[Hub]/) : Traits : Blood White Count : ←

chr22:41,790,179-44,282,307

Best TWAS P=5.43e-15 · Best GWAS P=5.69e-13 conditioned to 0.0347

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Brain Frontal Cortex BA9	TTLL12	0.34	0.06	enet	21	0.10	1.6e-03	7.0	7.8	5.4e-15	0.68	0.02	0.75	TRUE
45	GTEx	Thyroid	NDUFA6-AS1	0.21	0.16	enet	22	0.19	3.3e-14	-5.1	5.8	7.0e-09	0.06	0.02	0.98	TRUE
7	GTEx	Adrenal Gland	TSPO	0.38	0.11	lasso	7	0.17	1.3e-06	6.2	-7.1	1.1e-12	-0.83	0.01	0.99	FALSE
30	GTEx	Nerve Tibial	TSPO	0.33	0.26	lasso	6	0.28	8.4e-20	-5.7	-6.5	1.1e-10	-0.59	0.95	0.05	FALSE
6	GTEx	Adipose Visceral Omentum	TSPO	0.29	0.28	lasso	3	0.26	6.1e-14	-6.1	-6.1	1.1e-09	-0.54	0.63	0.37	FALSE
18	GTEx	Cells Transformed fibroblasts	TSPO	0.31	0.16	lasso	3	0.26	3.2e-19	-5.2	-5.9	2.9e-09	-0.50	0.98	0.02	FALSE
4	GTEx	Adipose Subcutaneous	TSPO	0.32	0.17	lasso	3	0.17	1.7e-13	-6.1	-5.8	6.5e-09	-0.52	0.63	0.37	FALSE
16	GTEx	Breast Mammary Tissue (Female)	TSPO	0.24	0.06	lasso	5	0.02	6.6e-02	-6.1	-5.8	7.2e-09	-0.56	0.07	0.17	FALSE
21	GTEx	Colon Sigmoid	ARFGAP3	0.16	-0.01	lasso	5	0.00	3.9e-01	-5.1	5.8	8.2e-09	0.01	0.16	0.04	FALSE
14	GTEx	Breast Mammary Tissue	TSPO	0.23	0.10	lasso	6	0.08	6.0e-05	-6.1	-5.7	1.4e-08	-0.56	0.18	0.61	FALSE
19	GTEx	Colon Sigmoid	SMDT1	0.60	0.53	enet	24	0.52	3.1e-21	-5.1	5.6	1.7e-08	0.05	0.02	0.98	FALSE
25	GTEx	Esophagus Mucosa	CYP2D7P1	0.23	0.09	lasso	10	0.09	9.5e-07	-5.3	5.6	1.8e-08	0.07	0.02	0.98	FALSE
28	GTEx	Lung	SMDT1	0.47	0.45	enet	17	0.48	8.7e-41	-5.1	5.6	2.0e-08	0.07	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	C22orf32	0.19	0.20	blup	13	0.20	1.9e-22	-5.2	5.6	2.3e-08	0.06	0.00	0.99	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	NAGA	0.09	0.09	enet	7	0.11	7.0e-07	3.9	5.5	3.3e-08	0.00	0.06	0.88	FALSE
44	GTEx	Testis	RP4-669P10.16	0.35	0.33	enet	28	0.36	8.9e-17	-5.1	5.4	5.5e-08	0.06	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TTLL12	0.43	0.15	lasso	12	0.27	1.9e-33	7.0	5.4	5.8e-08	0.74	0.00	1.00	FALSE
20	GTEx	Colon Sigmoid	RP4-669P10.16	0.13	0.06	lasso	5	0.02	8.0e-02	-5.3	5.4	6.9e-08	0.06	0.02	0.90	FALSE
10	GTEx	Artery Coronary	SMDT1	0.39	0.37	lasso	6	0.34	5.0e-12	-5.2	5.4	7.1e-08	0.06	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	C22orf32	0.11	0.13	enet	5	0.14	2.4e-08	-5.2	5.4	8.4e-08	0.05	0.00	1.00	FALSE
41	GTEx	Stomach	CYP2D7P1	0.22	0.10	lasso	14	0.07	2.7e-04	-5.3	5.3	8.6e-08	0.08	0.02	0.95	FALSE
39	GTEx	Skin Sun Exposed Lower leg	CYP2D7P1	0.08	0.04	enet	10	0.07	2.0e-06	-5.1	5.3	9.1e-08	0.08	0.02	0.96	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	NAGA	0.02	0.00	blup	18	0.01	1.5e-02	-5.1	5.3	1.0e-07	0.02	0.01	0.77	FALSE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C22orf32	0.08	0.09	lasso	2	0.08	3.4e-06	-5.3	5.3	1.0e-07	0.06	0.00	0.99	FALSE
22	GTEx	Colon Transverse	CYP2D7P1	0.13	0.11	lasso	10	0.09	4.1e-05	-5.3	5.3	1.1e-07	0.06	0.02	0.97	FALSE
23	GTEx	Colon Transverse	NDUFA6-AS1	0.13	0.08	lasso	3	0.08	1.9e-04	-5.1	5.3	1.1e-07	0.09	0.02	0.97	FALSE
70	The Cancer Genome Atlas	Rectum Adenocarcinoma	C22orf32	0.22	0.16	lasso	1	0.15	2.3e-04	-5.3	5.3	1.1e-07	0.06	0.00	0.81	FALSE
71	The Cancer Genome Atlas	Soft Tissue Sarcoma	C22orf32	0.12	0.11	lasso	3	0.11	4.0e-07	-5.3	5.3	1.1e-07	0.06	0.00	1.00	FALSE
43	GTEx	Testis	TTLL12	0.38	0.20	enet	31	0.28	6.3e-13	-4.2	5.3	1.2e-07	0.24	1.00	0.00	FALSE
33	GTEx	Ovary	RP4-669P10.16	0.24	0.34	lasso	6	0.30	4.0e-08	-5.1	5.3	1.3e-07	0.06	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM109B	0.06	0.02	blup	337	0.03	7.4e-05	-3.7	5.3	1.4e-07	0.04	0.03	0.96	FALSE
38	GTEx	Skin Sun Exposed Lower leg	SMDT1	0.49	0.63	lasso	5	0.64	4.0e-69	-5.1	5.3	1.4e-07	0.06	0.02	0.98	FALSE
48	GTEx	Vagina	SMDT1	0.45	0.51	lasso	4	0.50	3.7e-13	-5.1	5.2	1.5e-07	0.06	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	C22orf32	0.11	0.16	lasso	3	0.16	3.0e-31	-5.2	5.2	1.5e-07	0.06	0.00	0.99	FALSE
66	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C22orf32	0.15	0.15	lasso	2	0.15	9.6e-07	-5.3	5.2	1.5e-07	0.06	0.00	0.99	FALSE
8	GTEx	Adrenal Gland	SMDT1	0.28	0.22	lasso	2	0.20	1.3e-07	-5.2	5.2	1.6e-07	0.06	0.02	0.98	FALSE
15	GTEx	Breast Mammary Tissue (Male)	SMDT1	0.40	0.38	lasso	1	0.38	1.2e-09	-5.2	5.2	1.6e-07	0.06	0.02	0.98	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	SMDT1	0.40	0.57	lasso	7	0.58	3.4e-25	-5.2	5.2	1.6e-07	0.06	0.02	0.98	FALSE
27	GTEx	Heart Atrial Appendage	RP4-669P10.16	0.08	0.11	lasso	8	0.11	1.3e-05	-5.1	5.2	1.6e-07	0.06	0.02	0.98	FALSE
46	GTEx	Uterus	SMDT1	0.53	0.52	lasso	10	0.44	2.3e-10	-5.1	5.2	1.6e-07	0.07	0.02	0.98	FALSE
51	YFS	Blood	TSPO	0.22	0.08	bslmm	550	0.11	2.5e-34	7.2	5.2	1.6e-07	0.76	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	C22orf32	0.16	0.18	enet	4	0.19	2.3e-21	-5.2	5.2	1.6e-07	0.06	0.00	0.99	FALSE
72	The Cancer Genome Atlas	Stomach Adenocarcinoma	NAGA	0.05	0.03	lasso	2	0.02	8.9e-03	3.9	5.2	1.6e-07	-0.03	0.01	0.17	FALSE
36	GTEx	Prostate	NDUFA6-AS1	0.26	0.05	enet	18	0.15	1.5e-04	-5.1	5.2	1.7e-07	0.04	0.02	0.90	FALSE
47	GTEx	Uterus	RRP7A	0.44	0.07	enet	16	0.19	1.0e-04	-3.7	-5.2	1.7e-07	-0.05	0.05	0.09	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C22orf32	0.20	0.24	lasso	2	0.24	1.1e-26	-5.2	5.2	1.7e-07	0.06	0.00	0.99	FALSE
29	GTEx	Muscle Skeletal	RP4-669P10.16	0.07	0.06	lasso	4	0.06	5.7e-07	-5.1	5.2	1.8e-07	0.06	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTLL12	0.16	0.00	blup	81	0.04	1.6e-03	1.1	5.2	1.8e-07	0.46	0.01	0.28	FALSE
5	GTEx	Adipose Subcutaneous	FAM109B	0.06	0.04	lasso	3	0.03	1.1e-03	-5.1	5.2	1.9e-07	0.07	0.02	0.97	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTLL12	0.07	0.02	blup	83	0.05	9.9e-06	-4.2	5.2	1.9e-07	0.24	0.24	0.06	FALSE
26	GTEx	Heart Atrial Appendage	SMDT1	0.13	0.14	lasso	6	0.10	2.9e-05	-5.2	5.2	2.1e-07	0.06	0.02	0.98	FALSE
32	GTEx	Ovary	SMDT1	0.55	0.70	enet	16	0.70	2.5e-23	-5.2	5.2	2.1e-07	0.07	0.02	0.98	FALSE
49	GTEx	Whole Blood	SMDT1	0.37	0.36	lasso	3	0.37	1.4e-35	-5.1	5.2	2.1e-07	0.06	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PACSIN2	0.07	0.05	lasso	3	0.04	7.7e-06	-4.7	5.2	2.2e-07	0.08	1.00	0.00	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	SMDT1	0.46	0.54	lasso	8	0.53	7.4e-34	-5.1	5.2	2.2e-07	0.06	0.02	0.98	FALSE
42	GTEx	Testis	CYP2D6	0.17	0.12	lasso	5	0.09	6.0e-05	-5.0	5.2	2.2e-07	0.06	0.03	0.96	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARFGAP3	0.05	0.05	lasso	5	0.06	6.5e-12	4.8	5.2	2.3e-07	0.14	0.03	0.96	FALSE
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C22orf32	0.10	0.10	lasso	4	0.11	8.4e-07	-5.3	5.2	2.4e-07	0.06	0.00	0.99	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	C22orf32	0.22	0.30	lasso	3	0.29	8.8e-31	-5.2	5.2	2.4e-07	0.06	0.00	0.99	FALSE
35	GTEx	Prostate	SMDT1	0.44	0.34	enet	10	0.34	2.7e-09	-5.2	5.2	2.5e-07	0.07	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NAGA	0.04	0.07	enet	3	0.07	1.1e-06	-5.2	5.2	2.5e-07	0.04	0.01	0.99	FALSE
9	GTEx	Artery Aorta	SMDT1	0.37	0.49	lasso	7	0.48	1.9e-29	-5.1	5.2	2.6e-07	0.07	0.02	0.97	FALSE
17	GTEx	Breast Mammary Tissue (Female)	SMDT1	0.50	0.38	lasso	5	0.36	1.1e-11	-5.1	5.2	2.6e-07	0.06	0.02	0.98	FALSE
50	NTR	Blood	C22orf32	0.09	0.18	lasso	3	0.18	2.7e-54	-5.2	5.2	2.6e-07	0.06	0.01	0.98	FALSE
11	GTEx	Artery Tibial	SMDT1	0.37	0.45	lasso	6	0.45	2.7e-38	-5.1	5.1	2.7e-07	0.06	0.02	0.98	FALSE
12	GTEx	Artery Tibial	ARFGAP3	0.07	0.05	enet	11	0.04	2.2e-04	4.7	5.1	2.7e-07	0.13	0.73	0.01	FALSE
34	GTEx	Pancreas	SMDT1	0.46	0.37	lasso	7	0.39	1.0e-17	-5.1	5.1	2.7e-07	0.07	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	C22orf32	0.14	0.07	lasso	4	0.07	3.1e-03	-5.1	5.1	2.8e-07	0.06	0.00	0.70	FALSE
67	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C22orf32	0.11	0.13	lasso	4	0.12	1.5e-05	-5.1	5.1	2.8e-07	0.06	0.00	0.98	FALSE
73	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C22orf32	0.34	0.25	lasso	4	0.25	2.0e-09	-5.1	5.1	2.8e-07	0.06	0.00	0.99	FALSE
31	GTEx	Nerve Tibial	RP4-669P10.16	0.06	0.08	lasso	2	0.05	1.2e-04	-5.1	5.1	2.9e-07	0.06	0.02	0.97	FALSE
40	GTEx	Stomach	SMDT1	0.47	0.52	enet	12	0.51	3.3e-28	-5.1	5.1	2.9e-07	0.07	0.02	0.97	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C22orf32	0.08	0.04	lasso	2	0.04	2.1e-05	-5.3	5.1	3.0e-07	0.06	0.00	0.99	FALSE