TWAS hub - ASPRV1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0190	3.4e-04	0.026	0.029	0.022	0.031	0.026	3.2e-04	1.7e-04	8.5e-04	1.0e-04	3.4e-04
2	GTEx	Artery Aorta	0.2290	0.0840	2.0e-03	0.001	NA	0.010	NA	-0.003	2.8e-01	NA	9.0e-02	NA	5.4e-01
3	GTEx	Lung	0.0937	0.0434	3.3e-03	-0.004	NA	0.001	NA	-0.002	9.2e-01	NA	2.8e-01	NA	5.6e-01
4	GTEx	Pancreas	0.2100	0.0930	2.7e-03	0.016	NA	0.044	NA	0.010	6.9e-02	NA	5.8e-03	NA	1.2e-01
5	METSIM	Adipose	0.0465	0.0178	1.9e-05	0.061	0.031	0.043	0.042	0.060	1.9e-09	1.4e-05	3.8e-07	5.5e-07	2.6e-09
6	ROSMAP	Brain Pre-frontal Cortex	0.0648	0.0237	2.9e-06	0.039	0.047	0.044	0.056	0.048	8.4e-06	8.8e-07	2.4e-06	8.7e-08	6.9e-07
7	YFS	Blood	0.1014	0.0239	0.0e+00	0.104	0.129	0.121	0.120	0.126	3.7e-32	7.7e-40	1.5e-37	3.7e-37	3.6e-39
8	TCGA	Breast Invasive Carcinoma	0.0134	0.0083	3.7e-03	0.013	0.012	0.009	NA	0.011	9.4e-04	1.1e-03	4.8e-03	NA	1.9e-03
9	TCGA	Lung Adenocarcinoma	0.0650	0.0347	1.0e-06	0.073	0.064	0.064	NA	0.068	6.0e-09	5.4e-08	5.7e-08	NA	2.5e-08
10	TCGA	Pancreatic Adenocarcinoma	0.0830	0.0520	1.5e-03	0.058	0.053	0.055	NA	0.045	1.9e-03	2.9e-03	2.4e-03	NA	5.6e-03
11	TCGA	Prostate Adenocarcinoma	0.0244	0.0144	1.6e-03	0.016	0.017	0.010	NA	0.013	8.1e-03	5.4e-03	2.9e-02	NA	1.3e-02
12	TCGA	Thyroid Carcinoma	0.0560	0.0300	3.3e-05	0.037	0.032	0.017	NA	0.025	1.4e-04	4.2e-04	8.2e-03	NA	1.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8	9	10	11	12
Breast Cancer	4.8	11.7	22.0	4.7	4.3	3.4	2.9	3.4	3.4	4.2	3.0	3.0	2.6	3.7
Blood White Count	4.6	34.0	50.4	4.7	5.8	4.5	6.4	6.2	7.1	6.4	5.4	6.7	6.6	6.5
Age started oral contraceptive pill	4.4	5.5	9.9	1.5	3.0	1.2	2.5	2.5	2.7	1.4	2.9	2.8	3.1	2.4
Stomach or abdominal pain in last month	3.7	4.6	6.8	-2.3	-1.5	-2.0	-1.9	-2.6	-2.5	-2.3	-1.5	-2.5	-2.5	-2.5
Bipolar Disorder (2011)	3.6	3.5	6.8	2.5	1.3	2.6	1.6	1.8	2.5	1.9	1.9	1.8	1.6	1.5
Primary Biliary Cirrhosis	3.6	5.1	7.9	-2.2	-2.5	-1.7	-2.2	-2.5	-2.3	-1.8	-2.8	-2.7	-2.8	-2.2
Hearing difficulty/problems: Yes	3.6	5.4	8.3	-2.8	-1.9	-1.6	-2.4	-2.6	-2.5	-2.3	-2.5	-2.8	-2.9	-2.3
Hair/balding pattern: Pattern 3	3.5	5.2	9.1	-2.2	-2.1	-1.4	-2.5	-2.4	-2.1	-1.8	-3.0	-3.0	-3.0	-2.2
Supplements: Calcium	3.4	3.8	6.4	0.4	2.1	1.5	2.5	1.6	2.5	1.5	2.0	2.2	2.5	2.5
Sensitivity / hurt feelings	3.1	5.4	11.6	2.3	2.0	2.0	2.5	2.5	2.4	3.4	1.6	2.4	2.2	2.8
Alcohol usually taken with meals	2.8	4.5	8.9	2.3	2.1	1.3	1.9	2.4	2.4	1.8	3.0	2.4	2.4	1.8
Time employed in main current job	2.7	3.1	4.8	1.2	1.6	1.1	2.1	1.9	2.0	2.1	1.7	2.0	1.9	2.2
Depression (self-reported)	2.7	3.2	5.4	-2.3	-1.6	-1.9	-2.1	-1.8	-2.2	-1.5	-1.4	-2.0	-2.2	-1.5
Standing height	2.7	27.0	51.0	3.7	4.0	4.9	6.2	5.7	6.6	4.0	4.3	6.3	7.1	5.6
Neck or shoulder pain in last month	2.7	3.8	7.2	-2.0	-2.7	-1.0	-1.8	-2.0	-2.7	-1.5	-2.3	-2.0	-2.0	-1.8
Systolic Blood Pressure	2.6	13.2	20.1	-3.8	-3.4	-4.5	-3.8	-3.8	-3.5	-3.9	-3.1	-4.0	-3.9	-3.9
Medication: Lansoprazole	2.5	2.9	5.1	-1.9	-1.4	-2.1	-1.8	-1.9	-1.6	-1.2	-1.0	-1.9	-2.2	-1.9
Had major operations	2.5	2.9	5.3	2.1	1.6	1.7	1.9	1.6	1.6	2.3	1.4	1.7	1.4	2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	8.2	2.1	1.9	1.9	2.8	2.3	2.9	2.0	2.1	2.8	2.8	2.3
Medication for cholesterol	2.3	3.4	5.6	2.0	1.1	2.1	1.9	2.0	1.8	1.8	1.6	2.3	2.4	1.9
Back pain experienced in last month	2.3	3.3	6.4	-1.2	-2.5	-0.8	-1.8	-2.1	-2.3	-1.7	-1.4	-1.9	-2.1	-2.3
High blood pressure (mother)	2.2	3.1	5.1	-1.6	-1.2	-2.0	-2.3	-2.1	-2.1	-1.4	-0.8	-1.9	-2.2	-2.0
Tinnitus: Yes, now most or all of the time	2.2	2.6	4.2	-2.1	-1.1	-0.5	-1.5	-1.8	-1.9	-1.8	-1.9	-1.9	-1.8	-1.7
Hair/balding pattern: Pattern 2	2.1	2.7	4.0	1.9	1.9	0.9	1.6	1.7	1.7	2.0	1.8	2.0	1.9	1.5
Ever had bowel cancer screening	2.1	2.5	4.0	1.5	1.9	2.0	1.9	1.6	1.0	1.7	1.1	1.6	1.7	1.7
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	8.1	-1.0	-0.1	-1.6	-2.5	-2.6	-2.2	-2.4	-2.1	-2.9	-2.7	-2.7
Ever taken oral contraceptive pill	2.0	2.2	4.7	1.4	0.5	1.1	1.4	1.8	1.7	1.3	2.2	1.7	1.8	1.5
Lung cancer (father)	1.9	2.3	3.9	-2.0	-1.7	-1.4	-1.5	-1.5	-1.0	-1.8	-1.9	-1.6	-1.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.8	-1.7	-1.8	-0.6	-1.9	-1.7	-1.6	-1.7	-0.8	-1.5	-1.7	-1.9
Chronic bronchitis/emphysema (father)	1.8	2.1	5.6	-1.2	-2.4	-0.8	-1.5	-1.4	-1.2	-1.7	-1.5	-1.6	-1.3	-1.6
Qualifications: None of the above	1.8	3.9	8.6	-1.7	-2.9	-1.5	-2.1	-2.2	-1.6	-1.3	-1.8	-2.1	-2.7	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.3	-1.2	-1.4	-0.6	-2.1	-1.5	-1.5	-1.2	-0.7	-1.6	-2.0	-2.0
Blood Platelet Count	1.7	19.3	66.7	-8.2	-4.5	-6.2	-2.1	-3.9	-3.4	-6.3	-2.4	-2.6	-1.8	-4.4
Pack years adult smoking proportion	1.7	2.6	6.7	-1.2	-1.6	-1.9	-2.6	-1.6	-1.6	-1.4	-0.7	-1.5	-1.9	-2.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	4.5	2.1	1.3	2.1	1.2	1.3	1.4	1.9	1.3	1.2	1.0	1.2
Tense / ‘highly strung’	1.7	2.9	4.7	-1.9	-1.3	-0.8	-1.8	-2.0	-1.8	-1.4	-1.8	-2.1	-2.2	-2.1
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.1	1.2	0.8	1.5	1.4	1.6	1.5	2.0	1.2	1.8	1.3	1.7
Osteoarthritis (self-reported)	1.7	2.1	7.3	-2.7	-1.0	-2.0	-1.0	-1.7	-1.2	-1.5	-1.1	-1.2	-1.2	-1.3
Pack years of smoking	1.7	2.4	6.4	-1.2	-1.6	-1.7	-2.5	-1.5	-1.5	-1.4	-0.6	-1.5	-1.8	-1.9
Crohns Disease (2012)	1.6	2.5	8.8	3.0	1.3	2.5	1.4	1.5	1.4	1.8	0.2	1.0	1.1	1.4
Blood Eosinophil Count	1.6	12.1	18.7	3.4	4.0	3.1	3.5	3.6	4.2	3.0	3.4	3.9	4.3	3.2
Cardiovascular Disease	1.6	5.3	9.8	-2.2	-2.1	-2.5	-3.1	-2.7	-1.7	-1.7	-1.6	-2.7	-3.1	-2.4
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.1	1.6	1.8	1.2	0.9	1.4	1.6	1.1	2.2	1.5	1.5	1.1
Hearing difficulty/problems with background noise	1.6	2.6	5.0	-1.8	-0.8	-1.7	-1.6	-1.8	-1.2	-1.3	-2.2	-2.0	-2.0	-1.7
Prospective memory result	1.6	2.0	3.2	-1.6	-1.7	-0.9	-1.3	-1.6	-0.9	-1.3	-1.8	-1.7	-1.7	-1.3
Medication: Aspirin	1.6	2.1	4.3	-2.1	-0.6	-1.7	-1.7	-1.7	-1.1	-1.5	-0.7	-1.5	-1.6	-1.7
Hand grip strength (left)	1.5	3.9	12.4	3.5	0.5	3.1	1.9	2.2	2.0	2.0	0.7	1.5	1.6	1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	5.8	-1.0	-0.8	-1.5	-2.2	-2.2	-2.0	-2.0	-1.8	-2.3	-2.3	-2.4
Medication: Ibuprofen	1.5	1.8	3.3	1.2	1.4	1.6	1.6	1.0	1.3	1.1	1.8	1.5	1.5	1.1
Had other major operations	1.4	1.6	3.3	-1.7	-1.8	-1.0	-1.3	-1.1	-1.1	-0.9	-1.8	-1.3	-1.4	-1.0
Alcohol intake versus 10 years previously	1.4	2.1	6.7	-0.9	-2.6	0.2	-1.6	-1.4	-1.0	-0.9	-2.0	-1.6	-1.7	-1.1
Medication: Omeprazole	1.4	1.7	3.2	-1.4	-1.8	-0.5	-1.6	-1.5	-1.3	-1.4	-0.6	-1.2	-1.4	-1.6
Knee pain experienced in last month	1.4	2.2	3.4	-1.8	-0.8	-1.0	-1.7	-1.8	-1.7	-1.0	-1.8	-1.5	-1.8	-1.6
Long-standing illness, disability or infirmity	1.4	2.1	4.7	-2.2	-1.5	-1.8	-1.6	-1.4	-1.4	-1.4	-0.7	-1.3	-1.3	-1.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.6	0.9	1.6	0.5	1.9	1.4	0.8	1.3	0.4	1.4	1.6	1.7
HbA1C	1.3	1.5	4.3	-0.9	-0.6	-0.7	-1.4	-1.2	-1.3	-0.9	-2.1	-1.4	-1.4	-1.2
Qualifications: A levels/AS levels or equivalent	1.3	2.9	13.8	1.5	3.7	0.9	1.4	1.5	1.8	0.5	1.4	1.4	1.9	1.5
Pulse wave reflection index	1.3	1.6	3.8	-0.1	-1.0	-0.0	-2.0	-1.5	-1.1	-1.9	-0.1	-1.4	-1.3	-1.8
Medication: Amlodipine	1.3	1.9	4.2	-2.1	-0.9	-1.6	-1.4	-1.4	-0.8	-1.4	-1.2	-1.6	-1.6	-1.3
Health satisfaction	1.3	1.7	5.3	1.7	1.5	2.3	1.1	1.3	1.2	1.4	0.6	1.1	1.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.2	-0.9	-1.1	-1.4	-1.2	-1.3	-1.8	-1.0	-1.4	-1.3	-1.3	-1.4
Breast cancer (self-reported)	1.3	1.5	3.8	-1.9	-0.7	-1.6	-1.0	-0.9	-1.4	-1.1	-1.8	-1.1	-1.1	-1.1
Medication: Blood pressure	1.3	2.5	4.4	-2.0	-0.4	-2.1	-1.6	-1.6	-1.5	-1.4	-1.8	-1.9	-1.9	-1.4
Heart disease (siblings)	1.3	1.6	2.9	-0.8	-1.4	0.0	-1.4	-1.5	-1.7	-1.2	-1.2	-1.2	-1.4	-1.7
Triglycerides	1.2	2.0	3.3	-1.8	-0.9	-1.2	-1.6	-1.7	-1.6	-1.5	-0.9	-1.7	-1.7	-1.4
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.2	-1.5	-1.6	-0.7	-2.1	-1.9	-1.0	-1.4	-1.1	-1.6	-1.9	-1.8
Heart attack	1.2	1.5	4.3	-2.0	-0.6	-2.1	-1.5	-1.3	-1.1	-0.7	-0.6	-0.8	-1.1	-1.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.2	1.8	0.5	2.3	1.2	1.3	0.9	1.3	0.8	1.1	1.1	1.4
Medication: Ramipril	1.2	1.5	3.2	-1.8	-0.4	-1.7	-1.4	-1.2	-1.1	-1.5	-1.1	-1.2	-1.0	-1.3
Father’s age at death	1.2	1.7	3.0	1.0	0.7	0.3	0.9	1.5	1.7	1.6	1.4	1.6	1.6	1.5
Length of working week for main job	1.2	1.3	2.6	0.5	0.8	0.1	1.0	1.0	1.6	1.0	1.6	1.5	1.4	1.4
Heart disease (mother)	1.2	1.5	3.6	-1.1	-0.7	-1.2	-1.8	-1.2	-1.9	-0.9	-0.5	-1.0	-1.2	-1.5
Hearing aid user	1.2	1.3	2.7	-0.7	0.2	-0.6	1.5	1.4	1.3	1.5	0.6	1.5	1.4	1.6
Average weekly beer plus cider intake	1.2	1.7	3.6	1.1	0.9	1.9	1.3	1.4	1.5	1.8	-0.2	1.4	1.4	1.5
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.8	-1.8	-0.7	-1.9	-1.6	-1.4	-1.2	-0.7	-0.7	-0.9	-1.2	-1.4
Depression (Nagel 2018)	1.1	1.6	3.1	0.7	-0.0	1.7	1.1	1.3	1.7	1.6	1.2	1.5	1.2	1.5
Blood Red Count	1.1	10.2	21.3	-3.9	-2.3	-3.9	-3.2	-3.5	-2.8	-4.6	-2.4	-3.0	-2.2	-4.0
Age when periods started (menarche)	1.1	2.6	4.6	-1.0	-0.5	-1.5	-1.7	-1.7	-2.1	-2.1	-1.2	-2.1	-1.8	-1.8
Number of incorrect matches in round	1.1	1.8	3.5	-1.6	-1.1	-1.6	-1.8	-1.3	-1.2	-1.9	0.3	-0.9	-0.9	-1.8
Comparative height size at age 10	1.1	5.9	14.0	1.1	1.5	1.9	3.3	2.5	3.5	1.7	1.2	3.1	3.7	2.8
Mineral and other dietary supplements	1.1	1.5	4.2	-1.1	-0.4	-2.0	-1.4	-1.0	-1.3	-1.3	-1.2	-1.3	-1.2	-1.3
Medication: Lisinopril	1.1	1.4	2.7	0.8	1.2	0.9	1.3	1.2	1.6	1.0	1.5	1.4	1.4	1.3
Worry (Nagel 2018)	1.0	2.2	4.7	1.2	0.4	1.6	1.9	1.8	1.7	2.2	0.1	1.5	1.4	2.0
Ulcerative Colitis	1.0	1.4	2.7	1.3	0.5	1.2	1.6	1.5	1.2	1.5	0.5	1.1	1.2	1.4
Height	1.0	19.6	39.9	2.3	2.9	4.2	5.7	4.7	6.0	3.3	3.3	5.4	6.3	4.7
Ever had hysterectomy (womb removed)	1.0	1.1	2.0	-1.2	-1.2	-0.6	-0.9	-1.1	-1.2	-1.1	-1.2	-0.9	-0.9	-1.4
Diabetes (mother)	1.0	1.3	3.7	1.7	0.3	1.6	1.2	1.3	0.5	1.9	-1.0	0.3	0.2	1.5
Severe depression (siblings)	1.0	1.1	5.6	1.3	0.6	2.4	1.0	0.7	0.6	0.8	1.2	0.7	0.7	0.7
Falls in the last year	1.0	1.4	3.1	1.1	0.7	1.2	1.3	0.9	1.4	1.4	1.8	1.4	1.1	1.1
Medication: Aspirin	1.0	1.3	3.6	-1.9	0.2	-1.7	-1.2	-1.3	-0.8	-1.2	-0.1	-1.0	-1.1	-1.3
High cholesterol (Self-reported)	1.0	1.8	3.6	-1.9	-0.3	-1.9	-1.6	-1.8	-1.0	-0.8	-0.6	-1.6	-1.9	-0.9
Risk taking	1.0	1.5	3.3	-1.1	-0.3	-0.9	-1.0	-1.4	-1.5	-1.3	-1.8	-1.5	-1.5	-1.2
Unable to work because of sickness or disability	1.0	1.3	2.2	-1.4	-1.2	-1.1	-1.3	-1.0	-1.5	-1.1	0.0	-0.9	-1.1	-1.5
Schizophrenia (2018)	0.9	1.9	6.2	-0.6	-1.2	-0.2	-1.2	-1.4	-1.1	-1.2	-2.5	-1.9	-1.8	-1.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	9.3	1.3	3.0	0.8	1.2	1.2	1.4	-0.1	1.9	1.3	1.9	1.0
Coronary Artery Disease (CAD)	0.9	1.1	2.3	-0.3	-0.4	-0.8	-1.2	-1.1	-1.5	-1.0	-1.0	-1.2	-1.2	-1.5
Neuroticism (2016)	0.9	1.3	4.0	1.1	0.9	1.2	1.5	1.0	1.2	2.0	0.3	1.0	0.7	1.5
Systolic blood pressure, automated reading	0.9	2.5	6.0	-1.6	-0.1	-2.4	-1.7	-1.8	-1.3	-1.2	-1.5	-1.9	-2.0	-1.4
Hayfever, allergic rhinitis or eczema	0.9	1.9	6.5	1.5	0.6	2.5	1.6	1.6	0.8	1.0	0.6	1.3	1.6	1.4
Age at first live birth	0.9	1.5	3.9	1.2	1.2	0.9	1.2	1.2	1.4	0.7	2.0	1.3	1.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.3	-1.2	-0.8	-1.4	-1.4	-1.1	-1.5	-1.1	-0.2	-0.8	-0.9	-1.2
Osteoporosis (self-reported)	0.9	1.2	2.0	0.6	1.4	1.4	1.1	1.0	1.2	0.7	0.9	1.0	1.2	1.4
Diastolic blood pressure, automated reading	0.9	2.8	4.9	-1.7	-1.5	-1.7	-1.8	-2.0	-1.7	-1.3	-1.8	-2.0	-2.2	-1.5
Alcohol drinker status: Previous	0.9	1.0	2.6	0.9	1.6	0.9	0.8	0.5	1.1	1.3	1.4	1.0	0.6	0.7
Irritable Bowel Disease (IBD)	0.8	2.0	5.0	2.2	1.5	1.8	1.4	1.4	1.1	1.9	-0.0	0.9	1.0	1.6
Ulcerative Colitis (UC)	0.8	1.6	3.1	1.4	0.9	1.5	1.5	1.4	1.3	1.8	0.3	1.1	1.1	1.6
Heel T-Score	0.8	6.1	8.9	-2.0	-1.4	-2.3	-2.9	-3.0	-2.6	-2.8	-2.5	-2.9	-2.8	-3.0
Supplements: Zinc	0.8	0.9	2.7	-1.3	-0.3	-0.5	-0.4	-0.8	-1.1	-0.9	-1.6	-1.3	-1.1	-0.7
Leg fat-free mass (left)	0.8	4.0	9.4	1.9	0.9	3.1	2.0	1.9	3.0	1.9	0.9	2.0	2.2	2.1
Hand grip strength (right)	0.8	2.2	7.8	2.8	-0.0	2.4	1.4	1.6	1.5	1.5	0.4	0.9	0.9	1.4
Trunk fat-free mass	0.8	4.5	9.2	1.8	0.7	2.9	2.3	2.3	3.0	1.7	1.1	2.4	2.7	2.2
Trunk predicted mass	0.8	4.5	9.4	1.8	0.7	2.8	2.3	2.3	3.1	1.7	1.2	2.4	2.8	2.2
Breastfed as a baby	0.8	1.0	2.1	0.2	0.8	0.2	1.1	1.2	1.3	0.8	0.9	1.3	1.5	1.3
Hair/balding pattern: Pattern 4	0.8	2.0	4.0	0.7	0.2	1.2	1.3	1.6	1.4	1.9	2.0	1.6	1.2	1.9
Whole body fat-free mass	0.8	4.4	9.4	1.9	0.7	3.1	2.1	2.2	3.1	1.9	1.0	2.3	2.5	2.1
Whole body water mass	0.8	4.6	9.8	1.9	0.8	3.1	2.2	2.3	3.1	1.9	1.1	2.3	2.6	2.2
Lupus	0.7	1.0	2.4	-1.1	-1.6	-0.5	-1.1	-1.1	-1.1	-0.4	-0.7	-0.9	-1.5	-0.8
Lung FEV1/FVC ratio	0.7	3.6	6.8	-1.6	-0.8	-1.2	-2.4	-2.6	-2.2	-1.6	-1.8	-2.4	-2.6	-1.9
Vitamin and mineral supplements	0.7	0.9	3.7	-0.8	-0.8	-1.9	-0.8	-0.8	-0.9	-1.0	-0.7	-0.9	-0.8	-0.9
Sitting height	0.7	5.0	11.0	1.3	2.5	2.3	2.2	2.2	2.8	0.9	2.4	2.8	3.3	1.8
Leg predicted mass (left)	0.7	3.9	9.1	1.8	0.9	3.0	1.9	1.9	3.0	1.9	0.9	2.0	2.1	2.0
Fluid intelligence score	0.7	1.5	3.0	1.4	1.7	0.6	0.9	1.1	1.5	0.3	1.7	1.3	1.6	0.9
Illnesses of mother	0.7	0.8	2.4	0.5	0.3	0.8	1.5	1.1	1.4	0.7	-0.4	0.7	1.1	1.1
Birth weight of first child	0.7	1.2	4.7	1.3	2.2	1.5	0.8	0.8	0.8	1.2	0.3	0.9	0.8	0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.3	1.1	0.5	0.7	0.9	1.4	0.5	0.7	1.5	1.1	1.1	0.9
Forced vital capacity (FVC), Best measure	0.7	2.6	6.4	1.4	1.4	2.1	2.0	1.7	1.9	0.7	0.7	1.9	2.5	1.4
Illnesses of siblings: Diabetes	0.7	0.8	2.0	-0.8	-0.5	0.4	-0.9	-0.9	-0.9	-1.0	-1.4	-1.2	-1.1	-0.7
Leg fat-free mass (right)	0.7	3.8	9.7	1.9	0.9	3.1	1.9	1.9	2.9	1.9	0.8	2.0	2.1	2.0
Leg predicted mass (right)	0.7	3.9	9.9	1.9	0.9	3.1	1.9	1.9	3.0	1.9	0.8	2.0	2.1	2.0
Commuting to job workplace: Public transport	0.7	0.8	4.0	-0.4	2.0	0.1	1.0	0.7	1.1	0.4	-0.1	0.6	0.9	1.3
Illnesses of father: High blood pressure	0.7	0.8	2.0	-1.0	-0.3	-0.8	-0.5	-1.1	-0.7	-0.7	-1.4	-1.3	-1.2	-0.9
Alcohol drinker status: Never	0.7	0.9	2.5	-1.0	-0.5	-0.9	-1.1	-1.0	-0.9	-0.6	-1.6	-1.0	-1.1	-0.8
Basal metabolic rate	0.7	3.7	8.6	1.7	0.6	2.8	2.0	1.9	2.9	1.8	1.0	2.1	2.2	2.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	5.6	1.4	2.4	1.2	1.1	1.1	1.6	0.1	1.7	1.1	1.6	1.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.3	-0.2	-1.3	0.4	-0.5	-0.6	-0.5	-0.6	-1.5	-1.1	-0.9	-0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.1	0.8	0.9	1.4	1.0	0.8	0.8	0.7	0.8	0.8	1.0	0.9
Body mass index (BMI)	0.6	2.6	6.3	-1.2	-1.9	-0.9	-2.1	-2.0	-0.9	-0.8	-1.7	-2.0	-2.5	-1.5
Happiness	0.6	0.7	3.5	1.1	1.2	1.9	0.5	0.3	0.7	0.7	0.7	0.4	0.4	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	0.6	1.1	0.9	1.1	0.5	0.7	0.8	1.4	1.1	1.0	0.6
Exposure to tobacco smoke at home	0.6	0.6	1.5	-1.2	-0.6	-0.6	-0.5	-0.9	-1.0	-1.2	-0.6	-0.8	-0.6	-0.8
Qualifications: College or University degree	0.6	1.9	7.1	1.2	2.7	1.1	1.3	1.2	1.6	-0.0	1.2	1.2	1.9	1.3
Medication for pain relief, constipation, heartburn	0.6	1.1	2.5	1.6	0.5	1.1	1.1	1.3	1.3	0.7	-0.5	0.6	1.1	1.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	3.1	1.8	1.1	0.3	0.7	1.0	0.4	0.8	0.8	0.6	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	0.5	0.6	0.5	0.8	1.2	1.2	0.8	0.5	1.0	1.1	0.9
Illnesses of father: Heart disease	0.6	0.8	1.5	-0.8	-0.2	-0.4	-1.1	-1.2	-1.2	-1.0	-0.6	-0.9	-1.0	-1.2
Loneliness, isolation	0.6	0.8	3.0	0.1	0.8	0.4	0.7	0.7	1.3	1.7	0.8	1.1	0.7	1.1
Friendships satisfaction	0.6	0.7	1.7	0.1	0.5	0.5	-1.0	-1.3	-0.4	-1.0	-0.9	-1.2	-1.0	-1.1
Commuting to job workplace: Walk	0.6	0.7	1.8	0.6	1.0	1.3	0.8	0.5	1.2	0.3	0.7	0.8	0.9	0.8
Average weekly champagne plus white wine intake	0.6	0.9	5.1	0.5	1.8	-0.3	0.2	0.4	0.6	0.0	2.2	0.8	0.8	-0.1
Medication: Paracetamol	0.6	0.9	1.7	0.8	0.8	1.2	1.3	1.0	0.9	1.1	0.9	1.0	0.9	1.0
Arm fat-free mass (left)	0.6	3.1	6.6	1.5	0.4	2.4	1.8	1.9	2.6	1.6	1.0	2.0	2.1	1.8
Commuting to job workplace: Cycle	0.6	0.7	2.0	0.6	0.6	0.5	1.1	0.8	0.8	0.4	1.4	1.0	1.3	0.5
Alzheimer’s Disease (in mother)	0.5	0.6	3.0	1.7	1.0	1.5	-0.1	0.2	0.2	0.2	0.9	0.2	0.1	0.2
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-1.0	-0.6	-0.7	-0.3	-0.8	-0.8	-0.7	-0.8	-0.9	-0.8	-0.6
Angina	0.5	0.6	3.3	-1.5	-0.1	-1.8	-0.6	-0.4	-0.5	0.0	0.7	0.2	-0.4	-0.6
Medication for hormone replacement therapy	0.5	0.5	1.0	-0.7	-0.9	0.1	-1.0	-0.7	-0.8	-0.8	-0.6	-0.7	-0.8	-0.9
Medication: Metformin	0.5	0.6	2.5	0.9	0.6	1.6	0.8	0.5	0.9	1.0	0.2	0.5	0.5	0.8
Average weekly fortified wine intake	0.5	0.6	1.6	0.1	0.9	-0.2	1.2	0.9	0.6	0.6	-0.6	0.7	1.0	1.0
Fed-up feelings	0.5	0.9	3.2	0.9	-0.0	1.5	0.9	0.8	0.8	1.8	-0.9	0.5	0.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	0.1	0.1	0.9	1.0	0.9	1.0	1.1	0.6	1.1	0.9	0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.4	-1.2	-0.9	-0.6	-0.6	-0.9	-0.6	-0.7	-0.7	-0.7	-0.6	-0.8
Medication: Atenolol	0.5	0.6	1.5	0.4	0.7	0.8	0.8	1.0	1.1	1.0	0.1	0.7	0.5	1.2
Forced vital capacity (FVC)	0.5	2.0	5.6	1.2	0.9	2.0	1.6	1.4	1.7	0.4	0.5	1.7	2.4	1.1
Medication: Simvastatin	0.5	0.8	2.4	-1.5	0.0	-1.5	-1.0	-1.0	-0.5	-0.7	-0.6	-0.9	-0.9	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.5	0.6	0.8	0.7	0.7	0.4	1.1	1.1	0.9	0.6	0.9
Glaucoma (self-reported)	0.5	0.6	4.1	-0.8	-2.0	-0.5	-0.7	-0.8	-0.3	-0.8	-0.2	-0.4	-0.4	-0.8
Arm fat-free mass (right)	0.5	2.7	6.3	1.5	0.1	2.5	1.6	1.8	2.4	1.5	0.7	1.8	2.0	1.7
Pulse wave peak to peak time	0.5	0.6	1.2	0.9	0.4	0.6	0.9	1.0	0.8	1.1	0.1	0.9	0.8	0.9
Eye problems/disorders: None of the above	0.5	0.5	1.2	-0.0	-0.7	-0.1	-0.6	-1.0	-0.8	-0.6	-1.1	-1.0	-1.0	-0.4
Medication: Allopurinol	0.5	0.6	1.7	0.9	0.2	0.7	1.1	1.3	0.8	0.4	0.1	0.7	1.1	0.8
Mean time to correctly identify matches	0.5	0.9	2.0	-1.1	1.1	-1.2	-1.4	-1.1	-0.6	-0.7	0.5	-0.7	-0.7	-1.1
Arm predicted mass (right)	0.5	2.4	6.6	1.4	-0.1	2.6	1.5	1.6	2.3	1.3	0.6	1.6	1.8	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.1	-0.1	-0.5	-0.8	0.9	1.0	0.6	0.9	0.4	1.0	1.0	0.8
Smoking status: Current	0.5	0.8	1.8	-0.6	0.1	-1.0	-1.2	-0.9	-1.4	-0.3	-0.9	-0.9	-1.2	-0.6
Mother’s age at death	0.5	0.7	2.9	1.2	1.1	0.5	-0.1	0.5	0.6	0.4	1.7	0.7	0.8	0.2
Medication: Atorvastatin	0.5	0.6	3.7	0.6	0.7	0.2	0.2	0.2	0.9	0.7	1.9	0.8	0.4	0.4
Irritability	0.5	0.8	1.4	-0.7	-1.1	0.3	-1.1	-1.0	-1.2	-0.7	-0.5	-0.9	-1.1	-1.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	0.1	0.0	-0.0	1.1	1.2	0.5	0.7	0.5	1.0	1.3	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.9	0.6	0.3	1.4	1.0	0.9	0.5	0.7	0.6	1.1	1.2	0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	4.5	0.2	-0.6	0.6	-0.6	-0.7	-0.7	-0.6	-2.1	-1.3	-1.2	-1.0
Neuroticism (Nagel 2018)	0.4	1.0	2.6	0.7	-0.3	1.6	1.3	0.9	1.2	1.6	-0.0	0.8	0.7	1.2
Crohns Disease (2017)	0.4	0.9	3.9	2.0	1.4	1.8	0.5	0.6	0.2	0.9	-0.6	0.0	0.2	0.6
HDL Cholesterol	0.4	0.6	1.6	-0.8	-1.2	-0.6	-0.8	-0.7	-1.0	-0.5	-0.6	-0.7	-1.0	-0.8
Schizophrenia (2014)	0.4	0.9	2.9	0.5	-0.6	0.8	-0.7	-0.7	-0.9	-0.7	-1.7	-1.3	-1.2	-1.2
Past tobacco smoking	0.4	0.8	1.5	-0.2	-0.1	-1.1	1.1	1.1	0.6	1.0	0.9	1.2	1.0	1.2
Impedance of arm (left)	0.4	1.9	5.3	0.3	2.3	-0.0	1.6	1.0	1.6	0.8	1.9	1.5	1.8	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.5	-1.0	-0.2	-0.9	-0.9	-0.7	-0.2	-0.7	-0.9	-1.1	-0.8
Loud music exposure frequency	0.4	0.5	1.6	0.4	-0.6	0.5	-0.8	-0.3	-0.6	-0.4	-1.3	-0.8	-0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.5	-0.1	-0.3	0.3	-0.8	-1.2	-0.7	-0.4	-0.5	-1.0	-1.2	-0.9
Blood clot in the leg (DVT)	0.4	0.5	1.7	0.5	0.1	1.3	0.9	0.7	0.2	0.4	0.7	1.0	1.1	0.3
Comparative body size at age 10	0.4	1.2	3.1	1.8	0.6	1.4	1.1	0.8	1.7	1.3	-0.3	0.8	0.8	1.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.5	-0.7	-1.6	-0.8	-0.3	-0.3	-1.5	-0.5	-1.3	-0.6	-0.6	-0.6
Emphysema/chronic bronchitis	0.4	0.4	1.2	-1.1	-0.0	-1.1	-0.5	-0.5	-0.8	-0.5	0.1	-0.6	-0.7	-0.8
Qualifications: nursing, teaching	0.4	0.6	4.6	0.6	2.1	-0.2	0.3	0.3	0.6	-0.3	0.6	0.4	0.9	0.4
Medication: Gliclazide	0.4	0.5	1.5	0.6	0.1	1.2	0.7	0.5	0.8	0.9	0.7	0.6	0.5	0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	1.2	0.9	0.3	0.5	0.5	0.8	0.6	0.8	0.7	0.6	0.5	1.1
Financial situation satisfaction	0.4	0.6	2.7	1.6	1.2	1.5	0.0	0.2	0.3	0.3	-0.0	0.0	0.1	-0.3
Fractured/broken bones in last 5 years	0.4	0.6	2.0	0.3	0.3	0.8	1.4	0.6	1.0	0.5	0.7	0.7	0.9	0.9
Ever depressed for a whole week	0.4	0.5	1.4	0.7	0.5	0.7	0.4	0.6	0.3	1.1	1.2	0.8	0.5	0.6
Pain experienced in last month	0.4	0.7	2.0	0.0	1.4	-0.2	0.9	1.0	1.2	-0.0	0.6	0.8	1.2	0.9
Arm predicted mass (left)	0.4	1.9	4.6	1.0	-0.0	1.9	1.4	1.5	2.1	1.3	0.7	1.6	1.7	1.4
BMI	0.3	2.0	4.5	-0.9	-1.6	-1.1	-2.1	-1.7	-0.4	-0.8	-1.2	-1.7	-2.1	-1.6
Allergy or Eczema	0.3	0.9	4.2	0.9	0.2	2.0	0.9	1.1	0.4	0.5	0.5	0.8	1.1	0.9
Respiratory disease	0.3	0.6	1.7	0.2	-0.4	0.7	1.1	1.1	0.5	1.3	0.2	0.8	0.6	1.3
Number of treatments/medications taken	0.3	0.5	1.1	-0.7	0.6	0.6	1.0	0.5	0.7	0.5	1.1	0.7	0.6	0.8
Average weekly spirits intake	0.3	0.4	1.4	-0.1	-0.5	0.1	-0.5	-0.7	-0.1	-0.7	-1.2	-1.0	-0.7	-0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.4	-0.3	-0.9	0.6	-0.2	-0.2	0.0	-0.2	-1.2	-0.6	-0.4	-0.2
Diabetes (father)	0.3	0.4	0.8	-0.4	-0.7	0.2	-0.6	-0.7	-0.8	-0.7	-0.9	-0.7	-0.6	-0.7
Townsend deprivation index at recruitment	0.3	0.5	1.6	-1.0	-1.2	-0.9	-0.6	-0.6	-0.6	-0.5	0.6	-0.3	-0.4	-0.7
Current tobacco smoking	0.3	0.4	1.1	-0.4	0.3	-0.8	-0.9	-0.6	-1.0	-0.1	-0.9	-0.7	-0.9	-0.2
Taking other prescription medications	0.3	0.5	1.4	-0.5	0.4	0.1	0.9	0.7	0.6	0.4	1.2	0.9	0.8	0.8
Qualifications: CSEs or equivalent	0.3	0.5	2.1	-1.0	-1.5	-0.3	-0.2	-0.6	-0.7	-0.3	-0.4	-0.6	-0.7	-0.6
Supplements: Glucosamine	0.3	0.4	0.7	-0.1	0.3	0.8	0.4	0.4	0.6	0.8	0.6	0.9	0.7	0.7
Had menopause	0.3	0.3	2.0	-0.1	0.3	0.2	0.3	0.1	0.7	0.6	1.4	0.5	0.3	0.6
Pain all over the body in last month	0.3	0.3	0.8	0.8	-0.3	0.9	-0.5	-0.3	-0.5	-0.7	0.1	-0.4	-0.4	-0.7
Diabetes (self-reported)	0.3	0.5	1.3	0.1	-0.7	0.8	-0.9	-0.8	0.0	-0.3	-0.8	-1.0	-1.1	-0.8
Neuroticism score	0.3	0.5	2.1	0.4	-0.3	1.5	0.7	0.4	0.2	1.3	-1.0	0.1	-0.0	0.8
Impedance of arm (right)	0.3	1.4	4.2	-0.0	2.0	-0.4	1.5	0.7	1.3	0.6	1.6	1.3	1.5	1.0
Arm fat percentage (right)	0.3	1.0	3.2	-0.7	-0.5	-0.6	-1.4	-1.5	0.1	-0.1	-0.9	-1.4	-1.8	-0.9
Worrier / anxious feelings	0.3	0.6	1.7	0.5	-0.1	1.3	0.9	0.7	0.3	1.2	-1.1	0.2	0.2	0.8
High blood pressure (siblings)	0.3	0.4	0.8	0.2	-0.3	0.5	-0.6	-0.8	-0.5	-0.4	-0.6	-0.9	-0.9	-0.8
Worry too long after embarrassment	0.3	0.5	1.4	0.0	0.2	1.0	1.0	0.7	0.3	1.2	-0.5	0.3	0.1	1.1
Number of children fathered	0.3	0.3	0.6	0.2	-0.2	-0.1	-0.8	-0.5	-0.8	-0.5	-0.6	-0.6	-0.7	-0.7
Angina (self-reported)	0.3	0.4	2.1	-1.0	0.4	-1.4	-0.1	0.1	-0.0	0.5	1.0	0.7	0.2	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.6	1.0	-0.2	0.9	0.7	0.2	0.2	-0.6	0.4	0.7	0.8
Chest pain or discomfort	0.3	0.5	1.3	-0.5	-0.6	-0.8	-1.0	-0.5	-1.1	-0.4	0.5	-0.3	-0.7	-1.1
Arm fat percentage (left)	0.3	1.0	3.5	-0.6	-0.6	-0.4	-1.5	-1.6	0.0	-0.2	-0.8	-1.4	-1.9	-1.0
Asthma (self-reported)	0.3	0.6	1.3	0.7	-0.5	0.8	0.8	1.1	0.4	1.1	0.9	0.9	0.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.6	-1.1	-0.2	-0.8	-0.8	-1.1	-0.6	-1.3	-0.9	-0.8	-0.6	-1.0
Eye problems/disorders: Glaucoma	0.3	0.3	2.5	-0.4	-1.6	-0.6	-0.3	-0.4	-0.3	-0.4	-0.1	-0.2	-0.1	-0.4
Ever smoked	0.3	0.6	1.3	0.3	0.0	1.2	-0.9	-0.8	-0.7	-0.6	-1.0	-1.0	-1.0	-0.8
Leg fat percentage (left)	0.3	1.1	3.8	-0.3	-0.9	-0.6	-1.7	-1.4	-0.6	-0.2	-0.5	-1.4	-1.9	-1.1
Cholesterol lowering medication	0.3	0.5	2.2	-0.7	-0.2	-1.5	-0.5	-0.9	-0.3	-0.4	0.5	-0.6	-0.7	-0.6
Bipolar Disorder (2018)	0.2	0.4	1.7	1.0	0.6	1.3	0.5	0.7	0.3	0.6	-0.2	0.3	0.3	0.2
Reaction Time	0.2	0.3	1.4	-0.4	1.2	-0.9	-0.7	-0.6	0.0	-0.1	0.7	-0.1	-0.3	-0.5
Mean Putamen Volume	0.2	0.2	1.1	-0.5	-1.1	-0.2	-0.3	-0.1	0.5	-0.0	0.7	0.3	0.1	-0.0
Rheumatoid Arthritis	0.2	0.3	1.4	0.1	-1.2	0.4	-0.6	-0.6	0.2	0.3	-0.7	-0.6	-0.9	0.1
Smoking Status	0.2	0.5	1.1	-0.3	0.1	-0.4	-1.0	-0.8	-0.5	-0.9	-1.0	-1.0	-0.8	-0.8
Hypothyroidism (self reported)	0.2	0.4	0.9	-0.4	-0.9	0.0	-0.8	-0.5	-0.6	-0.3	-0.9	-0.9	-1.0	-0.3
Chronotype (morning person)	0.2	0.4	0.8	-0.5	-0.8	-0.7	-0.9	-0.7	-0.9	-0.1	0.3	-0.2	-0.7	-0.6
Hair Pigment	0.2	5.4	10.8	2.9	2.1	3.3	2.4	2.0	2.1	2.8	2.4	1.6	1.3	3.1
High blood pressure	0.2	0.5	1.5	-0.7	-0.0	-0.2	-0.9	-0.8	-0.1	-0.1	-1.0	-1.1	-1.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.2	1.1	-0.1	0.4	0.2	0.6	-0.1	0.7	0.7	0.6	0.3	0.2
Nervous feelings	0.2	0.4	1.3	0.5	1.1	0.3	0.6	0.8	0.5	0.9	0.2	0.6	0.5	0.9
Allergy	0.2	0.5	2.7	-0.5	0.7	-1.6	-0.8	-0.8	0.2	-0.4	-0.1	-0.7	-0.8	-0.6
Illnesses of siblings	0.2	0.2	1.3	-0.8	-0.4	-1.1	-0.1	0.2	0.0	-0.3	0.4	0.3	0.2	-0.0
Weight	0.2	1.2	4.9	0.7	0.1	1.5	0.9	0.8	2.2	1.2	0.4	1.0	1.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	2.2	0.1	-0.2	1.0	0.1	-0.3	-0.5	-0.1	-1.5	-0.7	-0.6	-0.3
Number of live births	0.2	0.3	1.2	0.7	0.6	1.1	0.8	0.3	0.6	0.7	-0.0	0.4	0.2	0.2
Pulse rate	0.2	0.3	1.1	-1.1	0.1	-1.0	-0.0	-0.4	-0.4	-0.2	-0.8	-0.5	-0.6	-0.2
Noisy workplace	0.2	0.3	0.7	0.1	-0.7	-0.3	-0.5	-0.6	-0.5	-0.5	-0.8	-0.6	-0.5	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.4	-1.2	0.9	-1.1	0.1	-0.1	0.4	0.4	-0.2	0.3	0.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.3	0.8	0.4	1.5	0.9	0.6	0.9	-0.0	0.4	0.9	1.3	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.7	-0.1	-0.4	-0.5	-0.6	-0.3	-0.8	0.1	-0.4	-0.3	-0.5
Peak expiratory flow (PEF)	0.2	0.5	1.3	-0.3	-0.4	-0.1	-0.7	-1.0	-1.0	-1.1	-0.2	-0.6	-0.6	-1.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	2.1	-0.2	1.5	-1.0	-0.1	0.1	-0.5	-0.2	-0.6	-0.4	-0.1	0.2
Headache pain in last month	0.2	0.3	0.8	0.9	0.8	0.8	0.5	0.3	0.5	0.7	0.2	0.2	0.1	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.2	-0.7	0.4	-0.8	-0.5	-0.3	-0.5	-0.9	-1.0	-1.0	-0.4
Birth weight	0.2	0.4	1.9	-1.2	-0.9	-0.6	0.2	0.2	-0.1	-0.1	-1.4	-0.1	0.1	-0.1
Leg fat percentage (right)	0.2	0.7	2.4	-0.2	-0.7	-0.6	-1.3	-1.1	-0.3	0.0	-0.2	-1.0	-1.5	-0.8
Exposure to tobacco smoke outside home	0.2	0.2	1.3	0.3	-1.1	0.8	0.2	-0.2	-0.1	0.6	-0.2	0.0	-0.1	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	-0.7	0.2	-0.2	0.6	0.4	0.3	0.2	1.0	0.7	0.6	-0.2
Shortness of breath walking on level ground	0.2	0.2	1.3	-0.0	-1.1	0.3	-0.5	-0.3	-0.5	-0.1	0.2	-0.4	-0.5	-0.4
Migraine (self-reported)	0.2	0.2	0.6	0.6	0.8	0.7	0.1	0.1	0.5	0.3	0.5	0.1	0.1	0.7
Alcohol intake frequency.	0.2	0.4	2.1	0.3	-0.1	1.1	0.4	0.3	0.6	1.5	0.2	0.6	0.0	0.7
Number of full sisters	0.2	0.3	1.8	0.1	-1.3	-0.0	0.6	-0.1	-0.1	0.9	-0.3	-0.0	-0.5	0.4
Suffer from ‘nerves’	0.2	0.3	0.9	-0.3	0.0	-0.7	0.8	0.6	0.2	1.0	-0.4	0.4	0.3	0.9
Overall health rating	0.2	0.5	1.0	-0.7	-1.0	0.7	-0.8	-0.7	-0.8	-0.2	-0.2	-0.6	-0.9	-0.8
Leg pain on walking	0.2	0.3	1.2	-0.8	-1.1	-0.5	-0.4	-0.4	-0.8	0.1	-0.6	-0.3	-0.4	-0.3
Smoking status: Previous	0.2	0.3	2.1	0.5	-0.0	1.5	-0.2	-0.3	0.1	-0.6	-0.6	-0.6	-0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.5	-0.8	0.9	-0.4	0.0	-0.6	-0.4	-0.5	-0.3	-0.2	-0.9
Mood swings	0.2	0.4	1.4	0.1	-1.2	1.1	-0.1	-0.3	-0.2	0.6	-0.9	-0.4	-0.6	-0.2
Diabetes diagnosed by doctor	0.2	0.3	1.2	0.1	-0.3	1.1	-0.4	-0.4	0.3	0.2	-0.7	-0.5	-0.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.5	-0.4	0.1	-0.1	-0.3	-0.8	0.0	-0.7	-0.4	-0.5	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	2.3	-0.6	-0.7	1.5	-0.2	-0.3	-0.2	-0.3	-0.4	-0.2	-0.1	-0.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-1.0	-0.7	0.7	-0.4	-0.7	-0.2	-0.3	-0.5	-0.7	-0.9	-0.1
Miserableness	0.2	0.3	1.4	0.6	0.2	1.2	0.4	0.2	0.3	0.9	-0.4	-0.0	-0.0	0.3
Guilty feelings	0.2	0.3	3.2	0.6	-0.4	1.8	0.4	0.1	0.0	0.3	-0.4	0.1	0.0	0.1
Wears glasses or contact lenses	0.2	0.3	1.1	0.1	1.0	1.0	-0.2	-0.2	-0.4	-0.5	-0.4	-0.5	-0.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.0	0.3	-0.8	1.0	0.1	-0.2	0.3	0.0	0.7	0.3	0.1	-0.1
Medication: Bendroflumethiazide	0.2	0.3	1.4	0.4	1.0	-0.5	0.2	0.7	0.3	1.2	-0.1	0.3	-0.0	0.8
Number of operations (self-reported)	0.2	0.3	1.5	-0.6	-0.4	-0.3	-0.3	-0.6	-0.5	-0.2	-1.2	-0.6	-0.6	-0.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	-0.1	-0.7	0.8	0.3	-0.0	0.9	0.7	-0.7	-0.0	-0.1	0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	0.6	0.4	0.6	-0.2	-0.2	-0.6	-0.4	-0.2	-0.3	0.0	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.8	0.6	0.6	0.0	-0.2	-0.3	-0.3	0.5	-0.2	-0.2	-0.2
Major Depression (MDD)	0.1	0.2	1.2	0.3	-0.1	0.0	-0.1	0.1	-0.3	0.4	-1.1	-0.5	-0.6	0.3
Ovarian Cancer	0.1	0.1	0.3	0.4	-0.3	-0.0	0.3	0.2	-0.2	0.5	0.4	0.2	0.2	0.1
Prostate Cancer	0.1	0.1	0.2	-0.1	-0.4	0.0	0.4	0.0	-0.2	-0.4	-0.4	-0.2	0.1	-0.4
Age at First Birth	0.1	0.1	0.2	0.0	-0.1	0.0	-0.1	-0.4	0.1	-0.5	0.3	-0.3	-0.3	-0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.6	0.3	-0.3	0.7	0.4	0.1	0.4	-0.1	-0.7	0.0	0.3	0.4
Fasting Glucose	0.1	0.1	0.5	-0.4	-0.1	-0.1	0.5	0.1	0.7	0.2	0.3	0.6	0.4	0.4
LDL Cholesterol	0.1	0.2	0.8	0.0	-0.7	0.4	-0.2	-0.3	0.1	0.0	-0.9	-0.6	-0.7	0.2
Waist Hip Ratio (WHR)	0.1	0.6	1.7	-1.0	-0.6	-0.2	-0.4	-0.8	-1.0	-1.3	-0.9	-0.8	-0.5	-0.9
Lung FVC	0.1	0.4	1.5	-0.0	-0.1	1.2	0.7	0.3	0.2	-0.3	0.4	0.9	1.2	-0.0
Neuroticism	0.1	0.3	1.3	-0.1	-0.8	1.1	0.2	0.0	0.4	0.9	-0.9	-0.1	-0.2	0.4
Relative age of first facial hair	0.1	0.1	0.5	-0.5	-0.7	-0.7	0.2	-0.0	-0.2	0.2	-0.0	0.2	0.1	-0.0
Medication: Co-codamol	0.1	0.2	0.7	-0.8	-0.3	-0.7	-0.1	-0.2	-0.5	0.1	-0.5	0.2	0.1	0.1
Impedance of leg (right)	0.1	0.5	2.2	-0.3	0.3	-1.2	0.7	0.4	-0.1	-0.0	1.5	0.8	0.9	0.3
Maternal smoking around birth	0.1	0.1	0.4	-0.6	-0.3	0.3	0.4	-0.1	0.3	-0.1	-0.6	-0.1	0.0	0.3
Relative age voice broke	0.1	0.2	0.4	-0.1	-0.0	-0.6	0.2	0.4	0.3	0.6	0.6	0.6	0.4	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.4	0.6	0.4	-0.2	-0.4	-0.4	-0.3	0.5	-0.3	-0.4	-0.6	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.6	0.1	0.3	-0.0	0.6	0.3	-0.4	0.4	-0.8	-0.0	0.1	0.4
Multivitamins +/- minerals	0.1	0.1	1.4	0.2	0.0	1.2	0.2	0.0	-0.1	-0.2	-0.0	-0.1	0.1	-0.0
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.2	0.3	0.6	-0.1	0.2	0.4	0.1	-0.4	-0.2	-0.2	0.3
Impedance of leg (left)	0.1	0.3	2.0	-0.5	-0.0	-1.4	0.1	-0.0	-0.5	-0.4	1.0	0.3	0.3	-0.2
Trunk fat mass	0.1	0.4	2.7	0.3	0.2	0.9	0.3	0.1	1.6	0.9	0.4	0.3	0.0	0.5
Waist circumference	0.1	0.2	0.7	-0.3	-0.9	0.3	-0.4	-0.6	0.5	-0.1	-0.5	-0.5	-0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.5	-0.1	-0.2	0.1	-0.4	-0.7	-0.4	-0.6	-0.4	-0.5	-0.4
Financial difficulties in last 2 years	0.1	0.1	0.5	0.4	-0.0	-0.5	-0.2	-0.1	-0.6	0.7	-0.0	0.0	-0.4	0.1
Mouth/teeth dental problems	0.1	0.2	1.3	1.2	0.1	-0.1	0.3	0.5	0.0	-0.0	0.6	0.2	0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.5	0.2	0.1	1.2	0.5	0.2	0.6	-0.4	-0.2	0.5	1.0	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.7	0.2	0.3	-0.1	0.1	0.0	0.5	-0.2	0.8	0.1	0.3	-0.2
Asthma	0.1	0.3	0.6	0.5	-0.4	0.5	0.4	0.7	0.0	0.8	0.7	0.6	0.3	0.7
Medication: Cholesterol lowering	0.1	0.2	0.6	-0.7	0.2	-0.4	-0.8	-0.5	0.3	-0.3	0.3	-0.4	-0.6	-0.3
Arm fat mass (right)	0.1	0.3	0.8	-0.3	-0.5	0.2	-0.7	-0.7	0.8	0.3	-0.5	-0.6	-0.9	-0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.5	0.1	0.4	-0.0	0.4	0.3	-0.7	-0.1	-0.0	0.4	0.5	-0.1
Gout (self-reported)	0.1	0.2	0.5	0.3	-0.6	0.2	-0.2	0.2	-0.3	-0.7	-0.4	-0.5	-0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.7	-0.8	-0.0	-0.5	0.7	0.1	-0.3	0.2	0.3	0.4	0.3	0.4
Body fat percentage	0.1	0.4	1.8	-0.4	-0.3	-0.2	-0.9	-1.0	0.3	0.2	-0.3	-0.9	-1.3	-0.6
Number of full brothers	0.1	0.2	0.8	0.9	-0.0	0.9	-0.1	-0.2	-0.2	0.3	0.2	-0.0	-0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	1.1	0.1	-1.0	-0.2	-0.4	-0.2	0.0	-0.2	0.3	-0.0	0.0	-0.2
Medication: Blood pressure	0.1	0.2	1.0	0.4	-0.0	0.1	0.4	0.4	1.0	0.8	0.1	0.2	0.1	0.7
Whole body fat mass	0.1	0.2	1.3	0.1	-0.1	0.7	-0.3	-0.3	1.1	0.7	-0.1	-0.2	-0.5	0.1
Leg fat mass (right)	0.1	0.3	1.0	-0.1	-1.0	0.3	-0.7	-0.7	0.5	0.3	-0.3	-0.6	-1.0	-0.3
Pulse rate, automated reading	0.1	0.3	1.5	-0.6	-0.4	0.2	-0.4	-0.6	-0.3	0.0	-1.2	-0.7	-0.9	-0.0
Age at last live birth	0.1	0.1	0.7	0.1	0.8	0.1	-0.0	-0.1	0.5	-0.2	0.8	-0.0	0.0	-0.1
Family relationship satisfaction	0.1	0.1	0.6	0.3	0.5	0.4	0.4	0.0	0.8	0.5	0.2	0.3	0.2	0.2
Supplements: Vitamin C	0.1	0.1	0.2	-0.2	0.2	-0.4	-0.4	-0.4	0.3	0.1	0.3	-0.1	-0.3	-0.2
Hypertension (Self-reported)	0.1	0.4	1.1	-0.7	-0.1	-0.4	-0.6	-0.7	0.1	0.1	-0.9	-0.9	-1.1	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.5	0.3	-0.1	-0.2	-0.0	-0.2	-0.1	0.4	0.3	0.1	-0.2
Arm fat mass (left)	0.1	0.3	0.7	-0.3	-0.4	0.3	-0.7	-0.7	0.8	0.4	-0.3	-0.5	-0.9	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.5	0.7	0.7	0.5	-0.2	0.0	-0.2	0.0	-0.0	-0.1	-0.1	-0.2
Myopia	0.1	0.2	1.0	0.5	-0.5	1.0	-0.1	0.1	0.1	-0.2	0.5	0.2	0.3	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.1	0.8	-0.1	0.5	1.0	0.8	0.1	0.1	0.4	0.8	1.0	0.5
Impedance of whole body	0.1	0.7	2.2	-0.3	1.2	-0.9	1.1	0.5	0.6	0.1	1.5	1.0	1.1	0.6
Leg fat mass (left)	0.1	0.4	1.3	-0.1	-1.1	0.2	-0.9	-0.9	0.4	0.2	-0.5	-0.7	-1.1	-0.5
Tanning	0.0	0.3	1.8	-0.2	0.0	-0.3	0.3	0.4	0.2	0.2	1.4	0.8	0.6	-0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.2	-0.2	0.3	0.4	-0.2	0.0	0.0	0.2	0.1	0.0	-0.2	0.1
Trunk fat percentage	0.0	0.2	0.7	-0.3	-0.1	-0.0	-0.4	-0.6	0.8	0.5	0.1	-0.3	-0.8	-0.1
Hip circumference	0.0	0.2	0.7	-0.1	-0.8	0.1	-0.5	-0.4	0.8	0.3	-0.3	-0.2	-0.5	-0.1
Medication: Paracetamol	0.0	0.1	0.3	-0.1	0.2	0.4	0.4	0.0	-0.3	0.3	0.5	0.3	0.1	0.0
Average weekly red wine intake	0.0	0.1	0.3	0.0	-0.6	-0.4	0.0	0.1	-0.1	0.2	0.3	0.1	-0.2	0.2

Hub : Genes

ASPRV1

Models

Trait associations