Hub : Genes

RBBP8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.068 0.031 2.5e-03 -0.002 0.024 0.013 0.023 -0.002 8.8e-01 0.00059 0.00900 0.00068 6.2e-01
2 GTEx Brain Cerebellar Hemisphere 0.220 0.085 2.0e-03 0.156 NA 0.132 NA 0.123 8.4e-05 NA 0.00030 NA 4.8e-04
3 GTEx Brain Cerebellum 0.353 0.097 2.5e-05 0.230 NA 0.138 NA 0.192 2.0e-07 NA 0.00007 NA 2.4e-06
4 GTEx Testis 0.204 0.067 7.5e-05 0.117 NA 0.065 NA 0.079 7.1e-06 NA 0.00079 NA 2.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.1 0.2 -0.3 -0.1 0.4 -0.4
Bipolar Disorder or Schizophrenia 0.4 1.0 1.6 0.2 0.9 1.2 -1.3
Depressed Affect (Nagel 2018) 0.4 0.9 1.2 -1.0 -0.8 -1.1 0.9
Depression (Nagel 2018) 0.1 0.1 0.2 0.4 0.3 -0.4 0.4
Intelligence (Savage-Jansen 2018) 0.5 1.4 2.0 0.3 -1.4 -1.4 1.4
Neuroticism (Nagel 2018) 1.0 2.4 3.0 -1.5 -1.2 -1.7 1.6
Schizophrenia (2018) 0.6 1.2 1.7 0.5 1.2 1.2 -1.3
Schizophrenia vs Biploar Disorder 1.3 1.8 2.9 0.8 1.0 1.7 -1.6
Worry (Nagel 2018) 0.1 0.3 0.7 -0.2 0.9 -0.5 0.4
Alzheimer’s Disease (in mother) 0.5 0.6 1.5 -1.2 -1.0 0.2 -0.1
Alzheimer’s Disease (in father) 1.2 1.3 2.5 0.2 -1.6 -1.2 1.1
Alzheimer’s Disease (including proxy) 0.7 1.0 2.4 -1.1 -1.6 -0.4 0.3
Crohns Disease (2017) 0.1 0.2 0.2 0.5 0.4 0.4 -0.3
Irritable Bowel Disease (IBD) 0.2 0.5 1.4 1.2 0.1 -0.4 0.5
Ulcerative Colitis (UC) 0.4 0.7 1.6 1.3 0.0 -0.7 0.8
Major Depression (MDD) 0.0 0.0 0.1 0.2 -0.1 -0.2 0.3
Reaction Time 0.0 0.0 0.2 -0.0 -0.4 -0.0 0.0
Verbal and Numeric Reasoning (VNR) 0.8 1.8 2.8 0.4 -1.2 -1.7 1.7
Breast Cancer 5.8 14.0 18.9 1.9 3.9 4.3 -4.2
Ovarian Cancer 1.2 1.6 3.4 -1.2 -1.8 -1.0 0.8
Prostate Cancer 0.8 1.1 1.3 1.0 1.2 1.1 -0.9
Age at First Birth 0.1 0.1 0.3 -0.4 -0.5 -0.2 0.2
Bipolar Disorder (2011) 0.6 0.6 0.9 -0.6 -1.0 -0.8 0.7
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 0.2 0.4 0.4 -0.3
Coronary Artery Disease (CAD) 0.4 0.4 0.8 -0.7 -0.9 -0.5 0.3
Crohns Disease (2012) 0.2 0.4 1.1 1.0 0.7 -0.0 0.1
Mean Putamen Volume 2.1 2.3 3.4 -1.8 -0.8 -1.7 1.6
Fasting Glucose 0.5 0.6 1.8 0.1 -1.4 -0.4 0.6
HbA1C 0.5 0.5 1.2 -1.1 -0.6 -0.6 0.5
HDL Cholesterol 0.4 0.6 0.8 0.7 -0.9 -0.7 0.8
LDL Cholesterol 0.0 0.0 0.2 0.4 0.0 0.0 0.0
Lupus 1.0 1.5 5.6 -2.4 -0.1 0.5 -0.3
Neuroticism (2016) 0.3 0.5 0.7 -0.3 -0.7 -0.8 0.7
Primary Biliary Cirrhosis 0.9 1.2 1.8 1.3 1.0 1.1 -0.9
Rheumatoid Arthritis 4.6 6.4 8.8 1.3 3.0 2.8 -2.7
Schizophrenia (2014) 1.4 3.0 4.6 0.8 1.6 2.1 -2.1
Triglycerides 0.4 0.7 1.5 -0.0 0.5 1.0 -1.2
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.9 0.0 0.0 -1.0 0.7
Ulcerative Colitis 0.6 0.9 1.9 1.4 -0.3 -0.8 1.0
Blood Eosinophil Count 4.4 34.0 42.2 3.8 6.2 6.4 -6.5
Blood Platelet Count 0.1 0.6 1.1 -0.3 1.1 1.0 -0.4
Blood Red Count 0.4 3.6 6.5 1.6 2.5 1.7 -1.6
Blood White Count 2.6 19.2 26.3 -3.7 -3.3 -5.1 5.1
Heel T-Score 0.0 0.4 0.8 -0.9 -0.7 -0.3 0.3
BMI 0.1 0.4 1.1 -0.7 1.1 0.2 0.1
Height 4.4 84.2 104.0 9.0 10.2 8.8 -8.6
Waist Hip Ratio (WHR) 2.2 9.8 18.4 2.0 4.3 3.0 -2.8
Systolic Blood Pressure 0.6 3.1 4.5 -2.1 0.7 1.8 -2.0
Smoking Status 0.2 0.5 0.9 0.3 0.3 -0.9 0.9
Allergy or Eczema 5.3 13.9 18.1 3.1 4.3 3.7 -3.8
Cardiovascular Disease 0.6 1.9 3.1 -0.4 1.3 1.6 -1.8
Hypothyroidism (self reported) 0.4 0.9 1.6 0.6 0.0 1.3 -1.3
Respiratory disease 4.5 10.0 11.7 3.4 3.4 2.8 -2.9
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 -0.5 -0.2 0.8 -0.9
Lung FEV1/FVC ratio 3.2 16.0 31.1 -3.8 -5.6 -3.1 3.1
Lung FVC 5.0 25.2 39.5 -6.3 -5.3 -4.1 4.1
Neuroticism 1.5 3.6 4.3 -1.6 -1.8 -2.1 2.1
Chronotype (morning person) 2.0 4.6 7.1 -0.9 -2.0 -2.6 2.7
Hair Pigment 0.1 2.1 3.8 -0.1 1.0 1.9 -2.0
Tanning 0.9 11.3 15.0 -2.1 -3.4 -3.9 3.8
Hand grip strength (left) 0.7 1.9 2.9 1.1 1.0 1.5 -1.7
Number of treatments/medications taken 2.5 4.4 6.9 0.8 2.1 2.4 -2.6
Average weekly spirits intake 0.7 0.9 1.3 -0.6 -1.1 -0.9 1.1
Sensitivity / hurt feelings 0.5 0.8 1.2 -0.7 -0.8 -1.1 1.1
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 0.2 -0.1 -0.5 0.6
Hearing difficulty/problems: Yes 0.5 0.7 1.3 -1.1 -0.5 -0.9 0.7
Relative age of first facial hair 0.1 0.2 0.4 -0.3 0.2 0.5 -0.6
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 -0.4 0.4 -0.2 0.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.2 -0.5 -1.1 -1.0 1.1
Ever had hysterectomy (womb removed) 2.7 3.1 4.1 -1.8 -1.3 -1.8 2.0
Systolic blood pressure, automated reading 0.3 1.0 3.8 -2.0 -0.3 0.1 -0.2
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 0.8 -0.7 -0.9 -0.7 0.8
Angina 1.2 1.5 5.7 -2.4 -0.7 -0.2 -0.0
Medication for hormone replacement therapy 2.0 2.2 3.4 0.7 1.8 1.6 -1.6
Vitamin and mineral supplements 0.1 0.2 0.4 0.3 -0.7 -0.3 0.3
Supplements: Zinc 0.7 0.8 1.8 1.4 0.3 0.7 -0.8
Medication: Co-codamol 0.6 0.7 0.9 0.9 1.0 0.7 -0.7
Medication: Metformin 0.1 0.1 0.2 -0.1 -0.5 0.2 -0.3
Diabetes (father) 0.1 0.1 0.3 -0.1 0.0 0.5 -0.5
Diabetes (mother) 0.4 0.5 0.9 -0.9 -0.8 -0.4 0.4
Severe depression (siblings) 1.8 2.0 3.7 -1.9 -0.8 -1.4 1.2
Pack years adult smoking proportion 0.3 0.4 0.7 -0.2 -0.6 -0.9 0.7
Impedance of leg (right) 0.7 3.3 5.4 1.1 2.3 1.9 -1.7
Leg fat-free mass (left) 1.3 7.0 9.6 2.9 3.1 2.2 -2.2
Trunk fat percentage 0.4 1.4 4.1 0.7 2.0 1.0 -0.5
Hand grip strength (right) 0.8 2.1 3.2 0.9 1.4 1.6 -1.8
Townsend deprivation index at recruitment 0.3 0.5 0.8 -0.6 -0.9 -0.5 0.7
Current tobacco smoking 0.8 1.3 2.3 0.2 -0.9 -1.5 1.5
Average weekly fortified wine intake 5.0 5.9 9.6 1.7 3.1 2.4 -2.3
Maternal smoking around birth 0.5 0.7 1.1 0.8 1.0 0.7 -0.6
Fed-up feelings 0.3 0.5 1.0 -0.5 -0.4 -1.0 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 -0.2 -0.2 -0.8 0.8
Relative age voice broke 0.3 0.5 1.7 -1.3 -0.1 0.3 -0.2
Taking other prescription medications 1.2 1.9 3.2 0.1 1.3 1.6 -1.8
Age when periods started (menarche) 0.1 0.2 0.3 -0.6 0.0 -0.3 0.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.9 -1.0 -0.2 -0.3 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.2 4.9 -2.2 -1.2 -1.0 1.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 -0.9 0.2 -0.2 0.5
Qualifications: CSEs or equivalent 1.1 1.5 1.9 1.4 1.2 1.2 -1.1
Serious illness, injury or assault to yourself 0.0 0.1 0.1 -0.1 -0.1 -0.3 0.3
High blood pressure 0.7 1.9 3.1 -1.3 0.9 1.5 -1.7
Hayfever, allergic rhinitis or eczema 6.0 13.1 19.2 2.8 4.4 3.5 -3.6
Multivitamins +/- minerals 0.8 1.0 1.9 -0.2 1.4 1.1 -1.0
Stomach or abdominal pain in last month 0.6 0.7 0.9 0.6 0.9 1.0 -0.8
Supplements: Glucosamine 0.2 0.2 0.8 -0.3 -0.9 -0.0 -0.2
Diverticular disease/diverticulitis (self-reported) 5.3 6.3 7.4 -2.4 -2.3 -2.7 2.6
Medication: Atenolol 0.0 0.0 0.0 -0.0 -0.0 -0.1 0.0
Medication: Levothyroxine sodium 1.1 1.9 3.3 1.0 0.6 1.7 -1.8
Sitting height 1.9 13.4 15.3 3.7 3.9 3.5 -3.5
Chronic bronchitis/emphysema (father) 1.0 1.2 2.2 0.3 1.5 1.2 -1.0
High blood pressure (mother) 0.6 0.8 2.7 -0.4 1.6 0.4 -0.5
Body mass index (BMI) 0.0 0.2 0.5 -0.2 0.7 -0.1 0.3
Impedance of leg (left) 0.7 3.2 5.4 1.1 2.3 1.9 -1.6
Leg predicted mass (left) 1.3 7.1 9.7 3.0 3.1 2.2 -2.2
Trunk fat mass 1.0 4.4 9.6 1.6 3.1 1.8 -1.4
Waist circumference 1.6 5.7 14.0 1.8 3.7 1.8 -1.6
Number of incorrect matches in round 0.3 0.4 0.8 -0.3 0.5 0.9 -0.8
Past tobacco smoking 0.2 0.4 0.6 0.8 -0.5 0.7 -0.5
Alcohol usually taken with meals 0.2 0.3 0.5 0.7 0.7 0.3 -0.4
Nervous feelings 1.1 2.0 4.4 0.8 2.1 1.2 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.1 0.3 0.0 -0.0 0.1
Hearing difficulty/problems with background noise 0.1 0.2 0.5 -0.7 -0.2 0.1 -0.3
Hair/balding pattern: Pattern 2 0.1 0.2 0.4 -0.1 0.3 0.5 -0.6
Had menopause 0.3 0.4 0.6 -0.1 -0.8 -0.8 0.7
Had other major operations 0.4 0.5 1.3 -1.1 -0.5 -0.3 0.5
Forced vital capacity (FVC) 0.1 0.2 0.4 -0.4 0.1 0.7 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.9 -1.7 -1.0 -0.9 0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.3 -1.1 0.2 -0.4 0.6
Qualifications: None of the above 0.2 0.4 0.7 -0.6 0.5 0.7 -0.8
Financial difficulties in last 2 years 0.2 0.3 0.5 -0.4 -0.4 -0.7 0.7
Mouth/teeth dental problems 1.6 2.4 3.1 1.7 1.8 1.3 -1.4
Heart attack 0.3 0.4 0.6 -0.7 0.6 0.6 -0.7
Allergy 9.9 22.9 29.8 -4.4 -5.5 -4.6 4.7
Pain all over the body in last month 0.1 0.1 0.1 0.3 -0.2 -0.3 0.3
Diabetes (self-reported) 0.5 0.8 1.1 -0.5 -1.1 -1.0 0.9
Hayfever/allergic rhinitis (self-reported) 5.7 7.5 11.2 0.9 2.6 3.3 -3.3
Medication: Ramipril 2.0 2.6 4.0 -2.0 -1.9 -1.3 1.1
Medication: Simvastatin 0.1 0.1 0.1 0.2 -0.4 0.2 -0.3
Fluid intelligence score 0.8 1.7 2.5 -0.6 -1.4 -1.5 1.6
Illnesses of siblings 0.6 0.9 1.3 -0.3 -0.9 -1.1 1.2
Neuroticism score 0.6 1.3 1.6 -1.0 -1.0 -1.2 1.3
Weight 1.9 9.4 15.9 2.8 4.0 2.7 -2.5
Impedance of arm (right) 0.1 0.3 0.7 -0.4 -0.8 -0.4 0.6
Arm fat percentage (right) 0.1 0.2 0.4 -0.4 0.6 -0.3 0.5
Trunk fat-free mass 3.6 20.9 27.9 4.4 5.3 4.3 -4.3
Hip circumference 1.9 8.2 13.4 3.0 3.7 2.3 -2.2
Time employed in main current job 0.4 0.5 1.0 1.0 0.5 0.5 -0.6
Alcohol intake versus 10 years previously 0.1 0.2 0.4 -0.0 0.2 -0.5 0.6
Father’s age at death 0.2 0.3 1.2 1.1 0.2 0.2 -0.2
Worrier / anxious feelings 0.2 0.4 1.3 0.3 1.1 0.3 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.3 -0.6 0.5 -0.1 0.2
Falls in the last year 0.5 0.7 1.6 1.3 0.9 0.6 -0.4
Hair/balding pattern: Pattern 3 0.6 0.9 1.4 -0.9 -0.8 -0.9 1.2
Number of live births 0.3 0.4 1.3 -1.1 0.2 -0.4 0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 3.4 -1.8 -1.3 -0.2 0.4
Pulse rate 0.3 0.5 1.3 0.5 1.1 0.5 -0.3
Happiness 0.1 0.2 0.4 0.6 0.1 -0.2 0.5
Noisy workplace 0.1 0.1 0.2 0.5 -0.3 0.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.1 0.1 -0.2 -0.3 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 4.5 -0.1 2.1 0.2 -0.2
Mouth/teeth dental problems: Dentures 0.9 1.6 4.2 -2.1 -0.9 -0.7 0.9
Asthma 4.9 9.6 12.2 3.5 3.2 2.8 -2.9
Medication: Ibuprofen (e.g. Nurofen) 2.3 2.9 3.4 1.3 1.8 1.9 -1.8
Medication: Cholesterol lowering 0.6 0.9 2.5 -1.6 -0.9 -0.4 0.2
Depression (self-reported) 0.2 0.3 0.5 -0.2 0.7 0.6 -0.5
Medication: Lansoprazole 0.1 0.2 0.2 -0.4 0.3 -0.5 0.4
Prospective memory result 1.7 2.1 3.4 0.5 1.8 1.5 -1.6
Lung cancer (father) 0.0 0.0 0.0 0.0 0.1 -0.1 0.1
Illnesses of mother 0.7 0.8 3.0 1.7 -0.1 -0.3 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.2 -1.5 -1.5 -0.4 0.6
Pulse wave Arterial Stiffness index 0.6 0.8 0.9 0.7 1.0 0.9 -0.9
Impedance of arm (left) 0.0 0.0 0.0 -0.1 -0.2 0.2 0.1
Arm fat mass (right) 0.5 2.0 4.9 1.1 2.2 1.1 -0.9
Trunk predicted mass 3.5 20.3 27.0 4.3 5.2 4.2 -4.2
Standing height 4.7 46.7 56.6 6.9 7.5 6.5 -6.4
Length of working week for main job 1.4 1.6 4.3 2.1 1.1 0.7 -0.5
Exposure to tobacco smoke at home 0.8 0.9 1.4 -0.6 -0.9 -1.2 1.1
Breastfed as a baby 0.7 0.9 1.6 -0.6 -0.8 -1.3 1.0
Tense / ‘highly strung’ 0.0 0.1 0.1 0.3 0.0 -0.2 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.2 -1.1 -0.5 -1.0 1.1
Hair/balding pattern: Pattern 4 1.9 4.6 6.6 -1.5 -2.6 -2.3 2.0
Birth weight of first child 1.3 2.3 3.4 0.3 -1.8 -1.9 1.5
Peak expiratory flow (PEF) 0.3 0.6 2.4 -1.5 -0.3 -0.0 0.0
Pulse wave reflection index 0.3 0.4 1.3 1.2 -0.2 0.2 -0.5
Ever highly irritable/argumentative for 2 days 1.2 1.5 2.2 1.2 1.5 1.1 -1.0
Loud music exposure frequency 0.4 0.5 0.9 -0.1 -0.4 -0.9 0.9
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 0.1 -0.0 0.2 -0.3
Mouth/teeth dental problems: Bleeding gums 3.4 4.4 6.1 -1.5 -2.0 -2.4 2.5
Blood clot in the leg (DVT) 0.1 0.1 0.2 0.3 0.4 0.0 0.1
Medication: Paracetamol 0.2 0.3 0.6 0.2 0.8 0.4 -0.6
Headache pain in last month 2.0 3.5 4.3 2.1 1.2 2.0 -2.0
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 3.8 2.0 0.2 -0.8 0.9
Glaucoma (self-reported) 0.2 0.3 0.9 -0.5 1.0 0.0 -0.1
Gout (self-reported) 0.4 0.6 2.0 -1.4 -0.2 0.3 -0.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.1 0.7 0.3 1.4 -1.4
Medication: Amlodipine 0.9 1.3 4.9 -2.2 0.3 0.2 -0.3
Medication: Ventolin 100micrograms inhaler 1.5 1.9 2.9 0.7 1.7 1.4 -1.5
Birth weight 0.3 0.6 2.2 1.5 0.4 -0.3 0.3
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.2 -1.5 -0.7 -0.7 0.8
High blood pressure (siblings) 0.3 0.4 0.7 -0.7 0.9 0.5 -0.5
Forced vital capacity (FVC), Best measure 0.0 0.0 0.1 -0.2 -0.2 0.2 -0.1
Body fat percentage 0.4 1.8 5.1 0.6 2.3 1.1 -0.7
Leg fat percentage (right) 0.5 2.0 6.1 0.5 2.5 1.0 -0.8
Arm fat-free mass (right) 3.2 16.4 23.9 3.8 4.9 3.7 -3.6
Exposure to tobacco smoke outside home 0.2 0.3 1.0 -1.0 0.1 -0.2 0.2
Comparative body size at age 10 0.2 0.5 0.6 -0.8 0.3 -0.7 0.8
Number of full brothers 1.0 1.3 3.2 0.6 1.8 1.0 -0.9
Worry too long after embarrassment 0.1 0.2 0.7 -0.8 0.0 -0.1 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.8 -0.1 1.3 0.7 -0.7
Wheeze or whistling in the chest in last year 4.8 8.6 11.0 2.7 3.3 2.7 -2.9
Number of children fathered 1.9 2.2 3.5 -1.5 -1.9 -1.3 1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 1.9 -1.4 -1.3 -1.1 0.9
Age at first live birth 0.3 0.5 0.9 -0.3 0.4 0.9 -1.0
Pulse wave peak to peak time 0.1 0.1 0.2 -0.0 -0.4 -0.4 0.4
Health satisfaction 0.3 0.4 1.1 -1.0 -0.4 -0.2 0.3
Shortness of breath walking on level ground 0.5 0.6 0.9 -0.1 0.9 0.8 -1.0
Qualifications: College or University degree 0.1 0.2 0.9 0.9 -0.0 0.2 -0.2
Eye problems/disorders: None of the above 1.0 1.1 1.7 -0.1 -1.1 -1.2 1.3
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.3 0.6 1.1 1.0 -1.0
Emphysema/chronic bronchitis 5.4 6.1 6.9 2.4 2.3 2.6 -2.6
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 0.2 -0.9 -0.4 0.6
Neck or shoulder pain in last month 2.7 3.9 4.6 1.8 2.1 2.0 -1.9
Medication: Blood pressure 1.9 3.3 12.4 -3.5 -0.8 0.1 -0.3
Angina (self-reported) 1.0 1.3 4.7 -2.2 -0.1 0.3 -0.5
Migraine (self-reported) 0.3 0.4 0.9 0.4 0.3 0.7 -0.9
Medication: Ibuprofen 2.1 2.6 3.3 1.4 1.8 1.6 -1.6
Medication: Allopurinol 0.8 1.1 4.3 -2.1 -0.3 -0.2 0.2
Medication: Omeprazole 2.3 2.8 6.2 0.4 2.5 1.5 -1.6
Medication: Seretide 50 evohaler 2.4 2.8 6.3 2.5 1.8 0.9 -0.9
Mean time to correctly identify matches 0.3 0.6 1.5 -1.2 -0.8 -0.5 0.4
Heart disease (mother) 0.9 1.0 3.3 -1.8 -0.6 -0.6 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 3.5 1.9 0.8 0.7 -0.9
Whole body fat mass 1.2 4.8 10.4 1.6 3.2 1.9 -1.6
Leg fat mass (right) 0.9 3.4 8.2 1.3 2.9 1.5 -1.2
Arm predicted mass (right) 3.8 19.7 28.9 4.2 5.4 4.1 -4.0
Pulse rate, automated reading 0.2 0.6 1.3 1.0 1.1 -0.0 0.4
Alcohol intake frequency. 1.0 2.3 2.9 1.7 1.7 1.4 -1.2
Comparative height size at age 10 4.7 26.1 31.8 4.8 5.6 5.0 -4.9
Number of full sisters 0.4 0.5 1.8 -1.4 0.4 -0.0 -0.1
Suffer from ‘nerves’ 0.3 0.5 1.4 -1.2 0.6 -0.2 0.2
Overall health rating 0.2 0.4 1.1 -1.0 -0.2 -0.4 0.5
Chest pain or discomfort 0.3 0.5 1.7 -1.3 0.2 0.1 -0.3
Had major operations 0.0 0.1 0.1 -0.0 -0.2 -0.2 0.4
Age at last live birth 0.4 0.6 1.1 0.1 0.8 1.1 -0.8
Family relationship satisfaction 0.1 0.1 0.4 0.6 0.4 0.1 0.2
Leg pain on walking 0.1 0.1 0.1 -0.3 0.3 -0.2 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 3.1 -1.2 -1.8 -1.3 1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.6 -0.8 -0.3 -0.7 0.6
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.3 0.5 -0.6 -0.4 0.4
Medication: Aspirin 1.4 1.9 4.6 -2.1 -1.1 -1.0 0.9
Supplements: Vitamin C 0.3 0.3 0.4 -0.6 -0.5 -0.6 0.7
Knee pain experienced in last month 0.2 0.3 1.0 -1.0 0.5 -0.0 0.0
Hypertension (Self-reported) 0.8 2.2 3.3 -1.1 1.3 1.6 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 3.6 0.7 1.9 1.1 -1.2
Illnesses of father: Heart disease 2.6 3.6 7.8 -2.8 -2.1 -1.2 0.9
Illnesses of siblings: Diabetes 0.3 0.3 0.5 0.4 0.3 0.7 -0.7
Smoking status: Previous 0.1 0.2 0.5 -0.7 0.6 -0.2 0.0
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 4.6 1.6 2.1 2.0 -2.0
Whole body fat-free mass 2.6 15.1 20.3 3.9 4.5 3.5 -3.5
Leg fat-free mass (right) 1.0 5.4 7.4 2.7 2.7 1.9 -1.9
Arm fat percentage (left) 0.1 0.3 1.1 -0.1 1.1 0.0 0.3
Average weekly red wine intake 1.3 1.9 2.7 -0.6 -1.4 -1.6 1.6
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.8 0.9 0.2 0.0 0.2
Mood swings 0.2 0.3 0.9 -0.3 -1.0 -0.3 0.4
Loneliness, isolation 1.3 1.7 2.2 1.1 1.3 1.5 -1.4
Long-standing illness, disability or infirmity 0.2 0.2 0.3 0.5 0.5 0.4 -0.4
Ever had bowel cancer screening 1.7 2.0 2.2 -1.5 -1.2 -1.5 1.4
Diabetes diagnosed by doctor 0.3 0.5 1.0 -0.6 -1.0 -0.6 0.5
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 3.5 -1.8 -1.3 -1.9 1.8
Friendships satisfaction 0.3 0.3 0.5 0.7 -0.5 -0.4 0.6
Qualifications: nursing, teaching 0.4 0.6 2.0 1.4 -0.0 0.5 -0.4
Commuting to job workplace: Walk 0.2 0.2 0.6 0.8 -0.4 -0.1 0.2
Eye problems/disorders: Cataract 0.4 0.4 0.6 0.1 0.8 0.8 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.3 -0.0 -0.3 0.3
Medication for cholesterol 0.9 1.4 1.6 -1.3 -0.9 -1.3 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.1 0.2 0.2 0.4 -0.1 0.1
Back pain experienced in last month 0.2 0.2 0.6 -0.5 0.8 -0.2 0.3
Mineral and other dietary supplements 0.2 0.2 0.5 0.1 -0.1 -0.6 0.7
Breast cancer (self-reported) 0.5 0.6 1.1 -0.2 -1.0 -0.8 0.8
Asthma (self-reported) 5.8 11.6 14.9 3.9 3.5 3.1 -3.1
Osteoporosis (self-reported) 0.1 0.1 0.4 0.6 -0.0 -0.1 0.2
Osteoarthritis (self-reported) 3.1 4.0 4.9 1.4 2.2 2.1 -2.2
Medication: Aspirin 1.7 2.2 4.0 -2.0 -1.2 -1.3 1.2
Medication: Gliclazide 0.0 0.0 0.1 0.4 -0.1 0.1 -0.0
Illnesses of father: None of the above (group 1) 2.3 2.8 8.1 2.9 1.2 1.0 -0.8
Smoking status: Current 0.7 1.1 2.1 -0.0 -0.7 -1.4 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.0 -1.4 -2.2 -1.4 1.4
Whole body water mass 2.8 15.9 21.1 4.0 4.6 3.6 -3.6
Leg predicted mass (right) 1.1 5.6 7.7 2.8 2.7 2.0 -1.9
Arm fat mass (left) 0.7 2.8 6.2 1.4 2.5 1.3 -1.1
Number of self-reported non-cancer illnesses 3.3 5.8 8.2 0.5 2.8 2.6 -2.9
Average weekly champagne plus white wine intake 0.4 0.6 2.0 -1.4 -0.5 0.3 -0.3
Miserableness 0.4 0.6 0.8 -0.9 -0.6 -0.8 0.8
Guilty feelings 1.4 2.2 2.4 -1.3 -1.5 -1.5 1.5
Wears glasses or contact lenses 0.9 1.0 1.6 0.7 1.0 1.0 -1.2
Ever taken oral contraceptive pill 3.1 3.4 4.8 1.8 1.2 2.2 -2.0
Hearing aid user 1.0 1.2 1.7 1.1 0.6 1.2 -1.3
Mother’s age at death 1.9 2.4 5.3 -0.0 2.3 1.6 -1.3
Financial situation satisfaction 0.8 0.9 1.7 -0.2 -1.0 -1.1 1.3
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.9 1.4 0.7 -0.1 0.0
Commuting to job workplace: Public transport 0.5 0.6 1.7 1.3 0.2 0.6 -0.5
Eye problems/disorders: Glaucoma 0.9 1.0 2.5 0.6 1.6 0.8 -0.8
Medication: Blood pressure 0.2 0.5 0.7 0.3 0.7 0.7 -0.8
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.5 -0.6 0.7 0.2 -0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.5 0.6 0.4 1.0 -1.2
High cholesterol (Self-reported) 0.2 0.4 0.7 0.8 -0.2 0.6 -0.8
Medication: Bendroflumethiazide 1.1 1.7 3.4 -1.9 -0.6 -1.3 1.2
Medication: Paracetamol 0.4 0.6 1.2 0.6 1.1 0.6 -0.8
Medication: Lisinopril 0.4 0.5 1.0 -0.5 -0.3 0.8 -1.0
Medication: Atorvastatin 2.9 3.5 9.1 -3.0 -2.0 -0.8 0.7
Illnesses of father: High blood pressure 1.0 1.2 3.2 -1.8 1.0 0.6 -0.7
Alcohol drinker status: Never 0.4 0.5 1.1 -1.0 0.4 0.7 -0.6
Ever smoked 0.6 1.0 1.9 -0.8 -0.5 -1.4 1.1
Basal metabolic rate 2.7 14.9 20.8 3.8 4.6 3.5 -3.4
Leg fat percentage (left) 0.5 1.6 5.1 0.5 2.2 0.9 -0.6
Arm fat-free mass (left) 3.5 17.9 24.4 4.1 4.9 3.9 -3.9
Number of operations (self-reported) 0.5 0.7 2.5 -1.6 -0.2 -0.3 0.4
Average weekly beer plus cider intake 0.1 0.1 0.4 0.7 0.4 -0.1 -0.0
Irritability 1.2 2.0 3.8 -1.2 -1.9 -1.2 1.2
Risk taking 0.6 0.9 1.3 0.9 0.4 1.1 -1.1
Ever had prostate specific antigen (PSA) test 1.1 1.3 1.9 1.2 0.6 1.3 -1.4
Fractured/broken bones in last 5 years 0.9 1.1 1.3 1.1 1.0 1.1 -1.0
Age started oral contraceptive pill 0.1 0.1 0.3 0.6 0.3 0.0 -0.2
Diastolic blood pressure, automated reading 0.6 1.8 3.9 0.2 2.0 1.3 -1.3
Ever depressed for a whole week 0.9 1.1 1.7 -0.9 -0.9 -1.0 1.3
Unable to work because of sickness or disability 0.7 0.9 1.4 -0.2 1.0 1.2 -1.1
Commuting to job workplace: Cycle 3.5 4.2 4.6 2.2 2.0 2.0 -2.0
Myopia 1.6 2.3 3.5 -1.0 -1.4 -1.6 1.9
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.6 1.6 -0.3 -0.8 1.1
Cholesterol lowering medication 0.6 0.9 2.9 -0.2 -1.7 -0.6 0.6
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.3 -0.6 1.8 0.7 -0.9
Pain experienced in last month 0.7 1.2 2.0 -0.3 -1.4 -1.2 1.1
Supplements: Calcium 0.9 1.0 1.8 -0.5 0.2 1.3 -1.4
Basal cell carcinoma (self-reported) 3.1 3.7 5.3 1.5 2.3 1.8 -2.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.5 -0.6 0.6 0.6 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.3 0.6 0.5 0.1 -0.1
Heart disease (siblings) 0.2 0.3 0.4 -0.3 0.4 0.7 -0.6
Alcohol drinker status: Previous 0.2 0.3 0.6 0.6 0.8 -0.1 -0.0
Pack years of smoking 0.3 0.4 0.6 -0.5 -0.7 -0.8 0.6
Impedance of whole body 0.1 0.4 0.6 0.1 0.8 0.8 -0.5
Leg fat mass (left) 0.9 3.4 8.1 1.2 2.8 1.5 -1.3
Arm predicted mass (left) 3.2 16.0 21.5 4.0 4.6 3.7 -3.6