TWAS hub - NQO1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0176	0.0100	0.0011	0.008	0.009	0.002	NA	0.005	0.0058	0.0043	0.1300	NA	0.032
2	TCGA	Colon Adenocarcinoma	0.0550	0.0390	0.0096	0.036	0.012	0.012	NA	0.013	0.0038	0.0640	0.0630	NA	0.053
3	TCGA	Prostate Adenocarcinoma	0.0993	0.0718	0.0036	0.000	0.007	0.016	NA	0.002	0.3500	0.0490	0.0068	NA	0.190

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Falls in the last year	9.9	13.4	21.2	4.6	4.1	1.7
Arm fat percentage (right)	9.4	37.1	63.2	8.0	6.8	1.5
Arm fat percentage (left)	9.2	36.8	62.7	7.9	6.8	1.5
Sitting height	8.3	59.0	102.0	-10.1	-7.0	-5.2
Past tobacco smoking	7.7	14.2	22.7	-4.2	-4.8	-1.5
Forced vital capacity (FVC), Best measure	7.6	28.0	44.8	-6.7	-5.6	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.9	14.5	24.5	-4.3	-5.0	-0.8
Glaucoma (self-reported)	6.8	8.0	8.5	2.7	2.9	2.9
Ulcerative Colitis	6.7	9.7	15.2	3.4	3.9	1.5
Heel T-Score	6.3	50.2	56.1	-7.5	-6.4	-7.3
Eye problems/disorders: Glaucoma	6.1	7.3	9.2	2.5	2.5	3.0
Smoking Status	6.0	14.3	22.3	3.3	4.7	3.1
Body fat percentage	5.9	23.4	40.4	6.4	5.4	0.8
Trunk fat percentage	5.7	22.9	39.2	6.3	5.4	0.8
Long-standing illness, disability or infirmity	5.7	8.8	14.7	3.8	3.4	-0.1
Ever smoked	5.7	10.0	15.7	3.6	4.0	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	5.6	17.7	25.1	-5.0	-4.9	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	5.5	12.7	17.4	-3.4	-3.0	-4.2
Angina (self-reported)	5.5	7.2	12.8	2.6	3.6	1.4
Hand grip strength (left)	5.4	14.3	22.2	-4.5	-4.7	-0.6
Forced vital capacity (FVC)	5.4	20.8	33.8	-5.8	-4.9	-2.2
Alcohol drinker status: Previous	5.4	6.1	9.1	3.0	2.4	1.8
Angina	5.2	6.8	11.9	2.6	3.4	1.4
Fractured/broken bones in last 5 years	5.1	6.6	9.1	2.5	3.0	2.1
Height	4.9	94.5	158.8	-12.6	-9.7	-5.5
Body mass index (BMI)	4.9	20.8	36.4	6.0	5.1	0.3
Arm fat mass (right)	4.9	20.2	33.6	5.8	5.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	4.8	11.0	15.1	-3.2	-2.8	-3.9
Heart attack	4.8	6.1	8.8	2.3	3.0	2.1
Smoking status: Previous	4.8	7.1	12.2	2.8	3.5	1.3
Arm fat mass (left)	4.7	19.5	32.0	5.7	5.1	0.2
Leg fat percentage (left)	4.6	16.6	29.5	5.4	4.4	1.0
Age at last live birth	4.5	6.6	8.9	1.7	2.8	3.0
Happiness	4.3	5.2	8.2	-2.9	-2.1	-1.6
Exposure to tobacco smoke at home	4.3	4.8	6.2	-2.0	-2.0	-2.5
Lung FVC	4.2	21.5	31.9	-5.7	-5.5	-1.4
Leg fat percentage (right)	4.2	15.1	27.1	5.2	4.2	0.5
Heart attack/myocardial infarction (self-reported)	4.2	5.4	8.0	2.1	2.8	1.9
Eye problems/disorders: None of the above	4.1	4.7	7.8	-2.8	-2.4	-0.6
Forced expiratory volume in 1-second (FEV1)	4.0	13.5	19.5	-4.4	-4.4	-1.5
Ulcerative Colitis (UC)	3.9	7.3	12.1	2.7	3.5	1.6
Fluid intelligence score	3.9	8.2	14.8	3.9	3.1	0.2
Financial situation satisfaction	3.9	4.9	6.7	-2.6	-2.0	-2.0
Hand grip strength (right)	3.8	10.2	14.6	-3.8	-3.7	-1.5
BMI	3.6	21.1	39.3	6.3	4.8	-0.7
Father’s age at death	3.6	4.8	8.1	-2.5	-2.8	-0.2
Pulse rate	3.6	6.2	6.8	2.6	2.5	2.4
Whole body fat mass	3.6	15.1	25.3	5.0	4.5	-0.2
Standing height	3.5	34.3	61.6	-7.8	-5.5	-3.4
Ever had prostate specific antigen (PSA) test	3.5	4.0	5.5	-1.6	-2.0	-2.4
Wheeze or whistling in the chest in last year	3.4	6.0	11.8	2.5	3.4	-0.1
Knee pain experienced in last month	3.4	5.2	7.7	2.8	2.8	0.6
Mineral and other dietary supplements	3.4	4.5	5.2	-1.9	-2.3	-2.2
Serious illness, injury or assault to yourself	3.3	4.0	5.9	2.4	2.3	-0.8
Worry too long after embarrassment	3.3	5.6	8.9	-2.6	-3.0	-1.1
Smoking status: Current	3.2	5.1	9.1	2.4	3.0	0.6
Risk taking	3.2	4.8	9.3	3.0	1.7	1.5
Average weekly fortified wine intake	3.1	3.6	6.5	1.4	2.6	1.5
Maternal smoking around birth	3.1	4.5	7.1	2.4	2.7	-0.8
Trunk fat mass	3.1	13.3	21.9	4.7	4.2	-0.3
Worrier / anxious feelings	3.1	5.9	8.6	-2.9	-2.8	-1.2
Medication: Cholesterol lowering	3.1	4.8	7.5	2.7	2.6	0.4
Back pain experienced in last month	3.1	4.5	6.4	-2.4	-1.2	-2.5
Commuting to job workplace: Public transport	3.1	3.7	4.2	2.0	2.0	1.7
Blood White Count	3.0	22.3	30.5	5.5	5.5	2.6
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.4	6.8	-1.6	-2.6	-1.1
Leg fat mass (left)	3.0	11.7	19.7	4.4	3.9	-0.4
Verbal and Numeric Reasoning (VNR)	2.9	6.9	11.7	3.4	3.0	0.2
Leg fat mass (right)	2.9	11.1	18.6	4.3	3.8	-0.7
Fasting Glucose	2.8	3.4	5.2	2.3	2.2	0.1
Type 2 Diabetes (T2D) (2012)	2.8	3.2	6.6	-0.7	-1.6	-2.6
Number of treatments/medications taken	2.8	5.1	8.8	3.0	1.8	1.8
Medication: Atenolol	2.8	3.5	4.9	2.2	2.0	1.3
Current tobacco smoking	2.7	4.4	7.9	2.2	2.8	0.6
Waist circumference	2.7	10.0	17.8	4.2	3.5	-0.4
Loneliness, isolation	2.7	3.7	10.7	-0.5	-0.4	-3.3
Respiratory disease	2.6	5.9	14.2	1.6	3.8	0.9
Medication: Ibuprofen	2.6	3.2	4.3	2.0	2.1	1.0
Type 2 Diabetes (T2D) (2018)	2.5	4.6	8.3	1.7	1.7	-2.9
Medication: Amlodipine	2.5	3.5	6.5	2.5	1.1	1.7
Asthma (self-reported)	2.5	4.9	11.0	1.7	3.3	0.9
Illnesses of father: None of the above (group 1)	2.5	3.1	5.9	-1.8	-0.5	-2.4
Irritable Bowel Disease (IBD)	2.4	5.7	8.4	2.6	2.9	1.5
Pain all over the body in last month	2.4	2.5	4.0	-1.1	-1.5	-2.0
Diabetes (self-reported)	2.4	3.8	5.4	1.8	1.6	-2.3
Asthma	2.4	4.7	10.8	1.7	3.3	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	6.1	1.2	1.0	2.5
Alcohol usually taken with meals	2.3	3.7	6.6	-2.0	-2.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	4.2	-1.9	-1.8	-2.0
Pulse rate, automated reading	2.3	7.3	14.0	3.7	2.4	1.6
Systolic blood pressure, automated reading	2.2	6.4	9.6	-0.7	-3.0	-3.1
Medication: Ramipril	2.2	2.8	6.5	1.1	0.9	2.5
Hip circumference	2.2	9.7	16.1	4.0	3.6	0.2
Diabetes diagnosed by doctor	2.2	3.6	4.1	1.9	1.8	-2.0
Coronary Artery Disease (CAD)	2.1	2.6	3.2	-1.8	-1.6	-1.4
Bilateral oophorectomy (both ovaries removed)	2.1	2.5	4.6	-1.7	-2.1	-0.1
Hypothyroidism/myxoedema (self-reported)	2.1	4.1	8.4	2.0	2.9	0.4
Number of self-reported non-cancer illnesses	2.1	3.6	8.1	2.9	1.6	0.1
Relative age voice broke	2.0	3.1	7.0	-1.4	-0.6	2.7
Trunk fat-free mass	2.0	11.3	16.4	-4.0	-2.6	-3.2
Depression (self-reported)	2.0	2.4	5.6	1.1	0.5	-2.4
Trunk predicted mass	2.0	11.4	16.4	-4.0	-2.7	-3.2
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	7.3	0.0	0.4	2.7
Ever taken oral contraceptive pill	2.0	2.2	4.7	1.4	2.2	0.0
Unable to work because of sickness or disability	2.0	2.7	5.2	2.3	1.4	-1.0
Systolic Blood Pressure	1.9	9.6	15.1	-1.0	-3.9	-3.5
Age when periods started (menarche)	1.9	4.5	7.1	-2.0	-1.6	2.7
Arm fat-free mass (right)	1.9	9.5	12.7	-3.3	-2.2	-3.6
Exposure to tobacco smoke outside home	1.9	2.5	3.8	-1.6	-1.1	-1.9
Medication: Simvastatin	1.8	2.6	4.7	2.2	1.7	-0.3
Alcohol intake versus 10 years previously	1.8	2.7	4.4	-1.1	-2.1	-1.6
Supplements: Fish oil (including cod liver oil)	1.8	2.3	2.6	1.6	1.6	1.4
Number of incorrect matches in round	1.7	2.7	4.3	-2.1	-1.9	-0.5
Had menopause	1.7	2.1	4.0	-1.5	-2.0	-0.3
Number of live births	1.7	2.4	3.4	-0.7	-1.8	-1.9
Arm predicted mass (right)	1.7	8.5	11.1	-3.2	-2.0	-3.3
Commuting to job workplace: Walk	1.7	1.9	3.9	1.2	0.5	2.0
Basal cell carcinoma (self-reported)	1.7	2.1	3.7	-0.9	-1.9	-1.3
Intelligence (Savage-Jansen 2018)	1.6	5.0	8.5	2.9	2.5	0.0
Ovarian Cancer	1.6	2.1	3.3	-1.6	-0.8	-1.8
Primary Biliary Cirrhosis	1.6	2.3	3.8	1.4	2.0	1.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.2	-1.8	-1.4	-1.1
Gout (self-reported)	1.6	2.2	6.0	0.3	-0.7	-2.4
Supplements: Vitamin C	1.6	1.9	3.3	-1.4	-0.7	1.8
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.1	-1.4	-1.8	0.8
Medication: Blood pressure	1.6	3.1	5.5	2.3	1.1	1.6
Mean Putamen Volume	1.4	1.6	3.8	0.8	-0.5	2.0
Noisy workplace	1.4	1.8	3.8	-1.9	-1.2	0.4
Length of working week for main job	1.4	1.6	3.4	1.9	1.1	0.3
Loud music exposure frequency	1.4	1.6	4.1	-0.8	-0.1	-2.0
Pulse wave peak to peak time	1.4	1.7	2.0	-1.3	-1.4	-1.1
Health satisfaction	1.4	1.8	2.5	-1.6	-1.4	-1.1
Eye problems/disorders: Cataract	1.4	1.6	2.6	1.4	1.6	-0.5
Lupus	1.3	1.9	3.4	-1.1	-1.1	-1.8
Hypothyroidism (self reported)	1.3	3.1	5.9	1.8	2.4	0.2
Supplements: Glucosamine	1.3	1.8	2.6	1.0	1.3	1.6
Lung cancer (father)	1.3	1.5	2.9	-1.7	-1.0	-0.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.3	1.8	1.6	-0.1
Had major operations	1.3	1.5	2.6	1.6	1.3	0.5
Friendships satisfaction	1.3	1.6	2.2	-1.5	-1.4	-0.8
Medication: Aspirin	1.3	1.8	2.9	1.7	1.5	0.4
Pain type(s) experienced in last month: Hip pain	1.3	1.7	1.9	1.4	1.3	-1.3
Arm fat-free mass (left)	1.3	6.4	9.6	-2.7	-1.6	-3.1
Average weekly beer plus cider intake	1.3	1.9	3.6	1.3	1.9	0.7
Breast Cancer	1.2	3.0	4.3	-2.0	-2.1	-0.9
Triglycerides	1.2	2.0	4.9	2.2	0.9	-0.4
Chronotype (morning person)	1.2	2.7	5.7	-2.4	-1.6	0.1
Relative age of first facial hair	1.2	2.5	7.3	0.2	0.5	2.7
Chest pain or discomfort	1.2	1.7	2.7	1.5	1.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	1.9	-1.1	-1.0	-1.4
Medication: Aspirin	1.2	1.6	2.7	1.6	1.4	0.1
Illnesses of siblings: Diabetes	1.2	1.5	3.6	0.9	0.3	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	4.1	-0.5	-0.0	-2.0
Arm predicted mass (left)	1.2	6.3	9.8	-2.6	-1.6	-3.1
Depression (Nagel 2018)	1.1	1.7	3.8	-0.5	-1.0	-2.0
Crohns Disease (2012)	1.1	1.8	3.3	1.8	1.3	0.8
Blood Platelet Count	1.1	13.0	19.3	3.5	2.7	4.4
Neuroticism	1.1	2.6	3.0	-1.7	-1.6	-1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.9	1.7	0.9	-0.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.5	-1.0	-1.6	0.8
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	2.7	1.6	0.9	-0.4
Supplements: Zinc	1.1	1.2	2.1	-1.0	-0.7	1.5
Medication: Co-codamol	1.1	1.3	1.7	1.3	1.3	-0.7
Severe depression (siblings)	1.1	1.2	2.1	-0.1	-1.3	-1.4
Pack years adult smoking proportion	1.1	1.7	2.0	1.3	1.3	-1.4
Hair/balding pattern: Pattern 3	1.1	1.6	3.3	1.8	1.1	-0.4
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.8	-0.4	0.2	-2.0
Qualifications: nursing, teaching	1.1	1.7	3.2	1.3	0.3	1.8
Age started oral contraceptive pill	1.1	1.4	1.9	-1.2	-1.4	0.9
Pack years of smoking	1.1	1.6	2.0	1.2	1.1	-1.4
Neuroticism (Nagel 2018)	1.0	2.4	3.0	-1.7	-1.4	-1.5
Worry (Nagel 2018)	1.0	2.1	3.7	-1.9	-1.3	-0.9
Blood Eosinophil Count	1.0	7.9	11.8	3.4	3.4	-0.5
Diabetes (mother)	1.0	1.2	2.8	1.7	0.9	-0.2
Taking other prescription medications	1.0	1.6	2.9	1.7	1.1	-0.8
Medication: Lansoprazole	1.0	1.2	2.2	1.5	1.1	-0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.3	-2.1	-0.8	-0.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.4	-0.5	0.1	-1.8
Whole body fat-free mass	1.0	5.4	8.8	-2.4	-1.3	-3.0
Whole body water mass	1.0	5.4	8.8	-2.4	-1.3	-3.0
Reaction Time	0.9	1.7	2.6	-1.6	-1.5	0.5
Impedance of leg (right)	0.9	4.1	7.2	-2.7	-2.3	-0.1
Townsend deprivation index at recruitment	0.9	1.3	1.8	1.2	0.7	1.4
Fed-up feelings	0.9	1.6	3.0	-1.7	-1.3	-0.4
Impedance of leg (left)	0.9	4.1	6.7	-2.6	-2.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.1	1.8	1.1	-0.4
Impedance of arm (left)	0.9	4.4	6.8	2.0	1.5	2.6
Neck or shoulder pain in last month	0.9	1.2	1.7	1.3	1.3	0.6
Comparative height size at age 10	0.9	4.9	10.5	-1.9	-0.8	-3.2
Wears glasses or contact lenses	0.9	1.0	2.2	-0.2	-1.5	-0.9
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.9	-1.4	-1.2	0.1
Age at First Birth	0.8	1.1	1.6	-0.9	-1.0	-1.3
Sensitivity / hurt feelings	0.8	1.3	1.5	-1.2	-1.1	-1.1
Weight	0.8	4.1	5.8	2.2	2.4	-1.2
Impedance of arm (right)	0.8	3.8	5.3	1.9	1.5	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	1.2	1.3	-0.1
Birth weight of first child	0.8	1.4	1.8	1.2	0.9	-1.3
Number of full brothers	0.8	1.0	2.2	-0.9	-1.5	-0.5
Shortness of breath walking on level ground	0.8	0.9	1.7	1.1	1.3	-0.0
Medication: Blood pressure	0.8	1.5	4.0	2.0	0.2	0.6
Medication: Allopurinol	0.8	1.1	3.0	0.4	-0.4	-1.7
Ever had bowel cancer screening	0.8	1.0	2.3	-1.5	-0.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.6	-0.1	-0.0	1.6
Illnesses of father: High blood pressure	0.8	1.0	2.9	0.1	-1.7	0.4
Alcohol drinker status: Never	0.8	0.9	1.6	-0.8	-1.2	-0.7
Depressed Affect (Nagel 2018)	0.7	1.4	2.7	-0.9	-0.9	-1.6
Alzheimer’s Disease (including proxy)	0.7	1.0	1.6	-0.7	-0.9	-1.3
Allergy or Eczema	0.7	1.8	2.7	-1.6	-1.2	1.2
Medication: Metformin	0.7	1.0	2.8	0.3	-0.2	-1.7
Diabetes (father)	0.7	0.9	2.3	0.0	-0.6	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.4	-0.1	-0.0	-1.5
Financial difficulties in last 2 years	0.7	1.0	2.5	0.5	0.4	-1.6
Neuroticism score	0.7	1.4	1.8	-1.4	-1.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	1.2	0.6	-0.7
Pulse wave Arterial Stiffness index	0.7	0.8	1.2	0.9	1.1	0.7
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.3	0.7	1.5	0.3
Birth weight	0.7	1.5	3.7	-1.9	-0.7	0.6
Medication: Seretide 50 evohaler	0.7	0.8	1.1	1.0	1.0	-0.6
Suffer from ‘nerves’	0.7	1.1	2.6	-1.6	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.2	1.0	1.1	0.7
Prostate Cancer	0.6	0.8	0.9	1.0	0.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.9	0.6	-0.0	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.6	-1.3	-0.2	-0.6
Stomach or abdominal pain in last month	0.6	0.8	1.5	-0.8	-0.4	-1.2
High blood pressure (mother)	0.6	0.8	1.4	1.2	0.7	0.7
Blood clot in the leg (DVT)	0.6	0.8	1.1	0.9	1.0	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.8	0.8	0.9	-0.7
Mean time to correctly identify matches	0.6	1.2	2.0	-1.4	-1.3	-0.1
Leg pain on walking	0.6	0.8	1.6	0.2	1.3	-0.8
Medication: Gliclazide	0.6	0.7	1.5	0.6	1.2	0.1
Ever depressed for a whole week	0.6	0.7	1.7	-0.5	-0.3	-1.3
Commuting to job workplace: Cycle	0.6	0.7	1.3	-1.1	-0.9	-0.3
Myopia	0.6	0.9	2.3	-0.5	-0.4	1.5
Cholesterol lowering medication	0.6	0.9	1.8	0.8	-0.3	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	-0.5	-1.3	0.4
Lung FEV1/FVC ratio	0.5	2.8	3.3	1.7	-1.5	1.8
Average weekly spirits intake	0.5	0.7	1.0	1.0	0.9	-0.4
Hearing difficulty/problems: Yes	0.5	0.7	1.9	0.5	0.4	-1.4
Prospective memory result	0.5	0.6	1.3	-1.1	-0.3	-0.7
Breastfed as a baby	0.5	0.6	1.1	0.3	1.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.8	0.5	-0.6	-1.3
Hair/balding pattern: Pattern 4	0.5	1.2	2.1	-0.9	-1.5	-0.7
Age at first live birth	0.5	1.0	2.1	0.4	1.5	0.8
Heart disease (mother)	0.5	0.6	1.7	0.1	0.4	1.3
Hypertension (Self-reported)	0.5	1.3	1.8	1.4	-1.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.0	-0.4	-0.0	1.4
Average weekly champagne plus white wine intake	0.5	0.6	1.1	-1.0	-0.6	0.6
Miserableness	0.5	0.9	2.0	0.1	0.9	-1.4
Medication: Bendroflumethiazide	0.5	0.8	2.1	0.1	-1.4	0.5
Medication: Atorvastatin	0.5	0.6	1.4	0.5	0.0	-1.2
Basal metabolic rate	0.5	2.9	6.9	-1.3	-0.4	-2.6
Pain experienced in last month	0.5	0.8	2.5	-0.0	-0.2	1.6
Bipolar Disorder (2018)	0.4	0.7	1.2	1.1	0.7	0.4
Cardiovascular Disease	0.4	1.4	2.4	1.5	-0.9	-1.0
Leg fat-free mass (left)	0.4	2.1	5.5	0.2	0.9	-2.3
Qualifications: CSEs or equivalent	0.4	0.5	1.4	0.3	0.1	1.2
High blood pressure	0.4	1.1	1.8	1.1	-1.3	0.4
Leg predicted mass (left)	0.4	2.0	5.4	0.1	0.8	-2.3
Had other major operations	0.4	0.4	1.1	1.1	0.5	0.0
Allergy	0.4	0.9	1.7	-0.0	-1.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.2	1.1	0.8	0.9
Illnesses of mother	0.4	0.5	1.2	-1.1	-0.4	-0.2
Tense / ‘highly strung’	0.4	0.7	1.9	0.0	1.4	-0.5
Peak expiratory flow (PEF)	0.4	1.0	2.2	-0.8	-1.5	0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.1	1.2	0.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	0.6	0.8	-0.6
Alcohol intake frequency.	0.4	0.9	1.6	-0.2	-1.0	-1.3
Breast cancer (self-reported)	0.4	0.5	1.0	-0.8	-1.0	0.1
Guilty feelings	0.4	0.5	0.7	-0.9	-0.7	-0.6
Hearing aid user	0.4	0.4	0.6	0.7	0.8	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.7	-1.6	0.3	-0.7
Supplements: Calcium	0.4	0.5	0.6	0.6	0.8	0.8
Heart disease (siblings)	0.4	0.5	1.3	0.2	-0.2	1.1
Schizophrenia (2018)	0.3	0.7	0.9	-1.0	-0.6	-0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.8	0.3	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.3	-0.2	-1.0
HbA1C	0.3	0.4	0.4	0.7	0.5	-0.6
HDL Cholesterol	0.3	0.5	1.2	-0.5	0.1	1.1
Blood Red Count	0.3	2.6	7.1	0.6	0.7	-2.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.8	-0.9	-0.6	0.8
Nervous feelings	0.3	0.6	1.6	-1.3	-0.3	-0.5
Qualifications: None of the above	0.3	0.6	1.2	-1.1	-0.8	0.1
Headache pain in last month	0.3	0.5	1.0	1.0	0.8	0.0
Medication: Omeprazole	0.3	0.3	0.7	0.1	-0.5	0.8
Family relationship satisfaction	0.3	0.4	0.6	-0.5	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.6	-1.3	-0.3	0.1
Osteoporosis (self-reported)	0.3	0.4	0.9	0.9	0.4	0.5
Mother’s age at death	0.3	0.3	0.7	-0.4	-0.8	-0.2
High cholesterol (Self-reported)	0.3	0.5	0.8	0.9	0.1	-0.9
Medication: Lisinopril	0.3	0.4	0.7	0.1	-0.6	-0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	0.2	0.6	-0.6
Crohns Disease (2017)	0.2	0.5	1.0	1.0	0.3	0.7
Major Depression (MDD)	0.2	0.3	0.8	0.1	0.2	-0.9
Bipolar Disorder (2011)	0.2	0.2	0.3	-0.2	-0.5	-0.5
Neuroticism (2016)	0.2	0.3	0.6	-0.8	-0.2	-0.4
Schizophrenia (2014)	0.2	0.5	1.3	-0.5	-0.1	-1.1
Waist Hip Ratio (WHR)	0.2	0.9	2.4	-0.1	-0.6	-1.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	-0.2	0.1	-0.9
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	0.5	0.2	0.7
Vitamin and mineral supplements	0.2	0.3	0.8	0.9	0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.8	-0.3	0.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.6	0.5	0.1
Illnesses of siblings	0.2	0.3	0.6	-0.4	0.1	0.8
Time employed in main current job	0.2	0.2	0.6	-0.8	-0.2	-0.1
Comparative body size at age 10	0.2	0.5	1.0	1.0	0.2	-0.6
Migraine (self-reported)	0.2	0.3	0.5	0.6	0.0	0.7
Overall health rating	0.2	0.5	1.3	0.0	-0.3	-1.1
Leg fat-free mass (right)	0.2	1.2	3.1	0.1	0.8	-1.8
Mood swings	0.2	0.3	0.5	-0.4	-0.4	0.7
Medication for cholesterol	0.2	0.3	0.6	-0.8	0.4	-0.2
Leg predicted mass (right)	0.2	1.3	3.6	-0.1	0.6	-1.9
Number of operations (self-reported)	0.2	0.2	0.7	0.8	0.2	-0.1
Diastolic blood pressure, automated reading	0.2	0.7	1.9	1.4	0.3	0.3
Impedance of whole body	0.2	1.0	3.0	0.0	-0.1	1.7
LDL Cholesterol	0.1	0.2	0.2	0.4	0.4	-0.4
Rheumatoid Arthritis	0.1	0.1	0.3	0.0	-0.1	-0.6
Hair Pigment	0.1	2.1	4.7	1.0	2.2	0.9
Tanning	0.1	0.7	1.8	-1.3	-0.6	0.3
Medication for hormone replacement therapy	0.1	0.1	0.3	0.1	0.0	-0.6
Multivitamins +/- minerals	0.1	0.1	0.2	-0.3	-0.4	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.1	0.5	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.7	0.3	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	0.6	-0.2	0.0
Pulse wave reflection index	0.1	0.2	0.5	0.0	0.7	0.0
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.2	-0.4
High blood pressure (siblings)	0.1	0.1	0.2	0.4	-0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.3	-0.3	0.3
Number of children fathered	0.1	0.1	0.3	-0.0	0.3	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	-0.2	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.1	-0.4	-0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	0.3	0.2	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.3	0.4	-0.2	0.5
Average weekly red wine intake	0.1	0.1	0.3	0.5	0.4	0.0
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.4	0.0	-0.5
Medication: Paracetamol	0.1	0.2	0.6	0.8	-0.1	-0.1
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	-0.1	0.0	-0.4
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.1	-0.2	0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.1	0.1	0.1
Mouth/teeth dental problems	0.0	0.0	0.1	-0.2	-0.3	-0.1
Qualifications: College or University degree	0.0	0.1	0.2	0.4	-0.3	-0.3
Number of full sisters	0.0	0.0	0.1	-0.2	-0.2	0.1
Irritability	0.0	0.1	0.1	0.1	0.4	0.2

Hub : Genes

NQO1

Models

Trait associations