.1
Fluid intelligence score	1.7	3.6	10.4	-2.0	-1.5	-0.5	-3.2	-2.1	0.6
Illnesses of siblings	0.5	0.7	1.6	-0.2	-0.3	-1.1	1.3	0.2	-1.0
Neuroticism score	1.9	3.9	6.6	2.6	1.7	2.1	1.6	2.2	-1.5
Weight	1.5	7.5	17.1	-1.9	-2.8	0.2	-4.1	-3.2	2.5
Impedance of arm (right)	0.5	2.4	8.4	1.4	1.0	-0.0	-1.0	1.3	-2.9
Arm fat percentage (right)	8.3	32.7	91.6	-5.4	-4.6	-2.5	-9.6	-6.6	2.2
Trunk fat-free mass	0.6	3.4	6.0	1.9	0.1	2.5	2.4	1.1	1.9
Hip circumference	1.9	8.1	29.2	-1.8	-1.9	0.1	-5.4	-3.2	1.6
Time employed in main current job	1.6	1.8	2.7	-1.6	-1.7	-1.4	0.1	-1.1	1.5
Alcohol intake versus 10 years previously	1.5	2.2	5.6	0.8	1.2	2.4	-0.4	0.7	2.2
Father’s age at death	1.8	2.4	6.0	1.2	1.5	-0.0	2.4	1.8	-1.2
Worrier / anxious feelings	4.4	8.3	16.2	4.0	2.9	2.5	2.8	3.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.6	1.4	1.2	1.9	-1.3	0.5	-0.8
Falls in the last year	6.1	8.2	12.2	-3.0	-2.8	-2.9	-3.5	-3.2	-1.4
Hair/balding pattern: Pattern 3	1.4	2.1	6.6	-0.9	-1.7	-0.4	-2.6	-1.4	0.3
Number of live births	1.9	2.8	5.1	1.0	2.3	1.9	1.6	1.9	-0.6
Forced expiratory volume in 1-second (FEV1)	8.8	29.8	54.6	6.2	4.3	2.9	7.4	6.2	-4.6
Pulse rate	2.8	4.7	9.7	-2.0	-2.2	-1.6	-3.1	-2.6	0.7
Happiness	1.5	1.8	3.5	0.5	1.3	1.5	1.9	1.8	0.4
Noisy workplace	0.5	0.7	3.2	0.1	0.2	-0.2	1.8	0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.4	0.6	0.4	-1.2	-0.3	-0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	6.2	1.2	1.4	1.7	-2.5	-0.1	1.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.2	-0.4	-0.6	-0.4	-0.4	-0.6	-1.1
Asthma	2.7	5.2	9.7	-2.6	-2.3	-1.2	-3.1	-2.6	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	-0.1	0.7	0.7	-0.5	-0.5	-0.0
Medication: Cholesterol lowering	5.9	9.2	15.1	-2.9	-3.4	-1.8	-3.5	-3.9	2.1
Depression (self-reported)	0.3	0.3	0.7	0.3	0.7	0.5	-0.9	-0.3	-0.5
Medication: Lansoprazole	2.2	2.5	6.0	-0.9	-2.4	-1.7	-1.4	-1.8	-0.0
Prospective memory result	0.1	0.1	0.6	-0.2	-0.1	-0.3	0.8	0.3	-0.0
Lung cancer (father)	1.0	1.2	4.1	0.2	0.3	1.6	0.4	0.2	2.0
Illnesses of mother	0.6	0.7	1.5	1.2	1.1	0.3	0.6	0.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	9.0	28.7	54.5	6.2	4.3	2.9	7.4	6.2	-3.8
Pulse wave Arterial Stiffness index	1.1	1.3	1.9	-1.3	-1.4	-1.4	-1.1	-1.0	-0.0
Impedance of arm (left)	0.5	2.2	6.5	1.4	1.3	0.4	-1.1	1.2	-2.5
Arm fat mass (right)	5.3	21.7	57.3	-4.3	-4.1	-1.5	-7.6	-5.5	2.4
Trunk predicted mass	0.6	3.4	5.8	1.9	0.0	2.4	2.4	1.1	1.9
Standing height	2.5	24.9	50.6	6.1	2.8	4.6	7.1	5.7	-0.7
Length of working week for main job	1.0	1.1	2.4	0.5	1.6	0.6	-1.2	0.4	-1.3
Exposure to tobacco smoke at home	1.2	1.3	4.9	-0.4	0.2	1.6	0.4	0.2	2.2
Breastfed as a baby	0.3	0.4	1.2	0.1	-0.0	-1.1	1.0	0.0	-0.7
Tense / ‘highly strung’	0.4	0.7	2.2	-0.2	-0.2	1.2	-1.5	-0.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.6	-0.1	0.6	-0.7	-1.0	0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	-0.0	-0.8	-0.6	0.4	-0.5	1.2
Birth weight of first child	0.8	1.5	4.3	-1.0	-1.2	-0.9	-0.5	-2.1	1.1
Peak expiratory flow (PEF)	4.2	9.6	18.4	3.3	1.9	-0.2	4.0	3.0	-4.3
Pulse wave reflection index	0.9	1.1	2.9	-0.8	-1.7	-1.7	0.2	-0.6	-0.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.2	0.0	-0.8	0.3	-0.9	-1.0	1.8
Loud music exposure frequency	0.2	0.2	0.8	-0.3	0.1	0.9	0.1	0.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.5	-0.2	-0.3	-0.9	-2.1	-1.0	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	-0.4	-1.2	0.2	-0.8	-0.2	0.0
Blood clot in the leg (DVT)	1.0	1.3	2.9	-0.9	-0.8	-0.9	-1.7	-1.3	1.0
Medication: Paracetamol	0.6	0.9	2.4	-1.3	-1.5	-0.1	-0.3	-1.0	0.6
Headache pain in last month	0.8	1.3	2.7	-1.3	-1.3	0.1	-1.6	-1.1	0.9
Medication for cholesterol, blood pressure or diabetes	2.3	3.9	5.8	2.1	2.3	0.9	2.1	2.4	-1.6
Glaucoma (self-reported)	1.2	1.5	3.6	-1.2	-0.7	-1.1	-1.9	-1.1	-0.9
Gout (self-reported)	3.3	4.5	13.1	1.2	1.9	3.6	-0.8	0.5	2.8
Hypothyroidism/myxoedema (self-reported)	3.9	7.6	13.4	-2.2	-2.3	-0.1	-3.7	-3.6	3.1
Medication: Amlodipine	0.5	0.7	1.4	0.4	-0.4	-1.0	-0.8	-1.2	-1.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	-0.2	0.3	0.8	-0.1	0.3	0.5
Birth weight	0.7	1.6	4.4	-0.1	-1.4	-1.4	2.1	-0.7	0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-0.5	-0.3	0.5	-1.2	-1.0	0.9
High blood pressure (siblings)	0.3	0.4	1.2	0.2	1.1	0.8	-0.3	0.7	-0.5
Forced vital capacity (FVC), Best measure	10.1	36.8	69.1	6.8	4.8	3.9	8.3	7.3	-3.7
Body fat percentage	5.3	20.9	64.3	-4.0	-3.5	-1.3	-8.0	-5.2	2.1
Leg fat percentage (right)	3.4	12.4	41.8	-3.2	-2.3	-0.6	-6.5	-3.8	1.4
Arm fat-free mass (right)	0.5	2.5	6.1	1.1	-0.5	2.1	1.8	0.3	2.5
Exposure to tobacco smoke outside home	0.6	0.8	1.8	1.3	0.5	0.3	1.4	0.8	-0.1
Comparative body size at age 10	1.5	4.3	7.7	-1.8	-2.4	-1.3	-1.8	-2.8	2.0
Number of full brothers	1.6	2.0	5.0	1.6	1.5	2.2	0.4	1.4	0.4
Worry too long after embarrassment	5.0	8.3	12.6	3.6	2.8	2.5	2.8	3.4	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.0	0.7	-0.3	0.4	-0.4	-0.5
Wheeze or whistling in the chest in last year	2.6	4.6	9.2	-2.0	-2.3	-1.7	-3.0	-2.6	0.3
Number of children fathered	0.8	0.9	1.9	1.3	0.4	0.8	1.0	1.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.1	1.4	1.1	0.8	1.8	1.0	0.6
Age at first live birth	0.2	0.3	0.8	-0.8	-0.3	-0.9	-0.5	-0.5	-0.0
Pulse wave peak to peak time	1.9	2.3	3.5	1.7	1.7	1.9	1.5	1.4	-0.0
Health satisfaction	1.1	1.4	3.0	1.2	1.7	1.5	0.9	0.9	0.4
Shortness of breath walking on level ground	2.1	2.5	5.8	-1.8	-0.8	-0.0	-2.4	-1.9	1.4
Qualifications: College or University degree	0.1	0.3	0.9	0.5	0.5	-0.9	-0.1	-0.6	0.2
Eye problems/disorders: None of the above	2.2	2.6	6.0	1.6	1.5	0.3	2.5	2.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.9	-0.6	-1.4	-0.7	-1.3	-1.1	1.0
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.5	-0.5	-0.5	0.2	-0.6	0.2
Medication for pain relief, constipation, heartburn	1.1	1.9	3.7	1.6	1.5	0.6	0.7	1.9	-1.4
Neck or shoulder pain in last month	0.8	1.1	1.6	1.1	0.8	1.3	-1.1	0.7	-1.2
Medication: Blood pressure	0.2	0.3	0.8	-0.5	-0.9	-0.3	-0.7	-0.7	0.0
Angina (self-reported)	7.9	10.4	18.8	-3.2	-4.3	-2.4	-3.2	-3.8	1.7
Migraine (self-reported)	0.3	0.4	1.1	-1.1	-0.7	-0.6	-0.2	-0.7	-0.1
Medication: Ibuprofen	0.3	0.3	0.7	-0.3	0.5	0.4	-0.5	-0.8	-0.7
Medication: Allopurinol	1.8	2.4	6.8	0.7	1.2	2.2	-0.9	0.0	2.6
Medication: Omeprazole	0.1	0.1	0.5	0.1	-0.3	-0.7	0.3	-0.4	-0.0
Medication: Seretide 50 evohaler	1.3	1.5	2.5	-1.3	-0.6	-1.5	-1.4	-1.6	0.5
Mean time to correctly identify matches	0.4	0.7	2.2	-0.6	-1.1	-0.3	-0.2	-0.6	1.5
Heart disease (mother)	0.6	0.7	1.4	-0.5	-1.0	-1.2	0.8	-0.5	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	2.9	6.8	-1.7	-1.8	-2.6	-0.3	-2.1	-0.0
Whole body fat mass	3.8	16.0	46.0	-3.4	-3.4	-0.8	-6.8	-4.6	2.3
Leg fat mass (right)	3.5	13.5	37.0	-3.2	-3.1	-0.4	-6.1	-4.3	2.4
Arm predicted mass (right)	0.5	2.3	7.3	0.8	-0.9	1.8	1.5	-0.0	2.7
Pulse rate, automated reading	1.8	5.8	12.2	-1.9	-2.0	-1.0	-3.5	-3.4	1.5
Alcohol intake frequency.	2.0	4.8	13.7	1.1	2.4	3.7	-1.6	0.7	2.3
Comparative height size at age 10	0.5	2.8	10.2	0.3	-1.5	1.9	-0.8	-0.5	3.2
Number of full sisters	0.3	0.4	1.2	1.1	0.6	0.5	0.2	0.4	-0.3
Suffer from ‘nerves’	0.2	0.3	0.4	0.7	-0.2	0.6	0.6	0.2	0.6
Overall health rating	0.2	0.4	1.8	0.6	0.3	1.3	0.2	0.5	-0.3
Chest pain or discomfort	0.8	1.2	2.8	-0.1	-1.0	0.3	-1.7	-1.4	1.1
Had major operations	1.2	1.5	2.3	-1.0	-1.1	-1.3	-1.3	-1.0	-1.5
Age at last live birth	2.3	3.4	6.1	-2.5	-1.9	-2.4	-1.2	-1.8	-0.2
Family relationship satisfaction	0.2	0.2	0.9	-1.0	-0.3	0.2	-0.2	0.0	0.3
Leg pain on walking	0.6	0.7	1.5	0.0	0.4	1.2	-1.1	-0.3	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.5	0.0	0.9	0.7	0.4	1.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	5.0	-0.4	-1.1	0.3	-1.0	-1.2	2.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.2	-0.7	-0.8	-1.1	1.5	-0.1	-1.3
Medication: Aspirin	2.9	3.8	5.9	-2.0	-2.1	-1.7	-2.0	-2.4	1.2
Supplements: Vitamin C	0.9	1.1	2.6	0.4	-0.4	-1.2	1.6	0.2	-1.4
Knee pain experienced in last month	2.4	3.7	12.5	-1.2	-1.6	-0.4	-3.5	-2.2	0.7
Hypertension (Self-reported)	0.1	0.2	0.4	0.0	-0.6	0.6	0.2	0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.2	0.2	-0.4	0.6
Illnesses of father: Heart disease	1.8	2.5	6.1	-1.3	-2.0	-2.5	0.9	-1.3	-0.7
Illnesses of siblings: Diabetes	0.9	1.2	3.3	-0.1	-0.2	1.0	-1.8	-0.7	1.4
Smoking status: Previous	12.5	18.6	29.9	-4.9	-5.5	-4.0	-3.5	-5.0	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	5.5	1.2	0.6	0.6	2.4	1.3	-1.5
Whole body fat-free mass	0.3	1.6	4.7	0.8	-1.0	1.6	0.8	-0.3	2.2
Leg fat-free mass (right)	0.6	3.4	6.0	-0.8	-2.5	0.0	-1.5	-2.4	2.4
Arm fat percentage (left)	8.3	33.0	92.9	-5.3	-4.5	-2.3	-9.6	-6.7	2.6
Average weekly red wine intake	0.3	0.4	1.1	-0.2	-0.6	-1.0	0.5	-0.4	-0.7
Handedness (chirality/laterality): Left-handed	3.7	4.5	8.9	2.7	1.2	1.5	3.0	2.1	-1.5
Mood swings	1.4	2.5	4.4	1.6	1.2	1.1	1.6	1.6	-2.1
Loneliness, isolation	0.4	0.6	1.9	0.0	0.0	1.4	-0.8	0.3	0.8
Long-standing illness, disability or infirmity	6.3	9.6	18.2	-3.3	-2.8	-1.2	-4.3	-4.1	1.4
Ever had bowel cancer screening	2.0	2.3	5.8	-1.0	-2.4	-1.3	0.4	-1.4	1.8
Diabetes diagnosed by doctor	6.7	11.0	17.9	-3.4	-3.2	-0.3	-4.2	-3.3	4.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.1	1.0	0.8	0.2	0.9	0.3	-0.3
Friendships satisfaction	0.6	0.7	1.9	0.2	0.6	1.1	1.0	1.4	0.1
Qualifications: nursing, teaching	0.6	1.0	2.0	-0.3	0.8	-1.4	0.9	-0.8	-1.3
Commuting to job workplace: Walk	1.3	1.4	6.9	0.0	0.5	-0.7	0.8	0.3	-2.6
Eye problems/disorders: Cataract	3.0	3.5	6.0	-2.0	-1.8	-0.2	-2.4	-2.1	1.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.1	-0.8	-0.8	0.4	-0.4	0.4
Medication for cholesterol	0.5	0.7	2.5	-0.2	0.6	1.0	-0.6	-0.2	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.2	0.1	-0.0	0.4	0.3	-0.0	0.0
Back pain experienced in last month	1.3	1.9	3.6	1.8	1.0	1.2	1.9	1.3	-0.1
Mineral and other dietary supplements	1.8	2.4	10.7	-1.2	-0.8	1.2	0.5	-0.4	3.3
Breast cancer (self-reported)	0.8	0.9	2.2	0.7	1.1	1.2	0.1	1.5	0.4
Asthma (self-reported)	2.6	5.2	8.5	-2.6	-2.5	-1.4	-2.9	-2.5	1.0
Osteoporosis (self-reported)	1.5	1.9	4.8	-0.9	-1.6	-2.2	-0.5	-1.4	-0.9
Osteoarthritis (self-reported)	1.9	2.5	3.9	-1.6	-1.7	-1.2	-1.3	-2.0	1.6
Medication: Aspirin	2.3	3.0	4.9	-1.7	-2.0	-1.8	-1.6	-2.2	0.6
Medication: Gliclazide	1.7	1.9	6.2	-0.7	-0.8	0.8	-1.6	-0.9	2.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	0.6	0.3	1.0	0.8	0.7	1.1
Smoking status: Current	5.1	8.2	12.5	-3.5	-2.9	-2.0	-3.5	-3.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.8	14.3	36.5	3.4	3.2	1.6	6.0	4.4	-2.4
Whole body water mass	0.3	1.6	5.0	0.7	-1.1	1.5	0.8	-0.4	2.2
Leg predicted mass (right)	0.6	3.2	5.6	-0.7	-2.4	0.1	-1.4	-2.3	2.4
Arm fat mass (left)	5.5	22.6	57.3	-4.3	-4.2	-1.5	-7.6	-5.6	2.9
Number of self-reported non-cancer illnesses	2.3	4.0	10.8	-1.9	-1.7	-0.3	-3.3	-2.4	1.0
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.2	-0.3	-0.8	1.0	-0.0	0.0
Miserableness	0.2	0.4	1.0	0.6	0.8	1.0	-0.2	0.4	0.0
Guilty feelings	0.6	0.8	1.1	0.9	0.9	1.0	0.9	0.9	-0.8
Wears glasses or contact lenses	0.2	0.2	0.6	0.7	0.7	0.1	-0.1	0.5	0.1
Ever taken oral contraceptive pill	3.9	4.3	9.8	-1.3	-1.7	-1.4	-3.1	-2.6	1.6
Hearing aid user	0.3	0.3	0.7	-0.8	0.5	-0.0	-0.8	-0.4	0.1
Mother’s age at death	0.8	1.0	2.7	0.3	-0.5	-1.1	1.0	0.6	-1.6
Financial situation satisfaction	4.9	6.1	9.9	2.7	3.1	2.4	1.9	3.1	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.3	0.5	0.5	0.6	0.2	0.4
Commuting to job workplace: Public transport	1.1	1.3	3.5	-1.1	-0.8	-0.9	-1.9	-1.0	-0.7
Eye problems/disorders: Glaucoma	1.2	1.4	3.6	-0.8	-1.0	-1.0	-1.3	-0.5	-1.9
Medication: Blood pressure	1.5	2.9	4.5	-2.1	-2.1	-1.9	-1.2	-1.8	-0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.4	-0.5	-1.0	0.1	-1.2	-0.5	-0.8
Supplements: Fish oil (including cod liver oil)	2.9	3.8	14.9	2.0	1.6	-0.2	0.4	1.1	-3.9
High cholesterol (Self-reported)	1.0	1.7	4.5	-0.4	-0.3	0.8	-2.1	-1.3	1.8
Medication: Bendroflumethiazide	0.4	0.6	1.1	1.0	0.7	0.8	0.2	1.0	0.6
Medication: Paracetamol	0.1	0.1	0.2	-0.5	-0.4	0.3	0.0	-0.3	-0.2
Medication: Lisinopril	0.6	0.8	2.3	-1.3	-0.7	0.1	-0.7	-0.4	1.5
Medication: Atorvastatin	1.4	1.7	2.8	-1.2	-1.4	-0.0	-1.4	-1.7	1.4
Illnesses of father: High blood pressure	1.5	1.9	2.9	1.6	1.7	0.7	0.8	1.5	-1.5
Alcohol drinker status: Never	1.6	1.9	4.1	1.4	1.6	2.0	-0.7	1.1	1.0
Ever smoked	8.2	14.4	21.1	-4.2	-4.6	-3.9	-3.6	-4.4	0.5
Basal metabolic rate	0.3	1.9	6.1	0.2	-1.4	1.4	-0.5	-1.0	2.5
Leg fat percentage (left)	3.8	13.9	41.3	-3.6	-2.8	-1.4	-6.4	-4.2	1.1
Arm fat-free mass (left)	0.3	1.7	4.9	0.8	-0.9	1.6	1.1	-0.0	2.2
Number of operations (self-reported)	0.6	0.9	1.4	-0.9	-1.2	-0.8	-0.8	-1.1	-0.7
Average weekly beer plus cider intake	0.3	0.5	0.8	-0.6	-0.3	-0.8	-0.8	-0.9	-0.7
Irritability	0.1	0.1	0.4	-0.2	-0.1	0.3	-0.5	-0.7	-0.0
Risk taking	4.3	6.4	10.7	-2.6	-3.1	-2.9	-1.3	-3.3	-1.0
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.8	1.3	2.0	1.2	1.0	1.9	-0.7
Fractured/broken bones in last 5 years	4.3	5.5	9.2	-2.6	-2.6	-3.0	-1.6	-2.4	-1.5
Age started oral contraceptive pill	3.3	4.1	7.1	2.3	1.9	1.7	1.9	2.7	-1.4
Diastolic blood pressure, automated reading	0.7	2.3	5.6	-1.0	-2.1	-1.6	0.3	-0.1	-2.4
Ever depressed for a whole week	1.5	1.8	3.9	-1.3	-1.8	-0.7	-0.2	-1.4	2.0
Unable to work because of sickness or disability	0.4	0.5	2.3	0.1	-0.1	0.1	-1.5	-0.8	-0.4
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.6	-0.5	-0.6	0.4	0.2	0.4
Myopia	1.0	1.5	3.2	-1.4	-1.5	-1.8	0.2	-1.0	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.1	0.9	1.4	-0.2	0.7	1.0	-0.6
Cholesterol lowering medication	0.3	0.5	1.2	-0.6	-0.2	0.2	-1.1	-0.7	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	0.6	0.0	-0.5	1.0	0.1	-0.3
Pain experienced in last month	0.5	0.9	2.4	-1.2	-0.4	-1.6	0.4	-1.0	0.5
Supplements: Calcium	2.0	2.2	7.9	-0.2	-0.9	-2.8	0.6	-0.6	-1.9
Basal cell carcinoma (self-reported)	1.2	1.4	2.8	1.5	1.4	0.6	0.8	1.7	-0.9
Heart attack/myocardial infarction (self-reported)	7.5	9.7	16.6	-3.9	-4.1	-2.6	-2.1	-3.6	1.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.3	-1.0	-1.0	-1.0	-1.5	-1.4	0.9
Heart disease (siblings)	0.3	0.4	1.0	-0.5	-0.7	-1.0	0.3	-0.7	0.5
Alcohol drinker status: Previous	2.6	3.0	5.9	-2.0	-1.1	-1.1	-2.4	-2.4	-0.3
Pack years of smoking	3.1	4.5	10.6	-2.4	-1.3	-0.1	-3.3	-2.1	2.1
Impedance of whole body	1.2	6.2	12.1	2.5	2.4	1.1	1.5	3.1	-3.5
Leg fat mass (left)	3.5	13.7	35.5	-3.4	-3.3	-0.9	-6.0	-4.4	2.1
Arm predicted mass (left)	0.3	1.8	5.2	0.8	-1.0	1.6	1.1	-0.0	2.3