Hub : Genes

RBBP8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.068	0.031	2.5e-03	-0.002	0.024	0.013	0.023	-0.002	8.8e-01	0.00059	0.00900	0.00068	6.2e-01
2	GTEx	Brain Cerebellar Hemisphere	0.220	0.085	2.0e-03	0.156	NA	0.132	NA	0.123	8.4e-05	NA	0.00030	NA	4.8e-04
3	GTEx	Brain Cerebellum	0.353	0.097	2.5e-05	0.230	NA	0.138	NA	0.192	2.0e-07	NA	0.00007	NA	2.4e-06
4	GTEx	Testis	0.204	0.067	7.5e-05	0.117	NA	0.065	NA	0.079	7.1e-06	NA	0.00079	NA	2.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.3	-0.1	0.4	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	1.6	0.2	0.9	1.2	-1.3
Depressed Affect (Nagel 2018)	0.4	0.9	1.2	-1.0	-0.8	-1.1	0.9
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	0.3	-0.4	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.0	0.3	-1.4	-1.4	1.4
Neuroticism (Nagel 2018)	1.0	2.4	3.0	-1.5	-1.2	-1.7	1.6
Schizophrenia (2018)	0.6	1.2	1.7	0.5	1.2	1.2	-1.3
Schizophrenia vs Biploar Disorder	1.3	1.8	2.9	0.8	1.0	1.7	-1.6
Worry (Nagel 2018)	0.1	0.3	0.7	-0.2	0.9	-0.5	0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	-1.2	-1.0	0.2	-0.1
Alzheimer’s Disease (in father)	1.2	1.3	2.5	0.2	-1.6	-1.2	1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	2.4	-1.1	-1.6	-0.4	0.3
Crohns Disease (2017)	0.1	0.2	0.2	0.5	0.4	0.4	-0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	1.2	0.1	-0.4	0.5
Ulcerative Colitis (UC)	0.4	0.7	1.6	1.3	0.0	-0.7	0.8
Major Depression (MDD)	0.0	0.0	0.1	0.2	-0.1	-0.2	0.3
Reaction Time	0.0	0.0	0.2	-0.0	-0.4	-0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.8	1.8	2.8	0.4	-1.2	-1.7	1.7
Breast Cancer	5.8	14.0	18.9	1.9	3.9	4.3	-4.2
Ovarian Cancer	1.2	1.6	3.4	-1.2	-1.8	-1.0	0.8
Prostate Cancer	0.8	1.1	1.3	1.0	1.2	1.1	-0.9
Age at First Birth	0.1	0.1	0.3	-0.4	-0.5	-0.2	0.2
Bipolar Disorder (2011)	0.6	0.6	0.9	-0.6	-1.0	-0.8	0.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.2	0.4	0.4	-0.3
Coronary Artery Disease (CAD)	0.4	0.4	0.8	-0.7	-0.9	-0.5	0.3
Crohns Disease (2012)	0.2	0.4	1.1	1.0	0.7	-0.0	0.1
Mean Putamen Volume	2.1	2.3	3.4	-1.8	-0.8	-1.7	1.6
Fasting Glucose	0.5	0.6	1.8	0.1	-1.4	-0.4	0.6
HbA1C	0.5	0.5	1.2	-1.1	-0.6	-0.6	0.5
HDL Cholesterol	0.4	0.6	0.8	0.7	-0.9	-0.7	0.8
LDL Cholesterol	0.0	0.0	0.2	0.4	0.0	0.0	0.0
Lupus	1.0	1.5	5.6	-2.4	-0.1	0.5	-0.3
Neuroticism (2016)	0.3	0.5	0.7	-0.3	-0.7	-0.8	0.7
Primary Biliary Cirrhosis	0.9	1.2	1.8	1.3	1.0	1.1	-0.9
Rheumatoid Arthritis	4.6	6.4	8.8	1.3	3.0	2.8	-2.7
Schizophrenia (2014)	1.4	3.0	4.6	0.8	1.6	2.1	-2.1
Triglycerides	0.4	0.7	1.5	-0.0	0.5	1.0	-1.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	0.0	0.0	-1.0	0.7
Ulcerative Colitis	0.6	0.9	1.9	1.4	-0.3	-0.8	1.0
Blood Eosinophil Count	4.4	34.0	42.2	3.8	6.2	6.4	-6.5
Blood Platelet Count	0.1	0.6	1.1	-0.3	1.1	1.0	-0.4
Blood Red Count	0.4	3.6	6.5	1.6	2.5	1.7	-1.6
Blood White Count	2.6	19.2	26.3	-3.7	-3.3	-5.1	5.1
Heel T-Score	0.0	0.4	0.8	-0.9	-0.7	-0.3	0.3
BMI	0.1	0.4	1.1	-0.7	1.1	0.2	0.1
Height	4.4	84.2	104.0	9.0	10.2	8.8	-8.6
Waist Hip Ratio (WHR)	2.2	9.8	18.4	2.0	4.3	3.0	-2.8
Systolic Blood Pressure	0.6	3.1	4.5	-2.1	0.7	1.8	-2.0
Smoking Status	0.2	0.5	0.9	0.3	0.3	-0.9	0.9
Allergy or Eczema	5.3	13.9	18.1	3.1	4.3	3.7	-3.8
Cardiovascular Disease	0.6	1.9	3.1	-0.4	1.3	1.6	-1.8
Hypothyroidism (self reported)	0.4	0.9	1.6	0.6	0.0	1.3	-1.3
Respiratory disease	4.5	10.0	11.7	3.4	3.4	2.8	-2.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.5	-0.2	0.8	-0.9
Lung FEV1/FVC ratio	3.2	16.0	31.1	-3.8	-5.6	-3.1	3.1
Lung FVC	5.0	25.2	39.5	-6.3	-5.3	-4.1	4.1
Neuroticism	1.5	3.6	4.3	-1.6	-1.8	-2.1	2.1
Chronotype (morning person)	2.0	4.6	7.1	-0.9	-2.0	-2.6	2.7
Hair Pigment	0.1	2.1	3.8	-0.1	1.0	1.9	-2.0
Tanning	0.9	11.3	15.0	-2.1	-3.4	-3.9	3.8
Hand grip strength (left)	0.7	1.9	2.9	1.1	1.0	1.5	-1.7
Number of treatments/medications taken	2.5	4.4	6.9	0.8	2.1	2.4	-2.6
Average weekly spirits intake	0.7	0.9	1.3	-0.6	-1.1	-0.9	1.1
Sensitivity / hurt feelings	0.5	0.8	1.2	-0.7	-0.8	-1.1	1.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.2	-0.1	-0.5	0.6
Hearing difficulty/problems: Yes	0.5	0.7	1.3	-1.1	-0.5	-0.9	0.7
Relative age of first facial hair	0.1	0.2	0.4	-0.3	0.2	0.5	-0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.4	0.4	-0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.2	-0.5	-1.1	-1.0	1.1
Ever had hysterectomy (womb removed)	2.7	3.1	4.1	-1.8	-1.3	-1.8	2.0
Systolic blood pressure, automated reading	0.3	1.0	3.8	-2.0	-0.3	0.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.8	-0.7	-0.9	-0.7	0.8
Angina	1.2	1.5	5.7	-2.4	-0.7	-0.2	-0.0
Medication for hormone replacement therapy	2.0	2.2	3.4	0.7	1.8	1.6	-1.6
Vitamin and mineral supplements	0.1	0.2	0.4	0.3	-0.7	-0.3	0.3
Supplements: Zinc	0.7	0.8	1.8	1.4	0.3	0.7	-0.8
Medication: Co-codamol	0.6	0.7	0.9	0.9	1.0	0.7	-0.7
Medication: Metformin	0.1	0.1	0.2	-0.1	-0.5	0.2	-0.3
Diabetes (father)	0.1	0.1	0.3	-0.1	0.0	0.5	-0.5
Diabetes (mother)	0.4	0.5	0.9	-0.9	-0.8	-0.4	0.4
Severe depression (siblings)	1.8	2.0	3.7	-1.9	-0.8	-1.4	1.2
Pack years adult smoking proportion	0.3	0.4	0.7	-0.2	-0.6	-0.9	0.7
Impedance of leg (right)	0.7	3.3	5.4	1.1	2.3	1.9	-1.7
Leg fat-free mass (left)	1.3	7.0	9.6	2.9	3.1	2.2	-2.2
Trunk fat percentage	0.4	1.4	4.1	0.7	2.0	1.0	-0.5
Hand grip strength (right)	0.8	2.1	3.2	0.9	1.4	1.6	-1.8
Townsend deprivation index at recruitment	0.3	0.5	0.8	-0.6	-0.9	-0.5	0.7
Current tobacco smoking	0.8	1.3	2.3	0.2	-0.9	-1.5	1.5
Average weekly fortified wine intake	5.0	5.9	9.6	1.7	3.1	2.4	-2.3
Maternal smoking around birth	0.5	0.7	1.1	0.8	1.0	0.7	-0.6
Fed-up feelings	0.3	0.5	1.0	-0.5	-0.4	-1.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.2	-0.2	-0.8	0.8
Relative age voice broke	0.3	0.5	1.7	-1.3	-0.1	0.3	-0.2
Taking other prescription medications	1.2	1.9	3.2	0.1	1.3	1.6	-1.8
Age when periods started (menarche)	0.1	0.2	0.3	-0.6	0.0	-0.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	-1.0	-0.2	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.2	4.9	-2.2	-1.2	-1.0	1.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.9	0.2	-0.2	0.5
Qualifications: CSEs or equivalent	1.1	1.5	1.9	1.4	1.2	1.2	-1.1
Serious illness, injury or assault to yourself	0.0	0.1	0.1	-0.1	-0.1	-0.3	0.3
High blood pressure	0.7	1.9	3.1	-1.3	0.9	1.5	-1.7
Hayfever, allergic rhinitis or eczema	6.0	13.1	19.2	2.8	4.4	3.5	-3.6
Multivitamins +/- minerals	0.8	1.0	1.9	-0.2	1.4	1.1	-1.0
Stomach or abdominal pain in last month	0.6	0.7	0.9	0.6	0.9	1.0	-0.8
Supplements: Glucosamine	0.2	0.2	0.8	-0.3	-0.9	-0.0	-0.2
Diverticular disease/diverticulitis (self-reported)	5.3	6.3	7.4	-2.4	-2.3	-2.7	2.6
Medication: Atenolol	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.0
Medication: Levothyroxine sodium	1.1	1.9	3.3	1.0	0.6	1.7	-1.8
Sitting height	1.9	13.4	15.3	3.7	3.9	3.5	-3.5
Chronic bronchitis/emphysema (father)	1.0	1.2	2.2	0.3	1.5	1.2	-1.0
High blood pressure (mother)	0.6	0.8	2.7	-0.4	1.6	0.4	-0.5
Body mass index (BMI)	0.0	0.2	0.5	-0.2	0.7	-0.1	0.3
Impedance of leg (left)	0.7	3.2	5.4	1.1	2.3	1.9	-1.6
Leg predicted mass (left)	1.3	7.1	9.7	3.0	3.1	2.2	-2.2
Trunk fat mass	1.0	4.4	9.6	1.6	3.1	1.8	-1.4
Waist circumference	1.6	5.7	14.0	1.8	3.7	1.8	-1.6
Number of incorrect matches in round	0.3	0.4	0.8	-0.3	0.5	0.9	-0.8
Past tobacco smoking	0.2	0.4	0.6	0.8	-0.5	0.7	-0.5
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	0.7	0.3	-0.4
Nervous feelings	1.1	2.0	4.4	0.8	2.1	1.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.3	0.0	-0.0	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.7	-0.2	0.1	-0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.1	0.3	0.5	-0.6
Had menopause	0.3	0.4	0.6	-0.1	-0.8	-0.8	0.7
Had other major operations	0.4	0.5	1.3	-1.1	-0.5	-0.3	0.5
Forced vital capacity (FVC)	0.1	0.2	0.4	-0.4	0.1	0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.9	-1.7	-1.0	-0.9	0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-1.1	0.2	-0.4	0.6
Qualifications: None of the above	0.2	0.4	0.7	-0.6	0.5	0.7	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.4	-0.4	-0.7	0.7
Mouth/teeth dental problems	1.6	2.4	3.1	1.7	1.8	1.3	-1.4
Heart attack	0.3	0.4	0.6	-0.7	0.6	0.6	-0.7
Allergy	9.9	22.9	29.8	-4.4	-5.5	-4.6	4.7
Pain all over the body in last month	0.1	0.1	0.1	0.3	-0.2	-0.3	0.3
Diabetes (self-reported)	0.5	0.8	1.1	-0.5	-1.1	-1.0	0.9
Hayfever/allergic rhinitis (self-reported)	5.7	7.5	11.2	0.9	2.6	3.3	-3.3
Medication: Ramipril	2.0	2.6	4.0	-2.0	-1.9	-1.3	1.1
Medication: Simvastatin	0.1	0.1	0.1	0.2	-0.4	0.2	-0.3
Fluid intelligence score	0.8	1.7	2.5	-0.6	-1.4	-1.5	1.6
Illnesses of siblings	0.6	0.9	1.3	-0.3	-0.9	-1.1	1.2
Neuroticism score	0.6	1.3	1.6	-1.0	-1.0	-1.2	1.3
Weight	1.9	9.4	15.9	2.8	4.0	2.7	-2.5
Impedance of arm (right)	0.1	0.3	0.7	-0.4	-0.8	-0.4	0.6
Arm fat percentage (right)	0.1	0.2	0.4	-0.4	0.6	-0.3	0.5
Trunk fat-free mass	3.6	20.9	27.9	4.4	5.3	4.3	-4.3
Hip circumference	1.9	8.2	13.4	3.0	3.7	2.3	-2.2
Time employed in main current job	0.4	0.5	1.0	1.0	0.5	0.5	-0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.0	0.2	-0.5	0.6
Father’s age at death	0.2	0.3	1.2	1.1	0.2	0.2	-0.2
Worrier / anxious feelings	0.2	0.4	1.3	0.3	1.1	0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.6	0.5	-0.1	0.2
Falls in the last year	0.5	0.7	1.6	1.3	0.9	0.6	-0.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.4	-0.9	-0.8	-0.9	1.2
Number of live births	0.3	0.4	1.3	-1.1	0.2	-0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.4	-1.8	-1.3	-0.2	0.4
Pulse rate	0.3	0.5	1.3	0.5	1.1	0.5	-0.3
Happiness	0.1	0.2	0.4	0.6	0.1	-0.2	0.5
Noisy workplace	0.1	0.1	0.2	0.5	-0.3	0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.1	-0.2	-0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	4.5	-0.1	2.1	0.2	-0.2
Mouth/teeth dental problems: Dentures	0.9	1.6	4.2	-2.1	-0.9	-0.7	0.9
Asthma	4.9	9.6	12.2	3.5	3.2	2.8	-2.9
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	3.4	1.3	1.8	1.9	-1.8
Medication: Cholesterol lowering	0.6	0.9	2.5	-1.6	-0.9	-0.4	0.2
Depression (self-reported)	0.2	0.3	0.5	-0.2	0.7	0.6	-0.5
Medication: Lansoprazole	0.1	0.2	0.2	-0.4	0.3	-0.5	0.4
Prospective memory result	1.7	2.1	3.4	0.5	1.8	1.5	-1.6
Lung cancer (father)	0.0	0.0	0.0	0.0	0.1	-0.1	0.1
Illnesses of mother	0.7	0.8	3.0	1.7	-0.1	-0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.2	-1.5	-1.5	-0.4	0.6
Pulse wave Arterial Stiffness index	0.6	0.8	0.9	0.7	1.0	0.9	-0.9
Impedance of arm (left)	0.0	0.0	0.0	-0.1	-0.2	0.2	0.1
Arm fat mass (right)	0.5	2.0	4.9	1.1	2.2	1.1	-0.9
Trunk predicted mass	3.5	20.3	27.0	4.3	5.2	4.2	-4.2
Standing height	4.7	46.7	56.6	6.9	7.5	6.5	-6.4
Length of working week for main job	1.4	1.6	4.3	2.1	1.1	0.7	-0.5
Exposure to tobacco smoke at home	0.8	0.9	1.4	-0.6	-0.9	-1.2	1.1
Breastfed as a baby	0.7	0.9	1.6	-0.6	-0.8	-1.3	1.0
Tense / ‘highly strung’	0.0	0.1	0.1	0.3	0.0	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.2	-1.1	-0.5	-1.0	1.1
Hair/balding pattern: Pattern 4	1.9	4.6	6.6	-1.5	-2.6	-2.3	2.0
Birth weight of first child	1.3	2.3	3.4	0.3	-1.8	-1.9	1.5
Peak expiratory flow (PEF)	0.3	0.6	2.4	-1.5	-0.3	-0.0	0.0
Pulse wave reflection index	0.3	0.4	1.3	1.2	-0.2	0.2	-0.5
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.2	1.2	1.5	1.1	-1.0
Loud music exposure frequency	0.4	0.5	0.9	-0.1	-0.4	-0.9	0.9
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.1	-0.0	0.2	-0.3
Mouth/teeth dental problems: Bleeding gums	3.4	4.4	6.1	-1.5	-2.0	-2.4	2.5
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.3	0.4	0.0	0.1
Medication: Paracetamol	0.2	0.3	0.6	0.2	0.8	0.4	-0.6
Headache pain in last month	2.0	3.5	4.3	2.1	1.2	2.0	-2.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.8	2.0	0.2	-0.8	0.9
Glaucoma (self-reported)	0.2	0.3	0.9	-0.5	1.0	0.0	-0.1
Gout (self-reported)	0.4	0.6	2.0	-1.4	-0.2	0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.1	0.7	0.3	1.4	-1.4
Medication: Amlodipine	0.9	1.3	4.9	-2.2	0.3	0.2	-0.3
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.9	0.7	1.7	1.4	-1.5
Birth weight	0.3	0.6	2.2	1.5	0.4	-0.3	0.3
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	-1.5	-0.7	-0.7	0.8
High blood pressure (siblings)	0.3	0.4	0.7	-0.7	0.9	0.5	-0.5
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1
Body fat percentage	0.4	1.8	5.1	0.6	2.3	1.1	-0.7
Leg fat percentage (right)	0.5	2.0	6.1	0.5	2.5	1.0	-0.8
Arm fat-free mass (right)	3.2	16.4	23.9	3.8	4.9	3.7	-3.6
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-1.0	0.1	-0.2	0.2
Comparative body size at age 10	0.2	0.5	0.6	-0.8	0.3	-0.7	0.8
Number of full brothers	1.0	1.3	3.2	0.6	1.8	1.0	-0.9
Worry too long after embarrassment	0.1	0.2	0.7	-0.8	0.0	-0.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.8	-0.1	1.3	0.7	-0.7
Wheeze or whistling in the chest in last year	4.8	8.6	11.0	2.7	3.3	2.7	-2.9
Number of children fathered	1.9	2.2	3.5	-1.5	-1.9	-1.3	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	1.9	-1.4	-1.3	-1.1	0.9
Age at first live birth	0.3	0.5	0.9	-0.3	0.4	0.9	-1.0
Pulse wave peak to peak time	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.4
Health satisfaction	0.3	0.4	1.1	-1.0	-0.4	-0.2	0.3
Shortness of breath walking on level ground	0.5	0.6	0.9	-0.1	0.9	0.8	-1.0
Qualifications: College or University degree	0.1	0.2	0.9	0.9	-0.0	0.2	-0.2
Eye problems/disorders: None of the above	1.0	1.1	1.7	-0.1	-1.1	-1.2	1.3
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.3	0.6	1.1	1.0	-1.0
Emphysema/chronic bronchitis	5.4	6.1	6.9	2.4	2.3	2.6	-2.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.2	-0.9	-0.4	0.6
Neck or shoulder pain in last month	2.7	3.9	4.6	1.8	2.1	2.0	-1.9
Medication: Blood pressure	1.9	3.3	12.4	-3.5	-0.8	0.1	-0.3
Angina (self-reported)	1.0	1.3	4.7	-2.2	-0.1	0.3	-0.5
Migraine (self-reported)	0.3	0.4	0.9	0.4	0.3	0.7	-0.9
Medication: Ibuprofen	2.1	2.6	3.3	1.4	1.8	1.6	-1.6
Medication: Allopurinol	0.8	1.1	4.3	-2.1	-0.3	-0.2	0.2
Medication: Omeprazole	2.3	2.8	6.2	0.4	2.5	1.5	-1.6
Medication: Seretide 50 evohaler	2.4	2.8	6.3	2.5	1.8	0.9	-0.9
Mean time to correctly identify matches	0.3	0.6	1.5	-1.2	-0.8	-0.5	0.4
Heart disease (mother)	0.9	1.0	3.3	-1.8	-0.6	-0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.5	1.9	0.8	0.7	-0.9
Whole body fat mass	1.2	4.8	10.4	1.6	3.2	1.9	-1.6
Leg fat mass (right)	0.9	3.4	8.2	1.3	2.9	1.5	-1.2
Arm predicted mass (right)	3.8	19.7	28.9	4.2	5.4	4.1	-4.0
Pulse rate, automated reading	0.2	0.6	1.3	1.0	1.1	-0.0	0.4
Alcohol intake frequency.	1.0	2.3	2.9	1.7	1.7	1.4	-1.2
Comparative height size at age 10	4.7	26.1	31.8	4.8	5.6	5.0	-4.9
Number of full sisters	0.4	0.5	1.8	-1.4	0.4	-0.0	-0.1
Suffer from ‘nerves’	0.3	0.5	1.4	-1.2	0.6	-0.2	0.2
Overall health rating	0.2	0.4	1.1	-1.0	-0.2	-0.4	0.5
Chest pain or discomfort	0.3	0.5	1.7	-1.3	0.2	0.1	-0.3
Had major operations	0.0	0.1	0.1	-0.0	-0.2	-0.2	0.4
Age at last live birth	0.4	0.6	1.1	0.1	0.8	1.1	-0.8
Family relationship satisfaction	0.1	0.1	0.4	0.6	0.4	0.1	0.2
Leg pain on walking	0.1	0.1	0.1	-0.3	0.3	-0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	3.1	-1.2	-1.8	-1.3	1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	-0.8	-0.3	-0.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.5	-0.6	-0.4	0.4
Medication: Aspirin	1.4	1.9	4.6	-2.1	-1.1	-1.0	0.9
Supplements: Vitamin C	0.3	0.3	0.4	-0.6	-0.5	-0.6	0.7
Knee pain experienced in last month	0.2	0.3	1.0	-1.0	0.5	-0.0	0.0
Hypertension (Self-reported)	0.8	2.2	3.3	-1.1	1.3	1.6	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.6	0.7	1.9	1.1	-1.2
Illnesses of father: Heart disease	2.6	3.6	7.8	-2.8	-2.1	-1.2	0.9
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.4	0.3	0.7	-0.7
Smoking status: Previous	0.1	0.2	0.5	-0.7	0.6	-0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	4.6	1.6	2.1	2.0	-2.0
Whole body fat-free mass	2.6	15.1	20.3	3.9	4.5	3.5	-3.5
Leg fat-free mass (right)	1.0	5.4	7.4	2.7	2.7	1.9	-1.9
Arm fat percentage (left)	0.1	0.3	1.1	-0.1	1.1	0.0	0.3
Average weekly red wine intake	1.3	1.9	2.7	-0.6	-1.4	-1.6	1.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.9	0.2	0.0	0.2
Mood swings	0.2	0.3	0.9	-0.3	-1.0	-0.3	0.4
Loneliness, isolation	1.3	1.7	2.2	1.1	1.3	1.5	-1.4
Long-standing illness, disability or infirmity	0.2	0.2	0.3	0.5	0.5	0.4	-0.4
Ever had bowel cancer screening	1.7	2.0	2.2	-1.5	-1.2	-1.5	1.4
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.6	-1.0	-0.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	3.5	-1.8	-1.3	-1.9	1.8
Friendships satisfaction	0.3	0.3	0.5	0.7	-0.5	-0.4	0.6
Qualifications: nursing, teaching	0.4	0.6	2.0	1.4	-0.0	0.5	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.6	0.8	-0.4	-0.1	0.2
Eye problems/disorders: Cataract	0.4	0.4	0.6	0.1	0.8	0.8	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.3	-0.0	-0.3	0.3
Medication for cholesterol	0.9	1.4	1.6	-1.3	-0.9	-1.3	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.2	0.2	0.4	-0.1	0.1
Back pain experienced in last month	0.2	0.2	0.6	-0.5	0.8	-0.2	0.3
Mineral and other dietary supplements	0.2	0.2	0.5	0.1	-0.1	-0.6	0.7
Breast cancer (self-reported)	0.5	0.6	1.1	-0.2	-1.0	-0.8	0.8
Asthma (self-reported)	5.8	11.6	14.9	3.9	3.5	3.1	-3.1
Osteoporosis (self-reported)	0.1	0.1	0.4	0.6	-0.0	-0.1	0.2
Osteoarthritis (self-reported)	3.1	4.0	4.9	1.4	2.2	2.1	-2.2
Medication: Aspirin	1.7	2.2	4.0	-2.0	-1.2	-1.3	1.2
Medication: Gliclazide	0.0	0.0	0.1	0.4	-0.1	0.1	-0.0
Illnesses of father: None of the above (group 1)	2.3	2.8	8.1	2.9	1.2	1.0	-0.8
Smoking status: Current	0.7	1.1	2.1	-0.0	-0.7	-1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.0	-1.4	-2.2	-1.4	1.4
Whole body water mass	2.8	15.9	21.1	4.0	4.6	3.6	-3.6
Leg predicted mass (right)	1.1	5.6	7.7	2.8	2.7	2.0	-1.9
Arm fat mass (left)	0.7	2.8	6.2	1.4	2.5	1.3	-1.1
Number of self-reported non-cancer illnesses	3.3	5.8	8.2	0.5	2.8	2.6	-2.9
Average weekly champagne plus white wine intake	0.4	0.6	2.0	-1.4	-0.5	0.3	-0.3
Miserableness	0.4	0.6	0.8	-0.9	-0.6	-0.8	0.8
Guilty feelings	1.4	2.2	2.4	-1.3	-1.5	-1.5	1.5
Wears glasses or contact lenses	0.9	1.0	1.6	0.7	1.0	1.0	-1.2
Ever taken oral contraceptive pill	3.1	3.4	4.8	1.8	1.2	2.2	-2.0
Hearing aid user	1.0	1.2	1.7	1.1	0.6	1.2	-1.3
Mother’s age at death	1.9	2.4	5.3	-0.0	2.3	1.6	-1.3
Financial situation satisfaction	0.8	0.9	1.7	-0.2	-1.0	-1.1	1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.9	1.4	0.7	-0.1	0.0
Commuting to job workplace: Public transport	0.5	0.6	1.7	1.3	0.2	0.6	-0.5
Eye problems/disorders: Glaucoma	0.9	1.0	2.5	0.6	1.6	0.8	-0.8
Medication: Blood pressure	0.2	0.5	0.7	0.3	0.7	0.7	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.6	0.7	0.2	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	0.6	0.4	1.0	-1.2
High cholesterol (Self-reported)	0.2	0.4	0.7	0.8	-0.2	0.6	-0.8
Medication: Bendroflumethiazide	1.1	1.7	3.4	-1.9	-0.6	-1.3	1.2
Medication: Paracetamol	0.4	0.6	1.2	0.6	1.1	0.6	-0.8
Medication: Lisinopril	0.4	0.5	1.0	-0.5	-0.3	0.8	-1.0
Medication: Atorvastatin	2.9	3.5	9.1	-3.0	-2.0	-0.8	0.7
Illnesses of father: High blood pressure	1.0	1.2	3.2	-1.8	1.0	0.6	-0.7
Alcohol drinker status: Never	0.4	0.5	1.1	-1.0	0.4	0.7	-0.6
Ever smoked	0.6	1.0	1.9	-0.8	-0.5	-1.4	1.1
Basal metabolic rate	2.7	14.9	20.8	3.8	4.6	3.5	-3.4
Leg fat percentage (left)	0.5	1.6	5.1	0.5	2.2	0.9	-0.6
Arm fat-free mass (left)	3.5	17.9	24.4	4.1	4.9	3.9	-3.9
Number of operations (self-reported)	0.5	0.7	2.5	-1.6	-0.2	-0.3	0.4
Average weekly beer plus cider intake	0.1	0.1	0.4	0.7	0.4	-0.1	-0.0
Irritability	1.2	2.0	3.8	-1.2	-1.9	-1.2	1.2
Risk taking	0.6	0.9	1.3	0.9	0.4	1.1	-1.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	1.9	1.2	0.6	1.3	-1.4
Fractured/broken bones in last 5 years	0.9	1.1	1.3	1.1	1.0	1.1	-1.0
Age started oral contraceptive pill	0.1	0.1	0.3	0.6	0.3	0.0	-0.2
Diastolic blood pressure, automated reading	0.6	1.8	3.9	0.2	2.0	1.3	-1.3
Ever depressed for a whole week	0.9	1.1	1.7	-0.9	-0.9	-1.0	1.3
Unable to work because of sickness or disability	0.7	0.9	1.4	-0.2	1.0	1.2	-1.1
Commuting to job workplace: Cycle	3.5	4.2	4.6	2.2	2.0	2.0	-2.0
Myopia	1.6	2.3	3.5	-1.0	-1.4	-1.6	1.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.6	1.6	-0.3	-0.8	1.1
Cholesterol lowering medication	0.6	0.9	2.9	-0.2	-1.7	-0.6	0.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.3	-0.6	1.8	0.7	-0.9
Pain experienced in last month	0.7	1.2	2.0	-0.3	-1.4	-1.2	1.1
Supplements: Calcium	0.9	1.0	1.8	-0.5	0.2	1.3	-1.4
Basal cell carcinoma (self-reported)	3.1	3.7	5.3	1.5	2.3	1.8	-2.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.5	-0.6	0.6	0.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.6	0.5	0.1	-0.1
Heart disease (siblings)	0.2	0.3	0.4	-0.3	0.4	0.7	-0.6
Alcohol drinker status: Previous	0.2	0.3	0.6	0.6	0.8	-0.1	-0.0
Pack years of smoking	0.3	0.4	0.6	-0.5	-0.7	-0.8	0.6
Impedance of whole body	0.1	0.4	0.6	0.1	0.8	0.8	-0.5
Leg fat mass (left)	0.9	3.4	8.1	1.2	2.8	1.5	-1.3
Arm predicted mass (left)	3.2	16.0	21.5	4.0	4.6	3.7	-3.6