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chr2:84,849,386-86,571,415

Best TWAS P=4.23e-16 · Best GWAS P=2.21e-12 conditioned to 0.00023

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Cells EBV-transformed lymphocytes	TGOLN2	0.49	0.15	enet	50	0.32	3.0e-11	6.6	8.1	4.2e-16	0.65	0.04	0.95	TRUE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	RNF181	0.03	0.00	blup	39	0.01	1.5e-02	-5.4	5.5	3.3e-08	-0.18	0.01	0.53	TRUE
60	The Cancer Genome Atlas	Thyroid Carcinoma	TGOLN2	0.09	0.13	blup	64	0.13	7.6e-13	7.0	7.9	2.4e-15	0.91	0.01	0.99	FALSE
27	GTEx	Thyroid	ELMOD3	0.10	0.01	enet	10	0.02	7.7e-03	4.6	-7.4	9.9e-14	-0.76	0.03	0.91	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	TGOLN2	0.13	0.20	enet	10	0.22	3.1e-22	-6.4	7.3	2.3e-13	0.98	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	TGOLN2	0.02	0.02	enet	9	0.02	7.1e-04	-6.4	7.2	8.0e-13	0.98	0.01	0.95	FALSE
22	GTEx	Skin Sun Exposed Lower leg	TGOLN2	0.26	0.15	lasso	7	0.18	6.0e-15	7.0	7.1	1.4e-12	0.94	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TGOLN2	0.09	0.09	lasso	9	0.08	2.8e-05	6.9	7.0	1.9e-12	0.97	0.01	0.98	FALSE
6	GTEx	Cells Transformed fibroblasts	TGOLN2	0.22	0.26	enet	15	0.27	2.4e-20	6.8	7.0	2.2e-12	0.99	0.01	0.99	FALSE
8	GTEx	Esophagus Mucosa	TGOLN2	0.17	0.19	enet	15	0.18	3.0e-12	7.0	7.0	2.7e-12	0.99	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	TGOLN2	0.05	0.10	lasso	5	0.11	5.5e-21	7.0	7.0	2.7e-12	0.98	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Stomach Adenocarcinoma	TGOLN2	0.09	0.08	lasso	9	0.08	1.1e-06	6.9	7.0	3.1e-12	0.97	0.02	0.98	FALSE
12	GTEx	Liver	TGOLN2	0.29	0.28	lasso	3	0.27	4.2e-08	6.6	7.0	3.3e-12	0.87	0.06	0.91	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	TGOLN2	0.31	0.19	enet	10	0.15	1.8e-04	-6.4	7.0	3.3e-12	0.95	0.02	0.96	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	TGOLN2	0.08	0.08	blup	64	0.12	2.0e-13	7.0	6.9	4.9e-12	0.92	0.02	0.98	FALSE
14	GTEx	Muscle Skeletal	CAPG	0.12	0.04	lasso	6	0.04	4.8e-05	6.9	6.9	5.2e-12	0.91	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TGOLN2	0.06	0.09	lasso	2	0.08	8.6e-10	6.9	6.9	5.2e-12	0.97	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TGOLN2	0.18	0.16	lasso	6	0.16	3.5e-11	6.9	6.8	8.7e-12	0.97	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TGOLN2	0.05	0.10	lasso	1	0.09	1.1e-10	6.8	6.8	1.1e-11	1.00	0.01	0.99	FALSE
13	GTEx	Lung	TGOLN2	0.07	0.04	enet	9	0.04	6.4e-04	-6.4	6.8	1.4e-11	0.96	0.01	0.99	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	AC093162.5	0.30	0.00	lasso	6	0.00	2.3e-01	6.9	-6.8	1.5e-11	-0.91	0.02	0.86	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TGOLN2	0.13	0.18	enet	18	0.20	1.5e-22	6.9	6.7	1.8e-11	0.95	0.02	0.98	FALSE
32	NTR	Blood	RETSAT	0.07	0.09	enet	21	0.09	2.9e-28	6.9	-6.7	2.2e-11	-0.96	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	TGOLN2	0.26	0.18	enet	14	0.15	5.1e-09	7.0	6.7	2.2e-11	0.90	0.01	0.99	FALSE
11	GTEx	Esophagus Muscularis	AC093162.5	0.14	0.09	lasso	2	0.06	1.3e-04	6.5	-6.5	6.5e-11	-0.94	0.03	0.95	FALSE
31	GTEx	Whole Blood	AC093162.5	0.11	0.03	lasso	2	0.01	4.0e-02	6.5	-6.5	8.1e-11	-0.94	0.03	0.94	FALSE
16	GTEx	Nerve Tibial	AC093162.5	0.14	0.10	enet	11	0.07	1.6e-05	6.9	-6.4	1.2e-10	-0.95	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	SH2D6	0.12	0.09	enet	7	0.09	3.1e-10	5.7	6.4	1.7e-10	0.67	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CAPG	0.07	0.01	enet	15	0.04	6.1e-05	4.6	6.3	2.7e-10	0.36	0.01	0.35	FALSE
7	GTEx	Colon Transverse	TGOLN2	0.18	0.13	enet	16	0.12	2.8e-06	7.0	6.2	5.5e-10	0.94	0.01	0.99	FALSE
23	GTEx	Skin Sun Exposed Lower leg	AC093162.5	0.08	0.05	lasso	3	0.06	5.0e-06	-5.5	6.2	5.9e-10	0.73	0.26	0.72	FALSE
1	GTEx	Adipose Subcutaneous	TGOLN2	0.07	0.09	lasso	2	0.08	6.7e-07	-6.4	6.2	6.1e-10	0.92	0.07	0.92	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	TGOLN2	0.27	0.18	enet	19	0.15	2.1e-08	6.6	6.2	6.1e-10	0.85	0.03	0.97	FALSE
3	GTEx	Brain Cerebellum	MAT2A	0.41	0.08	enet	40	0.15	4.5e-05	-5.5	-6.1	1.2e-09	-0.63	0.03	0.92	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RETSAT	0.07	0.04	blup	56	0.05	4.8e-03	4.6	-6.0	1.6e-09	-0.91	0.03	0.67	FALSE
29	GTEx	Thyroid	AC093162.5	0.23	0.19	enet	22	0.20	6.5e-15	6.9	-6.0	1.9e-09	-0.93	0.02	0.98	FALSE
26	GTEx	Thyroid	CAPG	0.17	0.10	lasso	6	0.10	3.7e-08	-5.6	5.9	3.2e-09	0.66	0.69	0.30	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TGOLN2	0.08	0.05	blup	64	0.08	4.2e-04	-6.1	5.9	3.4e-09	0.94	0.02	0.95	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CAPG	0.06	0.01	enet	10	0.02	4.9e-03	-5.5	5.9	3.7e-09	0.58	0.01	0.66	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	SH2D6	0.10	0.08	lasso	6	0.14	1.5e-17	-5.8	-5.9	3.9e-09	-0.64	0.88	0.12	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	CAPG	0.08	0.03	blup	43	0.08	2.0e-08	3.8	5.8	5.7e-09	0.62	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	SH2D6	0.05	0.06	lasso	2	0.05	8.2e-11	5.7	5.8	6.9e-09	0.67	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	TGOLN2	0.18	0.06	lasso	5	0.06	7.0e-04	4.7	5.7	1.1e-08	0.80	0.04	0.88	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TGOLN2	0.15	0.17	enet	8	0.15	6.4e-08	6.9	5.7	1.3e-08	0.94	0.02	0.98	FALSE
24	GTEx	Stomach	TGOLN2	0.20	0.11	enet	14	0.11	5.4e-06	6.5	5.7	1.4e-08	0.93	0.02	0.98	FALSE
28	GTEx	Thyroid	TGOLN2	0.09	0.04	lasso	3	0.07	8.7e-06	4.7	5.6	1.8e-08	0.70	0.50	0.31	FALSE
41	The Cancer Genome Atlas	Esophageal Carcinoma	TGOLN2	0.15	0.07	blup	64	0.14	3.1e-05	7.0	5.6	2.5e-08	0.91	0.02	0.94	FALSE
17	GTEx	Pancreas	TGOLN2	0.30	0.00	enet	36	0.07	7.3e-04	-6.2	5.5	2.8e-08	0.57	0.06	0.72	FALSE
25	GTEx	Testis	CAPG	0.49	0.48	enet	20	0.49	2.6e-24	4.8	5.5	3.2e-08	0.66	1.00	0.00	FALSE
9	GTEx	Esophagus Mucosa	TMEM150A	0.10	0.05	enet	5	0.05	3.2e-04	-4.5	5.5	3.7e-08	-0.12	0.54	0.02	FALSE
30	GTEx	Whole Blood	RETSAT	0.13	0.08	lasso	5	0.14	8.0e-13	3.5	-5.5	3.7e-08	-0.85	0.05	0.95	FALSE
10	GTEx	Esophagus Muscularis	CAPG	0.17	0.16	lasso	4	0.14	8.2e-09	5.7	5.5	4.0e-08	0.68	0.95	0.05	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	CAPG	0.18	0.14	lasso	4	0.10	6.5e-06	-5.6	5.5	4.0e-08	0.59	0.86	0.06	FALSE
21	GTEx	Skin Sun Exposed Lower leg	CAPG	0.24	0.22	lasso	5	0.21	4.1e-17	-5.5	5.5	4.9e-08	0.65	0.99	0.01	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM150A	0.06	0.05	lasso	3	0.04	3.9e-05	-5.4	5.5	4.9e-08	-0.08	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	C2orf68	0.06	0.06	lasso	2	0.05	1.1e-03	-5.4	5.3	1.1e-07	-0.14	0.00	0.91	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	VAMP8	0.04	0.05	lasso	3	0.05	1.2e-05	-4.5	5.2	1.5e-07	-0.13	0.16	0.75	FALSE
40	The Cancer Genome Atlas	Esophageal Carcinoma	CAPG	0.24	0.08	lasso	3	0.14	3.6e-05	3.1	5.2	2.2e-07	0.42	0.00	0.94	FALSE
15	GTEx	Muscle Skeletal	USP39	0.18	0.10	lasso	3	0.10	1.1e-09	-5.4	5.2	2.3e-07	-0.08	0.99	0.01	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFTPB	0.03	0.02	blup	44	0.02	3.8e-05	-5.4	5.2	2.4e-07	-0.04	0.00	0.99	FALSE
18	GTEx	Pancreas	AC093162.5	0.21	0.07	enet	18	0.02	4.0e-02	7.0	-5.2	2.6e-07	-0.73	0.02	0.95	FALSE