Best TWAS P=9.16e-17 · Best GWAS P=2.35e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CDC42BPA | 0.10 | 0.05 | lasso | 5 | 0.02 | 3.6e-03 | -7.6 | 7.0 | 2.5e-12 | -0.89 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CDC42BPA | 0.08 | 0.12 | lasso | 2 | 0.07 | 1.5e-04 | -7.6 | 7.6 | 2.3e-14 | -0.88 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | ADCK3 | 0.11 | 0.00 | enet | 36 | 0.03 | 1.7e-02 | -3.5 | 5.3 | 1.4e-07 | -0.52 | 0.20 | 0.14 | FALSE |
| 4 | GTEx | Artery Aorta | CDC42BPA | 0.30 | 0.19 | lasso | 6 | 0.29 | 3.7e-16 | -7.6 | 8.1 | 6.4e-16 | -0.82 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Artery Coronary | CDC42BPA | 0.19 | 0.04 | lasso | 7 | 0.04 | 2.1e-02 | -7.8 | 7.1 | 9.8e-13 | -0.94 | 0.02 | 0.92 | FALSE |
| 6 | GTEx | Artery Tibial | CDC42BPA | 0.36 | 0.21 | enet | 41 | 0.26 | 2.0e-20 | -7.7 | 6.9 | 5.5e-12 | -0.82 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Artery Tibial | RP5-1087E8.3 | 0.12 | 0.03 | enet | 19 | 0.07 | 5.2e-06 | -7.7 | 7.4 | 1.4e-13 | -0.67 | 0.03 | 0.95 | FALSE |
| 8 | GTEx | Brain Cerebellum | CDC42BPA | 0.24 | 0.04 | lasso | 9 | 0.06 | 6.6e-03 | 6.3 | 7.6 | 2.1e-14 | -0.61 | 0.06 | 0.72 | FALSE |
| 9 | GTEx | Brain Cortex | CDC42BPA | 0.25 | 0.00 | enet | 24 | 0.06 | 9.1e-03 | -7.8 | 7.7 | 1.1e-14 | -0.85 | 0.03 | 0.89 | FALSE |
| 10 | GTEx | Breast Mammary Tissue | CDC42BPA | 0.15 | 0.04 | enet | 17 | 0.04 | 4.4e-03 | -7.6 | 7.6 | 4.1e-14 | -0.90 | 0.03 | 0.95 | FALSE |
| 11 | GTEx | Breast Mammary Tissue (Female) | CDC42BPA | 0.12 | -0.01 | lasso | 14 | -0.01 | 6.4e-01 | -7.7 | 7.4 | 1.3e-13 | -0.83 | 0.05 | 0.56 | FALSE |
| 12 | GTEx | Cells Transformed fibroblasts | CDC42BPA | 0.17 | 0.13 | lasso | 3 | 0.14 | 2.7e-10 | 5.3 | 5.3 | 1.4e-07 | -0.33 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Colon Sigmoid | CDC42BPA | 0.15 | 0.18 | lasso | 3 | 0.16 | 1.9e-06 | -4.3 | 5.5 | 3.2e-08 | -0.65 | 0.05 | 0.93 | FALSE |
| 14 | GTEx | Esophagus Gastroesophageal Junction | CDC42BPA | 0.27 | 0.09 | lasso | 13 | 0.14 | 1.0e-05 | -3.8 | 6.3 | 3.1e-10 | -0.67 | 0.08 | 0.90 | FALSE |
| 15 | GTEx | Esophagus Muscularis | CDC42BPA | 0.26 | 0.10 | lasso | 19 | 0.23 | 6.8e-14 | -7.6 | 8.1 | 4.4e-16 | -0.81 | 0.03 | 0.97 | FALSE |
| 16 | GTEx | Esophagus Muscularis | RP5-1087E8.3 | 0.09 | 0.00 | lasso | 4 | 0.01 | 4.2e-02 | -4.8 | 6.0 | 1.6e-09 | -0.62 | 0.04 | 0.87 | FALSE |
| 17 | GTEx | Heart Atrial Appendage | CDC42BPA | 0.14 | 0.02 | lasso | 5 | 0.04 | 8.1e-03 | -7.8 | 5.3 | 1.1e-07 | -0.78 | 0.04 | 0.91 | FALSE |
| 18 | GTEx | Testis | CDC42BPA | 0.15 | 0.19 | lasso | 4 | 0.17 | 7.5e-08 | -3.7 | 5.2 | 1.5e-07 | -0.54 | 0.34 | 0.66 | FALSE |
| 19 | GTEx | Whole Blood | ADCK3 | 0.14 | 0.17 | lasso | 5 | 0.17 | 3.4e-15 | -7.8 | -7.9 | 3.7e-15 | 0.98 | 0.01 | 0.99 | FALSE |
| 20 | METSIM | Adipose | CDC42BPA | 0.06 | 0.01 | bslmm | 604 | 0.01 | 2.3e-03 | -2.8 | 5.4 | 7.6e-08 | -0.55 | 0.23 | 0.34 | FALSE |
| 21 | NTR | Blood | ADCK3 | 0.06 | 0.08 | enet | 9 | 0.08 | 2.5e-23 | -7.9 | -8.3 | 9.2e-17 | 0.99 | 0.01 | 0.99 | TRUE |
| 22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CABC1 | 0.04 | 0.01 | blup | 116 | 0.02 | 1.3e-03 | -7.7 | 7.9 | 2.7e-15 | -0.82 | 0.02 | 0.89 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC42BPA | 0.09 | 0.04 | blup | 221 | 0.07 | 2.3e-08 | -7.8 | 7.8 | 6.8e-15 | -0.77 | 0.02 | 0.98 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | CABC1 | 0.04 | 0.00 | blup | 116 | 0.00 | 7.6e-02 | 6.2 | 7.7 | 1.1e-14 | -0.73 | 0.03 | 0.46 | FALSE |
| 25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CABC1 | 0.04 | 0.00 | blup | 116 | 0.02 | 3.7e-03 | -7.7 | 6.7 | 2.1e-11 | -0.76 | 0.03 | 0.71 | FALSE |