Best TWAS P=2.91e-13 · Best GWAS P=1.38e-18 conditioned to 1.8e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | GTEx | Breast Mammary Tissue (Male) | SNORD89 | 0.27 | 0.16 | lasso | 3 | 0.23 | 5.1e-06 | 4.0 | 7.3 | 2.9e-13 | -0.35 | 0.04 | 0.24 | TRUE |
| 6 | METSIM | Adipose | RP11-299H21.1 | 0.06 | 0.05 | enet | 9 | 0.05 | 1.2e-07 | -7.8 | -7.3 | 3.1e-13 | 0.78 | 0.03 | 0.97 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MAP4K4 | 0.02 | 0.00 | blup | 67 | 0.01 | 3.7e-03 | 6.5 | 6.3 | 3.2e-10 | -0.09 | 0.02 | 0.73 | TRUE |
| 5 | GTEx | Testis | AC016738.4 | 0.20 | 0.09 | lasso | 3 | 0.12 | 6.0e-06 | 6.8 | 6.7 | 2.7e-11 | -0.40 | 0.15 | 0.13 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TBC1D8 | 0.06 | 0.05 | lasso | 3 | 0.02 | 7.8e-04 | 5.4 | 6.1 | 1.4e-09 | -0.41 | 0.90 | 0.08 | FALSE |
| 3 | GTEx | Colon Transverse | SNORD89 | 0.38 | 0.17 | lasso | 9 | 0.20 | 6.1e-10 | 3.2 | 5.4 | 5.7e-08 | -0.11 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | IL1R2 | 0.29 | 0.07 | lasso | 12 | 0.12 | 1.5e-10 | 4.3 | 5.2 | 1.7e-07 | -0.01 | 0.72 | 0.28 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | TBC1D8 | 0.14 | 0.09 | blup | 498 | 0.09 | 1.5e-10 | -8.7 | 5.2 | 2.6e-07 | -0.62 | 0.01 | 0.99 | FALSE |