TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Blood White Count
:
←
→
chr1:235,130,526-236,744,971
Best TWAS P=7.41e-34 · Best GWAS P=6.28e-69 conditioned to 4.95e-37
235.2M
235.4M
235.6M
235.8M
236M
236.2M
236.4M
236.6M
236.8M
0
20
40
60
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
LYST
0.21
0.20
lasso
6
0.20
1.3e-14
11.87
12.1
7.4e-34
0.71
0.70
0.30
TRUE
2
GTEx
Skin Not Sun Exposed Suprapubic
LYST
0.18
0.15
lasso
2
0.11
2.0e-06
8.45
8.4
3.0e-17
0.56
0.29
0.69
FALSE
3
YFS
Blood
LYST
0.05
0.01
bslmm
485
0.01
1.7e-04
0.57
-7.0
2.1e-12
-0.42
0.06
0.55
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
LYST
0.19
0.23
lasso
8
0.22
3.9e-21
5.76
6.5
6.5e-11
0.46
1.00
0.00
FALSE