Best TWAS P=7.41e-34 · Best GWAS P=6.28e-69 conditioned to 4.95e-37
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | LYST | 0.21 | 0.20 | lasso | 6 | 0.20 | 1.3e-14 | 11.87 | 12.1 | 7.4e-34 | 0.71 | 0.70 | 0.30 | TRUE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | LYST | 0.18 | 0.15 | lasso | 2 | 0.11 | 2.0e-06 | 8.45 | 8.4 | 3.0e-17 | 0.56 | 0.29 | 0.69 | FALSE |
| 3 | YFS | Blood | LYST | 0.05 | 0.01 | bslmm | 485 | 0.01 | 1.7e-04 | 0.57 | -7.0 | 2.1e-12 | -0.42 | 0.06 | 0.55 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | LYST | 0.19 | 0.23 | lasso | 8 | 0.22 | 3.9e-21 | 5.76 | 6.5 | 6.5e-11 | 0.46 | 1.00 | 0.00 | FALSE |