Best TWAS P=1.23e-12 · Best GWAS P=6.43e-13 conditioned to 0.0017
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | ASPRV1 | 0.23 | 0.00 | enet | 39 | 0.01 | 8.9e-02 | -6.6 | 5.8 | 5.2e-09 | -0.66 | 0.06 | 0.45 | FALSE |
2 | GTEx | Artery Tibial | FAM136A | 0.11 | 0.02 | enet | 13 | 0.05 | 8.2e-05 | -6.5 | -5.5 | 3.9e-08 | 0.78 | 0.15 | 0.76 | FALSE |
3 | GTEx | Artery Tibial | GFPT1 | 0.09 | 0.05 | lasso | 4 | 0.02 | 1.1e-02 | -5.2 | 5.3 | 1.2e-07 | 0.10 | 0.02 | 0.98 | TRUE |
4 | GTEx | Thyroid | PCBP1-AS1 | 0.11 | 0.07 | lasso | 3 | 0.07 | 6.6e-06 | -6.9 | 6.5 | 1.0e-10 | -0.93 | 0.05 | 0.94 | FALSE |
5 | METSIM | Adipose | ASPRV1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 2.6e-09 | -6.5 | 6.4 | 1.4e-10 | -0.91 | 0.16 | 0.84 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | PCBP1-AS1 | 0.08 | 0.10 | bslmm | 313 | 0.10 | 1.8e-12 | -6.3 | 6.8 | 1.4e-11 | -0.91 | 0.23 | 0.77 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | ASPRV1 | 0.06 | 0.04 | bslmm | 311 | 0.06 | 8.7e-08 | -6.3 | 6.2 | 6.6e-10 | -0.91 | 0.18 | 0.82 | FALSE |
8 | YFS | Blood | ASPRV1 | 0.10 | 0.10 | blup | 342 | 0.13 | 7.7e-40 | -7.2 | 7.1 | 1.2e-12 | -0.91 | 0.01 | 0.99 | TRUE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ASPRV1 | 0.01 | 0.01 | blup | 58 | 0.01 | 1.1e-03 | -6.3 | 6.4 | 2.0e-10 | -0.88 | 0.02 | 0.67 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GFPT1 | 0.05 | 0.00 | blup | 67 | 0.02 | 5.9e-03 | -5.0 | 5.2 | 1.7e-07 | 0.09 | 0.01 | 0.72 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GFPT1 | 0.12 | 0.05 | blup | 67 | 0.04 | 3.9e-05 | -5.0 | 5.2 | 2.3e-07 | 0.10 | 0.01 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | ASPRV1 | 0.07 | 0.07 | lasso | 6 | 0.07 | 2.5e-08 | -4.7 | 5.4 | 6.1e-08 | -0.66 | 0.48 | 0.52 | FALSE |
13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ASPRV1 | 0.08 | 0.06 | enet | 14 | 0.06 | 2.4e-03 | -6.7 | 6.7 | 1.7e-11 | -0.89 | 0.03 | 0.88 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ASPRV1 | 0.02 | 0.02 | blup | 58 | 0.02 | 5.4e-03 | -6.6 | 6.6 | 3.1e-11 | -0.90 | 0.02 | 0.90 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | ASPRV1 | 0.06 | 0.04 | blup | 58 | 0.03 | 4.2e-04 | -6.5 | 6.5 | 7.8e-11 | -0.91 | 0.02 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | PCBP1 | 0.05 | 0.02 | blup | 22 | 0.02 | 1.8e-03 | -7.0 | 6.4 | 1.8e-10 | -0.91 | 0.01 | 0.79 | FALSE |