Best TWAS P=1.83e-32 · Best GWAS P=5.07e-27 conditioned to 0.243
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CBX7 | 0.09 | 0.07 | bslmm | 416 | 0.06 | 2.7e-07 | -10.6 | -11.9 | 1.8e-32 | 0.88 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MGAT3 | 0.04 | 0.00 | blup | 392 | 0.00 | 1.9e-01 | 3.5 | -5.5 | 3.9e-08 | 0.12 | 0.12 | 0.04 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | COX5BP7 | 0.33 | 0.21 | lasso | 5 | 0.19 | 1.2e-15 | -8.1 | 7.9 | 2.0e-15 | -0.63 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Aorta | COX5BP7 | 0.20 | 0.13 | enet | 13 | 0.16 | 5.9e-09 | -8.1 | 6.9 | 6.0e-12 | -0.65 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Tibial | COX5BP7 | 0.42 | 0.27 | enet | 20 | 0.32 | 1.6e-25 | -8.1 | 6.7 | 1.5e-11 | -0.56 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Cortex | COX5BP7 | 0.32 | 0.11 | enet | 23 | 0.26 | 9.5e-08 | -8.1 | 7.6 | 3.7e-14 | -0.67 | 0.08 | 0.82 | FALSE |
| 7 | GTEx | Brain Hippocampus | COX5BP7 | 0.26 | 0.13 | enet | 24 | 0.11 | 1.5e-03 | -9.3 | 9.8 | 1.7e-22 | -0.72 | 0.02 | 0.90 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | MGAT3 | 0.25 | -0.01 | enet | 83 | 0.02 | 7.9e-02 | -3.5 | -6.6 | 3.2e-11 | 0.10 | 0.08 | 0.10 | TRUE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | COX5BP7 | 0.35 | 0.25 | lasso | 6 | 0.25 | 1.8e-09 | -8.1 | 7.7 | 1.4e-14 | -0.59 | 0.97 | 0.02 | FALSE |
| 10 | GTEx | Esophagus Muscularis | MGAT3 | 0.09 | 0.02 | enet | 15 | 0.02 | 1.3e-02 | 3.4 | -5.4 | 6.3e-08 | 0.14 | 0.21 | 0.05 | FALSE |
| 11 | GTEx | Esophagus Muscularis | COX5BP7 | 0.30 | 0.17 | enet | 8 | 0.21 | 5.7e-13 | -8.1 | 6.4 | 1.4e-10 | -0.57 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Heart Left Ventricle | APOBEC3G | 0.09 | 0.05 | lasso | 3 | 0.02 | 2.5e-02 | -8.1 | 9.3 | 1.1e-20 | -0.57 | 0.39 | 0.18 | FALSE |
| 13 | GTEx | Muscle Skeletal | COX5BP7 | 0.10 | 0.09 | lasso | 3 | 0.13 | 8.6e-13 | -9.3 | 6.5 | 9.3e-11 | -0.66 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Nerve Tibial | CBX6 | 0.14 | 0.01 | enet | 27 | 0.06 | 7.0e-05 | 1.7 | 5.8 | 7.2e-09 | -0.41 | 0.11 | 0.16 | FALSE |
| 15 | GTEx | Nerve Tibial | COX5BP7 | 0.44 | 0.25 | enet | 33 | 0.25 | 1.7e-17 | -8.1 | 8.0 | 1.4e-15 | -0.61 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | COX5BP7 | 0.17 | 0.15 | enet | 5 | 0.16 | 5.2e-09 | -8.1 | 8.3 | 1.1e-16 | -0.61 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | COX5BP7 | 0.21 | 0.13 | enet | 8 | 0.16 | 3.7e-13 | -3.0 | 6.0 | 2.4e-09 | -0.62 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Spleen | RP3-508I15.21 | 0.28 | -0.01 | enet | 24 | 0.03 | 4.9e-02 | 8.2 | -6.8 | 1.3e-11 | 0.37 | 0.05 | 0.12 | FALSE |
| 19 | GTEx | Thyroid | COX5BP7 | 0.09 | 0.04 | enet | 13 | 0.05 | 1.2e-04 | -8.3 | 7.5 | 7.8e-14 | -0.67 | 0.82 | 0.12 | FALSE |
| 20 | NTR | Blood | APOBEC3F | 0.03 | 0.00 | enet | 27 | 0.01 | 2.5e-04 | -7.6 | 7.3 | 3.5e-13 | -0.51 | 0.65 | 0.22 | FALSE |
| 21 | NTR | Blood | APOBEC3G | 0.04 | 0.02 | lasso | 5 | 0.02 | 3.9e-08 | -8.5 | 9.1 | 1.1e-19 | -0.26 | 0.97 | 0.00 | TRUE |
| 22 | YFS | Blood | APOBEC3G | 0.20 | 0.11 | enet | 21 | 0.14 | 1.8e-42 | -8.5 | 9.0 | 2.6e-19 | -0.28 | 1.00 | 0.00 | FALSE |
| 23 | YFS | Blood | CBX7 | 0.04 | 0.02 | blup | 395 | 0.02 | 1.2e-08 | 8.3 | -6.6 | 5.5e-11 | 0.68 | 0.73 | 0.27 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | APOBEC3H | 0.08 | 0.05 | lasso | 10 | 0.05 | 4.3e-11 | -6.6 | 9.3 | 1.7e-20 | -0.50 | 1.00 | 0.00 | FALSE |
| 25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | APOBEC3H | 0.09 | 0.00 | blup | 45 | 0.05 | 5.5e-06 | -8.5 | 9.0 | 2.9e-19 | -0.47 | 0.16 | 0.29 | FALSE |
| 26 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | APOBEC3H | 0.09 | 0.06 | lasso | 3 | 0.06 | 3.2e-04 | -6.6 | 9.8 | 1.0e-22 | -0.61 | 0.02 | 0.78 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Adenocarcinoma | APOBEC3H | 0.05 | 0.01 | enet | 12 | 0.01 | 1.8e-02 | -8.5 | 7.4 | 1.0e-13 | -0.43 | 0.02 | 0.25 | FALSE |
| 28 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | APOBEC3H | 0.08 | 0.06 | lasso | 3 | 0.06 | 3.6e-05 | -9.3 | 9.9 | 3.8e-23 | -0.68 | 0.18 | 0.70 | FALSE |
| 29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | APOBEC3H | 0.10 | 0.02 | enet | 6 | 0.04 | 3.8e-05 | -1.5 | 6.3 | 3.2e-10 | -0.28 | 0.03 | 0.06 | FALSE |
| 30 | The Cancer Genome Atlas | Stomach Adenocarcinoma | APOBEC3H | 0.15 | 0.01 | blup | 46 | 0.04 | 4.7e-04 | -6.6 | 7.0 | 2.6e-12 | -0.31 | 0.16 | 0.06 | FALSE |