Best TWAS P=2.39e-11 · Best GWAS P=1.27e-14 conditioned to 1.46e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C18orf8 | 0.26 | 0.35 | lasso | 6 | 0.40 | 1.9e-52 | 4.3 | 5.3 | 9.7e-08 | -0.15 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NPC1 | 0.08 | 0.07 | lasso | 3 | 0.08 | 5.2e-10 | -5.7 | 5.4 | 6.4e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | C18orf8 | 0.18 | 0.12 | lasso | 3 | 0.10 | 1.5e-08 | -5.7 | 5.7 | 1.3e-08 | -0.15 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | C18orf8 | 0.14 | 0.13 | lasso | 3 | 0.10 | 8.0e-07 | -5.7 | 5.5 | 3.9e-08 | -0.16 | 0.96 | 0.00 | FALSE |
| 5 | GTEx | Nerve Tibial | NPC1 | 0.19 | 0.12 | lasso | 6 | 0.16 | 1.1e-11 | -5.7 | 5.5 | 3.2e-08 | -0.14 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Testis | RBBP8 | 0.20 | 0.12 | lasso | 3 | 0.08 | 2.2e-04 | 5.1 | 5.1 | 2.9e-07 | -0.06 | 0.76 | 0.01 | TRUE |
| 7 | GTEx | Testis | C18orf8 | 0.12 | 0.07 | lasso | 6 | 0.08 | 1.9e-04 | 4.3 | 5.7 | 1.6e-08 | -0.23 | 0.30 | 0.06 | FALSE |
| 8 | YFS | Blood | TTC39C | 0.27 | 0.20 | bslmm | 511 | 0.21 | 4.6e-66 | 6.7 | 6.7 | 2.4e-11 | -0.04 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NPC1 | 0.03 | 0.03 | blup | 69 | 0.04 | 2.9e-09 | 4.2 | 5.3 | 1.0e-07 | -0.14 | 0.05 | 0.95 | FALSE |
| 10 | The Cancer Genome Atlas | Esophageal Carcinoma | NPC1 | 0.16 | 0.10 | lasso | 3 | 0.10 | 3.7e-04 | -5.7 | 5.6 | 2.8e-08 | -0.14 | 0.01 | 0.93 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C18orf8 | 0.07 | 0.05 | lasso | 5 | 0.03 | 9.5e-05 | -5.7 | 5.8 | 7.7e-09 | -0.14 | 0.00 | 1.00 | TRUE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NPC1 | 0.07 | 0.08 | lasso | 3 | 0.10 | 1.6e-11 | -5.7 | 5.1 | 3.0e-07 | -0.16 | 0.01 | 0.99 | FALSE |