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chr22:38,447,444-40,571,499

Best TWAS P=1.83e-32 · Best GWAS P=5.07e-27 conditioned to 0.243

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CBX7	0.09	0.07	bslmm	416	0.06	2.7e-07	-10.6	-11.9	1.8e-32	0.88	0.01	0.99	TRUE
21	NTR	Blood	APOBEC3G	0.04	0.02	lasso	5	0.02	3.9e-08	-8.5	9.1	1.1e-19	-0.26	0.97	0.00	TRUE
8	GTEx	Breast Mammary Tissue (Female)	MGAT3	0.25	-0.01	enet	83	0.02	7.9e-02	-3.5	-6.6	3.2e-11	0.10	0.08	0.10	TRUE
28	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	APOBEC3H	0.08	0.06	lasso	3	0.06	3.6e-05	-9.3	9.9	3.8e-23	-0.68	0.18	0.70	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	APOBEC3H	0.09	0.06	lasso	3	0.06	3.2e-04	-6.6	9.8	1.0e-22	-0.61	0.02	0.78	FALSE
7	GTEx	Brain Hippocampus	COX5BP7	0.26	0.13	enet	24	0.11	1.5e-03	-9.3	9.8	1.7e-22	-0.72	0.02	0.90	FALSE
12	GTEx	Heart Left Ventricle	APOBEC3G	0.09	0.05	lasso	3	0.02	2.5e-02	-8.1	9.3	1.1e-20	-0.57	0.39	0.18	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	APOBEC3H	0.08	0.05	lasso	10	0.05	4.3e-11	-6.6	9.3	1.7e-20	-0.50	1.00	0.00	FALSE
22	YFS	Blood	APOBEC3G	0.20	0.11	enet	21	0.14	1.8e-42	-8.5	9.0	2.6e-19	-0.28	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOBEC3H	0.09	0.00	blup	45	0.05	5.5e-06	-8.5	9.0	2.9e-19	-0.47	0.16	0.29	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	COX5BP7	0.17	0.15	enet	5	0.16	5.2e-09	-8.1	8.3	1.1e-16	-0.61	1.00	0.00	FALSE
15	GTEx	Nerve Tibial	COX5BP7	0.44	0.25	enet	33	0.25	1.7e-17	-8.1	8.0	1.4e-15	-0.61	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	COX5BP7	0.33	0.21	lasso	5	0.19	1.2e-15	-8.1	7.9	2.0e-15	-0.63	1.00	0.00	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	COX5BP7	0.35	0.25	lasso	6	0.25	1.8e-09	-8.1	7.7	1.4e-14	-0.59	0.97	0.02	FALSE
6	GTEx	Brain Cortex	COX5BP7	0.32	0.11	enet	23	0.26	9.5e-08	-8.1	7.6	3.7e-14	-0.67	0.08	0.82	FALSE
19	GTEx	Thyroid	COX5BP7	0.09	0.04	enet	13	0.05	1.2e-04	-8.3	7.5	7.8e-14	-0.67	0.82	0.12	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	APOBEC3H	0.05	0.01	enet	12	0.01	1.8e-02	-8.5	7.4	1.0e-13	-0.43	0.02	0.25	FALSE
20	NTR	Blood	APOBEC3F	0.03	0.00	enet	27	0.01	2.5e-04	-7.6	7.3	3.5e-13	-0.51	0.65	0.22	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	APOBEC3H	0.15	0.01	blup	46	0.04	4.7e-04	-6.6	7.0	2.6e-12	-0.31	0.16	0.06	FALSE
4	GTEx	Artery Aorta	COX5BP7	0.20	0.13	enet	13	0.16	5.9e-09	-8.1	6.9	6.0e-12	-0.65	1.00	0.00	FALSE
18	GTEx	Spleen	RP3-508I15.21	0.28	-0.01	enet	24	0.03	4.9e-02	8.2	-6.8	1.3e-11	0.37	0.05	0.12	FALSE
5	GTEx	Artery Tibial	COX5BP7	0.42	0.27	enet	20	0.32	1.6e-25	-8.1	6.7	1.5e-11	-0.56	1.00	0.00	FALSE
23	YFS	Blood	CBX7	0.04	0.02	blup	395	0.02	1.2e-08	8.3	-6.6	5.5e-11	0.68	0.73	0.27	FALSE
13	GTEx	Muscle Skeletal	COX5BP7	0.10	0.09	lasso	3	0.13	8.6e-13	-9.3	6.5	9.3e-11	-0.66	1.00	0.00	FALSE
11	GTEx	Esophagus Muscularis	COX5BP7	0.30	0.17	enet	8	0.21	5.7e-13	-8.1	6.4	1.4e-10	-0.57	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	APOBEC3H	0.10	0.02	enet	6	0.04	3.8e-05	-1.5	6.3	3.2e-10	-0.28	0.03	0.06	FALSE
17	GTEx	Skin Sun Exposed Lower leg	COX5BP7	0.21	0.13	enet	8	0.16	3.7e-13	-3.0	6.0	2.4e-09	-0.62	1.00	0.00	FALSE
14	GTEx	Nerve Tibial	CBX6	0.14	0.01	enet	27	0.06	7.0e-05	1.7	5.8	7.2e-09	-0.41	0.11	0.16	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MGAT3	0.04	0.00	blup	392	0.00	1.9e-01	3.5	-5.5	3.9e-08	0.12	0.12	0.04	FALSE
10	GTEx	Esophagus Muscularis	MGAT3	0.09	0.02	enet	15	0.02	1.3e-02	3.4	-5.4	6.3e-08	0.14	0.21	0.05	FALSE