[Hub]/) : Traits : Blood White Count : ← →

chr1:223,607,389-225,310,170

Best TWAS P=2.81e-25 · Best GWAS P=1.16e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Adipose Subcutaneous	CNIH4	0.24	0.16	enet	38	0.20	3.5e-16	9.4	-10.4	2.8e-25	-0.93	0.02	0.98	TRUE
30	METSIM	Adipose	CNIH4	0.16	0.20	lasso	2	0.20	2.4e-29	9.4	-9.4	4.1e-21	-0.98	0.02	0.98	TRUE
23	GTEx	Pancreas	CNIH4	0.21	0.07	enet	23	0.08	4.0e-04	9.3	-9.3	8.4e-21	-0.89	0.02	0.98	TRUE
48	The Cancer Genome Atlas	Thyroid Carcinoma	CNIH4	0.09	0.09	enet	10	0.09	3.7e-09	9.5	-9.2	3.7e-20	-0.90	0.01	0.99	TRUE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	DEGS1	0.11	0.02	blup	41	0.04	1.9e-03	-4.1	5.6	2.1e-08	0.16	0.02	0.31	TRUE
19	GTEx	Muscle Skeletal	DEGS1	0.08	0.05	lasso	6	0.05	1.5e-05	3.4	5.6	2.7e-08	0.16	0.32	0.22	TRUE
12	GTEx	Colon Transverse	CNIH4	0.28	0.20	enet	37	0.23	1.9e-11	9.4	-10.1	5.8e-24	-0.87	0.02	0.98	FALSE
5	GTEx	Adrenal Gland	CNIH4	0.21	0.05	lasso	6	0.13	2.5e-05	9.4	-10.1	8.0e-24	-0.93	0.02	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	CNIH4	0.23	0.19	enet	34	0.22	1.7e-11	9.4	-10.1	9.1e-24	-0.90	0.02	0.98	FALSE
11	GTEx	Cells Transformed fibroblasts	CNIH4	0.14	0.07	enet	9	0.10	3.3e-08	9.4	-10.0	1.1e-23	-0.87	0.02	0.98	FALSE
25	GTEx	Skin Sun Exposed Lower leg	CNIH4	0.28	0.26	lasso	8	0.26	8.6e-22	9.4	-9.9	4.6e-23	-0.98	0.02	0.98	FALSE
31	NTR	Blood	CNIH4	0.02	0.02	lasso	5	0.02	1.7e-06	9.4	-9.8	8.5e-23	-0.92	0.02	0.98	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	CNIH4	0.21	0.13	lasso	5	0.11	9.8e-05	9.5	-9.8	1.8e-22	-0.99	0.02	0.98	FALSE
8	GTEx	Breast Mammary Tissue	CNIH4	0.25	0.19	lasso	5	0.22	1.6e-11	9.6	-9.7	2.1e-22	-0.99	0.01	0.99	FALSE
14	GTEx	Esophagus Mucosa	CNIH4	0.20	0.19	lasso	5	0.18	2.0e-12	9.5	-9.6	5.4e-22	-0.95	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	CNIH4	0.04	0.02	blup	33	0.03	1.1e-06	9.4	-9.6	8.5e-22	-0.85	0.02	0.98	FALSE
9	GTEx	Breast Mammary Tissue (Male)	CNIH4	0.26	0.16	lasso	4	0.11	2.0e-03	9.6	-9.6	1.1e-21	-1.00	0.02	0.92	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	CNIH4	0.03	0.01	blup	33	0.01	6.1e-02	9.4	-9.6	1.1e-21	-0.97	0.02	0.96	FALSE
22	GTEx	Nerve Tibial	CNIH4	0.26	0.20	lasso	10	0.22	6.2e-16	9.5	-9.6	1.2e-21	-0.96	0.01	0.99	FALSE
32	YFS	Blood	CNIH4	0.12	0.13	bslmm	358	0.13	5.1e-40	9.5	-9.6	1.2e-21	-0.96	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	CNIH4	0.08	0.14	enet	13	0.15	2.4e-15	9.6	-9.6	1.3e-21	-1.00	0.01	0.99	FALSE
15	GTEx	Esophagus Muscularis	CNIH4	0.23	0.22	lasso	4	0.24	8.0e-15	9.4	-9.5	1.4e-21	-0.99	0.02	0.98	FALSE
16	GTEx	Heart Atrial Appendage	CNIH4	0.20	0.11	lasso	6	0.07	3.3e-04	9.5	-9.5	1.6e-21	-1.00	0.02	0.97	FALSE
10	GTEx	Breast Mammary Tissue (Female)	CNIH4	0.12	0.16	lasso	4	0.14	7.8e-05	9.5	-9.5	1.7e-21	-1.00	0.02	0.95	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CNIH4	0.02	0.02	lasso	5	0.01	1.0e-02	9.5	-9.5	1.8e-21	-1.00	0.01	0.88	FALSE
7	GTEx	Artery Tibial	CNIH4	0.15	0.14	lasso	4	0.16	1.1e-12	9.4	-9.5	2.1e-21	-1.00	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	CNIH4	0.07	0.05	lasso	10	0.04	7.1e-04	9.5	-9.5	2.1e-21	-0.99	0.02	0.98	FALSE
28	GTEx	Thyroid	CNIH4	0.20	0.23	lasso	3	0.25	8.4e-19	9.4	-9.5	2.6e-21	-0.99	0.02	0.98	FALSE
17	GTEx	Heart Left Ventricle	CNIH4	0.11	0.09	enet	12	0.09	2.0e-05	9.4	-9.5	2.7e-21	-0.99	0.02	0.96	FALSE
20	GTEx	Muscle Skeletal	CNIH4	0.13	0.16	lasso	7	0.16	4.5e-15	9.5	-9.5	2.8e-21	-0.99	0.03	0.97	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	CNIH4	0.22	0.22	lasso	4	0.21	7.4e-12	9.4	-9.5	3.2e-21	-0.99	0.03	0.97	FALSE
18	GTEx	Lung	CNIH4	0.25	0.20	lasso	15	0.25	1.9e-19	9.5	-9.4	3.3e-21	-0.95	0.02	0.98	FALSE
29	GTEx	Whole Blood	CNIH4	0.07	0.04	lasso	2	0.05	2.0e-05	9.4	-9.4	3.9e-21	-0.98	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CNIH4	0.19	0.22	lasso	15	0.20	7.3e-09	9.4	-9.4	4.0e-21	-0.98	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	CNIH4	0.10	0.07	lasso	7	0.06	7.3e-03	9.5	-9.4	4.1e-21	-1.00	0.01	0.74	FALSE
26	GTEx	Skin Sun Exposed Lower leg	WDR26	0.08	0.00	lasso	2	0.01	5.1e-02	-5.0	-9.2	2.9e-20	-0.78	0.03	0.78	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CNIH4	0.04	0.04	blup	33	0.04	2.3e-05	9.4	-9.2	3.5e-20	-0.91	0.02	0.97	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CNIH4	0.07	0.06	enet	29	0.07	3.1e-08	9.5	-8.9	7.5e-19	-0.87	0.01	0.99	FALSE
27	GTEx	Stomach	CNIH4	0.15	0.07	lasso	4	0.08	7.3e-05	9.5	-8.1	5.9e-16	-0.92	0.03	0.94	FALSE
6	GTEx	Artery Aorta	CNIH4	0.15	0.10	lasso	3	0.12	5.2e-07	-3.9	-7.9	2.3e-15	-0.66	0.04	0.86	FALSE
40	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CNIH4	0.15	0.08	blup	33	0.11	9.7e-06	9.5	-6.7	2.2e-11	-0.69	0.01	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FBXO28	0.03	0.01	bslmm	356	0.01	2.1e-02	-6.1	6.5	5.8e-11	0.32	0.14	0.03	FALSE
33	YFS	Blood	FBXO28	0.26	0.37	lasso	6	0.37	1.4e-129	-6.5	-6.5	1.2e-10	-0.21	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	DEGS1	0.09	0.06	lasso	4	0.05	7.6e-06	-5.8	6.0	2.1e-09	0.19	0.32	0.63	FALSE
46	The Cancer Genome Atlas	Rectum Adenocarcinoma	CNIH4	0.25	0.00	blup	33	0.07	1.2e-02	9.4	-5.5	3.1e-08	-0.74	0.01	0.32	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	DEGS1	0.03	0.03	enet	5	0.03	2.9e-04	-5.9	5.5	3.5e-08	0.16	0.06	0.31	FALSE
21	GTEx	Nerve Tibial	FBXO28	0.10	0.05	enet	6	0.09	7.3e-07	-6.6	-5.3	1.3e-07	-0.19	0.99	0.00	FALSE
2	GTEx	Adipose Subcutaneous	FBXO28	0.13	0.09	enet	6	0.10	1.8e-08	-6.1	-5.2	1.9e-07	-0.20	0.99	0.00	FALSE