TWAS hub - TTC39C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.1690	0.0680	5.5e-03	-0.007	NA	-0.006	NA	0.007	7.8e-01	NA	6.3e-01	NA	1.7e-01
2	GTEx	Esophagus Muscularis	0.1620	0.0530	7.3e-05	0.026	NA	0.027	NA	0.050	9.9e-03	NA	8.9e-03	NA	5.4e-04
3	GTEx	Heart Left Ventricle	0.3245	0.1101	6.2e-04	-0.003	NA	0.002	NA	0.001	4.9e-01	NA	2.3e-01	NA	2.7e-01
4	GTEx	Muscle Skeletal	0.0794	0.0303	8.4e-04	-0.003	NA	0.006	NA	-0.003	8.7e-01	NA	7.8e-02	NA	7.6e-01
5	GTEx	Pancreas	0.1600	0.0620	5.0e-03	0.024	NA	0.026	NA	0.043	3.4e-02	NA	2.9e-02	NA	6.5e-03
6	YFS	Blood	0.2669	0.0338	0.0e+00	0.199	0.174	0.206	0.208	0.202	6.2e-63	1.4e-54	2.2e-65	4.6e-66	5.6e-64
7	TCGA	Lung Adenocarcinoma	0.0577	0.0262	3.4e-03	0.004	0.015	0.011	NA	0.014	1.0e-01	5.8e-03	1.6e-02	NA	7.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Long-standing illness, disability or infirmity	5.0	7.7	16.5	-3.1	-4.1	-3.3	-1.7	-2.7	-2.4	0.5
Had other major operations	3.7	4.5	6.8	-2.6	-2.6	-1.6	-2.5	-1.7	-1.8	2.0
Noisy workplace	3.4	4.2	9.4	0.9	1.7	2.0	2.9	3.1	1.8	0.4
Age started oral contraceptive pill	3.3	4.1	8.7	2.2	2.7	2.9	2.1	1.4	1.1	-0.2
Current tobacco smoking	3.2	5.2	13.5	-2.8	-3.7	0.4	-2.8	-1.8	1.0	1.8
Ever had hysterectomy (womb removed)	3.1	3.5	7.8	-2.5	-2.8	-0.2	-1.5	-1.9	-1.9	0.6
Exposure to tobacco smoke at home	3.1	3.5	6.3	-2.0	-1.7	-1.4	-2.5	-2.1	-2.0	0.6
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	7.8	-2.8	-2.7	-2.4	-1.1	-1.6	-1.1	1.0
Medication: Ventolin 100micrograms inhaler	2.8	3.6	7.9	2.8	2.6	1.4	1.7	1.8	1.2	-1.1
Number of live births	2.7	3.9	13.4	-1.3	-2.5	-0.9	-0.7	-2.1	-3.7	0.5
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	13.3	1.9	3.0	3.6	2.4	2.4	1.8	-0.8
Bipolar Disorder (2011)	2.5	2.5	11.6	-1.1	-1.1	-1.0	0.4	-1.3	-3.4	0.4
Relative age voice broke	2.5	3.8	8.0	1.4	1.6	-1.0	2.8	1.7	2.2	-2.4
Medication: Lansoprazole	2.4	2.8	5.0	-1.5	-2.0	-2.2	-2.2	-1.1	-0.1	1.3
Smoking status: Current	2.4	3.8	9.5	-2.3	-3.1	0.6	-2.3	-1.7	0.9	1.5
Osteoarthritis (self-reported)	2.3	2.9	9.7	-0.9	-1.2	-0.1	-2.3	-0.9	-3.1	1.5
Medication: Metformin	2.2	3.2	6.0	-1.9	-2.4	-1.2	-2.4	-1.9	-1.1	-0.9
Medication: Gliclazide	2.2	2.5	4.2	-2.0	-2.0	0.3	-1.8	-1.0	-2.0	0.7
Medication: Co-codamol	2.1	2.4	5.3	-2.3	-1.4	-0.6	-2.0	-0.1	-1.7	1.5
Taking other prescription medications	2.1	3.2	6.9	-1.9	-2.0	-2.6	-1.6	-0.8	-1.8	1.2
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	11.6	1.5	2.1	3.4	1.5	2.6	2.4	-0.3
Hair/balding pattern: Pattern 3	2.1	3.2	6.2	2.3	2.5	1.1	2.0	2.0	0.0	-1.4
Ovarian Cancer	1.9	2.5	7.9	-2.8	-1.8	-0.3	-0.2	-0.2	-0.3	2.4
Hayfever, allergic rhinitis or eczema	1.9	4.0	9.9	-1.2	-1.5	-1.1	-3.1	-2.7	-2.1	1.4
Chronic bronchitis/emphysema (father)	1.9	2.2	4.8	0.7	1.9	2.2	1.7	1.8	0.5	-0.6
Alcohol usually taken with meals	1.9	3.1	7.5	-2.0	-1.2	-2.3	-1.3	-1.1	-2.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	3.1	-1.4	-1.6	-1.6	-1.8	-1.5	0.9	1.0
Number of operations (self-reported)	1.9	2.8	6.0	-2.2	-2.4	-1.5	-1.1	-0.8	-1.8	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	6.3	-1.4	-0.9	-2.5	-1.8	-1.0	-2.5	-0.3
High cholesterol (Self-reported)	1.8	3.2	6.3	-2.5	-2.3	-0.3	-2.2	-1.9	-1.5	0.6
Length of working week for main job	1.7	1.9	4.1	-2.0	-1.6	-0.4	-0.7	-1.2	-1.3	1.6
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.8	-2.1	-1.6	-1.4	-2.2	-0.1	0.1	1.3
Pain all over the body in last month	1.6	1.7	10.7	0.4	0.3	3.3	0.1	-0.3	1.0	0.1
Illnesses of siblings	1.6	2.2	5.3	1.9	1.9	0.8	1.3	0.5	0.8	-2.3
Chronic bronchitis/emphysema (mother)	1.6	1.8	4.1	1.3	2.0	0.1	1.4	1.7	-1.2	0.8
Exposure to tobacco smoke outside home	1.6	2.2	4.5	-2.1	-1.5	-1.2	-0.9	-0.9	-2.0	1.3
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.2	-0.9	-0.8	-1.4	-1.1	-0.8	-2.0	-1.6
Relative age of first facial hair	1.5	3.1	7.2	1.9	2.3	0.7	2.7	1.4	0.9	-1.5
Shortness of breath walking on level ground	1.5	1.8	5.2	1.2	1.6	2.3	-0.6	1.5	0.8	0.3
Diabetes diagnosed by doctor	1.5	2.4	6.0	-1.8	-2.5	-1.1	-1.5	-1.5	-0.9	-0.8
Alzheimer’s Disease (including proxy)	1.4	2.1	3.8	0.9	1.9	1.0	1.7	1.8	1.7	-0.5
Number of treatments/medications taken	1.4	2.5	4.8	-1.8	-1.4	-1.1	-1.1	0.3	-2.2	2.2
Falls in the last year	1.4	1.9	5.3	-1.1	-1.5	-1.8	-0.5	-1.1	-2.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	6.8	-1.8	-1.9	-0.7	-0.4	0.2	-0.5	2.6
High blood pressure (siblings)	1.4	2.0	5.4	-2.3	-1.8	-0.1	-1.4	-0.1	0.1	1.7
Medication: Omeprazole	1.4	1.7	5.7	-0.9	-0.8	-0.5	-2.4	0.2	-1.3	1.6
Back pain experienced in last month	1.4	2.1	3.4	-1.3	-1.8	-1.2	-1.6	-1.8	-1.5	0.5
Lupus	1.3	2.0	5.8	-2.0	-0.2	-1.9	-0.1	2.4	-0.6	0.2
Townsend deprivation index at recruitment	1.3	1.8	8.2	0.3	0.6	2.9	0.7	0.7	1.6	-0.4
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	6.7	-0.7	-1.2	-0.1	-2.6	-0.8	0.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.4	1.1	0.8	2.0	-0.2	1.5	2.5	-0.4
Number of full sisters	1.3	1.6	5.0	-0.7	-1.2	-1.0	-2.2	-1.3	-1.0	0.4
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.1	-0.9	-0.9	-1.1	-2.3	0.3	-0.4	1.8
Blood White Count	1.2	9.1	44.6	0.3	1.2	3.7	0.2	1.6	6.7	0.9
Diabetes (self-reported)	1.2	1.9	3.6	-1.2	-1.9	-1.1	-1.0	-1.7	-1.2	-1.3
Medication: Ibuprofen	1.2	1.5	6.0	-0.3	-0.3	-1.3	-1.3	-0.7	-2.4	-0.1
Age at last live birth	1.2	1.8	3.6	-1.4	-1.3	-1.9	-0.7	-1.4	1.4	0.8
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.0	1.5	1.7	0.9	0.7	0.7	1.2	1.2
BMI	1.1	6.2	16.3	-2.6	-4.0	1.1	-3.5	-2.0	0.8	1.4
Respiratory disease	1.1	2.4	4.4	1.6	2.1	1.0	1.5	1.8	-1.8	-0.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.6	-1.9	-1.8	-0.7	-2.4	-0.4	-1.3	0.1
Had menopause	1.1	1.4	4.7	0.9	1.4	0.9	2.2	1.1	-0.3	-0.0
Mouth/teeth dental problems	1.1	1.7	4.0	-1.4	-1.6	-1.7	-0.4	-2.0	-0.7	-0.4
Asthma	1.1	2.1	4.5	2.1	1.9	0.8	2.0	0.7	-0.5	-1.0
Blood clot in the leg (DVT)	1.1	1.5	3.0	-1.3	-1.7	-1.1	-1.7	-0.7	0.2	1.1
Commuting to job workplace: Walk	1.1	1.2	2.7	-1.6	-1.3	-1.2	-1.6	-0.6	-0.3	0.1
Medication: Atorvastatin	1.1	1.4	5.6	-0.4	-0.4	-1.1	-1.2	-0.9	-2.4	-0.0
Irritability	1.1	1.8	4.5	0.7	1.6	1.8	0.4	1.0	2.1	-0.8
Pain experienced in last month	1.1	1.8	4.6	0.6	1.0	0.1	2.1	2.0	1.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.9	-1.1	-1.7	-1.2	-1.6	-0.6	0.2	1.3
Age at First Birth	1.0	1.5	3.6	1.3	1.4	0.3	0.5	1.9	1.6	0.4
Lung FVC	1.0	5.0	18.2	-2.1	-2.2	-1.9	-0.9	-4.3	-0.3	-1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-0.9	-1.1	-1.8	0.5	-0.8	-1.2	-0.5
Supplements: Zinc	1.0	1.1	2.8	-1.7	-1.0	-1.7	-0.7	-0.2	0.1	0.9
Time employed in main current job	1.0	1.2	2.5	-1.0	-1.6	-1.1	-0.8	-1.4	-0.9	0.5
Depression (self-reported)	1.0	1.2	3.1	-1.8	-1.2	-0.0	-0.6	0.6	0.7	1.5
Birth weight of first child	1.0	1.8	3.5	-1.4	-1.4	0.0	-1.5	-1.0	-1.9	-1.3
Emphysema/chronic bronchitis	1.0	1.1	2.1	0.4	1.4	0.4	-1.2	1.2	-1.2	1.1
Heart disease (mother)	1.0	1.2	4.5	-1.0	-0.7	1.0	0.1	0.8	-2.1	0.8
Illnesses of siblings: Diabetes	1.0	1.3	3.3	-1.1	-0.8	0.3	-1.1	-0.2	-1.8	1.5
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.7	1.2	1.5	1.3	1.6	0.7	-0.4	-1.0
Alcohol drinker status: Previous	1.0	1.1	2.2	-0.6	-1.2	-1.1	-0.9	-0.1	-1.5	1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	6.4	-0.1	0.1	0.1	0.4	0.7	2.5	-1.2
Alzheimer’s Disease (in father)	0.9	1.0	3.6	0.5	0.1	-1.0	0.7	0.5	1.9	-1.1
Blood Red Count	0.9	8.2	15.4	3.1	3.7	2.8	2.7	3.9	1.8	-0.5
Severe depression (siblings)	0.9	1.0	2.6	-1.3	-0.7	-0.9	-0.4	-0.8	-1.6	0.9
Age when periods started (menarche)	0.9	2.1	4.1	1.4	1.4	2.0	1.6	1.3	1.6	0.1
Body mass index (BMI)	0.9	3.6	11.7	-1.7	-3.4	0.6	-2.4	-2.0	0.7	-0.2
Father’s age at death	0.9	1.2	4.0	-1.8	-0.6	-0.1	-0.7	-0.5	0.1	2.0
Worrier / anxious feelings	0.9	1.7	4.6	1.4	2.0	-0.2	0.5	2.1	0.3	-0.9
Mouth/teeth dental problems: Dentures	0.9	1.5	2.7	1.5	1.3	0.6	1.4	1.2	1.6	-0.3
Pulse wave reflection index	0.9	1.1	2.7	1.3	1.6	1.3	0.5	0.7	0.7	-0.5
Number of full brothers	0.9	1.1	2.6	-1.6	-0.0	0.5	-0.1	1.6	0.4	1.6
Number of children fathered	0.9	1.0	1.8	0.9	1.2	0.4	1.3	0.9	-0.7	-1.3
Medication for pain relief, constipation, heartburn	0.9	1.6	3.8	1.4	1.0	0.4	1.7	-0.1	1.9	-1.0
Angina (self-reported)	0.9	1.1	2.1	-1.1	-1.5	-1.0	-0.8	-1.3	-0.1	1.1
Medication: Aspirin	0.9	1.2	2.4	-1.3	-1.4	-1.5	-1.0	-0.6	-0.4	1.0
Qualifications: nursing, teaching	0.9	1.4	2.4	-1.5	-1.5	-1.5	0.0	-0.8	0.3	1.5
Breast cancer (self-reported)	0.9	1.1	2.7	0.1	-0.5	-1.4	1.3	-0.8	-0.8	-1.7
Asthma (self-reported)	0.9	1.7	3.5	1.8	1.8	0.7	1.9	0.7	-0.8	-0.7
Number of self-reported non-cancer illnesses	0.9	1.6	5.0	-1.7	-1.0	-0.0	-0.8	0.6	-1.2	2.2
Miserableness	0.9	1.6	4.9	-1.2	-0.9	-0.1	-0.8	-0.1	2.2	1.8
Alzheimer’s Disease (in mother)	0.8	0.9	2.2	-0.3	1.2	1.0	1.1	1.5	-0.4	0.7
Major Depression (MDD)	0.8	0.9	2.2	-0.7	0.1	1.2	1.1	1.5	-0.5	0.9
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	-1.1	-1.6	-0.7	-0.8	-1.1	0.3	-1.2
Mean Putamen Volume	0.8	0.9	2.9	-1.7	-0.6	-0.2	-0.1	0.9	-1.2	1.0
Triglycerides	0.8	1.3	4.2	-1.0	-0.7	-1.1	-1.1	-0.7	-2.1	-0.7
Allergy or Eczema	0.8	2.1	5.0	-0.7	-0.7	-0.1	-2.2	-1.7	-1.5	1.9
Medication for hormone replacement therapy	0.8	0.9	1.7	0.2	0.8	1.1	1.3	1.1	1.1	0.0
Qualifications: CSEs or equivalent	0.8	1.1	3.1	-0.2	-0.3	-1.1	-1.6	-0.8	-1.8	0.0
Past tobacco smoking	0.8	1.4	7.5	0.1	0.3	1.3	0.7	0.2	2.7	-0.5
Qualifications: None of the above	0.8	1.6	2.8	1.5	1.6	1.7	1.1	1.1	-0.7	-0.8
Arm fat percentage (right)	0.8	3.0	10.4	-1.3	-3.2	0.6	-2.0	-1.7	1.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	5.1	0.2	0.1	-0.5	-1.0	-0.2	-2.3	-0.6
Lung cancer (father)	0.8	1.0	2.3	-1.5	-1.1	0.1	-1.1	0.5	-0.2	1.2
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.8	1.2	0.8	1.4	-0.1	0.0	1.1	-1.1
Eye problems/disorders: None of the above	0.8	0.9	2.5	1.4	1.1	0.6	-0.7	0.1	0.2	-1.6
Migraine (self-reported)	0.8	1.0	3.2	0.0	-0.4	-0.8	-1.3	-1.8	-0.7	-0.8
Overall health rating	0.8	1.6	6.3	-0.6	-1.3	-1.2	-2.5	-1.1	-0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.8	0.2	0.1	-2.0	-0.4	0.9	-0.0	1.2
Smoking status: Previous	0.8	1.2	6.3	0.7	0.7	-1.1	0.1	0.2	-2.5	0.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.8	0.2	0.3	1.1	-1.7	-0.3	0.0	-1.5
Medication: Aspirin	0.8	1.0	2.5	-1.3	-1.3	-1.6	-0.7	-0.7	-0.2	0.4
Ever taken oral contraceptive pill	0.8	0.9	3.9	0.3	0.6	1.0	0.6	2.0	0.1	0.4
Ever smoked	0.8	1.5	6.2	-0.7	-0.8	-0.7	-1.5	0.3	-2.5	0.1
Bipolar Disorder (2018)	0.7	1.1	3.8	-0.7	-0.0	1.2	0.2	-0.3	-1.9	1.4
Average weekly spirits intake	0.7	0.8	2.7	-0.1	-0.0	0.6	1.6	0.8	1.5	0.1
Sensitivity / hurt feelings	0.7	1.1	4.2	-1.1	-1.0	-0.5	-2.1	0.1	-0.9	0.6
Diabetes (father)	0.7	0.9	3.2	-0.6	-1.1	-1.2	-0.1	-0.1	-1.8	0.2
Serious illness, injury or assault to yourself	0.7	0.8	1.9	-0.9	-0.9	-1.4	-1.1	-0.4	-0.6	-0.7
Hearing difficulty/problems with background noise	0.7	1.0	4.6	0.0	1.1	-0.7	-0.5	-0.6	-2.1	-0.6
Medication: Ramipril	0.7	0.9	3.1	-0.5	-1.4	0.5	0.3	-0.4	-0.2	1.8
Alcohol intake versus 10 years previously	0.7	1.1	2.2	-1.4	-1.5	-1.1	-1.2	-0.5	0.3	-0.7
Prospective memory result	0.7	0.8	2.4	-0.1	-0.7	-0.9	-0.6	-1.5	-1.0	-0.8
Headache pain in last month	0.7	1.3	3.5	-1.0	-1.0	-0.6	-1.9	-1.5	-0.9	0.5
Gout (self-reported)	0.7	0.9	3.0	1.4	1.1	0.0	-0.2	0.2	0.3	-1.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.5	0.6	1.0	1.6	-0.3	0.4	-0.1	1.2
Pulse rate, automated reading	0.7	2.2	6.8	-1.6	-1.9	1.0	0.1	0.0	2.6	1.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.5	-0.2	0.2	0.8	1.6	0.4	1.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.8	-1.0	-0.5	-1.7	-0.2	0.2	-0.9	1.1
Arm fat percentage (left)	0.7	2.7	9.1	-1.1	-3.0	0.8	-1.9	-1.5	1.4	0.1
Average weekly red wine intake	0.7	1.0	4.9	-0.3	0.4	-1.0	0.8	0.2	-2.2	-0.4
Mood swings	0.7	1.3	2.4	0.0	1.5	1.0	-0.7	1.6	1.2	1.3
Eye problems/disorders: Cataract	0.7	0.8	2.1	-1.5	-1.2	-0.8	0.5	0.2	0.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	4.2	-0.3	0.2	0.3	0.4	-0.8	-0.9	-2.0
Hearing aid user	0.7	0.8	2.7	0.6	1.6	0.2	0.4	1.1	-0.4	0.9
Mother’s age at death	0.7	0.8	2.6	0.7	1.0	0.1	1.2	0.3	1.6	-0.4
Medication: Paracetamol	0.7	1.1	3.6	-1.0	0.1	0.7	-1.9	0.8	-0.6	1.2
Cholesterol lowering medication	0.7	1.0	3.4	-1.8	-1.2	0.8	-0.9	-0.6	-0.6	0.5
Basal cell carcinoma (self-reported)	0.7	0.9	2.3	-1.5	-1.1	-1.2	-0.7	0.1	-0.0	1.0
Primary Biliary Cirrhosis	0.6	0.8	2.0	-1.4	-0.4	-1.4	-0.1	0.9	-0.3	0.9
Ulcerative Colitis	0.6	0.9	3.7	0.3	-0.3	-1.1	1.1	-0.2	-0.5	-1.9
Smoking Status	0.6	1.4	2.9	-0.8	-1.7	-0.2	-1.6	-1.2	-0.9	1.1
Systolic blood pressure, automated reading	0.6	1.9	8.3	0.4	0.3	1.1	-0.1	1.3	2.9	-1.2
Diabetes (mother)	0.6	0.7	2.9	-0.2	-1.7	0.5	0.3	-1.3	0.3	-0.3
Maternal smoking around birth	0.6	0.9	2.5	0.7	-0.0	1.2	-1.2	-0.0	-0.5	1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.9	-1.3	-0.9	0.3	-0.0	-0.6	1.4	0.6
Stomach or abdominal pain in last month	0.6	0.8	2.0	-0.6	-0.7	-1.4	-0.3	-1.4	-0.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.6	-0.7	-0.9	-1.6	0.5	-0.1	0.7	-0.4
Waist circumference	0.6	2.0	6.0	-1.5	-2.4	1.1	-1.9	-0.9	0.6	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.7	-0.2	-0.5	-0.8	-0.3	-1.3	-0.5	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.2	-1.7	-1.5	-0.7	-0.7	-1.7	-1.8	-0.7
Pulse wave Arterial Stiffness index	0.6	0.6	1.6	-0.1	0.4	1.3	-1.1	0.8	0.7	0.6
Arm fat mass (right)	0.6	2.6	9.0	-1.6	-3.0	0.8	-1.9	-1.1	1.0	-0.1
Loud music exposure frequency	0.6	0.6	2.1	0.0	0.7	1.4	0.4	0.5	0.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.5	0.1	-0.1	1.4	-1.6	0.3	-0.1	0.5
Glaucoma (self-reported)	0.6	0.7	3.0	-0.9	-0.0	-0.2	-0.6	-0.2	-0.6	1.7
Forced vital capacity (FVC), Best measure	0.6	2.3	5.8	-1.8	-1.3	-0.9	-0.5	-1.8	-2.4	-1.0
Comparative body size at age 10	0.6	1.8	7.6	-0.3	-1.5	0.2	-1.4	-2.8	-0.7	-0.3
Worry too long after embarrassment	0.6	1.0	2.2	-1.1	-0.8	-0.8	-1.0	-0.4	-1.1	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.8	-1.1	0.1	-0.4	-0.9	0.3	0.1	1.7
Age at first live birth	0.6	1.1	2.7	-1.6	-0.6	-1.4	-1.0	-0.2	0.9	1.0
Pulse wave peak to peak time	0.6	0.7	1.5	0.0	-0.2	-1.2	1.2	-0.6	-0.9	-0.7
Medication: Blood pressure	0.6	1.1	3.0	-0.3	-1.7	-0.3	-0.6	-1.2	1.2	-0.9
Alcohol intake frequency.	0.6	1.5	4.2	-0.5	-2.1	-0.1	-1.5	-1.4	-1.4	0.4
Knee pain experienced in last month	0.6	1.0	2.2	-1.2	-0.5	-0.4	-1.0	0.4	-1.5	1.2
Loneliness, isolation	0.6	0.8	2.6	-0.7	0.2	0.0	-1.5	0.7	0.1	1.6
Friendships satisfaction	0.6	0.8	1.7	1.2	1.3	0.3	0.4	0.7	0.8	-1.1
Medication for cholesterol	0.6	0.8	1.7	1.2	0.2	-1.2	-1.0	-0.7	0.2	-1.3
Arm fat mass (left)	0.6	2.4	8.4	-1.4	-2.9	0.8	-1.8	-1.1	1.1	-0.0
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.8	1.3	1.2	0.4	0.6	-0.1	0.1	-1.2
Risk taking	0.6	0.8	2.9	-0.7	-1.0	-0.5	-1.0	-1.7	-0.0	-0.2
Diastolic blood pressure, automated reading	0.6	1.8	9.5	-0.9	-1.0	0.9	0.1	0.4	3.1	-0.5
Ever depressed for a whole week	0.6	0.8	2.0	-0.4	-1.1	-1.4	-0.9	-0.0	-1.1	-0.3
Supplements: Calcium	0.6	0.7	1.7	-1.0	-0.2	-0.1	-1.0	-1.1	-0.2	1.3
Ulcerative Colitis (UC)	0.5	1.0	2.6	0.6	-0.2	-1.6	0.2	-1.0	-0.7	-1.5
HDL Cholesterol	0.5	0.9	3.7	0.9	0.7	0.7	0.5	0.5	1.9	0.1
Heel T-Score	0.5	3.9	8.3	1.1	1.3	2.9	2.7	1.5	2.6	-0.0
Neuroticism	0.5	1.3	3.0	0.7	1.5	1.1	0.2	1.7	1.1	0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.7	-0.4	0.2	0.3	0.6	0.0	-1.7	-0.8
Impedance of leg (right)	0.5	2.2	6.5	1.9	2.5	-0.6	1.5	1.5	-0.6	0.3
Fed-up feelings	0.5	0.9	1.7	0.2	1.3	0.7	-1.0	1.3	-0.5	1.0
Supplements: Glucosamine	0.5	0.6	1.6	-0.4	0.2	0.8	0.1	0.9	-1.1	1.2
Medication: Levothyroxine sodium	0.5	0.8	2.1	-0.7	-1.3	-1.0	-0.6	-1.4	-0.2	0.3
Impedance of leg (left)	0.5	2.3	6.5	1.6	2.6	-0.2	1.6	1.8	-0.7	0.7
Allergy	0.5	1.1	2.5	0.2	0.4	0.4	1.6	1.4	1.1	-1.4
Weight	0.5	2.4	7.8	-2.2	-2.8	0.6	-1.9	-0.1	0.7	-0.0
Hip circumference	0.5	2.1	8.2	-1.9	-2.9	0.2	-1.5	-0.7	0.2	0.1
Hair/balding pattern: Pattern 4	0.5	1.3	4.0	1.2	0.6	-1.7	0.3	-0.0	0.8	-2.0
Medication: Paracetamol	0.5	0.8	2.5	-1.2	-0.3	-0.0	-1.6	0.5	-0.8	0.9
Body fat percentage	0.5	1.9	6.6	-1.1	-2.6	0.9	-1.6	-0.8	1.3	0.4
Health satisfaction	0.5	0.6	3.0	0.4	-0.2	-0.0	-1.7	-0.9	-0.4	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	-0.5	-0.7	0.3	-1.1	-0.8	0.1	1.2
Whole body fat mass	0.5	1.9	6.3	-1.4	-2.5	0.9	-1.6	-0.2	1.2	0.3
Supplements: Vitamin C	0.5	0.6	2.4	0.3	0.8	-0.6	0.4	-0.2	1.6	-0.9
Leg fat-free mass (right)	0.5	2.5	7.3	-2.7	-2.6	0.5	-1.6	0.1	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	-1.4	-1.5	0.1	0.2	-1.4	0.4	-0.9
Leg predicted mass (right)	0.5	2.4	7.2	-2.7	-2.6	0.4	-1.5	0.0	0.4	0.2
Illnesses of father: High blood pressure	0.5	0.6	1.4	-1.2	-1.2	-1.0	0.4	0.0	0.3	-0.7
Alcohol drinker status: Never	0.5	0.6	2.0	-0.1	-0.7	1.2	-0.1	-1.4	0.6	0.3
Commuting to job workplace: Cycle	0.5	0.7	1.6	-0.5	-0.6	1.3	-0.1	-0.9	-0.9	0.9
Leg fat mass (left)	0.5	1.8	6.1	-1.2	-2.5	0.9	-1.8	-0.4	0.9	0.1
Depressed Affect (Nagel 2018)	0.4	0.9	2.8	-0.1	1.0	0.5	-0.2	1.5	0.4	1.7
Schizophrenia (2018)	0.4	0.8	3.3	0.3	-0.1	-0.1	1.8	-0.1	1.4	-0.6
Prostate Cancer	0.4	0.6	1.0	-1.0	-0.8	0.5	-0.9	-0.3	0.9	0.4
Coronary Artery Disease (CAD)	0.4	0.5	1.5	-0.1	-0.0	0.4	-0.9	-0.3	-0.8	1.2
LDL Cholesterol	0.4	0.6	2.3	0.5	0.8	0.3	0.3	1.5	-0.9	0.1
Neuroticism (2016)	0.4	0.6	1.5	-1.1	-0.1	-1.2	-0.3	-0.2	-1.2	0.3
Blood Platelet Count	0.4	5.2	16.8	-1.3	-1.5	3.6	-0.7	-1.1	4.1	0.8
Systolic Blood Pressure	0.4	2.2	8.1	0.3	1.0	0.5	0.6	2.4	2.8	-0.2
Angina	0.4	0.6	1.4	-0.5	-1.0	-0.6	-0.7	-1.2	0.2	0.8
Leg fat-free mass (left)	0.4	2.3	6.9	-2.5	-2.6	0.3	-1.7	-0.0	0.5	0.0
Trunk fat percentage	0.4	1.5	4.6	-1.0	-2.2	1.1	-1.2	-0.3	1.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.5	0.2	-0.0	0.2	1.2	0.1	1.1	0.1
Medication: Atenolol	0.4	0.5	2.6	-0.1	-0.6	0.5	-1.6	0.4	0.5	0.3
Leg predicted mass (left)	0.4	2.4	7.0	-2.5	-2.6	0.4	-1.7	-0.1	0.6	0.0
Trunk fat mass	0.4	1.9	5.8	-1.4	-2.4	1.0	-1.5	-0.1	1.3	0.4
Forced vital capacity (FVC)	0.4	1.7	4.2	-1.9	-1.2	-0.8	-0.3	-1.3	-2.1	-0.6
Financial difficulties in last 2 years	0.4	0.6	1.7	0.5	0.7	0.9	-0.0	1.3	0.7	-0.5
Medication: Simvastatin	0.4	0.5	1.2	-1.1	-1.0	0.6	1.1	0.3	0.0	0.1
Pulse rate	0.4	0.6	2.2	-0.5	-1.1	0.6	0.1	0.3	1.5	0.4
Illnesses of mother	0.4	0.5	1.2	-0.8	-0.5	-1.1	-0.7	-0.5	0.6	0.8
Impedance of arm (left)	0.4	1.9	4.6	1.6	2.1	-0.4	1.8	1.4	0.4	0.5
Medication: Amlodipine	0.4	0.6	2.2	0.3	-0.3	0.0	-0.0	-1.1	-1.5	-0.6
Neck or shoulder pain in last month	0.4	0.6	2.1	1.3	1.4	0.3	0.0	0.0	0.3	-0.0
Medication: Allopurinol	0.4	0.5	1.3	0.5	0.4	-0.1	-1.1	1.2	0.6	-0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.8	0.1	-0.0	-1.0	-0.6	-0.4	-1.3	0.3
Mean time to correctly identify matches	0.4	0.8	1.9	0.4	0.7	1.3	0.3	1.0	-0.4	1.4
Leg fat mass (right)	0.4	1.7	6.0	-1.0	-2.5	0.6	-1.8	-0.6	0.9	-0.0
Ever had bowel cancer screening	0.4	0.5	1.8	-0.0	-0.6	0.4	1.1	-1.3	0.4	0.0
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	0.2	0.0	0.5	-1.4	-1.0	0.6	0.5
Average weekly champagne plus white wine intake	0.4	0.6	1.9	0.7	0.5	-1.4	-0.1	-0.4	-0.6	-0.8
Eye problems/disorders: Glaucoma	0.4	0.5	2.5	-0.4	0.5	-0.0	0.3	0.1	0.3	1.6
Basal metabolic rate	0.4	2.1	6.3	-2.5	-2.4	0.3	-1.6	0.3	0.2	-0.1
Leg fat percentage (left)	0.4	1.3	4.9	-0.8	-2.2	0.9	-1.5	-0.5	0.7	0.3
Fractured/broken bones in last 5 years	0.4	0.5	1.5	0.1	0.4	1.2	0.7	0.7	1.0	0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	1.2	-0.2	0.1	0.4	-0.6	-0.5	-1.0
Impedance of whole body	0.4	2.0	6.0	1.7	2.4	-0.3	1.8	1.4	-0.1	0.6
Depression (Nagel 2018)	0.3	0.4	1.0	-0.4	-0.4	0.0	-1.0	0.8	0.2	0.9
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.2	-0.9	-0.9	-1.8	-0.4	0.2	-1.1	-0.9
Crohns Disease (2012)	0.3	0.4	1.5	0.4	-0.3	-1.2	-0.9	-0.6	0.1	0.4
Fasting Glucose	0.3	0.4	1.3	-0.9	-0.8	-1.1	0.0	0.1	0.3	0.4
Rheumatoid Arthritis	0.3	0.4	1.0	-1.0	-0.8	-0.5	0.4	-0.1	0.2	-0.9
Schizophrenia (2014)	0.3	0.7	2.1	0.1	0.1	0.5	1.4	0.7	1.4	-0.3
Waist Hip Ratio (WHR)	0.3	1.4	4.1	1.2	2.0	1.5	0.2	0.8	-1.0	0.6
Cardiovascular Disease	0.3	0.9	2.7	-0.7	-0.8	-0.8	-0.2	1.2	-0.6	1.7
Lung FEV1/FVC ratio	0.3	1.7	4.5	-0.9	-2.1	-0.4	-2.1	-1.5	-0.2	-0.0
Hand grip strength (left)	0.3	0.9	2.2	-0.1	0.1	-1.1	0.9	1.4	-1.5	-0.1
Vitamin and mineral supplements	0.3	0.3	0.9	0.0	-0.9	0.6	-0.6	-0.9	-0.1	0.1
Pack years adult smoking proportion	0.3	0.4	1.3	-0.6	-0.8	0.2	-1.1	-0.4	0.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.1	0.2	0.0	0.0	-1.4	-0.7	0.1	-0.2
High blood pressure (mother)	0.3	0.5	2.1	-0.4	-1.5	0.1	-0.6	-0.4	0.2	-0.6
Number of incorrect matches in round	0.3	0.6	1.5	-0.9	-0.6	-1.2	-0.9	0.1	-0.4	0.7
Nervous feelings	0.3	0.5	1.9	0.3	0.5	-1.4	-0.1	0.5	-1.0	-0.2
Fluid intelligence score	0.3	0.7	1.5	-1.2	-0.6	-0.8	1.0	0.6	1.0	-0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	2.3	-1.5	-1.1	-0.2	-0.5	-1.5	-1.5	-0.5
Medication: Cholesterol lowering	0.3	0.5	1.3	1.1	0.3	0.2	0.5	0.6	0.9	-0.9
Standing height	0.3	2.8	15.1	-1.1	1.2	0.2	1.1	3.9	-0.3	0.8
Breastfed as a baby	0.3	0.3	1.1	0.6	0.2	0.3	0.7	0.1	0.0	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	-0.6	-1.1	-1.4	-0.1	-0.8	-0.0	0.4
Leg fat percentage (right)	0.3	1.2	4.6	-0.6	-2.1	0.5	-1.6	-0.7	0.6	0.1
Arm fat-free mass (right)	0.3	1.3	4.1	-2.0	-1.6	1.0	-1.1	0.8	0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.0	0.1	-0.5	0.2	0.8	-0.5	-1.0	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.0	0.6	1.0	1.0	0.9	0.5	0.1	0.2
Arm predicted mass (right)	0.3	1.6	5.3	-2.3	-1.8	0.7	-1.3	0.5	0.3	-0.1
Family relationship satisfaction	0.3	0.4	1.0	0.8	0.7	-1.0	-0.5	0.1	0.5	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	-0.2	-0.6	-0.8	-0.2	-0.5	-1.0	0.2
Whole body fat-free mass	0.3	1.8	6.1	-2.5	-2.1	0.4	-1.3	0.6	0.2	-0.0
Mineral and other dietary supplements	0.3	0.4	1.1	-0.2	-0.7	-0.5	-1.0	-0.3	1.1	0.4
Whole body water mass	0.3	2.0	6.6	-2.6	-2.2	0.3	-1.4	0.5	0.3	0.1
Wears glasses or contact lenses	0.3	0.3	1.5	0.0	0.6	0.4	0.5	1.2	-0.2	0.1
Medication: Blood pressure	0.3	0.7	2.3	-0.4	0.0	0.6	0.8	0.9	-1.5	0.5
Arm fat-free mass (left)	0.3	1.6	5.4	-2.3	-1.9	0.6	-1.3	0.6	0.1	-0.2
Myopia	0.3	0.4	1.3	-0.5	0.4	0.5	-0.3	0.4	-0.7	-1.1
Heart disease (siblings)	0.3	0.4	1.7	0.4	-0.5	-0.3	-0.6	-0.2	-1.3	0.5
Arm predicted mass (left)	0.3	1.7	5.6	-2.4	-2.1	0.4	-1.4	0.3	0.0	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	2.5	-0.2	-0.1	0.9	1.6	-0.3	-0.0	0.5
Neuroticism (Nagel 2018)	0.2	0.5	2.0	0.4	1.0	-0.4	-0.1	1.4	0.2	0.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	0.8	-0.0	-0.8	-0.0	-1.2	-0.3	-0.7
Reaction Time	0.2	0.4	1.2	-0.0	0.0	1.1	0.2	0.6	0.4	1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.7	-0.9	-1.3	-0.9	0.1	-0.1	0.1	-0.9
Breast Cancer	0.2	0.5	1.1	-0.9	0.5	0.8	0.5	1.1	-0.1	0.4
Blood Eosinophil Count	0.2	1.7	5.7	1.8	2.4	1.3	0.3	1.0	0.5	0.2
Height	0.2	4.2	23.2	-1.5	1.5	-0.2	1.0	4.8	-0.7	0.3
Hypothyroidism (self reported)	0.2	0.4	1.2	-0.2	-0.6	-1.1	-0.2	-0.6	0.1	0.9
Tanning	0.2	1.9	5.9	0.2	-1.5	0.5	-1.6	-2.4	-1.5	-0.0
Hearing difficulty/problems: Yes	0.2	0.3	1.5	-0.2	0.3	0.1	-0.4	-0.5	-0.6	1.2
Hand grip strength (right)	0.2	0.5	1.4	0.0	-0.1	-0.7	1.2	0.6	-1.0	0.3
Average weekly fortified wine intake	0.2	0.3	1.3	-0.0	0.3	-0.1	1.1	0.7	-0.3	0.1
Multivitamins +/- minerals	0.2	0.2	0.8	0.1	0.9	-0.7	0.0	0.3	0.3	0.3
Sitting height	0.2	1.4	4.1	-2.0	-1.0	-1.2	-0.3	1.6	-0.6	0.4
Hair/balding pattern: Pattern 2	0.2	0.3	1.2	0.4	0.1	-0.1	-0.6	-0.2	-0.2	1.1
Heart attack	0.2	0.3	0.7	0.8	-0.5	-0.1	0.1	-0.6	-0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.9	-0.5	0.3	-0.0	0.3	0.4	-1.0	-0.0
Neuroticism score	0.2	0.5	1.5	-0.1	0.6	0.2	-0.7	0.8	0.5	1.2
Impedance of arm (right)	0.2	1.0	2.1	1.3	1.4	-0.8	1.4	0.6	0.2	0.3
Trunk fat-free mass	0.2	1.4	5.3	-2.3	-1.6	-0.1	-1.0	1.0	-0.3	-0.1
Happiness	0.2	0.3	0.9	0.6	0.9	-0.6	-0.6	-0.0	0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.3	1.3	0.3	0.5	-0.0	-0.5	-1.1	0.3	0.7
Trunk predicted mass	0.2	1.4	5.2	-2.3	-1.6	-0.1	-1.0	1.0	-0.3	-0.0
Tense / ‘highly strung’	0.2	0.4	0.8	0.9	0.9	0.3	0.5	0.6	-0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.1	0.4	0.4	-1.0	-0.0	-0.3	-0.8	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-0.4	0.6	0.3	0.0	0.0	-1.0	0.5
Birth weight	0.2	0.4	1.4	-0.1	0.4	0.4	0.5	1.2	-0.6	-0.5
Comparative height size at age 10	0.2	1.3	4.6	-2.1	-0.3	0.5	-0.9	1.6	-0.8	0.5
Suffer from ‘nerves’	0.2	0.3	1.2	-0.1	-0.1	-0.2	-1.1	-0.3	-0.5	0.5
Had major operations	0.2	0.2	0.7	0.1	-0.0	0.4	0.5	0.6	-0.2	-0.8
Leg pain on walking	0.2	0.3	1.4	0.5	0.3	1.2	-0.3	-0.0	0.3	-0.2
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.3	-0.9	-0.4	-0.2	-0.6	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.0	-0.8	0.1	-0.8	-0.1	1.0	0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	-0.4	-0.1	0.9	-0.5	-0.2	-1.0	0.8
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.3	-0.1	-0.8	-0.2	-0.5	0.2	-0.4
Guilty feelings	0.2	0.2	0.5	-0.2	-0.2	-0.6	-0.7	-0.7	0.5	-0.1
Financial situation satisfaction	0.2	0.2	0.7	0.8	0.3	0.4	-0.4	-0.1	0.6	-0.3
Commuting to job workplace: Public transport	0.2	0.3	1.2	-0.2	-0.2	0.4	-0.0	0.1	1.1	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	0.4	0.4	0.2	0.1	-0.4	-1.1	-0.5
Average weekly beer plus cider intake	0.2	0.3	0.8	0.3	0.3	0.4	0.3	0.9	0.4	0.8
Unable to work because of sickness or disability	0.2	0.2	1.1	-0.0	-0.0	0.5	0.2	0.1	-1.0	-0.3
Worry (Nagel 2018)	0.1	0.3	1.0	0.4	0.4	-1.0	-0.3	0.7	-0.4	0.3
Crohns Disease (2017)	0.1	0.3	1.1	1.0	0.3	0.2	-0.3	-0.8	0.0	0.2
HbA1C	0.1	0.1	0.3	0.3	0.4	0.3	0.3	0.5	0.1	0.3
Chronotype (morning person)	0.1	0.3	1.4	-0.2	-0.1	-0.0	0.3	0.5	-1.2	0.6
High blood pressure	0.1	0.4	1.0	-0.2	-1.0	0.7	-0.2	1.0	0.5	0.4
Peak expiratory flow (PEF)	0.1	0.3	0.8	-0.1	-0.5	0.6	0.2	-0.3	-0.8	-0.9
Qualifications: College or University degree	0.1	0.4	1.3	-0.3	-0.4	-0.3	0.6	-1.2	0.4	-0.5
Hypertension (Self-reported)	0.1	0.3	0.8	-0.1	-0.8	0.7	-0.1	0.9	0.3	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.7	0.2	0.0	0.8	0.3	0.7	-0.1	-0.5
Medication: Lisinopril	0.1	0.2	0.5	0.4	0.1	-0.3	0.7	-0.3	-0.3	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.1	0.3	1.1	-0.1	0.0	-0.8	-0.5	-0.4
Pack years of smoking	0.1	0.1	0.3	-0.2	-0.3	0.3	-0.5	0.2	0.5	-0.6
Hair Pigment	0.0	1.1	3.1	1.0	1.6	0.4	1.8	1.0	0.0	-0.1
Chest pain or discomfort	0.0	0.1	0.2	0.3	0.2	0.2	-0.2	-0.0	0.2	-0.5

Hub : Genes

TTC39C

Models

Trait associations