TWAS hub - DEGS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1694	0.0577	2.0e-03	0.002	NA	0.037	NA	0.022	2.0e-01	NA	7.5e-04	NA	7.6e-03
2	GTEx	Muscle Skeletal	0.0782	0.0281	5.1e-04	0.049	NA	0.037	NA	0.048	1.2e-05	NA	1.4e-04	NA	1.5e-05
3	GTEx	Pancreas	0.1730	0.0740	4.5e-03	-0.007	NA	0.033	NA	0.003	9.9e-01	NA	1.5e-02	NA	2.4e-01
4	GTEx	Skin Sun Exposed Lower leg	0.1480	0.0460	1.6e-04	0.090	NA	0.091	NA	0.069	6.2e-08	NA	5.6e-08	NA	2.1e-06
5	METSIM	Adipose	0.0459	0.0209	4.0e-03	0.015	0.003	0.014	0.006	0.006	2.3e-03	1.2e-01	2.8e-03	4.3e-02	3.8e-02
6	NTR	Blood	0.0817	0.0217	1.8e-09	0.034	0.033	0.032	0.032	0.036	4.5e-11	7.9e-11	1.0e-10	1.2e-10	7.3e-12
7	YFS	Blood	0.2443	0.0394	0.0e+00	0.155	0.130	0.160	0.158	0.160	2.4e-48	3.9e-40	4.3e-50	2.1e-49	7.2e-50
8	TCGA	Colon Adenocarcinoma	0.1100	0.0640	2.8e-03	0.020	0.042	0.037	NA	0.028	2.3e-02	1.9e-03	3.2e-03	NA	8.9e-03
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0980	0.0500	3.6e-03	0.000	0.008	0.007	NA	-0.002	3.3e-01	1.1e-01	1.1e-01	NA	4.1e-01
10	TCGA	Brain Lower Grade Glioma	0.0289	0.0162	4.0e-03	0.028	0.012	0.029	NA	0.016	3.1e-04	1.4e-02	2.9e-04	NA	5.1e-03
11	TCGA	Prostate Adenocarcinoma	0.0883	0.0400	6.8e-06	0.060	0.043	0.019	NA	0.049	6.8e-07	2.6e-05	4.0e-03	NA	7.6e-06
12	TCGA	Thyroid Carcinoma	0.0750	0.0360	3.4e-04	0.002	0.014	0.021	NA	0.001	2.0e-01	1.6e-02	3.2e-03	NA	2.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Hayfever, allergic rhinitis or eczema	5.3	11.4	22.9	4.8	1.3	2.2	4.4	3.2	3.8	4.7	1.1	3.4	3.4	2.1	3.6
Age at First Birth	4.4	6.4	13.5	3.4	0.6	1.1	1.2	3.6	3.7	2.2	2.4	1.5	3.6	3.1	1.1
Wears glasses or contact lenses	3.9	4.5	6.8	2.5	2.6	2.1	1.6	1.4	2.4	1.5	1.8	2.0	2.5	2.0	2.4
Allergy or Eczema	3.8	10.0	18.7	4.3	1.2	1.9	3.8	3.4	3.7	4.2	1.3	3.2	3.4	2.4	3.2
Taking other prescription medications	3.8	5.9	10.2	2.5	3.2	-0.0	2.2	2.1	3.2	2.1	1.7	2.7	3.1	2.1	2.4
Pain all over the body in last month	3.6	3.8	7.9	2.5	1.1	0.1	1.8	2.8	2.4	1.1	2.5	1.0	2.6	2.5	0.6
Number of operations (self-reported)	3.4	5.0	10.0	1.4	2.8	0.3	1.7	1.6	2.5	2.4	2.1	3.2	2.4	2.0	2.9
Ever had bowel cancer screening	3.3	3.9	6.1	1.5	2.5	-1.2	1.1	2.3	1.9	1.5	2.4	2.4	2.0	1.8	2.4
Number of treatments/medications taken	3.2	5.7	10.0	2.7	2.3	1.1	2.3	2.1	2.9	3.2	1.4	3.0	2.5	1.3	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.2	7.2	2.7	1.5	1.6	1.4	2.3	2.6	2.1	1.9	1.9	2.4	1.8	2.1
HDL Cholesterol	3.1	5.1	11.4	-2.1	-3.4	-0.5	-0.9	-2.3	-2.6	-1.4	-2.4	-2.1	-2.8	-2.7	-2.1
Allergy	3.1	7.1	17.2	-4.2	-1.1	-2.0	-3.3	-2.2	-3.0	-3.4	-1.0	-2.5	-2.8	-1.7	-2.9
Multivitamins +/- minerals	2.8	3.5	9.1	3.0	-0.4	1.5	2.8	0.4	1.4	2.2	2.0	1.7	1.1	0.6	2.7
Falls in the last year	2.6	3.5	7.1	2.0	1.8	0.3	1.7	1.8	1.9	1.9	2.1	2.0	1.9	1.6	2.7
Rheumatoid Arthritis	2.4	3.3	8.0	2.2	0.0	1.6	1.9	0.9	2.0	1.5	2.8	1.2	2.0	1.7	2.1
Other serious medical condition/disability diagnosed by doctor	2.4	3.2	8.6	1.3	2.9	-0.8	0.5	2.2	1.5	1.3	2.5	1.6	1.9	1.5	1.7
Medication: Atenolol	2.4	3.0	6.1	1.7	2.1	1.2	0.8	1.2	2.3	0.9	2.0	2.2	2.5	1.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	11.7	-2.1	-1.1	-0.9	-1.2	-3.4	-3.0	-2.1	-2.5	-1.4	-3.0	-2.7	-1.5
Neck or shoulder pain in last month	2.3	3.3	6.2	1.8	1.1	2.0	1.8	1.5	2.1	2.0	1.1	2.5	1.9	1.4	1.9
Number of self-reported non-cancer illnesses	2.3	4.0	6.0	2.0	2.0	0.5	2.3	2.4	2.3	2.2	1.6	2.1	2.4	1.4	1.7
Illnesses of father: High blood pressure	2.3	2.9	6.5	-1.7	-1.3	1.9	-0.6	-2.5	-2.3	-1.5	-1.2	-1.2	-2.1	-1.8	-1.2
Blood White Count	2.2	16.2	35.9	2.8	5.6	3.4	-0.3	4.0	4.7	0.7	5.6	2.5	5.5	6.0	1.0
Ever used hormone-replacement therapy (HRT)	2.1	2.7	7.0	2.3	0.1	0.4	1.5	2.5	1.9	2.6	1.1	0.6	1.4	1.1	1.9
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	5.3	1.5	0.7	0.4	2.3	1.3	1.7	1.4	1.6	2.2	1.5	1.7	1.3
Commuting to job workplace: Cycle	2.1	2.5	4.5	2.0	0.4	1.4	0.5	1.6	2.1	1.3	1.8	1.0	2.0	1.9	1.7
Supplements: Zinc	2.0	2.1	4.1	2.0	0.0	1.6	1.1	1.4	1.8	1.8	1.9	0.4	1.5	1.1	1.4
Lung cancer (father)	2.0	2.3	5.7	1.1	2.4	0.3	1.3	1.4	1.5	1.6	0.6	2.2	1.5	0.6	2.1
LDL Cholesterol	1.9	3.0	5.4	-2.3	-1.9	-1.1	-1.2	-0.7	-1.8	-0.9	-2.2	-2.0	-2.0	-1.8	-2.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	6.5	1.1	0.8	-0.8	1.8	2.5	1.8	2.3	-0.0	1.7	1.3	1.4	0.9
Blood clot in the leg (DVT)	1.9	2.5	6.3	1.7	2.0	-1.1	1.4	0.7	1.0	1.0	1.5	2.3	1.5	1.1	2.5
Leg pain on walking	1.9	2.3	5.3	0.6	2.0	-2.2	0.2	1.9	2.0	0.3	0.7	1.2	2.0	2.3	0.1
Unable to work because of sickness or disability	1.9	2.4	8.4	1.3	2.9	0.3	0.7	0.8	1.5	0.9	0.9	2.6	1.5	0.9	2.1
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	6.5	1.7	2.1	-1.4	1.5	0.5	0.8	1.0	1.4	2.3	1.3	0.9	2.6
Coronary Artery Disease (CAD)	1.8	2.1	4.6	-1.0	1.4	0.5	-1.5	-2.1	-2.0	-1.3	-2.1	0.4	-1.9	-1.4	-0.0
Pulse wave Arterial Stiffness index	1.8	2.1	4.9	1.9	-0.3	0.3	1.1	2.2	1.8	2.2	1.5	0.5	1.5	0.7	1.6
Pulse wave peak to peak time	1.8	2.2	5.3	-1.9	0.5	-0.4	-1.1	-2.3	-1.7	-2.3	-1.4	-0.4	-1.5	-0.6	-1.6
Health satisfaction	1.8	2.4	5.4	1.9	1.8	0.1	1.4	2.3	1.5	1.3	1.0	1.9	1.6	1.3	1.4
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	4.8	-1.5	-2.2	0.6	-0.9	-0.8	-1.5	-0.7	-0.9	-1.9	-1.7	-1.7	-1.7
Blood Red Count	1.6	15.9	51.4	3.0	7.2	1.2	0.5	4.2	4.2	0.3	3.9	3.8	5.2	5.7	1.7
Mouth/teeth dental problems: Dentures	1.6	2.8	5.4	1.2	2.1	0.4	1.6	2.3	1.6	1.7	1.0	2.2	1.7	1.4	1.9
Age at last live birth	1.6	2.4	7.4	-0.5	-2.4	0.8	-1.5	-1.3	-0.6	-2.1	0.3	-2.7	-0.4	0.1	-2.3
Medication for cholesterol	1.6	2.5	6.0	-2.4	-1.3	-2.1	-1.1	-1.0	-1.7	-0.7	-1.4	-1.5	-1.9	-1.5	-1.4
Medication: Aspirin	1.6	2.1	3.6	1.5	0.8	0.5	1.7	1.2	1.7	1.6	1.9	1.7	1.6	0.7	1.5
Ever depressed for a whole week	1.6	2.0	4.3	1.5	0.7	-0.4	1.6	2.1	1.8	1.3	0.7	1.6	1.7	1.6	0.7
Average weekly fortified wine intake	1.5	1.7	6.1	-2.5	-1.5	-0.6	-1.3	0.7	-1.1	-1.0	-0.5	-1.5	-1.0	-0.6	-2.0
Mouth/teeth dental problems	1.5	2.3	11.4	-1.0	-3.4	-1.5	-0.6	-1.0	-1.1	-0.6	0.0	-2.2	-1.1	-1.6	-1.2
Had major operations	1.5	1.8	5.4	0.9	2.3	0.0	0.7	1.3	1.6	0.7	0.7	1.9	1.5	1.6	0.9
Knee pain experienced in last month	1.5	2.3	8.2	0.4	2.9	-1.0	-0.4	1.0	1.4	1.3	-0.0	2.5	1.5	1.0	1.8
Back pain experienced in last month	1.5	2.2	6.7	0.9	1.4	0.8	1.6	1.0	1.0	2.5	-0.4	2.3	0.6	-0.5	2.6
Medication for hormone replacement therapy	1.4	1.6	7.1	1.9	-0.1	2.7	1.7	0.5	0.8	1.0	0.8	0.8	0.6	0.7	1.1
Qualifications: CSEs or equivalent	1.4	1.9	6.0	0.3	0.9	1.8	-1.7	-2.5	-1.1	-1.7	-1.5	-1.0	-1.1	-0.7	-0.9
Breastfed as a baby	1.4	1.7	4.3	1.5	0.1	-0.7	0.4	2.1	1.7	1.2	1.9	0.6	1.7	1.1	0.8
Eye problems/disorders: None of the above	1.4	1.7	11.9	-0.1	-3.4	-0.7	0.2	0.9	0.3	0.5	-0.4	-1.9	-0.1	-0.4	-1.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.3	-1.5	-0.5	-1.3	-1.3	-1.5	-1.8	-1.4	-1.3	-0.3	-1.4	-1.0	-1.1
Tinnitus: Yes, now most or all of the time	1.4	1.6	4.4	1.4	0.5	0.6	1.3	0.4	1.0	1.5	1.9	1.6	0.9	0.6	2.1
Average weekly spirits intake	1.3	1.6	7.0	0.4	-1.8	-0.9	1.2	2.6	0.9	2.3	-0.2	0.3	0.5	0.2	0.2
Vitamin and mineral supplements	1.3	1.7	4.6	-2.1	1.3	-0.8	-2.0	-0.4	-0.5	-1.3	-1.9	-0.8	-0.8	-0.2	-1.8
Severe depression (siblings)	1.3	1.4	3.3	0.4	1.1	-1.4	0.3	1.6	1.4	-0.2	1.7	0.1	1.8	1.7	0.1
Townsend deprivation index at recruitment	1.3	1.9	9.1	-1.1	1.6	-1.2	-1.6	-1.4	-0.7	-3.0	0.1	-0.8	-0.2	0.3	-1.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	4.3	2.1	-0.2	2.0	2.1	1.1	1.2	1.9	-0.2	0.5	0.8	0.3	1.1
Migraine (self-reported)	1.3	1.6	3.7	-1.9	-0.4	-1.3	-0.9	-0.9	-1.8	-0.5	-1.9	-0.3	-1.7	-1.4	-0.3
Chronic bronchitis/emphysema (father)	1.2	1.4	3.8	1.2	-0.0	0.8	1.9	1.6	1.0	1.7	0.5	1.4	0.8	0.2	1.3
Average weekly champagne plus white wine intake	1.2	1.6	7.3	1.5	0.8	2.7	0.3	-1.0	-0.0	-0.0	1.8	0.6	0.3	-0.4	2.0
Fractured/broken bones in last 5 years	1.2	1.5	6.4	1.1	1.3	0.5	1.0	0.6	0.6	1.9	0.3	1.7	0.5	-0.2	2.5
Age when periods started (menarche)	1.1	2.8	7.8	-2.3	0.4	-2.8	-2.4	-1.1	-1.3	-1.9	-1.0	-1.5	-1.2	-0.2	-1.6
Nervous feelings	1.1	2.0	15.4	1.2	3.9	1.5	-0.2	-0.6	-0.2	-0.8	0.2	1.5	0.1	0.7	1.0
Long-standing illness, disability or infirmity	1.1	1.7	3.1	1.6	1.5	-0.2	1.6	1.1	1.6	0.8	0.6	1.8	1.7	1.0	0.7
Eye problems/disorders: Glaucoma	1.1	1.3	3.1	1.3	0.7	0.5	1.1	0.9	1.2	1.6	0.3	1.4	0.8	0.6	1.8
Cholesterol lowering medication	1.1	1.6	4.9	1.2	2.2	-0.7	0.3	1.3	1.4	0.8	-0.1	1.7	1.5	1.2	1.3
Schizophrenia (2018)	1.0	2.0	4.2	-1.2	-1.7	-1.3	0.0	-0.2	-1.9	-0.8	-1.3	-2.0	-1.6	-2.0	-1.2
HbA1C	1.0	1.1	2.1	1.0	1.4	0.4	0.7	1.1	1.5	0.7	0.8	1.0	1.1	1.5	0.8
Neuroticism (2016)	1.0	1.5	5.4	0.2	2.3	0.9	-0.1	-1.8	-1.3	0.1	-1.2	0.7	-1.4	-1.3	1.1
Chronotype (morning person)	1.0	2.3	5.4	1.6	0.1	-1.4	0.7	2.2	2.2	2.3	1.0	0.4	1.9	1.7	0.6
Diabetes (father)	1.0	1.2	3.4	1.1	1.2	1.8	1.0	1.2	0.9	1.1	-0.2	1.1	1.0	1.0	1.1
Had other major operations	1.0	1.3	2.2	1.1	1.5	0.3	0.9	0.8	1.5	1.1	1.1	0.7	1.4	1.1	1.2
Exposure to tobacco smoke outside home	1.0	1.3	5.5	-1.3	1.2	-2.3	0.3	-0.4	-0.6	0.6	-1.6	1.3	-0.6	-0.7	0.8
Suffer from ‘nerves’	1.0	1.6	10.0	1.6	1.5	3.2	1.2	0.3	0.4	0.2	0.6	1.3	0.5	0.7	0.5
Qualifications: nursing, teaching	1.0	1.5	4.7	0.0	-2.2	-1.3	0.6	0.2	-1.3	1.8	-0.6	0.2	-1.4	-1.7	1.4
Osteoarthritis (self-reported)	1.0	1.2	4.1	0.4	2.0	-1.2	-0.0	0.7	0.5	0.8	0.5	2.0	0.8	0.4	1.7
Medication: Atorvastatin	1.0	1.2	2.8	-1.7	0.5	-0.9	-1.3	-1.1	-1.1	-1.5	-1.2	-0.6	-0.8	-0.9	-0.8
Hearing difficulty/problems: Yes	0.9	1.3	3.3	1.2	0.2	0.8	0.6	1.8	1.4	0.3	1.1	1.4	1.5	1.6	0.2
Hearing difficulty/problems with background noise	0.9	1.4	4.9	1.2	1.9	0.4	1.0	0.8	0.7	0.3	0.4	2.2	0.9	1.2	1.6
Medication: Simvastatin	0.9	1.4	2.7	1.6	1.2	0.7	0.7	1.6	1.2	1.6	0.6	1.4	1.0	0.8	1.1
Number of live births	0.9	1.2	2.6	1.1	1.4	0.4	0.9	1.3	1.1	0.3	0.9	1.3	1.6	1.4	0.9
Medication: Lansoprazole	0.9	1.0	3.5	0.1	0.8	0.1	1.5	-0.1	0.2	1.3	0.1	1.9	-0.1	-0.3	1.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	4.1	-0.5	1.7	2.0	-1.5	-1.3	-0.3	-0.9	-0.8	-0.0	-0.3	0.0	-0.6
Medication: Aspirin	0.9	1.2	2.6	1.3	0.3	0.3	1.5	0.9	1.3	1.2	1.6	0.9	1.3	0.3	0.9
Prostate Cancer	0.8	1.1	2.4	-0.3	-0.4	1.1	-1.4	-1.2	-1.0	-0.7	-1.0	-1.5	-1.0	-1.2	-0.9
Crohns Disease (2012)	0.8	1.3	3.9	1.6	0.7	2.0	0.9	0.9	1.1	1.2	1.2	0.9	1.0	0.8	1.1
Mean Putamen Volume	0.8	0.9	3.9	1.1	-2.0	-0.5	0.6	0.8	1.1	0.7	1.1	-0.8	0.8	0.3	-0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.6	-1.3	0.3	-1.9	-0.7	-0.4	-0.3	-1.6	-0.1	-0.5	0.0	0.1	-1.5
Ever had hysterectomy (womb removed)	0.8	0.9	1.4	1.0	0.6	0.5	1.2	0.8	1.2	0.9	0.8	1.1	1.0	1.0	1.1
Number of incorrect matches in round	0.8	1.4	2.7	1.3	0.8	1.2	1.6	1.6	0.9	1.2	1.3	0.8	0.9	0.9	1.2
Length of working week for main job	0.8	0.9	3.5	0.3	0.3	0.8	0.8	1.2	1.3	0.0	0.5	0.1	1.3	1.9	-0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	-1.5	-0.4	-0.5	-0.4	-1.4	-0.9	-0.9	-1.5	0.3	-1.0	-1.2	-0.8
Loud music exposure frequency	0.8	0.8	2.4	-0.9	1.2	-0.9	-0.8	-1.5	-1.1	-1.0	-0.6	0.1	-0.9	-0.6	-0.2
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.6	-0.9	0.7	-0.4	0.3	-0.0	-1.1	0.7	-1.6	0.9	-1.3	-1.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.1	0.9	-1.2	1.8	0.2	-1.1	-0.8	-0.7	0.4	-0.9	-0.7	-1.1	0.2
Eye problems/disorders: Cataract	0.8	1.0	6.2	-0.7	2.5	0.7	-0.9	-0.3	-0.2	0.1	0.1	1.3	0.1	0.1	1.3
Breast cancer (self-reported)	0.8	1.0	6.2	0.3	0.2	2.5	-0.1	-0.2	0.3	-0.3	2.2	0.3	0.3	0.3	0.7
Illnesses of father: None of the above (group 1)	0.8	1.0	2.3	0.2	-1.3	-1.5	-0.9	1.5	1.0	1.2	0.8	-1.1	0.8	-0.2	0.3
Hearing aid user	0.8	0.9	4.8	1.0	0.5	2.2	0.8	-0.2	0.6	-0.1	1.5	1.0	0.6	0.6	0.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.8	1.4	0.6	-0.7	-0.5	0.7	1.5	0.2	1.3	0.0	1.5	1.7	0.1
Average weekly beer plus cider intake	0.8	1.1	5.1	-0.5	2.2	-1.0	-0.5	-0.5	-0.3	-1.0	0.6	2.0	0.2	0.9	0.7
Supplements: Calcium	0.8	0.9	3.1	1.0	-1.3	0.5	0.4	0.9	0.6	1.8	1.5	-0.1	0.4	-0.0	1.0
Depression (Nagel 2018)	0.7	1.1	4.5	0.4	1.1	0.3	1.8	0.5	0.0	0.9	-0.8	2.1	-0.0	-0.4	1.4
Worry (Nagel 2018)	0.7	1.5	6.8	1.2	2.6	2.3	-0.6	0.7	0.6	-0.9	0.0	0.6	0.8	1.2	-0.2
Breast Cancer	0.7	1.8	6.2	1.3	-1.7	-0.7	-0.2	1.5	1.4	1.1	2.5	0.3	1.5	1.3	0.8
Triglycerides	0.7	1.1	2.6	-1.1	-1.1	-0.3	-0.5	-0.9	-1.1	0.4	-1.2	-1.5	-1.4	-1.6	-0.2
Serious illness, injury or assault to yourself	0.7	0.8	4.9	0.1	2.2	-0.4	-0.6	-0.2	0.6	-1.0	0.9	0.2	0.8	1.3	-0.0
Hair/balding pattern: Pattern 2	0.7	0.8	2.4	0.2	0.7	0.6	0.6	-1.3	-1.1	-0.1	-0.1	0.8	-0.9	-1.3	1.6
Qualifications: None of the above	0.7	1.4	2.8	0.2	1.7	-1.7	0.2	1.2	1.6	1.1	0.4	1.1	1.4	1.4	0.8
Headache pain in last month	0.7	1.1	2.6	-1.4	1.3	-1.0	-1.0	-1.5	-1.2	-1.0	-1.6	0.3	-0.9	-0.2	-0.0
Glaucoma (self-reported)	0.7	0.8	2.9	1.2	0.0	0.8	0.6	0.5	0.9	1.7	-0.2	0.8	0.5	-0.0	1.5
Age at first live birth	0.7	1.2	2.6	0.1	-1.6	0.7	-1.5	-0.9	-0.8	-1.6	0.7	-1.6	-0.5	-0.1	-1.2
Shortness of breath walking on level ground	0.7	0.9	5.6	-0.2	2.4	-1.4	-0.6	0.7	0.3	0.5	-0.3	1.0	0.4	0.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.8	-0.8	0.6	0.0	-1.0	-1.0	-1.1	-1.9	-0.0	-0.2	-0.9	-0.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.7	0.2	0.9	0.1	1.6	0.3	1.3	0.8	0.9	1.1	0.9	0.7	0.8
Illnesses of father: Heart disease	0.7	0.9	4.6	0.8	1.1	0.6	0.3	-1.3	-0.6	-2.2	1.3	0.3	0.0	0.1	-0.4
Diabetes diagnosed by doctor	0.7	1.1	2.9	0.9	1.6	0.3	0.1	1.4	1.5	-0.2	-0.1	0.6	1.7	1.5	-0.5
Friendships satisfaction	0.7	0.8	2.5	-0.8	-1.0	-0.1	-0.2	0.0	-1.0	-0.8	-1.2	-0.8	-1.0	-0.9	-1.6
Mineral and other dietary supplements	0.7	1.0	2.7	-1.2	0.7	-0.7	-1.4	-0.1	0.1	-1.6	-0.7	-0.6	0.3	0.9	-1.5
Medication: Lisinopril	0.7	0.9	3.2	1.4	0.5	0.7	1.3	0.7	0.9	1.8	0.4	0.6	0.8	0.0	0.9
Risk taking	0.7	1.0	5.1	-0.8	-1.1	-2.2	-0.3	1.1	0.5	0.0	-0.7	-0.5	0.3	1.1	-1.2
Age started oral contraceptive pill	0.7	0.8	3.5	0.2	1.5	-0.5	0.6	0.1	0.1	0.5	-0.3	1.8	0.3	-0.0	1.9
Myopia	0.7	1.0	4.2	-1.1	0.9	-0.6	-1.6	-0.4	-0.2	-2.0	-0.2	-0.6	0.2	1.0	-1.3
Pain experienced in last month	0.7	1.1	3.5	-0.1	-1.9	0.7	0.2	-1.1	-0.9	-1.4	0.5	-1.6	-0.9	-0.3	-1.4
Bipolar Disorder or Schizophrenia	0.6	1.4	5.1	-0.8	-1.6	-0.0	-0.2	-0.0	-1.6	-0.8	-0.3	-2.3	-1.3	-1.5	-1.2
Major Depression (MDD)	0.6	0.8	2.6	-0.9	0.0	-1.1	0.7	-0.2	-1.2	-0.5	-1.6	0.4	-1.1	-1.1	0.0
Fasting Glucose	0.6	0.7	2.2	0.2	0.3	0.7	0.3	1.0	1.1	0.5	0.6	0.9	1.2	1.5	0.2
Lupus	0.6	0.9	2.1	0.9	0.0	-0.9	1.1	1.2	1.4	1.1	0.9	0.4	1.3	0.8	0.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.1	-0.9	1.1	-0.7	-0.4	-0.1	-0.3	-1.8	-0.3	-0.2	0.1	0.5	-1.5
Pack years adult smoking proportion	0.6	0.9	3.4	-1.6	1.2	-1.8	-0.7	-0.7	-0.2	-1.2	-0.9	0.4	-0.1	0.1	-0.5
Hand grip strength (right)	0.6	1.5	4.6	-1.0	1.9	-0.1	-1.3	-1.1	-1.4	-2.1	-1.4	0.8	-1.1	-0.2	-0.7
Fed-up feelings	0.6	1.0	3.2	-0.7	1.8	0.5	-1.4	-1.2	-0.8	-1.4	-1.2	0.7	-0.7	0.2	-0.4
High blood pressure	0.6	1.5	3.1	1.2	1.8	0.9	1.3	1.8	1.3	0.7	1.3	1.2	1.4	1.0	0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	-0.8	-0.4	0.1	-1.1	-0.4	-0.7	-1.1	0.9	-1.4	-0.5	-0.5	-0.9
Medication: Levothyroxine sodium	0.6	1.1	2.8	-1.0	-0.2	-1.7	-0.6	-0.4	-1.1	-0.5	-1.3	-0.5	-1.3	-1.3	-1.1
Had menopause	0.6	0.7	1.2	1.1	0.9	0.1	1.1	1.0	0.8	0.5	1.1	0.7	0.9	0.7	1.1
Diabetes (self-reported)	0.6	0.9	2.4	0.9	0.9	1.3	-0.1	1.3	1.5	0.3	-0.1	-0.0	1.5	1.1	-0.5
Happiness	0.6	0.7	1.8	-0.6	-0.4	0.5	0.6	-0.7	-0.9	-0.8	-1.4	0.1	-1.1	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	5.8	-1.1	1.8	-0.0	-2.0	-2.1	-1.4	-2.4	0.1	-0.3	-0.8	-0.1	-0.5
Exposure to tobacco smoke at home	0.6	0.7	2.3	-0.8	1.0	-1.1	-0.2	-0.2	-0.7	-0.9	-1.5	0.3	-0.6	0.1	-1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.8	0.5	1.1	0.8	0.5	0.4	0.8	1.3	0.2	1.2	0.6	0.3	1.3
Number of children fathered	0.6	0.7	2.8	-0.7	-1.7	0.2	-0.5	-1.2	-0.6	0.6	-0.0	-0.3	-0.9	-1.0	0.5
Medication: Allopurinol	0.6	0.8	2.3	0.5	1.1	0.0	0.8	0.8	1.5	1.1	-0.1	0.9	1.4	0.8	0.5
Mean time to correctly identify matches	0.6	1.2	6.4	-0.9	-2.5	-0.5	0.1	0.3	-0.2	-0.2	0.6	-2.1	-0.2	-0.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.7	0.3	0.0	0.4	-0.7	-1.6	-1.1	0.1	-0.3	0.4	-1.3	-1.4	0.6
Commuting to job workplace: Public transport	0.6	0.8	4.3	-0.7	-0.2	-2.1	-0.1	1.3	0.9	0.8	0.4	-0.4	0.6	0.7	0.2
Medication: Bendroflumethiazide	0.6	1.0	2.9	-0.9	-1.3	0.5	-0.6	0.0	-1.0	-0.1	-1.7	-0.9	-1.0	-1.1	-1.2
Basal cell carcinoma (self-reported)	0.6	0.7	2.8	-0.5	1.7	-1.3	0.4	1.3	0.3	0.1	0.6	0.9	0.5	0.7	0.6
Neuroticism (Nagel 2018)	0.5	1.2	6.9	0.6	2.6	1.5	-0.8	0.3	0.5	-0.6	-0.5	1.2	0.7	1.1	0.3
Ulcerative Colitis (UC)	0.5	0.9	3.1	-1.0	-0.7	-1.8	-1.7	-0.1	-0.9	-0.7	-0.9	-0.5	-0.7	-0.8	-0.4
Maternal smoking around birth	0.5	0.7	3.1	-1.0	0.7	-0.8	-1.8	0.2	-0.4	-0.2	-1.3	-0.5	-0.4	-0.3	-0.7
Alcohol usually taken with meals	0.5	0.9	2.1	1.0	0.1	0.7	0.9	0.6	1.0	1.5	1.2	0.7	0.8	0.5	1.3
Fluid intelligence score	0.5	1.1	2.4	0.7	0.2	1.4	1.4	-0.1	1.1	0.1	1.0	1.4	1.0	1.5	0.9
Neuroticism score	0.5	1.0	3.4	-0.1	1.8	1.5	-0.8	-1.1	-0.9	-1.5	-0.9	0.0	-0.7	-0.2	-0.7
Worrier / anxious feelings	0.5	1.0	3.7	-0.7	1.9	-0.0	-1.8	-0.4	-0.9	-1.4	-0.5	-0.6	-0.6	-0.3	-0.6
Impedance of arm (left)	0.5	2.5	6.1	-1.5	-1.6	0.3	-1.2	-1.6	-1.5	-1.7	-1.2	-2.5	-1.6	-1.6	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	6.5	-0.2	2.5	0.4	-1.1	0.7	0.2	0.1	-0.4	0.8	0.4	0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.0	-0.9	-0.6	-1.1	-0.6	-0.9	-0.9	-0.4	-1.4	-1.0	-1.1	-1.4	-1.1
Medication: Amlodipine	0.5	0.8	2.3	1.1	1.3	0.5	1.5	0.6	0.6	0.7	-0.3	1.4	0.4	0.2	0.6
Alcohol intake frequency.	0.5	1.1	2.9	0.5	1.1	-1.1	0.5	0.8	0.7	0.3	0.7	1.6	1.3	1.7	1.1
Overall health rating	0.5	1.1	4.1	0.5	2.0	0.3	1.1	-0.2	-0.2	1.1	-0.2	1.5	-0.3	-0.9	1.7
Family relationship satisfaction	0.5	0.6	1.7	-0.7	-0.8	-1.0	0.3	0.8	-0.9	-0.7	-0.7	-0.3	-0.7	-0.7	-1.3
Supplements: Vitamin C	0.5	0.6	2.3	-0.3	-1.5	-0.8	-0.8	-0.1	-1.0	-0.1	0.2	-1.1	-0.8	-1.0	-0.2
Hypertension (Self-reported)	0.5	1.3	2.8	1.1	1.6	1.1	0.8	1.7	1.1	0.4	1.3	1.0	1.3	1.1	-0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.3	0.3	1.8	-0.6	0.7	-0.0	0.3	0.2	-0.4	1.3	0.3	0.6	0.8
Loneliness, isolation	0.5	0.6	3.2	0.2	1.6	-0.2	0.2	-0.2	0.1	-0.2	-0.6	1.8	0.2	1.0	0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	3.2	0.6	1.8	0.5	0.6	-1.1	-0.0	0.4	-0.9	1.6	-0.1	0.3	1.3
Smoking status: Current	0.5	0.8	2.3	-1.1	-1.4	-0.7	0.4	-1.1	-0.5	-1.2	0.1	-0.3	-0.4	-0.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.4	0.2	1.7	-0.7	-0.7	1.0	0.6	-1.2	1.3	0.3	1.1	1.8	-0.6
Miserableness	0.5	0.9	3.4	-1.1	1.9	0.1	-1.0	-1.0	-0.9	-0.5	-1.4	0.7	-1.0	-0.6	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	0.9	-1.2	0.1	1.1	-0.1	-0.0	1.4	0.5	0.1	-0.2	-1.1	1.1
Heart disease (siblings)	0.5	0.6	1.3	0.5	0.7	-0.7	-0.8	1.1	1.0	0.2	0.2	-0.7	1.0	1.1	-0.4
Alcohol drinker status: Previous	0.5	0.5	2.0	-0.2	0.5	-0.9	0.5	0.1	0.4	0.7	-0.1	1.4	0.4	0.7	1.2
Depressed Affect (Nagel 2018)	0.4	0.8	3.5	-0.0	1.9	0.4	-0.6	-0.3	-0.1	-0.3	-1.2	1.6	-0.0	0.5	0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.9	-1.1	-0.5	-1.1	0.2	0.2	-0.5	0.2	-1.4	0.1	-0.5	-0.5	-0.3
Reaction Time	0.4	0.8	4.7	-1.1	-2.2	-0.5	0.2	0.4	-0.2	0.1	0.6	-1.4	-0.2	-0.6	-0.8
Ovarian Cancer	0.4	0.6	2.2	0.3	-1.5	0.4	1.3	0.4	0.1	1.2	-0.3	0.0	-0.5	-0.9	0.4
Bipolar Disorder (2011)	0.4	0.3	2.2	0.0	-1.5	1.3	0.0	0.0	0.0	-0.3	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	2.3	0.0	1.5	0.4	0.1	0.8	0.7	0.6	-0.4	0.9	0.6	0.8	0.4
Schizophrenia (2014)	0.4	0.9	2.4	-0.8	-0.7	-1.1	0.1	0.2	-1.6	-0.7	-1.0	-1.1	-1.1	-1.1	-0.9
Blood Eosinophil Count	0.4	3.1	9.4	0.9	1.9	-0.4	0.4	3.1	1.6	1.3	2.7	1.1	2.1	2.3	1.1
Smoking Status	0.4	0.9	2.5	0.5	-0.1	1.4	1.6	-1.1	-0.1	0.2	1.3	1.3	-0.1	-0.5	1.0
Neuroticism	0.4	1.0	6.1	0.2	2.5	0.9	-0.3	-0.6	-0.5	-1.6	-0.6	0.8	-0.1	0.6	-0.6
Hand grip strength (left)	0.4	1.2	4.2	-0.4	2.0	-0.3	-1.5	-1.1	-1.0	-1.4	-1.5	0.7	-0.7	0.0	-0.1
Relative age of first facial hair	0.4	0.9	2.5	0.1	-0.4	1.2	-0.1	1.2	1.1	0.4	1.6	-0.3	1.3	1.2	0.3
Current tobacco smoking	0.4	0.7	2.0	-1.1	-1.2	-1.0	0.9	-0.6	-0.2	-0.9	0.1	0.0	-0.2	0.1	-1.4
Relative age voice broke	0.4	0.6	2.1	-1.1	-1.0	-0.4	-1.4	0.4	-0.2	-0.6	-0.1	-0.8	-0.1	0.4	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.8	-0.4	0.5	0.1	-0.0	-1.1	-0.9	1.1	-0.3	0.0	-1.4	-1.7	1.2
Past tobacco smoking	0.4	0.7	2.7	-0.1	0.8	-1.1	-0.2	1.6	0.6	-0.1	-0.1	0.3	0.9	1.4	-0.4
Alcohol intake versus 10 years previously	0.4	0.6	1.9	0.8	-0.6	0.1	0.6	0.9	1.1	0.7	1.4	-0.5	1.0	0.5	-0.0
Father’s age at death	0.4	0.5	1.8	-0.4	-0.9	1.3	1.0	0.4	-0.2	1.0	-0.1	0.1	-0.4	-1.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.0	-0.3	1.7	-0.4	-0.4	-0.6	-0.3	0.4	-1.0	0.7	-0.5	-0.4	1.0
Hair/balding pattern: Pattern 3	0.4	0.6	2.0	0.1	-1.4	1.1	0.5	-0.8	-0.8	0.1	-0.6	-0.1	-0.8	-0.9	0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	5.3	-0.7	0.8	0.4	-2.3	-1.8	-1.0	-2.0	0.1	-0.9	-0.6	0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	2.6	-0.3	-1.6	0.7	-0.1	-0.8	-0.8	0.2	-0.9	-0.3	-0.8	-0.8	-0.4
Depression (self-reported)	0.4	0.4	3.4	-0.1	1.9	-0.5	-0.2	-0.1	-0.2	-0.4	-0.5	1.0	-0.0	-0.1	-0.0
Prospective memory result	0.4	0.5	1.7	1.3	0.4	0.7	0.8	0.9	0.7	0.3	0.7	0.4	0.8	0.6	0.4
Illnesses of mother	0.4	0.4	1.3	1.1	0.3	0.2	0.7	0.4	0.6	0.5	0.5	0.9	0.6	0.8	0.8
Hair/balding pattern: Pattern 4	0.4	0.9	4.5	-0.7	-0.6	-0.1	-0.9	-0.3	-0.3	-0.8	-0.9	-1.6	-0.7	-0.4	-2.1
Peak expiratory flow (PEF)	0.4	0.9	4.2	-0.4	1.0	0.9	-2.1	0.1	0.2	-1.4	0.5	-0.6	0.5	1.1	-1.0
Pulse wave reflection index	0.4	0.5	2.2	0.7	-1.5	1.1	-0.1	0.9	0.5	0.1	0.6	-0.4	0.5	0.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.5	-0.8	0.3	-0.5	-1.1	-1.2	-0.8	-1.0	-0.9	-0.3	-0.9	-0.3	0.2
Leg fat percentage (right)	0.4	1.5	4.1	0.3	0.4	-0.7	-0.8	1.8	1.7	0.9	2.0	0.5	1.8	1.5	0.2
Worry too long after embarrassment	0.4	0.7	4.5	-0.0	2.1	1.1	0.4	-0.2	-0.2	-0.1	-0.3	1.0	-0.2	-0.0	0.9
Emphysema/chronic bronchitis	0.4	0.4	1.3	0.2	0.8	-0.5	1.1	0.6	0.6	0.8	-0.5	0.9	0.4	-0.1	0.5
Medication: Ibuprofen	0.4	0.5	2.2	-0.1	-1.0	1.5	0.1	-0.9	-0.7	-0.2	-0.8	0.3	-0.6	-0.6	-0.3
Smoking status: Previous	0.4	0.6	2.0	0.5	-0.4	1.4	0.3	-1.3	-0.4	0.5	0.4	-0.2	-0.7	-1.2	0.9
Asthma (self-reported)	0.4	0.8	3.1	0.5	-1.8	1.6	0.1	-0.7	-0.0	-0.4	-0.7	-1.2	-0.2	-0.5	-1.0
Osteoporosis (self-reported)	0.4	0.4	1.6	-0.0	0.8	0.3	0.0	-0.9	-0.4	-0.2	0.7	1.2	-0.1	-0.0	1.2
Financial situation satisfaction	0.4	0.5	2.0	-0.4	0.3	-0.4	1.4	0.4	0.2	1.1	-0.9	1.0	-0.1	-0.1	0.1
Alcohol drinker status: Never	0.4	0.5	1.3	0.4	0.9	-0.8	1.1	0.6	0.1	0.3	0.3	1.1	0.4	0.1	1.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.7	-1.0	-1.5	-0.9	-1.1	-1.6	-1.2	-0.6	-1.4	-0.8	-1.3	-0.8	0.0
Pack years of smoking	0.4	0.6	3.1	-1.2	1.0	-1.8	-0.3	-0.2	0.1	-0.6	-1.0	0.5	0.1	0.0	-0.2
Bipolar Disorder (2018)	0.3	0.5	2.4	0.3	-0.3	1.5	-0.4	0.3	-0.2	-0.3	1.2	-1.1	-0.1	0.1	-0.4
Alzheimer’s Disease (in mother)	0.3	0.3	1.0	0.3	0.3	-0.0	0.5	0.8	0.5	0.2	1.0	0.3	0.6	0.8	0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.3	0.2	0.9	-0.7	0.1	0.2	-0.9	0.7	-0.5	0.4	0.9	-0.6
Ulcerative Colitis	0.3	0.4	2.3	-0.0	0.3	-1.5	-0.6	0.9	0.2	0.2	-0.0	0.5	0.5	0.4	0.6
Cardiovascular Disease	0.3	1.1	4.8	0.7	1.1	2.2	0.4	0.9	1.0	0.2	0.7	1.1	1.0	1.3	0.1
Respiratory disease	0.3	0.7	3.1	0.7	-1.8	1.6	0.8	-0.7	0.3	0.4	-0.3	-0.7	0.1	-0.3	-0.2
Lung FVC	0.3	1.4	5.0	0.3	2.2	2.0	-1.0	1.5	0.4	-0.8	1.0	0.0	0.7	1.1	-0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	-0.6	1.2	-0.8	0.1	-0.0	-0.6	-0.7	-0.6	0.6	-0.4	-0.4	-0.2
Angina	0.3	0.4	1.2	0.4	1.1	1.1	-0.0	0.2	0.4	-0.3	0.8	1.1	0.6	0.4	0.5
Medication: Metformin	0.3	0.4	1.4	-0.4	1.2	1.2	-0.7	-0.3	-0.1	-0.6	-0.6	-0.1	0.1	0.3	-0.5
Stomach or abdominal pain in last month	0.3	0.4	2.2	-0.3	1.5	0.4	0.1	0.5	-0.4	-0.0	-0.0	1.0	-0.3	-0.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.4	-0.4	1.6	0.0	-0.1	-0.7	-0.7	-1.2	-0.5	0.9	-0.3	-0.2	-0.1
Forced vital capacity (FVC)	0.3	1.0	4.6	-0.4	0.9	0.2	-1.2	-2.1	-1.2	-1.4	-0.2	-0.5	-1.1	-0.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.6	-0.5	0.5	0.3	0.2	-1.0	-0.9	0.8	-0.3	0.3	-1.2	-1.3	1.0
Impedance of arm (right)	0.3	1.2	4.1	-0.7	-1.6	0.9	-0.3	-1.1	-0.7	-0.6	-0.9	-2.0	-1.1	-1.3	-1.1
Pulse rate	0.3	0.4	1.9	0.1	0.0	-0.2	0.7	1.4	0.7	1.0	0.7	0.1	0.6	0.6	-0.0
Asthma	0.3	0.6	2.1	0.6	-1.5	1.4	0.0	-0.4	0.0	-0.2	-0.7	-1.0	-0.2	-0.4	-0.7
Standing height	0.3	2.7	13.7	-1.1	1.7	-1.9	-1.0	-3.7	-1.4	-1.6	-1.6	0.6	-1.5	-1.0	0.6
Tense / ‘highly strung’	0.3	0.5	2.2	0.6	1.5	1.5	0.0	0.5	0.1	-0.4	-0.6	-0.2	-0.1	-0.0	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.1	-0.8	-0.7	-0.2	-0.7	-0.2	-0.6	-0.1	-0.9	-1.0	-0.7	-0.7	-0.6
Birth weight	0.3	0.6	2.0	0.2	-0.9	-1.4	1.1	0.3	0.7	1.1	0.9	-0.5	0.4	-0.0	0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	3.3	-0.4	1.8	-0.1	-0.8	-1.8	-1.0	-1.8	0.2	-0.0	-0.6	-0.3	0.0
Number of full brothers	0.3	0.4	1.0	-0.1	-0.9	0.4	0.5	0.8	1.0	0.5	0.5	-0.9	0.8	0.6	-0.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	0.6	1.2	0.4	0.9	-0.6	0.3	0.3	0.6	0.9	0.6	-0.3	1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.7	-0.1	-0.5	1.6	-0.5	-0.1	-0.5	-0.7	0.2	-0.0	0.0	-0.0	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	-0.5	0.6	-0.4	-0.9	-0.5	-0.7	-1.2	-0.4	-1.0	-0.5	0.0	-0.7
Angina (self-reported)	0.3	0.4	1.2	0.4	1.0	1.1	-0.1	0.0	0.3	-0.5	1.0	0.9	0.5	0.4	0.4
Heart disease (mother)	0.3	0.4	1.3	0.2	-0.3	-0.1	0.6	1.1	0.6	-0.1	0.4	-0.1	0.5	1.0	-1.0
Pulse rate, automated reading	0.3	1.0	3.0	0.5	1.2	-0.4	0.5	1.0	1.1	0.1	1.4	1.3	1.3	1.7	0.3
Number of full sisters	0.3	0.3	1.0	-0.1	-0.1	1.0	0.1	-0.6	-0.8	0.3	-0.2	-0.1	-0.7	-0.8	0.8
Illnesses of siblings: Diabetes	0.3	0.3	1.4	-0.4	1.0	-0.4	0.1	1.2	0.5	0.3	-0.3	0.1	0.6	0.7	-0.2
Average weekly red wine intake	0.3	0.4	2.1	-0.8	-1.1	-1.4	0.3	0.5	-0.1	0.5	0.6	-0.4	-0.1	-0.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.3	0.1	-0.0	-1.2	-0.7	0.4	0.6	-0.1	-0.4	-0.7	0.3	0.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.8	-0.2	-1.3	0.8	0.3	0.3	0.2	0.0	1.0	-0.3	0.3	0.0	0.0
Ever taken oral contraceptive pill	0.3	0.3	1.1	-0.8	-1.1	-0.1	-0.7	-0.8	-0.3	-0.6	0.3	-0.3	-0.5	0.2	-0.7
Medication: Blood pressure	0.3	0.6	1.4	0.1	0.7	-0.2	-0.8	0.8	0.6	-1.2	0.6	-0.6	1.0	0.7	-1.1
Leg fat percentage (left)	0.3	1.1	3.5	-0.0	0.2	-0.2	-0.9	1.4	1.5	0.5	1.9	0.4	1.6	1.4	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.0	-0.6	-0.5	1.0	0.7	0.5	0.8	-0.6	-0.2	0.1	-0.3	-0.5
Diastolic blood pressure, automated reading	0.3	0.8	2.9	-1.1	1.6	0.1	-0.3	-1.0	-0.8	-0.8	-0.8	1.7	-0.5	0.2	0.1
Impedance of whole body	0.3	1.4	2.9	-0.7	-0.9	1.7	-0.4	-1.6	-0.9	-1.5	-0.9	-1.6	-1.0	-0.9	-1.3
Alzheimer’s Disease (in father)	0.2	0.3	1.3	-0.2	0.1	1.1	-0.8	-0.2	-0.0	-0.5	-0.1	-0.7	0.0	0.3	-0.5
Primary Biliary Cirrhosis	0.2	0.3	1.4	0.2	-0.1	0.1	0.3	0.9	-0.1	0.7	-0.7	1.2	-0.1	-0.4	0.6
Blood Platelet Count	0.2	2.9	7.3	-0.7	-0.0	-0.7	-1.6	1.8	1.5	-1.5	2.7	-1.2	2.1	2.7	-1.7
BMI	0.2	1.1	5.2	-0.5	0.6	-1.0	-1.1	1.2	1.0	0.4	2.3	0.1	1.2	1.0	0.1
Height	0.2	4.5	11.2	-1.3	2.5	-2.9	0.3	-3.4	-1.6	-0.0	-1.8	2.5	-1.7	-1.7	3.0
Waist Hip Ratio (WHR)	0.2	0.9	2.9	-1.2	0.4	-0.0	0.1	-1.3	-0.6	-1.4	-1.7	-0.4	-0.6	0.1	-1.5
Systolic Blood Pressure	0.2	0.8	1.9	-0.2	1.3	0.8	-0.1	-1.4	-0.7	-1.3	-1.3	1.2	-0.5	-0.1	-0.4
Hypothyroidism (self reported)	0.2	0.6	1.0	-0.8	-0.3	-0.6	-0.7	-0.7	-0.8	-0.4	-0.9	-0.8	-0.9	-1.0	-0.8
Lung FEV1/FVC ratio	0.2	0.9	5.0	0.8	0.2	0.3	-0.6	0.4	1.1	0.1	2.2	-0.4	1.3	1.2	0.4
Medication: Co-codamol	0.2	0.2	0.6	-0.2	0.8	-0.3	0.5	0.6	0.1	0.2	0.3	0.4	0.2	-0.1	0.6
Diabetes (mother)	0.2	0.3	1.0	0.2	0.1	-0.4	0.1	-0.3	-0.7	-0.6	-1.0	-0.6	-0.6	-1.0	-0.3
Leg fat-free mass (left)	0.2	0.9	3.8	-1.0	0.9	-2.0	-1.2	-1.5	-0.7	-0.4	-0.1	0.7	-0.6	-0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.9	-0.1	0.9	-0.5	0.7	0.3	-0.0	-0.1	-0.8	0.7	0.1	-0.1	0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.4	0.3	0.2	-0.3	0.6	0.1	-0.2	-0.9	-0.2	-0.1	0.7	-0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.0	0.4	-0.7	-1.0	0.2	-0.0	0.1	-0.4	0.0	-0.2	0.3	-0.1	-0.3
Supplements: Glucosamine	0.2	0.3	1.1	0.6	1.0	-0.2	0.9	-0.2	-0.2	0.2	0.1	0.7	-0.2	-0.4	0.9
Sitting height	0.2	1.3	5.9	-0.5	1.4	-0.6	-0.6	-2.4	-1.2	-0.2	-1.0	0.7	-1.3	-1.0	1.3
High blood pressure (mother)	0.2	0.2	1.0	0.2	-0.8	1.0	-0.7	-0.1	0.0	0.4	0.0	-0.3	0.1	-0.3	0.4
Body mass index (BMI)	0.2	0.8	1.9	-0.3	-0.2	-1.3	-0.9	1.2	0.9	1.0	1.4	0.4	1.0	0.6	0.3
Impedance of leg (left)	0.2	0.8	7.3	0.6	0.1	2.7	0.4	-0.9	0.4	-0.6	-0.0	-0.2	0.2	0.4	-0.4
Leg predicted mass (left)	0.2	0.9	3.8	-1.0	0.8	-1.9	-1.1	-1.4	-0.6	-0.3	0.0	0.6	-0.5	-0.4	0.7
Waist circumference	0.2	0.7	2.4	-0.2	0.0	-1.6	-0.5	0.8	1.2	0.5	1.0	0.2	1.3	0.9	-0.3
Financial difficulties in last 2 years	0.2	0.2	1.0	-0.6	0.6	0.2	-0.3	-1.0	-0.5	-0.5	-0.3	0.6	-0.2	-0.3	0.3
Medication: Ramipril	0.2	0.2	0.6	-0.2	0.2	-0.6	0.1	-0.4	0.3	-0.8	0.6	0.0	0.3	0.7	-0.4
Illnesses of siblings	0.2	0.3	1.0	1.0	0.1	0.3	0.5	-0.4	0.4	-0.1	0.9	0.8	0.4	0.6	0.6
Arm fat percentage (right)	0.2	0.9	2.7	-0.3	-1.2	-0.8	-1.0	1.2	1.1	1.1	1.7	-0.8	0.9	0.4	-0.2
Trunk fat-free mass	0.2	1.3	3.6	-0.0	1.9	-1.9	-0.2	-1.1	-0.0	0.7	-0.3	1.9	-0.1	0.1	1.8
Hip circumference	0.2	0.7	2.2	-0.5	-0.9	-1.5	-1.4	0.4	0.5	0.7	1.2	-0.5	0.4	-0.1	0.0
Time employed in main current job	0.2	0.2	1.1	0.1	1.0	0.5	0.4	-0.6	0.2	-0.3	-0.6	0.4	0.2	-0.1	0.3
Noisy workplace	0.2	0.2	0.7	0.8	-0.2	0.5	0.8	0.2	0.0	-0.5	0.5	0.3	0.1	0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	-0.8	0.2	-0.3	-0.5	0.1	-1.1	-0.8	-1.1	-0.2	-1.0	-0.3	-0.4
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.3	-0.6	0.9	0.3	0.1	-0.5	-0.1	-0.3	-0.8	-0.6	-0.8	-0.8
Arm fat mass (right)	0.2	0.7	1.9	-0.6	-0.9	-1.4	-1.2	0.5	0.8	1.0	1.4	-0.4	0.7	0.3	0.2
Trunk predicted mass	0.2	1.3	4.1	-0.2	1.8	-2.0	-0.3	-1.2	-0.1	0.7	-0.4	1.8	-0.2	0.0	1.8
Birth weight of first child	0.2	0.4	1.1	-0.5	1.0	-0.2	-1.0	-0.6	-0.7	-1.1	0.2	-0.1	-0.5	-0.0	-0.1
Gout (self-reported)	0.2	0.3	0.8	0.0	0.9	-0.5	0.2	-0.2	0.7	-0.5	-0.1	0.4	0.8	0.6	-0.3
High blood pressure (siblings)	0.2	0.3	0.6	-0.6	-0.6	-0.1	0.2	-0.5	-0.6	-0.4	-0.5	-0.5	-0.6	-0.5	-0.8
Body fat percentage	0.2	0.8	2.8	-0.6	-0.5	-0.8	-1.2	0.8	1.1	0.5	1.7	-0.3	1.1	0.7	-0.3
Arm fat-free mass (right)	0.2	1.0	3.5	-0.6	1.5	-1.9	-1.1	-1.3	-0.2	-0.4	0.0	1.3	-0.1	0.4	0.8
Comparative body size at age 10	0.2	0.6	4.7	-0.1	-0.7	-2.2	-0.5	-0.1	-0.3	-0.4	0.6	-0.7	-0.1	-0.3	-0.6
Qualifications: College or University degree	0.2	0.6	2.1	-0.5	-1.4	0.1	-0.0	-0.0	-0.8	-1.1	-0.2	-1.0	-0.5	-0.5	-1.0
Medication: Blood pressure	0.2	0.3	0.7	0.8	0.1	0.5	0.7	0.7	0.5	0.3	0.8	0.4	0.6	0.2	-0.3
Medication: Omeprazole	0.2	0.2	0.8	0.2	0.0	0.8	0.9	-0.3	0.6	0.0	0.4	0.5	0.5	-0.0	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.8	-0.3	-0.2	0.4	0.1	-0.1	-0.2	0.8	-0.3	-0.2	-0.4	-0.9	0.4
Leg fat mass (right)	0.2	0.9	2.8	-0.3	0.3	-1.3	-0.9	0.8	1.1	0.8	1.7	0.5	1.1	0.9	0.5
Arm predicted mass (right)	0.2	1.0	3.1	-0.2	1.8	-1.7	-0.8	-1.2	-0.0	0.1	-0.0	1.6	0.0	0.4	1.2
Whole body fat-free mass	0.2	1.0	3.2	-0.4	1.6	-1.8	-0.7	-1.4	-0.3	0.2	-0.2	1.4	-0.3	-0.0	1.3
Leg fat-free mass (right)	0.2	1.0	3.3	-1.1	0.8	-1.6	-1.2	-1.8	-0.9	-0.6	-0.3	0.6	-0.7	-0.6	0.5
Arm fat percentage (left)	0.2	0.9	2.4	-0.6	-1.0	-1.2	-1.4	1.0	0.8	0.7	1.6	-0.9	0.7	0.2	-0.3
Mood swings	0.2	0.3	1.9	-0.0	1.4	-0.1	-0.4	0.1	-0.0	0.5	-0.3	0.9	-0.1	0.0	0.8
Commuting to job workplace: Walk	0.2	0.3	0.9	0.3	-0.5	-0.7	0.5	0.9	0.3	1.0	-0.5	-0.4	0.1	0.0	0.1
Medication: Gliclazide	0.2	0.3	0.8	-0.3	0.7	0.2	-0.7	0.2	-0.4	-0.5	-0.9	-0.2	-0.3	-0.1	-0.8
Whole body water mass	0.2	0.9	3.5	-0.3	1.4	-1.9	-0.7	-1.3	-0.2	0.2	-0.1	1.3	-0.2	0.0	1.2
Leg predicted mass (right)	0.2	1.0	3.4	-1.1	0.8	-1.6	-1.2	-1.9	-0.9	-0.6	-0.3	0.6	-0.8	-0.7	0.5
Arm fat mass (left)	0.2	0.7	2.2	-0.7	-0.8	-1.5	-1.4	0.4	0.6	0.6	1.2	-0.5	0.6	0.2	-0.1
Guilty feelings	0.2	0.4	1.4	0.4	1.2	0.5	0.0	0.7	0.4	0.3	-1.0	0.7	0.2	0.2	-0.2
Mother’s age at death	0.2	0.2	1.4	0.5	0.3	-0.5	0.2	1.2	0.4	0.4	0.2	0.0	0.5	0.2	0.1
High cholesterol (Self-reported)	0.2	0.4	1.1	-0.1	0.7	0.1	-0.7	1.0	0.4	-0.2	-1.1	-0.0	0.4	0.5	-0.9
Ever smoked	0.2	0.4	1.5	-0.3	-0.8	0.2	0.6	-1.1	-0.6	-0.0	-0.4	-0.2	-0.8	-1.2	-0.3
Basal metabolic rate	0.2	0.9	3.3	-0.5	1.2	-1.8	-0.9	-1.4	-0.2	0.1	0.1	1.1	-0.2	-0.1	1.1
Arm fat-free mass (left)	0.2	0.9	2.9	-0.4	1.6	-1.7	-0.9	-1.0	0.1	-0.0	0.2	1.3	0.2	0.5	0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.2	0.8	0.0	-0.1	-0.7	0.1	-0.7	0.4	-0.5	0.2	0.2	-0.7
Leg fat mass (left)	0.2	0.7	2.5	-0.4	0.2	-1.0	-1.0	0.6	1.0	0.5	1.6	0.5	1.1	0.9	0.2
Arm predicted mass (left)	0.2	0.8	2.4	-0.2	1.6	-1.4	-0.8	-1.1	0.2	0.2	0.1	1.3	0.2	0.5	1.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.4	0.6	-0.2	1.2	1.2	-0.2	0.2	0.0	-0.2	0.8	0.2	0.2	0.8
Crohns Disease (2017)	0.1	0.2	1.1	0.1	0.5	0.6	0.2	0.8	0.2	1.0	0.1	0.3	0.0	0.0	0.4
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	-0.5	-0.1	-1.0	-1.0	0.6	-0.3	0.3	-0.6	-0.1	-0.4	-0.5	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.3	-0.1	0.2	1.2	0.3	-1.0	0.1	-0.2	0.2	0.9	0.1	0.4	0.7
Heel T-Score	0.1	0.9	3.2	0.8	1.8	1.0	-0.1	0.7	0.0	1.4	1.2	0.6	-0.3	-0.1	1.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.3	0.4	0.5	-0.4	0.0	0.5	-0.4	-0.2	-0.2	0.4	0.4	-0.5
Hair Pigment	0.1	2.3	5.7	0.1	-0.9	1.4	-2.0	-1.4	0.4	-2.4	1.4	-1.8	0.8	1.3	-2.4
Sensitivity / hurt feelings	0.1	0.2	0.7	0.0	0.8	0.8	-0.8	-0.8	-0.0	-0.4	-0.1	0.2	-0.1	0.2	0.0
Systolic blood pressure, automated reading	0.1	0.3	1.3	-0.3	0.9	-0.1	-0.2	-0.5	-0.6	-0.6	0.1	1.2	-0.3	0.1	0.5
Impedance of leg (right)	0.1	0.6	4.4	0.9	0.3	2.1	0.6	-0.4	0.7	-0.3	0.3	-0.1	0.5	0.8	-0.0
Trunk fat percentage	0.1	0.6	1.7	-0.9	-0.9	-0.9	-1.3	0.1	0.5	0.3	1.2	-0.6	0.5	0.1	-0.4
Trunk fat mass	0.1	0.5	1.8	-0.9	-0.4	-1.4	-1.2	-0.3	0.5	0.4	1.1	0.0	0.4	0.1	0.1
Heart attack	0.1	0.2	0.7	0.1	0.5	-0.2	-0.0	-0.8	-0.1	-0.6	0.1	-0.5	-0.0	-0.0	-0.7
Weight	0.1	0.7	4.2	-0.7	0.7	-2.0	-1.2	-0.4	0.4	0.3	0.8	0.7	0.5	0.2	0.6
Medication: Paracetamol	0.1	0.1	0.6	-0.3	0.1	0.1	-0.8	-0.5	0.1	-0.2	-0.1	0.1	-0.1	0.3	-0.5
Whole body fat mass	0.1	0.6	1.7	-0.8	-0.3	-1.3	-1.1	0.2	0.7	0.6	1.3	0.1	0.6	0.4	0.1
Comparative height size at age 10	0.1	0.6	2.8	-0.4	-0.9	-0.8	-0.4	-1.7	-0.2	-0.2	-1.2	-0.7	-0.5	-0.6	-0.6
Chest pain or discomfort	0.1	0.1	0.4	-0.4	0.2	0.3	-0.6	-0.4	-0.1	-0.5	-0.1	-0.4	-0.2	-0.3	-0.4
Medication: Paracetamol	0.1	0.2	0.6	-0.1	0.7	0.2	-0.5	-0.5	0.2	-0.1	0.2	0.7	-0.0	0.4	-0.1
Irritability	0.1	0.2	0.6	0.6	0.8	0.6	-0.1	-0.3	-0.0	-0.6	0.4	0.3	0.0	0.2	0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.7	-0.9	0.0	-0.2	0.2	-0.4	0.0	-0.6	-0.2	0.2	-0.0	-0.0	-0.3
Tanning	0.0	0.5	1.9	-0.6	0.5	0.5	-1.0	0.1	-0.1	-1.4	1.1	-0.5	0.3	0.6	-0.5

Hub : Genes

DEGS1

Models

Trait associations