Hub : Genes

LYST

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0997	0.0406	1.3e-03	0.034	NA	0.013	NA	0.026	1.0e-03	NA	2.9e-02	NA	4.0e-03
2	GTEx	Cells Transformed fibroblasts	0.2060	0.0480	6.4e-08	0.198	NA	0.179	NA	0.195	8.1e-15	NA	2.0e-13	NA	1.3e-14
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1850	0.0650	2.0e-03	0.148	NA	0.057	NA	0.106	1.6e-08	NA	4.7e-04	NA	2.0e-06
4	YFS	Blood	0.0462	0.0181	9.4e-04	0.009	0.007	0.001	0.01	0.004	3.6e-04	1.4e-03	1.8e-01	0.00017	1.4e-02
5	TCGA	Thyroid Carcinoma	0.1860	0.0510	0.0e+00	0.231	0.203	0.218	NA	0.220	3.2e-22	2.0e-19	5.8e-21	NA	3.9e-21

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	3.8	-1.9	0.2	-0.8	1.4	-0.5
Bipolar Disorder or Schizophrenia	0.6	1.4	4.9	-2.2	-0.1	-0.5	1.1	-0.9
Depressed Affect (Nagel 2018)	0.4	0.7	1.9	-0.7	-0.4	-0.9	-1.4	-0.6
Depression (Nagel 2018)	1.5	2.3	4.3	-2.1	-1.3	-2.0	-0.2	-1.2
Intelligence (Savage-Jansen 2018)	0.7	2.3	10.3	0.6	0.9	3.2	0.1	0.0
Neuroticism (Nagel 2018)	0.3	0.7	2.2	-0.8	-0.4	-1.5	-0.5	-0.3
Schizophrenia (2018)	0.2	0.5	1.7	-1.3	-0.2	0.1	0.2	-0.7
Schizophrenia vs Biploar Disorder	1.0	1.3	3.1	-0.1	-1.5	-0.8	-0.4	-1.8
Worry (Nagel 2018)	0.6	1.3	3.1	-1.0	-1.3	-1.8	0.5	-0.6
Alzheimer’s Disease (in mother)	0.8	1.0	2.0	0.0	1.3	1.0	-0.2	1.4
Alzheimer’s Disease (in father)	1.5	1.7	2.8	1.0	1.7	0.8	-1.6	1.1
Alzheimer’s Disease (including proxy)	1.5	2.1	4.8	0.8	2.2	0.7	-1.1	1.8
Crohns Disease (2017)	0.3	0.7	1.6	-0.7	0.6	1.3	1.0	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.7	0.0	0.1	0.6	-0.7
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.8	-0.3	-0.9	0.1	-0.5
Major Depression (MDD)	0.7	0.8	1.1	-1.0	1.1	0.2	-0.9	-1.0
Reaction Time	0.5	1.0	2.0	-1.1	-0.5	-1.4	1.3	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.4	0.5	0.7	0.4	-0.1
Breast Cancer	0.2	0.5	1.8	-0.1	-1.3	-0.5	0.6	-0.2
Ovarian Cancer	2.4	3.2	8.4	2.3	1.4	0.5	0.2	2.9
Prostate Cancer	1.7	2.4	6.9	-1.3	-1.3	-1.2	-0.4	-2.6
Age at First Birth	1.8	2.6	4.8	2.2	1.5	0.5	-1.9	1.4
Bipolar Disorder (2011)	1.7	1.6	4.1	-2.0	-0.7	-0.2	1.5	-1.2
Body Mass Index (BMI) (2010)	2.3	3.1	5.1	-1.7	-1.6	-1.1	1.9	-2.2
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.7	-0.4	-0.0	-0.7	0.0
Crohns Disease (2012)	0.2	0.3	0.7	-0.7	-0.1	0.4	0.8	-0.1
Mean Putamen Volume	0.5	0.6	1.2	0.0	-0.7	-0.3	-1.0	-1.1
Fasting Glucose	0.2	0.2	0.6	0.3	-0.3	0.8	0.3	-0.0
HbA1C	0.8	0.9	2.1	1.5	0.9	-0.1	-0.6	1.1
HDL Cholesterol	0.2	0.3	1.2	-0.1	0.5	1.1	0.2	0.3
LDL Cholesterol	1.0	1.5	3.4	-0.9	0.1	1.7	1.9	0.6
Lupus	2.1	3.2	11.0	-1.6	-1.4	-0.4	-0.6	-3.3
Neuroticism (2016)	0.9	1.4	3.1	-0.8	-0.9	-1.4	0.6	-1.8
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.7	-0.3	0.6	-0.1	-1.0
Rheumatoid Arthritis	4.6	6.3	15.1	-1.2	-3.9	-0.9	1.9	-3.2
Schizophrenia (2014)	1.0	2.1	2.9	-1.7	-1.6	-1.2	1.0	-1.7
Triglycerides	0.6	1.0	2.3	1.3	0.9	0.1	-0.3	1.5
Type 2 Diabetes (T2D) (2012)	1.4	1.7	4.8	-1.3	-0.6	0.9	0.9	-2.2
Ulcerative Colitis	0.9	1.3	4.8	-0.4	-0.4	-2.2	-0.7	-1.0
Blood Eosinophil Count	0.1	1.0	2.2	0.9	-1.5	-0.1	1.4	-0.2
Blood Platelet Count	0.4	4.7	11.4	1.4	-2.5	-1.7	3.4	-0.9
Blood Red Count	0.1	1.0	2.0	1.0	-0.8	0.9	1.4	-0.6
Blood White Count	8.4	62.0	146.4	0.4	12.1	8.4	-7.0	6.5
Heel T-Score	0.2	1.6	4.7	0.7	-1.7	-0.1	-2.2	0.1
BMI	0.3	1.8	3.1	-1.8	-0.4	1.4	1.3	-1.3
Height	0.1	1.7	5.3	-2.3	-0.2	0.4	0.7	-1.6
Waist Hip Ratio (WHR)	0.3	1.6	4.2	-0.5	-1.6	-2.0	0.2	0.8
Systolic Blood Pressure	0.3	1.3	4.7	-2.2	-0.4	0.1	1.1	-0.7
Smoking Status	0.3	0.7	2.3	-1.5	0.7	0.8	0.1	0.5
Allergy or Eczema	0.9	2.3	5.8	1.2	-1.6	-2.4	-1.4	-0.1
Cardiovascular Disease	0.7	2.2	6.4	-1.6	-0.8	1.1	2.5	0.4
Hypothyroidism (self reported)	1.9	4.4	11.8	-2.3	-1.3	0.5	1.6	-3.4
Respiratory disease	0.5	1.1	1.7	1.3	-1.2	-1.1	-1.0	0.1
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.3	-1.6	-1.6	-0.2	2.1	-1.0
Lung FEV1/FVC ratio	0.5	2.7	6.2	-0.7	-0.5	2.4	2.5	-0.9
Lung FVC	0.3	1.5	3.9	1.5	0.2	-2.0	-1.2	0.2
Neuroticism	0.5	1.2	2.3	0.4	-1.1	-1.5	-1.3	-0.8
Chronotype (morning person)	0.2	0.4	1.1	-0.3	0.0	1.0	0.8	-0.5
Hair Pigment	1.0	29.8	64.3	3.1	8.0	1.8	-3.1	7.9
Tanning	0.1	1.3	4.3	-0.8	-2.1	-0.1	1.3	-0.2
Hand grip strength (left)	0.1	0.3	0.9	-0.4	0.9	-0.3	0.7	-0.0
Number of treatments/medications taken	1.1	1.9	4.8	-2.2	-0.7	0.7	1.6	-1.1
Average weekly spirits intake	0.5	0.6	1.5	-0.1	0.1	-0.1	-1.2	-1.2
Sensitivity / hurt feelings	1.6	2.7	9.5	-0.7	-1.6	-3.1	0.3	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	-1.3	-0.2	-1.2	0.3	-0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.8	-0.9	-0.1	0.1	-0.5	0.1
Relative age of first facial hair	1.4	2.8	8.9	0.1	3.0	1.1	0.1	2.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.6	0.3	0.9	1.6	-0.2	0.8
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.9	-1.4	1.2	0.3	-0.3	0.2
Ever had hysterectomy (womb removed)	1.5	1.7	2.9	-1.5	-0.7	1.7	1.6	-0.2
Systolic blood pressure, automated reading	0.2	0.7	1.5	-1.1	1.2	0.6	0.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.6	0.3	0.7	0.5	0.1	1.3
Angina	0.2	0.2	0.5	-0.4	-0.7	-0.3	0.5	-0.0
Medication for hormone replacement therapy	0.2	0.2	0.6	0.2	0.5	0.2	-0.8	0.5
Vitamin and mineral supplements	1.4	1.9	3.2	-0.7	1.5	1.8	1.2	1.4
Supplements: Zinc	0.6	0.7	1.5	0.8	-0.3	-1.2	-0.8	0.7
Medication: Co-codamol	0.4	0.4	1.3	0.1	1.2	0.3	-0.2	0.8
Medication: Metformin	1.4	1.9	5.2	-2.3	-0.5	0.3	2.0	0.1
Diabetes (father)	0.1	0.1	0.4	-0.2	0.2	0.6	0.4	-0.3
Diabetes (mother)	0.5	0.7	1.4	0.1	-0.5	1.2	0.8	-1.1
Severe depression (siblings)	1.4	1.5	2.1	-1.5	-1.4	-0.9	1.2	-1.2
Pack years adult smoking proportion	0.8	1.2	2.2	-1.1	-0.1	-1.0	1.5	1.2
Impedance of leg (right)	0.8	3.9	11.8	1.5	1.8	1.2	-0.7	3.4
Leg fat-free mass (left)	0.9	4.9	10.8	-3.3	-1.6	0.1	2.4	-2.4
Trunk fat percentage	0.7	2.9	7.2	-1.8	-1.2	1.6	2.7	-0.6
Hand grip strength (right)	0.3	0.9	1.8	-1.4	0.0	-0.7	1.0	-1.0
Townsend deprivation index at recruitment	3.3	4.6	7.7	-2.4	-2.4	-1.1	1.6	-2.8
Current tobacco smoking	0.3	0.6	1.2	-0.5	-0.4	-0.5	1.1	0.9
Average weekly fortified wine intake	0.5	0.6	1.6	1.3	0.6	0.4	-0.6	-0.6
Maternal smoking around birth	0.2	0.2	0.6	-0.2	-0.1	0.1	0.8	0.6
Fed-up feelings	0.3	0.6	1.3	0.0	-1.0	-0.7	-1.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-1.5	-0.3	-0.7	-0.1	-0.7
Relative age voice broke	0.2	0.3	0.8	0.1	-0.4	-0.4	0.9	-0.7
Taking other prescription medications	1.0	1.5	3.6	-1.6	-1.0	0.1	1.9	-0.6
Age when periods started (menarche)	0.5	1.3	2.1	-1.4	-1.4	-1.1	1.0	-0.6
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.2	-1.7	-1.3	0.2	1.8	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.6	1.0	-0.1	1.6	-1.3	0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.2	-0.0	-0.9	-1.1	-0.9	0.1
Qualifications: CSEs or equivalent	0.7	0.9	2.2	-1.5	-0.1	0.9	1.1	-0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.9	0.1	-0.1	-0.1	0.5	0.9
High blood pressure	1.3	3.6	10.8	-2.4	-0.8	0.8	3.3	-0.1
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.2	1.9	-0.8	-1.5	-2.0	0.7
Multivitamins +/- minerals	0.8	1.0	2.2	1.2	-0.4	-0.9	-1.5	-0.7
Stomach or abdominal pain in last month	0.7	0.8	2.1	0.8	0.6	-0.0	-1.1	1.5
Supplements: Glucosamine	0.7	1.0	2.9	-0.3	-0.5	-1.7	-0.6	-1.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	-0.1	0.0	0.1	0.2	0.9
Medication: Atenolol	0.4	0.4	1.4	-0.3	0.0	0.4	1.2	0.7
Medication: Levothyroxine sodium	1.2	2.1	6.4	-1.7	-0.9	0.5	0.2	-2.5
Sitting height	0.6	4.1	7.8	-2.2	-2.7	-0.3	0.6	-2.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	0.7	-0.7	-0.6	1.4	0.5
High blood pressure (mother)	0.5	0.7	1.0	-0.8	-0.3	-1.0	0.8	-1.0
Body mass index (BMI)	0.4	1.6	2.9	-1.6	-0.4	1.4	1.7	-0.8
Impedance of leg (left)	0.6	3.0	9.1	1.4	1.5	1.2	-0.4	3.0
Leg predicted mass (left)	0.9	4.8	10.6	-3.3	-1.6	0.1	2.4	-2.3
Trunk fat mass	0.9	3.8	7.8	-2.4	-1.3	1.6	2.8	-1.0
Waist circumference	0.7	2.5	7.2	-1.8	-1.0	0.8	2.7	-0.6
Number of incorrect matches in round	0.4	0.6	1.7	-1.0	0.5	-1.3	-0.5	0.2
Past tobacco smoking	0.7	1.2	5.2	0.2	-0.6	-2.3	0.5	-0.4
Alcohol usually taken with meals	0.3	0.4	1.5	0.5	0.2	0.5	-1.2	-0.3
Nervous feelings	0.2	0.4	1.3	-0.5	0.0	-0.5	0.3	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	-0.7	-0.5	0.2	-0.9	-0.7
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.8	0.0	0.0	-0.3	0.3
Hair/balding pattern: Pattern 2	0.3	0.3	1.0	0.6	0.4	-0.2	0.3	1.0
Had menopause	0.6	0.7	1.6	-0.4	1.1	1.2	0.9	0.0
Had other major operations	0.9	1.1	3.6	-0.0	1.9	0.5	-0.4	1.2
Forced vital capacity (FVC)	0.1	0.3	1.3	-0.2	0.2	-0.3	0.3	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.0	-0.3	-0.9	0.7	-0.9	-1.0
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	4.4	-0.6	-1.2	-2.1	-0.8	-1.6
Qualifications: None of the above	0.3	0.6	1.3	-1.0	0.4	-0.3	1.1	0.6
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.1	-1.1	0.4	0.2	0.9
Mouth/teeth dental problems	0.6	0.9	1.8	-0.3	0.8	1.3	1.3	-0.7
Heart attack	0.2	0.3	0.9	-0.9	-0.8	-0.2	-0.1	0.2
Allergy	1.4	3.1	5.0	-2.1	1.5	2.2	1.9	-0.5
Pain all over the body in last month	0.2	0.3	0.7	-0.9	0.2	0.5	0.2	0.5
Diabetes (self-reported)	1.5	2.3	6.0	-2.1	-0.7	0.3	2.5	-0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.4	1.4	-0.9	-0.5	-1.9	-0.2
Medication: Ramipril	0.2	0.3	0.5	-0.7	-0.6	-0.6	0.6	-0.0
Medication: Simvastatin	0.9	1.4	4.7	-0.1	-1.4	-0.4	2.2	-0.4
Fluid intelligence score	0.4	0.8	1.8	1.3	0.4	1.3	-0.3	0.5
Illnesses of siblings	0.5	0.8	2.0	-1.2	0.3	-0.4	0.2	-1.4
Neuroticism score	0.6	1.3	3.2	0.3	-1.2	-1.8	-1.1	-0.7
Weight	0.9	4.2	8.0	-2.8	-1.0	1.7	2.7	-1.5
Impedance of arm (right)	0.0	0.2	0.4	-0.3	-0.5	-0.2	0.6	0.4
Arm fat percentage (right)	0.6	2.4	3.8	-1.8	-1.1	1.3	2.0	-1.3
Trunk fat-free mass	0.4	2.5	6.6	-2.6	-1.0	0.1	1.1	-1.9
Hip circumference	0.8	3.7	7.6	-2.3	-0.8	1.4	2.8	-1.6
Time employed in main current job	0.7	0.8	2.2	-0.0	-1.5	-0.8	-0.7	-0.8
Alcohol intake versus 10 years previously	0.6	0.9	2.9	1.7	0.4	0.3	-0.7	-0.9
Father’s age at death	0.8	1.1	3.4	0.1	-0.2	0.8	1.3	-1.9
Worrier / anxious feelings	0.2	0.4	1.0	-1.0	0.1	0.3	-0.2	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.1	-1.4	-1.1	-0.3	0.0	-0.3
Falls in the last year	1.1	1.5	2.8	-1.4	-0.3	1.5	1.7	0.7
Hair/balding pattern: Pattern 3	1.0	1.5	3.3	1.8	-1.1	-1.4	-0.9	-0.5
Number of live births	0.5	0.8	2.3	-0.7	-0.8	-0.5	1.5	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	-0.1	0.4	0.6	1.3	-0.9
Pulse rate	0.4	0.6	1.4	1.2	-0.6	0.5	0.8	0.5
Happiness	0.2	0.2	0.5	0.5	-0.2	-0.4	0.7	0.2
Noisy workplace	0.4	0.5	2.3	0.0	0.1	0.5	-0.0	1.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	1.1	0.4	-0.1	-0.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.9	2.0	-0.8	1.7	-0.3	0.8
Mouth/teeth dental problems: Dentures	0.5	0.8	2.3	-0.2	-1.5	-1.1	-0.6	-0.5
Asthma	1.4	2.7	4.9	1.9	-1.3	-2.2	-1.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.2	0.3	0.4	0.4	-0.1
Medication: Cholesterol lowering	1.0	1.5	4.7	-0.9	-1.2	-0.7	2.2	-0.3
Depression (self-reported)	1.1	1.4	2.9	-1.1	1.4	1.7	0.1	0.8
Medication: Lansoprazole	0.4	0.4	1.4	0.1	0.1	1.2	0.8	0.0
Prospective memory result	0.1	0.2	0.4	0.0	0.5	-0.3	-0.3	0.6
Lung cancer (father)	0.2	0.2	0.6	0.2	0.1	-0.7	0.1	0.8
Illnesses of mother	0.3	0.4	1.3	-0.5	-0.1	-0.4	-0.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.4	0.4	0.8	0.6	-0.7
Pulse wave Arterial Stiffness index	0.9	1.1	2.4	0.1	0.6	1.4	0.8	-1.6
Impedance of arm (left)	0.1	0.4	1.0	-0.2	-1.0	-0.6	0.6	-0.1
Arm fat mass (right)	0.7	2.9	5.0	-2.1	-1.4	1.2	2.2	-1.3
Trunk predicted mass	0.4	2.4	6.4	-2.5	-1.0	0.1	1.0	-1.9
Standing height	0.3	3.3	8.3	-2.9	-1.3	0.4	2.0	-1.5
Length of working week for main job	3.1	3.5	8.1	2.9	0.8	1.6	-0.4	2.4
Exposure to tobacco smoke at home	1.9	2.2	7.5	-2.7	0.1	1.1	0.7	-1.3
Breastfed as a baby	0.4	0.5	2.6	1.6	0.3	0.1	0.1	-0.1
Tense / ‘highly strung’	0.4	0.7	2.1	0.7	0.7	-0.4	-0.2	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.7	-1.6	-1.2	-0.2	0.9	-1.6
Hair/balding pattern: Pattern 4	1.0	2.3	5.9	-1.2	-2.4	-0.1	0.8	-1.9
Birth weight of first child	0.4	0.8	1.6	-0.2	-0.9	0.9	-1.3	-0.8
Peak expiratory flow (PEF)	0.4	0.9	1.7	0.3	1.3	1.2	1.1	0.3
Pulse wave reflection index	2.7	3.3	10.6	-2.2	-0.3	1.0	-0.2	-3.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	-1.0	-0.8	-1.4	0.2	-0.3
Loud music exposure frequency	1.4	1.5	4.1	-2.0	-0.5	-1.3	0.1	-1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.7	0.7	1.6	1.3	-0.7	-0.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.4	1.0	-0.5	-1.3	-0.6	1.5
Blood clot in the leg (DVT)	1.0	1.3	3.6	-0.3	1.5	1.9	-0.7	-0.2
Medication: Paracetamol	0.2	0.4	0.7	-0.8	-0.8	0.7	0.4	-0.2
Headache pain in last month	0.3	0.4	1.8	-0.3	-0.1	0.5	-1.3	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	0.3	0.9	0.9	-1.4	-0.0
Glaucoma (self-reported)	0.2	0.3	0.5	-0.2	-0.5	-0.2	0.7	-0.6
Gout (self-reported)	0.4	0.6	2.2	-0.6	0.5	1.5	-0.1	0.2
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	9.4	-1.7	-1.3	-0.4	0.8	-3.1
Medication: Amlodipine	0.5	0.8	1.8	0.6	-0.4	-1.3	1.2	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.5	-0.3	0.2	-0.1	-0.1
Birth weight	0.3	0.6	2.3	0.1	-1.5	-0.6	0.3	-0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	0.9	0.6	1.2	-0.4	0.5
High blood pressure (siblings)	0.3	0.4	1.0	1.0	-0.1	0.4	-0.8	0.5
Forced vital capacity (FVC), Best measure	0.0	0.1	0.5	-0.1	0.2	0.1	0.2	-0.7
Body fat percentage	0.6	2.4	6.1	-1.4	-0.8	1.9	2.5	-0.1
Leg fat percentage (right)	0.6	2.1	4.8	-0.6	0.3	2.2	1.9	1.3
Arm fat-free mass (right)	0.4	1.8	4.3	-2.1	-0.7	0.8	1.4	-1.3
Exposure to tobacco smoke outside home	0.1	0.1	0.4	-0.1	-0.2	0.6	-0.1	0.3
Comparative body size at age 10	0.4	1.0	4.2	-0.2	-2.1	0.1	0.7	-0.2
Number of full brothers	0.4	0.5	2.1	0.3	-0.1	-0.5	1.4	-0.0
Worry too long after embarrassment	0.7	1.2	1.5	1.1	1.0	-1.0	-1.2	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.2	0.2	-0.5	-1.1	0.5	0.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	-0.6	0.4	-0.0	-0.9	0.4
Number of children fathered	0.2	0.2	0.4	0.6	0.1	0.6	-0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.3	-0.7	-1.8	-1.3	0.0	-1.8
Age at first live birth	0.4	0.6	2.2	1.5	0.0	-0.0	-0.5	0.9
Pulse wave peak to peak time	1.0	1.2	2.8	-0.0	-0.9	-1.7	-0.6	1.5
Health satisfaction	0.4	0.5	0.9	-0.9	-0.8	-0.3	0.4	-0.8
Shortness of breath walking on level ground	0.1	0.2	0.7	-0.2	-0.8	0.0	-0.2	-0.1
Qualifications: College or University degree	0.4	1.3	3.1	-0.5	0.2	-0.7	-1.7	-1.8
Eye problems/disorders: None of the above	2.0	2.3	5.0	-0.3	-1.2	-2.2	1.9	-1.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	2.9	-0.2	-1.7	-1.5	1.2	-1.7
Emphysema/chronic bronchitis	0.5	0.5	1.4	0.8	-1.2	-0.4	0.6	0.1
Medication for pain relief, constipation, heartburn	0.8	1.3	5.7	0.7	0.3	-2.4	-0.4	0.5
Neck or shoulder pain in last month	0.2	0.4	1.7	-0.1	-0.1	-1.3	-0.0	0.2
Medication: Blood pressure	0.7	1.2	3.8	-1.2	-0.4	-0.8	2.0	0.2
Angina (self-reported)	0.2	0.2	0.4	-0.3	-0.6	-0.5	0.6	-0.0
Migraine (self-reported)	1.2	1.5	2.5	-0.1	-1.6	-0.7	-1.4	-1.6
Medication: Ibuprofen	0.3	0.3	0.7	-0.8	0.3	0.7	0.0	-0.4
Medication: Allopurinol	1.3	1.7	4.1	0.9	1.2	2.0	-0.1	1.5
Medication: Omeprazole	0.6	0.7	1.6	-0.1	1.0	1.0	-1.3	0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.8	0.3	-0.9	0.4	-0.4	0.0
Mean time to correctly identify matches	0.5	1.0	2.2	-1.0	-0.7	-1.5	1.0	-0.3
Heart disease (mother)	2.2	2.7	4.7	1.6	1.7	1.6	-2.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	-0.7	-1.0	-0.1	0.7	-1.2
Whole body fat mass	0.6	2.7	6.8	-1.8	-0.9	1.6	2.6	-0.5
Leg fat mass (right)	0.6	2.2	5.5	-1.5	-0.3	1.8	2.3	0.4
Arm predicted mass (right)	0.3	1.6	3.9	-2.0	-0.6	0.7	1.1	-1.4
Pulse rate, automated reading	0.2	0.6	1.5	1.2	-1.0	0.1	0.6	0.2
Alcohol intake frequency.	0.2	0.4	1.0	-0.6	-0.5	-0.5	1.0	-0.0
Comparative height size at age 10	0.4	2.0	3.3	-1.8	-1.2	0.3	1.7	-1.5
Number of full sisters	1.4	1.7	4.9	-0.8	-0.7	-1.6	2.2	-0.4
Suffer from ‘nerves’	0.5	0.8	2.2	-1.1	-0.3	-1.5	0.7	0.5
Overall health rating	0.4	0.9	3.7	-1.9	-0.2	0.0	0.8	-0.3
Chest pain or discomfort	0.0	0.1	0.1	-0.4	-0.3	-0.0	-0.2	-0.3
Had major operations	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.2	-0.5
Age at last live birth	0.4	0.6	1.3	1.0	-0.6	-1.2	-0.2	0.6
Family relationship satisfaction	0.1	0.1	0.3	-0.6	0.1	-0.2	0.0	-0.3
Leg pain on walking	1.2	1.4	5.4	-2.3	-0.2	-1.0	0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	1.0	-0.4	1.0	0.4	0.9
Commuting to job workplace: Car/motor vehicle	1.8	2.0	4.3	0.3	2.1	0.9	0.9	2.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.6	-1.6	0.5	-1.0	-0.5	-1.4
Medication: Aspirin	0.1	0.2	0.5	-0.2	-0.2	0.7	0.6	0.2
Supplements: Vitamin C	0.6	0.7	2.0	0.6	-0.9	-1.4	-0.6	0.3
Knee pain experienced in last month	0.4	0.6	1.9	-0.6	0.3	1.4	-0.7	-0.4
Hypertension (Self-reported)	1.5	4.1	12.2	-2.5	-1.0	0.8	3.5	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.9	1.4	0.9	1.7	-1.1	-0.5
Illnesses of father: Heart disease	0.5	0.7	1.4	-0.6	-0.1	-1.2	-1.1	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.0	0.7	-1.0	0.1	0.7	0.6
Smoking status: Previous	1.1	1.6	5.6	-0.1	1.1	2.4	-1.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.8	-0.7	-0.1	1.3	1.0	-0.5
Whole body fat-free mass	0.6	3.4	8.2	-2.9	-1.3	0.2	1.7	-2.1
Leg fat-free mass (right)	1.0	5.1	10.9	-3.3	-1.5	0.2	2.4	-2.6
Arm fat percentage (left)	0.5	2.0	3.4	-1.6	-1.1	1.0	1.9	-1.2
Average weekly red wine intake	0.5	0.8	1.9	-0.4	-1.4	-1.4	0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.9	0.1	0.6	1.4	-0.1	-0.2
Mood swings	0.5	0.9	3.7	0.1	-1.9	-0.9	-0.2	-0.5
Loneliness, isolation	0.3	0.4	1.1	-0.4	-0.4	-1.0	0.3	-0.5
Long-standing illness, disability or infirmity	0.8	1.2	4.1	-0.6	0.6	2.0	1.1	0.3
Ever had bowel cancer screening	0.4	0.5	1.2	1.1	-0.1	0.6	0.1	0.8
Diabetes diagnosed by doctor	1.2	1.9	5.1	-2.0	-0.7	0.5	2.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.4	0.0	-0.1	0.2	0.5
Friendships satisfaction	2.7	3.4	7.0	-0.8	-2.1	-1.8	1.4	-2.6
Qualifications: nursing, teaching	0.2	0.3	1.2	1.1	0.5	0.3	-0.3	0.2
Commuting to job workplace: Walk	0.3	0.3	0.6	-0.3	0.1	-0.6	-0.8	-0.6
Eye problems/disorders: Cataract	2.2	2.5	7.1	0.6	1.3	1.2	-2.7	1.5
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	3.6	1.9	0.9	0.1	-1.6	1.7
Medication for cholesterol	1.0	1.5	6.7	0.4	-0.3	-2.6	-0.6	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.5	0.2	-0.0	0.3	0.1
Back pain experienced in last month	0.7	1.0	1.8	1.3	0.6	-1.2	-0.3	1.2
Mineral and other dietary supplements	0.5	0.7	1.5	-0.5	-0.5	1.1	1.2	-0.5
Breast cancer (self-reported)	0.7	0.8	1.7	0.0	-0.5	1.3	1.1	-1.0
Asthma (self-reported)	1.3	2.6	5.1	1.8	-1.4	-2.3	-1.6	0.4
Osteoporosis (self-reported)	1.1	1.4	3.5	-0.9	-1.3	0.3	1.9	-0.9
Osteoarthritis (self-reported)	1.3	1.7	7.5	-0.9	0.1	2.7	0.6	-0.2
Medication: Aspirin	0.2	0.3	0.9	-0.4	-0.4	0.4	1.0	0.2
Medication: Gliclazide	2.5	2.8	12.6	-1.1	-0.3	0.2	3.5	0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	-0.7	-0.2	0.3	1.1	0.1
Smoking status: Current	0.5	0.7	2.2	-0.6	-0.4	-0.4	1.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.5	1.9	0.4	1.5	-1.5	-0.5
Whole body water mass	0.6	3.5	8.1	-2.9	-1.3	0.3	1.6	-2.2
Leg predicted mass (right)	1.0	5.2	11.0	-3.3	-1.7	0.1	2.4	-2.6
Arm fat mass (left)	0.6	2.6	4.4	-1.9	-1.5	0.9	2.1	-1.4
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	-1.2	0.1	1.3	1.2	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.4	-0.4	-0.5	-0.1	-0.6
Miserableness	0.3	0.5	0.9	-0.9	0.6	0.5	-0.9	-0.3
Guilty feelings	0.3	0.5	1.5	-0.2	-0.4	-1.2	-0.1	-0.9
Wears glasses or contact lenses	1.9	2.2	4.9	2.2	0.8	1.1	-1.1	1.8
Ever taken oral contraceptive pill	0.4	0.4	1.5	1.2	-0.3	-0.4	-0.6	0.1
Hearing aid user	1.2	1.3	3.1	1.8	-0.5	-1.0	-1.2	0.9
Mother’s age at death	0.2	0.2	0.6	0.4	-0.3	-0.3	-0.8	0.5
Financial situation satisfaction	0.6	0.7	1.7	0.6	-0.2	-0.9	0.8	1.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.7	0.4	1.6	0.7	-0.7	0.8
Commuting to job workplace: Public transport	0.6	0.8	2.6	1.0	0.3	0.2	-1.6	0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.8	-0.2	0.1	0.2	0.5
Medication: Blood pressure	0.9	1.7	4.1	-0.6	-0.8	2.0	1.8	0.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.8	-0.4	0.5	-2.0	0.8	0.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.1	0.3	0.8	-1.1	-0.8	1.4
High cholesterol (Self-reported)	0.5	0.9	3.3	-0.1	-0.6	-0.3	1.8	0.9
Medication: Bendroflumethiazide	0.6	0.9	4.1	-0.2	-0.6	0.2	2.0	-0.5
Medication: Paracetamol	0.6	1.0	2.5	-1.6	-0.7	0.3	-0.2	-1.4
Medication: Lisinopril	0.7	0.9	2.8	-0.0	-1.1	-0.4	1.7	0.3
Medication: Atorvastatin	0.5	0.7	2.2	-0.8	0.3	1.5	-0.5	-0.3
Illnesses of father: High blood pressure	1.2	1.5	3.5	-1.9	-0.1	-0.3	1.6	-1.2
Alcohol drinker status: Never	1.2	1.4	2.8	-1.0	1.3	-1.1	0.4	1.7
Ever smoked	0.2	0.4	1.5	-0.2	-0.2	1.2	-0.4	-0.5
Basal metabolic rate	0.7	4.0	9.1	-3.0	-1.4	0.5	2.0	-2.1
Leg fat percentage (left)	0.6	2.1	4.7	-0.7	0.0	2.1	2.2	1.1
Arm fat-free mass (left)	0.5	2.5	5.9	-2.4	-0.8	1.2	1.3	-1.8
Number of operations (self-reported)	1.0	1.5	4.0	0.5	0.9	2.0	-0.6	1.5
Average weekly beer plus cider intake	1.1	1.5	4.7	-0.6	1.4	2.2	0.4	0.7
Irritability	0.5	0.8	1.9	1.1	-1.4	-0.9	-0.3	-0.2
Risk taking	1.1	1.6	5.2	0.2	1.6	0.5	-0.1	2.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.7	0.4	-0.8	-1.3	1.0	0.9
Fractured/broken bones in last 5 years	1.6	2.1	8.0	-0.1	-0.1	0.9	2.8	1.2
Age started oral contraceptive pill	0.6	0.7	1.3	1.0	0.9	1.2	-0.0	0.8
Diastolic blood pressure, automated reading	0.3	0.9	2.4	-1.1	0.8	1.6	0.1	0.0
Ever depressed for a whole week	0.7	0.9	2.0	0.4	0.3	-0.9	-1.4	-1.0
Unable to work because of sickness or disability	0.2	0.3	1.2	0.1	-0.1	-0.2	1.1	0.3
Commuting to job workplace: Cycle	1.7	2.0	4.8	1.0	-0.8	2.2	-1.9	-0.4
Myopia	1.0	1.5	3.4	0.1	1.4	1.9	-1.3	0.7
Vascular/heart problems diagnosed by doctor	1.3	3.5	9.5	2.3	1.6	-0.6	-3.1	0.3
Cholesterol lowering medication	1.1	1.6	5.5	-0.4	-0.5	2.4	1.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.4	-0.3	1.0	1.2	-0.9	0.6
Pain experienced in last month	0.5	0.9	1.7	-0.1	-1.2	0.6	0.9	-1.3
Supplements: Calcium	2.3	2.5	4.2	-1.3	-2.0	-1.3	2.0	-1.0
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.1	-0.5	-0.7	-0.8	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	-1.0	-0.8	-0.6	-0.0	0.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	4.4	-0.0	1.7	2.1	-1.0	-0.0
Heart disease (siblings)	0.8	1.0	2.7	1.4	-0.1	-0.1	0.4	1.6
Alcohol drinker status: Previous	1.0	1.2	3.5	-1.9	-0.7	1.1	0.4	-0.8
Pack years of smoking	1.0	1.4	2.8	-1.0	-0.5	-1.4	1.7	1.0
Impedance of whole body	0.1	0.5	2.0	0.2	0.3	0.4	0.2	1.4
Leg fat mass (left)	0.6	2.4	6.2	-1.5	-0.6	1.7	2.5	0.2
Arm predicted mass (left)	0.5	2.4	5.7	-2.4	-0.8	1.0	1.3	-1.7