Hub : Genes

IL1R2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.2910	0.0720	9.6e-08	0.169	NA	0.120	NA	0.128	1.4e-09	NA	4.2e-07	NA	1.7e-07
2	GTEx	Skin Sun Exposed Lower leg	0.2930	0.0570	5.2e-12	0.073	NA	0.115	NA	0.125	1.2e-06	NA	8.7e-10	NA	1.5e-10
3	NTR	Blood	0.0174	0.0075	2.4e-03	0.012	0.006	0.013	0.009	0.013	5.6e-05	3.5e-03	3.8e-05	5.9e-04	3.5e-05
4	YFS	Blood	0.0472	0.0129	5.7e-12	0.051	0.047	0.045	0.052	0.049	3.1e-16	4.0e-15	1.5e-14	1.5e-16	1.2e-15
5	TCGA	Colon Adenocarcinoma	0.0970	0.0610	2.0e-03	0.037	0.031	0.019	NA	0.037	3.2e-03	6.5e-03	2.6e-02	NA	3.2e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0271	0.0158	6.6e-03	0.007	0.020	0.011	NA	0.015	4.4e-02	2.5e-03	1.8e-02	NA	6.5e-03
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.1960	0.0820	1.1e-03	0.026	0.032	0.036	NA	0.029	7.1e-03	2.8e-03	1.7e-03	NA	4.3e-03
8	TCGA	Pancreatic Adenocarcinoma	0.3240	0.1260	2.8e-07	0.076	0.141	0.195	NA	0.180	4.3e-04	1.7e-06	1.3e-08	NA	5.1e-08
9	TCGA	Stomach Adenocarcinoma	0.0750	0.0310	3.7e-05	0.046	0.056	0.060	NA	0.063	3.0e-04	6.7e-05	3.9e-05	NA	2.5e-05
10	TCGA	Thyroid Carcinoma	0.1130	0.0390	3.3e-08	0.093	0.084	0.097	NA	0.096	2.6e-09	1.5e-08	1.1e-09	NA	1.2e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.6	1.3	-0.9	-1.1	0.9	1.2	0.0	-0.0	-0.3	0.4	0.0	-1.1
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	-0.7	-1.4	-0.1	-0.1	1.5	0.7	-1.0	1.2	1.0	-0.4
Depressed Affect (Nagel 2018)	2.6	5.5	10.0	2.8	2.8	-3.2	-2.7	0.2	2.7	1.7	-0.7	1.4	2.9
Depression (Nagel 2018)	1.3	1.9	3.9	0.9	1.2	-2.0	-1.5	0.7	1.8	0.7	0.6	1.8	1.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.8	-0.2	0.0	-0.1	-0.3	0.9	1.3	-0.4	0.8	1.7	0.1
Neuroticism (Nagel 2018)	1.0	2.2	6.2	1.2	1.0	-2.2	-2.2	0.5	2.5	0.4	0.1	1.3	1.4
Schizophrenia (2018)	0.6	1.2	3.8	-0.2	-0.9	-1.0	-1.1	1.9	0.9	-1.1	1.2	1.3	0.3
Schizophrenia vs Biploar Disorder	0.6	0.8	2.2	0.2	-0.3	-0.8	-0.5	1.5	0.2	0.7	1.1	1.2	1.1
Worry (Nagel 2018)	0.1	0.2	0.5	0.2	-0.0	0.1	-0.5	-0.6	-0.1	-0.7	-0.6	-0.7	-0.1
Alzheimer’s Disease (in mother)	3.6	4.2	7.5	-1.7	-1.3	2.5	2.7	-2.4	-1.6	-0.2	-1.9	-2.1	-2.6
Alzheimer’s Disease (in father)	0.7	0.7	2.4	-0.1	-0.8	-0.6	-1.0	1.5	0.1	-0.8	1.2	0.8	0.4
Alzheimer’s Disease (including proxy)	1.6	2.3	4.2	-1.6	-1.5	1.8	2.0	-0.9	-1.2	-1.1	-1.2	-1.4	-2.0
Crohns Disease (2017)	2.3	5.1	12.5	-1.2	-2.1	-1.9	-1.4	2.9	3.5	0.0	3.1	3.0	0.2
Irritable Bowel Disease (IBD)	4.5	10.8	22.8	-2.0	-2.7	-3.3	-2.5	4.6	4.8	0.2	3.9	4.6	0.0
Ulcerative Colitis (UC)	5.0	9.3	21.3	-1.9	-2.1	-3.6	-2.8	4.1	4.6	-0.2	3.1	4.1	-0.1
Major Depression (MDD)	3.6	4.4	7.9	1.1	0.7	-2.8	-2.4	2.4	2.4	2.2	1.4	2.6	2.1
Reaction Time	0.1	0.1	0.4	0.4	0.2	0.3	-0.0	-0.4	-0.4	-0.0	0.4	-0.1	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.4	-0.5	-0.4	1.1	0.4	0.0	0.5	-1.8	0.2	0.8	-1.0
Breast Cancer	0.6	1.4	4.2	-1.8	-2.0	0.2	0.5	1.1	0.0	-1.5	0.4	-0.0	-1.6
Ovarian Cancer	1.1	1.4	3.0	-1.4	-1.7	0.9	0.7	1.7	-0.0	-0.1	1.4	1.6	-0.7
Prostate Cancer	3.0	4.2	9.5	1.3	1.2	-3.1	-3.1	0.9	2.8	0.4	1.5	2.3	1.9
Age at First Birth	0.2	0.3	1.0	0.2	0.4	-0.5	-1.0	-0.1	0.7	-0.2	0.0	-0.7	0.5
Bipolar Disorder (2011)	0.6	0.6	1.5	-0.7	-0.7	-0.4	0.2	0.9	1.0	0.1	0.8	1.2	-0.6
Body Mass Index (BMI) (2010)	0.4	0.5	2.2	0.4	-0.0	-0.9	-1.5	0.4	0.9	0.1	0.7	0.5	0.4
Coronary Artery Disease (CAD)	0.6	0.8	2.4	1.6	0.7	0.2	0.5	0.1	-1.3	0.7	-1.1	-0.8	0.6
Crohns Disease (2012)	2.8	4.5	9.9	-1.8	-2.4	-1.6	-1.0	2.7	2.9	-0.2	3.1	2.7	-0.2
Mean Putamen Volume	0.7	0.8	1.8	-0.7	-0.8	-1.1	-1.3	1.0	1.0	0.4	1.2	0.3	0.1
Fasting Glucose	1.0	1.2	3.7	-1.2	-1.4	1.2	0.7	-1.0	-0.1	-1.3	0.4	-0.6	-1.9
HbA1C	0.2	0.2	0.7	0.3	-0.5	0.6	0.2	-0.1	-0.6	-0.1	-0.0	-0.8	-0.2
HDL Cholesterol	0.5	0.8	2.3	0.7	0.9	-0.3	-0.3	0.4	-0.3	1.5	1.1	1.5	1.0
LDL Cholesterol	0.6	0.9	2.8	-0.4	-0.6	1.0	1.2	-0.8	-1.2	-1.7	-0.4	-0.5	-1.0
Lupus	0.9	1.4	2.6	1.2	0.7	-1.4	-1.3	1.1	1.0	0.7	0.9	1.4	1.6
Neuroticism (2016)	0.7	1.0	2.7	0.2	-0.4	-1.1	-1.6	1.3	1.6	-0.8	0.4	0.8	0.3
Primary Biliary Cirrhosis	0.9	1.3	4.4	0.5	-0.3	-1.5	-1.1	2.1	0.8	0.2	1.1	1.3	0.8
Rheumatoid Arthritis	0.3	0.5	0.9	-0.8	-0.9	0.9	0.7	0.3	-0.4	0.2	0.9	0.7	-0.4
Schizophrenia (2014)	1.5	3.2	8.9	-0.4	-1.1	-1.7	-1.6	3.0	2.1	-0.5	2.1	2.6	0.5
Triglycerides	0.5	0.8	1.7	-1.1	-1.1	0.6	1.1	-0.8	-0.8	-0.7	-0.3	-0.5	-1.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	-0.1	0.1	-0.2	-0.8	-0.4	0.5	-0.9	-0.1	-0.1	0.3
Ulcerative Colitis	5.2	7.5	16.4	-1.4	-1.7	-3.1	-2.0	3.6	3.9	1.0	3.3	4.0	0.7
Blood Eosinophil Count	10.6	81.8	148.8	7.1	7.6	8.5	7.5	-10.2	-11.5	12.2	-7.9	-11.3	2.5
Blood Platelet Count	0.7	8.5	17.2	3.8	4.1	-2.8	-2.1	-0.2	2.3	4.0	-1.6	0.9	4.2
Blood Red Count	0.0	0.2	0.8	-0.4	0.1	-0.7	0.2	-0.9	-0.0	0.4	-0.3	-0.2	0.1
Blood White Count	1.4	10.4	27.4	4.2	5.2	-1.5	-0.7	-2.5	-0.5	4.8	-3.2	-0.9	3.9
Heel T-Score	0.5	4.1	10.6	-2.4	-2.9	0.1	-0.7	2.7	0.2	-2.0	3.3	1.8	-1.3
BMI	1.4	8.2	18.4	0.3	-0.2	-4.3	-4.3	3.6	2.7	0.9	3.0	3.5	1.5
Height	0.9	18.2	39.6	2.6	2.7	4.1	4.0	-5.3	-5.3	-2.4	-5.8	-6.3	-0.5
Waist Hip Ratio (WHR)	0.6	2.6	5.8	2.2	2.4	1.0	1.5	-1.2	-1.8	0.6	-1.7	-1.1	1.6
Systolic Blood Pressure	0.3	1.7	6.1	-1.5	-1.8	0.4	0.3	0.5	0.4	-2.5	0.9	0.6	-1.7
Smoking Status	0.9	2.2	5.0	2.0	2.0	-1.6	-0.8	1.1	0.1	1.7	-0.8	0.5	2.2
Allergy or Eczema	5.9	15.6	31.6	5.6	5.0	0.6	0.3	-2.7	-3.7	5.2	-3.6	-4.6	4.0
Cardiovascular Disease	0.4	1.2	2.6	-1.0	-1.3	-0.8	-0.9	1.6	1.4	-0.7	0.8	1.3	-0.5
Hypothyroidism (self reported)	0.1	0.3	1.0	0.9	0.1	0.2	-0.7	0.4	-0.6	-0.0	0.0	-0.4	1.0
Respiratory disease	4.3	9.7	21.7	3.9	3.6	1.4	1.1	-3.2	-3.2	4.7	-2.5	-3.6	1.8
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.6	-1.6	-1.8	0.4	-0.3	1.5	-0.2	-1.2	1.9	1.0	-0.3
Lung FEV1/FVC ratio	1.6	8.1	21.8	-0.9	-1.3	-3.0	-1.9	4.5	2.3	-1.2	3.9	4.7	1.1
Lung FVC	0.9	4.6	11.4	0.9	-0.1	3.4	2.8	-2.5	-2.7	-0.4	-2.3	-2.5	-0.8
Neuroticism	1.0	2.4	4.5	2.1	1.8	-1.8	-1.7	0.1	2.1	0.7	-1.0	1.0	1.7
Chronotype (morning person)	1.0	2.2	5.2	2.3	1.6	-1.5	-1.5	-0.2	0.4	2.2	0.0	0.4	2.1
Hair Pigment	0.2	4.9	11.4	1.7	1.7	-3.1	-3.4	1.0	2.1	2.7	1.2	2.1	2.0
Tanning	0.3	3.1	9.8	0.7	0.1	2.8	2.4	-1.3	-3.1	0.2	-1.4	-1.6	-1.1
Hand grip strength (left)	2.0	5.4	15.7	-0.6	-0.5	2.8	2.5	-2.0	-2.2	-1.9	-2.7	-4.0	-2.0
Number of treatments/medications taken	0.8	1.4	2.9	0.3	0.1	-1.6	-1.7	1.5	0.9	0.6	1.7	1.5	0.5
Average weekly spirits intake	0.8	0.9	4.8	0.6	0.5	-0.5	0.1	0.3	-0.6	2.2	1.2	1.2	0.6
Sensitivity / hurt feelings	1.6	2.8	6.4	-0.7	-0.7	-1.9	-1.9	2.5	2.5	-0.4	1.6	2.2	-0.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.1	0.2	-0.6	-0.4	0.5	0.3	-0.3	0.5	0.4	0.3
Hearing difficulty/problems: Yes	0.7	1.1	3.1	0.6	0.1	-1.2	-1.0	0.8	0.9	-0.1	1.7	1.7	0.8
Relative age of first facial hair	0.3	0.6	1.6	-1.3	-1.0	1.3	0.9	0.4	-0.2	-0.1	0.7	0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.3	-1.1	-0.7	0.3	0.3	0.3	0.1	0.1	0.5	0.2	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	-1.1	-1.2	-0.1	-0.2	0.3	0.1	-0.7	0.9	0.8	-0.9
Ever had hysterectomy (womb removed)	1.1	1.3	2.7	1.4	1.1	-1.1	-1.6	0.0	0.5	1.5	0.4	0.6	1.6
Systolic blood pressure, automated reading	0.7	1.9	3.6	-1.5	-1.9	-0.7	-0.7	1.1	1.2	-1.9	1.4	1.5	-1.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	5.9	1.2	0.5	-1.8	-2.4	1.3	1.3	-0.1	0.7	1.0	1.5
Angina	0.7	1.0	3.2	1.4	1.7	-0.3	0.0	-1.8	-0.5	0.7	-0.6	-0.7	0.4
Medication for hormone replacement therapy	0.3	0.3	1.3	-0.4	-0.8	-0.6	-1.1	0.4	-0.2	-0.6	0.6	-0.1	-0.5
Vitamin and mineral supplements	0.3	0.5	1.5	-1.2	-0.8	0.5	0.7	0.2	0.0	0.3	0.8	0.5	-0.8
Supplements: Zinc	1.1	1.2	4.9	-1.0	-0.8	-1.0	-0.4	1.1	2.2	-0.8	0.8	1.2	-0.4
Medication: Co-codamol	0.3	0.4	1.1	0.3	0.3	-0.8	-0.6	0.3	1.1	-0.1	-0.5	0.7	0.6
Medication: Metformin	0.6	0.9	3.7	-0.6	-1.1	-0.4	-0.5	1.9	0.1	-1.4	0.6	0.8	0.3
Diabetes (father)	2.3	2.8	8.2	0.0	0.3	-2.6	-2.9	1.8	2.6	-0.2	0.2	1.4	0.9
Diabetes (mother)	2.0	2.5	7.4	0.6	-0.2	-1.4	-1.5	2.4	1.5	0.6	1.8	2.7	1.4
Severe depression (siblings)	0.1	0.1	0.8	-0.3	-0.3	-0.0	-0.1	-0.2	0.2	0.9	0.2	-0.3	-0.1
Pack years adult smoking proportion	0.7	1.1	2.6	-0.8	-0.8	-0.6	-0.4	1.6	0.3	-1.5	1.4	1.4	-0.2
Impedance of leg (right)	0.8	4.1	12.1	-0.5	-0.5	3.1	3.5	-2.1	-2.4	-0.5	-1.2	-1.8	-1.8
Leg fat-free mass (left)	0.7	3.9	8.9	3.0	2.4	-2.3	-2.9	0.7	0.4	1.2	-0.5	-0.4	2.8
Trunk fat percentage	0.6	2.4	6.1	1.4	1.2	-2.5	-1.7	1.2	1.3	1.6	0.6	1.8	1.5
Hand grip strength (right)	2.9	7.8	23.3	-0.1	-0.2	3.2	3.0	-2.5	-3.3	-1.7	-3.4	-4.8	-2.1
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.6	0.8	-0.8	-0.8	0.6	0.5	0.5	0.2	0.0	0.5
Current tobacco smoking	1.6	2.6	7.1	2.0	2.7	-0.1	0.6	-1.2	-0.8	1.4	-2.5	-1.5	1.2
Average weekly fortified wine intake	0.3	0.4	1.0	1.0	0.9	-0.8	-0.2	-0.3	0.2	0.7	-0.1	0.4	0.7
Maternal smoking around birth	1.5	2.1	6.1	0.4	0.3	-2.3	-2.5	1.8	2.1	-0.7	0.7	0.8	0.7
Fed-up feelings	0.9	1.7	3.6	1.9	1.9	-1.2	-1.0	-0.3	0.9	1.0	-1.6	-0.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	4.4	1.0	1.4	-2.1	-1.9	0.9	1.9	1.0	0.1	1.3	1.6
Relative age voice broke	0.4	0.7	2.7	-1.0	-1.7	0.8	-0.0	0.7	0.2	-0.8	1.0	0.4	-0.4
Taking other prescription medications	1.4	2.2	5.0	2.1	2.2	-1.6	-1.3	-0.2	-0.1	2.2	-0.5	-0.1	1.8
Age when periods started (menarche)	1.6	3.9	13.1	3.6	3.3	-1.3	-0.9	-0.3	0.1	1.1	-1.8	-0.3	2.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.8	0.8	0.8	-1.3	-1.7	-0.2	0.8	0.3	-0.5	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.8	-1.1	-0.9	-0.1	-0.5	0.8	0.5	-1.3	1.7	0.7	-0.4
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	9.1	0.1	0.2	2.2	2.4	-1.9	-3.0	0.3	-1.8	-2.2	-0.4
Qualifications: CSEs or equivalent	0.4	0.6	1.8	0.5	0.7	0.9	0.3	-1.3	-0.5	0.9	0.2	-0.9	0.4
Serious illness, injury or assault to yourself	0.2	0.3	1.2	-0.2	0.2	0.9	0.0	-1.1	-0.0	0.7	0.4	-0.5	0.2
High blood pressure	1.6	4.4	10.1	-1.1	-1.6	-2.2	-2.1	3.2	2.2	-0.8	2.3	3.1	-0.5
Hayfever, allergic rhinitis or eczema	4.1	9.0	16.6	3.8	3.1	1.4	1.1	-1.9	-3.8	4.1	-2.6	-3.9	2.5
Multivitamins +/- minerals	1.0	1.2	4.0	2.0	1.5	-0.7	-0.7	0.3	-0.3	-0.1	-1.2	-0.4	1.9
Stomach or abdominal pain in last month	1.4	1.7	5.4	1.8	1.5	-0.2	-0.1	0.6	-1.1	1.9	0.6	0.8	2.3
Supplements: Glucosamine	1.6	2.1	4.3	-2.0	-2.1	0.0	-0.5	1.6	1.1	-1.7	1.5	1.1	-1.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.5	0.8	1.1	-0.8	-0.0	-0.2	-0.1	2.4	-0.2	0.1	1.3
Medication: Atenolol	2.2	2.8	7.7	-0.3	-0.4	-1.6	-1.7	1.5	1.9	-2.8	1.9	2.1	0.2
Medication: Levothyroxine sodium	0.3	0.4	2.3	0.4	-0.1	0.0	-0.5	-0.2	-0.0	-1.5	-0.4	-1.1	0.5
Sitting height	0.6	4.2	9.9	3.1	2.3	0.7	0.5	-1.4	-2.6	-0.3	-2.4	-2.9	1.8
Chronic bronchitis/emphysema (father)	0.3	0.3	1.2	-0.2	-0.5	-0.5	-0.4	0.5	0.5	0.7	0.5	1.1	-0.2
High blood pressure (mother)	1.5	2.1	4.2	-1.7	-1.2	-1.4	-1.3	1.2	2.0	1.3	1.7	1.4	-0.7
Body mass index (BMI)	1.4	6.0	13.9	0.7	0.2	-3.7	-3.7	3.0	2.4	1.5	2.2	2.8	1.5
Impedance of leg (left)	0.9	4.3	13.9	-0.8	-0.7	3.1	3.7	-1.9	-2.4	-0.6	-1.3	-1.9	-1.9
Leg predicted mass (left)	0.7	3.8	8.7	3.0	2.4	-2.2	-2.8	0.7	0.2	1.1	-0.5	-0.5	2.8
Trunk fat mass	0.6	2.7	6.6	2.0	1.6	-2.6	-2.1	1.1	0.9	1.5	0.4	1.2	1.9
Waist circumference	0.6	2.2	4.9	1.4	1.0	-2.2	-2.1	1.8	0.6	0.8	1.1	1.4	1.6
Number of incorrect matches in round	0.7	1.1	3.5	-1.6	-1.1	0.6	0.7	-1.1	1.1	-0.0	0.5	0.3	-1.9
Past tobacco smoking	0.5	0.9	4.0	0.3	0.7	0.8	0.3	-2.0	-0.2	0.3	-1.0	-1.6	-0.3
Alcohol usually taken with meals	3.0	4.8	9.9	-2.5	-2.4	3.1	3.0	-1.8	-2.2	-0.3	-0.0	-1.1	-2.7
Nervous feelings	0.5	1.0	2.5	-0.2	-0.0	-1.0	-1.6	0.5	1.4	-1.2	0.8	1.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.3	1.0	1.4	-1.8	-1.6	0.3	1.3	0.3	-0.1	0.6	1.3
Hearing difficulty/problems with background noise	0.6	1.0	3.1	-0.8	-1.0	-0.4	0.2	1.5	0.4	-0.5	1.7	1.8	-0.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.4	0.7	0.2	0.2	-0.3	0.8	-1.2	0.1	0.2	0.0	1.2
Had menopause	0.8	1.0	3.0	-1.1	-0.9	-0.3	-0.1	-0.3	0.7	1.2	1.2	1.7	-1.2
Had other major operations	1.1	1.4	6.4	-0.2	-0.6	1.8	1.6	-0.2	-2.5	0.6	0.8	-0.1	-0.4
Forced vital capacity (FVC)	2.2	8.6	17.6	1.1	0.5	3.8	3.6	-3.2	-4.0	-0.1	-3.6	-4.2	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.1	-1.0	-1.4	0.5	-0.1	0.8	-0.4	-1.2	1.8	0.3	-0.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.2	-1.1	-1.2	1.2	0.7	0.2	-1.5	0.2	0.7	-0.7	-0.9
Qualifications: None of the above	0.1	0.3	0.9	-0.7	-0.7	-0.3	0.4	0.9	-0.0	0.0	0.1	0.6	-0.5
Financial difficulties in last 2 years	0.7	0.9	2.1	1.3	1.1	-1.0	-1.3	0.9	0.1	0.6	-0.2	-0.3	1.4
Mouth/teeth dental problems	0.6	1.0	3.7	-1.2	-1.2	-0.3	-0.5	0.1	0.1	-1.9	0.4	-0.8	-1.4
Heart attack	1.4	1.7	3.9	-0.2	-0.1	1.9	1.6	-2.0	-1.7	0.7	-0.5	-1.3	-1.5
Allergy	6.7	15.3	26.2	-4.8	-4.3	-2.4	-1.9	3.1	5.1	-4.8	3.3	5.0	-2.9
Pain all over the body in last month	0.3	0.3	1.3	-0.7	-0.9	-0.0	0.0	0.4	0.7	0.2	0.4	0.3	-1.1
Diabetes (self-reported)	2.2	3.4	9.5	-0.3	-1.2	-1.5	-1.9	3.1	1.4	-1.0	2.5	2.8	0.7
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	8.1	0.6	1.1	1.9	1.3	-2.2	-2.8	0.7	-1.4	-2.8	-0.4
Medication: Ramipril	1.6	2.0	4.7	-2.0	-2.2	-0.2	0.3	1.4	0.1	-1.7	1.4	1.2	-1.9
Medication: Simvastatin	1.5	2.2	5.8	-2.3	-2.2	0.5	0.1	0.4	0.4	-1.8	0.8	0.9	-2.4
Fluid intelligence score	0.6	1.1	6.7	-0.9	-0.6	-0.3	-0.8	0.4	1.1	-2.6	0.8	0.9	-0.4
Illnesses of siblings	0.8	1.2	3.3	1.2	1.8	-0.3	-0.1	-1.3	0.3	1.4	-1.0	-0.8	1.0
Neuroticism score	1.0	2.1	4.5	1.4	1.5	-2.1	-2.1	0.5	2.0	0.4	-0.6	0.9	1.4
Weight	0.5	2.4	5.2	2.2	1.5	-2.2	-2.3	0.9	0.2	1.4	0.2	0.3	1.9
Impedance of arm (right)	0.7	3.0	13.0	-0.2	0.4	2.5	3.6	-2.0	-1.9	-0.1	-1.5	-0.8	-0.4
Arm fat percentage (right)	1.0	3.8	8.5	1.2	1.1	-2.9	-2.4	2.0	1.5	2.0	1.3	2.3	1.9
Trunk fat-free mass	0.3	1.8	5.5	2.3	1.4	-0.6	-1.5	-0.0	-1.4	0.3	-0.6	-1.7	1.6
Hip circumference	0.3	1.2	3.7	0.9	0.5	-1.8	-1.9	0.9	0.7	1.0	0.8	0.7	0.9
Time employed in main current job	0.4	0.4	1.1	1.0	1.1	-0.1	0.2	-0.5	-0.4	0.8	-0.0	-0.3	1.0
Alcohol intake versus 10 years previously	0.9	1.3	3.3	1.4	1.5	-0.9	-0.6	-0.0	0.0	-1.3	-1.8	-1.2	1.0
Father’s age at death	0.9	1.2	4.2	-1.0	-1.3	-0.5	-0.3	1.1	0.8	0.6	1.6	2.1	0.0
Worrier / anxious feelings	0.0	0.0	0.1	0.3	-0.0	0.2	-0.1	-0.2	-0.1	-0.2	-0.0	-0.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	6.8	2.3	2.0	-2.1	-2.1	1.3	0.5	1.2	-0.1	1.0	2.6
Falls in the last year	0.4	0.5	1.6	0.5	0.5	-0.5	-0.7	0.3	-0.1	1.3	1.2	0.6	0.7
Hair/balding pattern: Pattern 3	0.7	1.0	2.3	-1.0	-0.2	-0.2	0.1	-1.3	1.0	-0.8	-1.0	-1.5	-1.5
Number of live births	0.3	0.5	1.3	-0.0	-0.1	1.1	0.6	-1.1	-1.1	-0.7	0.3	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	6.6	0.9	0.1	2.1	2.1	-1.0	-2.6	-0.4	-1.7	-2.1	-0.0
Pulse rate	2.2	3.8	6.5	2.0	1.8	-2.0	-2.4	2.2	1.1	2.1	0.7	1.7	2.5
Happiness	1.0	1.2	2.1	-0.9	-1.0	-1.1	-1.4	1.3	1.3	-0.9	1.4	0.7	-0.2
Noisy workplace	0.2	0.2	0.6	0.3	0.4	-0.3	-0.7	-0.4	0.4	0.7	-0.4	-0.7	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.3	0.1	0.6	0.6	-0.6	-0.4	-0.3	0.3	-0.4	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	3.5	0.6	0.6	-1.9	-1.4	1.2	0.7	0.0	0.1	0.7	0.9
Mouth/teeth dental problems: Dentures	0.2	0.4	1.2	-0.4	0.2	0.4	1.0	-0.2	-0.2	1.1	-0.6	0.6	-0.6
Asthma	6.8	13.5	25.3	3.4	3.1	3.4	3.1	-4.4	-5.0	4.5	-2.5	-4.5	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.0	0.7	0.9	-1.4	-0.9	1.3	-0.0	1.7	0.5	1.7	1.1
Medication: Cholesterol lowering	0.5	0.8	1.9	-0.9	-1.2	0.8	0.4	0.0	-0.7	-1.3	0.6	0.2	-1.4
Depression (self-reported)	0.4	0.4	1.3	0.6	0.5	-1.1	-0.8	0.2	0.2	1.0	0.5	0.3	0.7
Medication: Lansoprazole	0.9	1.0	2.7	0.9	1.4	-1.3	-0.4	-0.3	0.7	1.6	-0.5	0.3	1.4
Prospective memory result	0.3	0.4	0.9	-0.7	-0.9	0.6	0.9	-0.1	-0.6	0.7	0.6	-0.3	-0.6
Lung cancer (father)	2.0	2.3	6.8	-2.2	-2.6	0.7	0.6	1.4	-1.0	-0.8	1.8	0.5	-1.7
Illnesses of mother	2.3	2.9	4.9	1.6	1.6	1.7	1.8	-2.2	-1.9	0.2	-1.9	-2.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.2	0.9	0.1	1.7	1.5	-0.6	-1.8	-0.2	-0.9	-1.1	0.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.9	1.2	1.3	-0.2	-0.2	-1.4	0.8	1.3	-0.1	0.3	0.6
Impedance of arm (left)	0.8	3.9	13.5	0.2	0.9	2.4	3.7	-2.8	-1.6	-0.0	-2.4	-1.4	-0.5
Arm fat mass (right)	0.9	3.9	8.8	1.6	1.2	-3.0	-2.8	2.0	1.1	1.8	1.3	1.9	2.2
Trunk predicted mass	0.3	1.8	5.2	2.3	1.4	-0.5	-1.4	-0.1	-1.4	0.3	-0.7	-1.8	1.6
Standing height	1.2	11.9	26.2	3.4	3.0	2.8	2.8	-4.2	-4.6	-0.3	-4.1	-5.1	1.0
Length of working week for main job	2.1	2.3	6.2	2.5	2.2	-1.4	-1.5	-0.1	0.7	1.8	-0.5	-0.0	2.0
Exposure to tobacco smoke at home	0.3	0.4	1.1	0.8	0.8	0.3	0.1	-0.6	-0.6	1.0	-0.4	-0.5	0.6
Breastfed as a baby	1.0	1.3	2.6	-1.3	-1.5	-0.2	-0.1	1.1	1.3	-0.4	1.6	1.6	-1.0
Tense / ‘highly strung’	0.5	0.8	3.4	0.7	0.4	-0.0	-1.2	-0.4	0.3	1.9	1.1	1.0	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.2	0.4	0.3	-1.6	-0.8	1.8	0.6	-0.1	0.7	1.4	1.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.9	0.5	0.5	-0.1	0.3	0.0	0.1	0.5	0.6	0.9	0.6
Birth weight of first child	1.6	3.0	5.2	1.2	1.1	2.3	1.8	-1.5	-2.1	-1.6	-2.1	-2.2	0.4
Peak expiratory flow (PEF)	0.4	0.9	3.0	1.1	1.0	-0.0	0.5	-0.9	-0.3	0.3	-1.7	-1.7	0.3
Pulse wave reflection index	3.1	3.8	14.3	1.9	2.2	1.1	1.5	-3.8	-0.4	1.9	-1.9	-1.9	0.8
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.5	-1.6	-1.7	0.2	0.4	1.1	-0.1	1.7	1.9	1.8	-0.4
Loud music exposure frequency	0.2	0.3	0.8	0.4	0.5	0.9	0.6	-0.2	-0.3	-0.0	-0.9	-0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	2.5	-0.7	-0.8	0.8	0.3	0.0	-0.4	-1.6	0.9	-0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.0	1.7	1.2	1.0	0.7	-1.0	-1.3	0.8	-0.7	-0.8	1.5
Blood clot in the leg (DVT)	0.7	0.9	2.9	-0.1	-0.2	-0.3	-0.7	1.2	0.7	0.8	1.6	1.7	0.8
Medication: Paracetamol	0.5	0.9	2.5	1.6	1.3	-0.5	-1.2	-0.1	0.3	-0.1	-0.4	-0.9	1.4
Headache pain in last month	1.3	2.2	5.6	2.4	2.2	-1.5	-1.9	-0.1	0.0	1.2	-0.2	-0.2	2.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.5	0.6	0.9	0.4	-0.0	-0.9	0.1	1.2	-0.5	-0.5	0.6
Glaucoma (self-reported)	0.3	0.4	1.2	-0.1	0.3	-0.8	-0.9	0.4	-0.4	1.1	0.4	-0.4	0.8
Gout (self-reported)	0.5	0.7	1.8	-0.7	-0.9	-0.4	-0.1	1.1	1.3	-0.9	0.0	1.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	0.7	0.2	0.6	-0.4	-0.5	-0.4	-0.6	-0.2	-0.8	0.9
Medication: Amlodipine	0.2	0.3	1.4	0.1	0.4	-1.2	-0.8	0.8	0.2	0.0	-0.6	0.3	0.1
Medication: Ventolin 100micrograms inhaler	2.1	2.7	5.5	1.7	1.7	1.1	1.0	-1.3	-2.3	2.3	-1.2	-2.1	0.9
Birth weight	0.5	1.2	3.4	0.7	0.3	-1.1	-0.8	1.5	0.9	0.3	1.1	1.8	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	-0.7	-0.9	-0.7	-1.0	1.4	0.3	-1.0	-0.2	-0.1	-0.7
High blood pressure (siblings)	0.4	0.6	1.7	-1.0	-1.3	-0.0	-0.4	1.0	-0.2	-0.7	1.2	0.6	-0.5
Forced vital capacity (FVC), Best measure	1.5	5.7	10.5	1.4	0.8	3.1	2.8	-2.7	-3.1	-0.1	-2.9	-3.2	-0.0
Body fat percentage	0.7	2.8	7.1	1.1	0.9	-2.7	-2.1	1.5	1.5	1.8	1.1	2.0	1.3
Leg fat percentage (right)	0.8	2.8	6.4	0.7	0.3	-2.5	-2.4	2.0	1.4	1.3	1.7	2.0	0.7
Arm fat-free mass (right)	0.4	2.1	6.0	2.4	1.6	-1.4	-2.3	0.1	-0.4	0.6	-0.5	-1.2	1.7
Exposure to tobacco smoke outside home	0.8	1.1	2.8	1.7	1.5	-1.0	-1.1	0.1	-0.1	1.0	-0.5	-0.5	1.4
Comparative body size at age 10	2.6	7.3	16.8	-0.1	-0.9	-3.1	-3.5	3.6	3.0	-0.2	3.1	4.1	1.4
Number of full brothers	1.4	1.7	5.2	2.3	1.7	-1.1	-0.9	-0.0	0.2	1.1	-1.3	-0.7	1.8
Worry too long after embarrassment	0.7	1.2	2.2	1.2	1.4	-1.5	-1.1	-0.4	1.4	0.9	-0.9	0.7	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	4.0	-0.1	-0.3	-0.9	-0.8	2.0	0.3	0.5	1.2	1.5	1.1
Wheeze or whistling in the chest in last year	2.8	5.0	22.6	2.0	2.3	0.4	0.2	-1.8	-2.5	4.8	-0.7	-1.9	1.8
Number of children fathered	0.8	1.0	2.6	0.0	-0.0	1.4	1.3	-0.8	-1.6	1.4	-0.2	-0.7	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.5	-2.1	-1.8	0.9	1.1	0.6	0.2	-1.6	0.6	0.8	-1.7
Age at first live birth	0.3	0.5	1.8	-0.0	-0.8	0.6	0.5	1.2	-0.6	-0.4	1.4	0.7	0.2
Pulse wave peak to peak time	0.6	0.7	1.6	-0.9	-1.1	0.3	0.3	1.3	-1.1	-1.3	-0.1	-0.5	-0.5
Health satisfaction	0.7	0.9	1.9	0.9	1.2	-0.6	-0.7	-1.2	0.6	1.4	-1.4	-0.7	0.2
Shortness of breath walking on level ground	0.8	1.0	2.3	-0.1	0.5	0.7	0.9	-1.5	-1.0	0.9	-0.9	-1.2	-1.3
Qualifications: College or University degree	0.5	1.5	5.1	0.8	1.6	0.3	0.3	-2.2	-0.1	-0.5	-1.7	-1.8	0.3
Eye problems/disorders: None of the above	0.4	0.5	1.2	-0.7	-0.9	0.6	1.1	0.1	-0.9	-0.8	-0.0	-0.2	-0.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.8	1.5	1.3	1.0	1.0	-0.6	-0.9	1.7	-0.8	-0.1	1.1
Emphysema/chronic bronchitis	0.8	0.9	2.6	1.2	1.4	-0.4	-0.5	-1.0	-0.6	-0.1	-1.6	-0.9	0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.8	0.2	0.2	0.7	0.8	-1.3	0.2	0.2	-1.0	-1.1	0.5
Neck or shoulder pain in last month	2.1	3.0	13.6	1.6	1.1	-1.4	-1.3	0.8	0.3	3.7	1.4	1.3	2.2
Medication: Blood pressure	0.5	0.9	2.2	-0.7	-0.8	-0.4	0.2	1.5	-0.3	-1.3	1.3	1.4	-0.5
Angina (self-reported)	0.8	1.1	4.3	1.2	1.5	-0.0	0.3	-2.1	-0.8	0.6	-0.6	-1.1	0.1
Migraine (self-reported)	0.8	1.0	1.8	0.5	0.4	-1.0	-1.3	0.8	0.6	1.2	1.1	1.0	1.3
Medication: Ibuprofen	3.1	3.7	10.2	0.4	0.2	-2.3	-1.7	2.9	0.6	1.7	2.1	3.2	1.6
Medication: Allopurinol	1.0	1.4	4.8	0.2	0.2	-1.9	-1.6	1.1	2.2	-0.5	-0.1	0.9	0.3
Medication: Omeprazole	1.4	1.6	3.0	1.4	1.1	-1.6	-1.7	1.0	0.5	1.7	0.6	1.2	1.3
Medication: Seretide 50 evohaler	1.1	1.3	3.4	-0.5	0.4	1.4	1.4	-1.4	-1.1	0.3	-1.2	-1.8	-0.8
Mean time to correctly identify matches	0.1	0.3	0.9	-0.5	-0.7	0.0	-0.1	-0.2	0.1	-0.4	1.0	0.9	-0.3
Heart disease (mother)	0.8	0.9	2.6	-0.2	-0.2	-1.5	-1.6	1.2	1.2	-0.8	0.5	0.5	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.3	-1.3	-1.5	0.6	0.9	0.1	-0.1	0.3	1.1	0.5	-1.2
Whole body fat mass	0.7	2.9	7.4	1.8	1.4	-2.7	-2.5	1.3	1.0	1.7	0.7	1.2	1.8
Leg fat mass (right)	0.9	3.6	9.5	1.5	1.1	-3.0	-3.1	1.9	1.4	1.3	1.2	1.5	1.6
Arm predicted mass (right)	0.4	2.0	5.5	2.4	1.6	-1.3	-2.2	-0.1	-0.5	0.5	-0.5	-1.4	1.6
Pulse rate, automated reading	0.6	2.0	4.9	2.2	1.6	-0.4	-0.7	1.2	-1.0	2.2	-0.0	0.2	2.2
Alcohol intake frequency.	0.7	1.6	2.9	1.0	0.6	-1.7	-1.4	1.7	1.4	0.3	1.0	1.2	1.5
Comparative height size at age 10	0.7	4.0	9.3	2.5	2.3	0.7	0.6	-2.6	-2.0	0.2	-2.6	-3.0	0.7
Number of full sisters	0.2	0.3	0.8	-0.4	-0.5	-0.1	-0.2	0.5	0.5	-0.9	0.0	0.4	-0.9
Suffer from ‘nerves’	0.9	1.5	4.2	0.3	0.8	-0.4	-0.7	-1.5	-0.3	-1.9	-2.0	-1.7	-0.6
Overall health rating	2.1	4.5	14.1	1.1	1.5	-3.8	-3.5	1.6	3.0	0.4	0.4	1.6	1.2
Chest pain or discomfort	1.7	2.5	5.8	0.4	0.6	2.0	1.7	-1.8	-2.0	1.1	-1.7	-2.4	-0.4
Had major operations	0.7	0.8	2.7	0.6	0.9	-1.4	-1.6	0.7	1.0	0.6	-0.1	0.2	0.4
Age at last live birth	0.4	0.5	1.7	-0.3	-1.0	0.5	0.0	0.9	-0.1	-1.3	1.1	0.3	-0.1
Family relationship satisfaction	0.9	1.1	2.3	0.3	0.3	-1.2	-1.3	1.5	1.2	0.6	0.6	1.1	1.4
Leg pain on walking	0.3	0.3	1.2	-0.6	-0.8	0.2	-0.7	-0.3	0.3	0.2	0.5	0.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.2	-1.0	-1.4	-0.8	-1.4	2.0	0.8	0.0	2.0	1.6	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	0.5	0.6	0.4	0.8	-0.8	-0.9	0.4	-1.1	-0.8	-0.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.4	-0.3	-0.5	1.5	1.8	-1.3	-0.9	-1.6	-1.4	-1.2	-1.3
Medication: Aspirin	0.7	0.9	4.2	-1.3	-0.9	0.4	0.4	0.1	-0.2	-1.0	0.6	0.3	-2.1
Supplements: Vitamin C	0.3	0.4	1.2	-0.6	-0.7	0.3	-0.0	0.2	0.7	0.6	1.1	1.0	0.0
Knee pain experienced in last month	1.4	2.2	4.7	1.3	1.5	-2.2	-2.0	0.7	1.1	1.6	-0.1	1.7	1.8
Hypertension (Self-reported)	1.4	3.9	8.6	-0.9	-1.3	-2.2	-2.1	2.8	2.3	-0.7	2.1	2.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.2	0.6	1.3	-1.0	-0.4	-0.6	0.6	1.8	-0.7	-0.2	1.2
Illnesses of father: Heart disease	0.3	0.5	1.4	-0.4	-0.5	0.7	1.2	0.6	-0.8	-0.7	0.1	0.5	-0.8
Illnesses of siblings: Diabetes	0.7	0.8	1.8	-1.3	-1.3	-0.0	1.0	1.2	-0.5	-1.1	0.1	0.4	-0.6
Smoking status: Previous	0.9	1.3	3.8	-0.7	-1.4	-0.7	-0.5	2.0	0.3	-0.4	1.8	1.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	5.7	2.4	2.2	-0.3	-0.2	-1.0	-0.8	1.3	-1.5	-1.6	2.2
Whole body fat-free mass	0.4	2.5	7.0	2.6	1.8	-1.4	-2.2	0.3	-0.6	0.7	-0.6	-1.2	2.2
Leg fat-free mass (right)	0.7	4.0	8.9	3.0	2.5	-2.4	-2.8	0.6	0.4	1.3	-0.7	-0.5	2.9
Arm fat percentage (left)	0.9	3.6	8.5	1.5	1.4	-2.9	-2.3	1.5	1.6	2.1	0.8	2.0	2.0
Average weekly red wine intake	1.8	2.7	6.0	-1.3	-1.0	2.3	2.4	-1.9	-1.5	-0.4	-1.0	-1.9	-1.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	6.2	-1.6	-0.9	-0.8	-0.6	0.2	1.0	-2.5	0.2	-0.3	-1.1
Mood swings	2.0	3.6	8.4	2.2	2.3	-2.6	-2.9	0.7	2.1	0.9	-0.4	0.6	2.3
Loneliness, isolation	1.9	2.6	5.7	1.0	0.9	-2.4	-1.9	1.5	2.0	0.1	0.8	2.2	1.8
Long-standing illness, disability or infirmity	1.2	1.8	4.3	1.3	1.5	-2.1	-1.9	0.3	1.6	1.0	-0.1	0.6	1.2
Ever had bowel cancer screening	1.9	2.2	6.6	-1.3	-1.2	-1.0	-1.0	1.7	1.8	-0.5	1.9	2.6	-0.5
Diabetes diagnosed by doctor	1.6	2.6	6.8	-0.8	-1.3	-1.2	-1.7	2.6	1.4	-1.0	1.9	2.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.8	1.1	0.7	1.9	1.3	-0.9	-1.9	0.9	-0.7	-1.0	0.7
Friendships satisfaction	0.5	0.6	2.0	0.0	-0.5	-0.6	-0.9	1.3	0.2	-1.4	0.7	0.3	0.4
Qualifications: nursing, teaching	0.6	0.9	2.2	1.1	1.5	0.0	0.0	-1.3	-0.4	1.0	-1.2	-0.9	0.9
Commuting to job workplace: Walk	1.0	1.1	3.3	-1.5	-1.5	0.5	0.4	0.2	0.2	-1.8	0.4	-0.0	-1.6
Eye problems/disorders: Cataract	0.7	0.8	3.5	0.4	0.5	1.1	0.9	-1.9	-0.5	1.2	-0.3	-0.6	-0.1
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	8.4	0.8	0.4	-2.0	-1.7	2.1	2.2	1.3	2.1	2.9	1.8
Medication for cholesterol	1.6	2.4	5.9	0.8	1.1	1.9	2.4	-1.4	-2.2	0.6	-1.5	-1.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.0	-1.7	-1.6	-0.3	-1.1	0.9	0.9	-1.0	1.1	0.7	-0.8
Back pain experienced in last month	0.4	0.5	1.4	0.5	0.7	0.0	0.3	-1.1	-1.0	0.3	-1.2	-0.8	0.2
Mineral and other dietary supplements	0.5	0.7	1.1	-1.1	-1.0	-0.5	-0.9	1.0	0.8	0.0	1.0	0.3	-0.8
Breast cancer (self-reported)	2.3	2.7	8.8	2.4	2.3	-0.8	-0.8	-0.6	0.4	3.0	-0.0	0.8	2.1
Asthma (self-reported)	6.7	13.4	25.3	3.3	3.1	3.3	3.1	-4.2	-5.0	4.7	-2.5	-4.4	1.2
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.3	-0.1	0.2	0.5	-1.4	0.8	-0.6	-1.1	-0.7	-1.1
Osteoarthritis (self-reported)	1.3	1.7	4.6	-0.6	-0.6	1.6	1.4	-0.8	-2.2	-1.9	-0.5	-0.6	-1.4
Medication: Aspirin	0.3	0.4	2.3	-0.7	-0.4	0.2	0.3	-0.1	-0.4	-0.6	0.3	0.1	-1.5
Medication: Gliclazide	0.1	0.2	0.9	0.0	-0.2	-0.1	-0.2	0.3	-0.1	-0.9	-0.3	-0.6	0.3
Illnesses of father: None of the above (group 1)	1.3	1.6	4.9	0.4	1.0	0.5	1.0	-2.1	-1.2	1.0	-1.1	-2.2	0.4
Smoking status: Current	1.3	2.1	5.8	1.8	2.4	-0.2	0.4	-0.9	-0.6	1.3	-2.4	-1.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	7.0	1.4	0.6	-1.9	-2.6	2.1	1.3	-0.6	1.1	1.4	1.8
Whole body water mass	0.4	2.4	6.9	2.6	1.9	-1.4	-2.1	0.3	-0.6	0.8	-0.5	-1.1	2.2
Leg predicted mass (right)	0.7	3.9	8.9	3.0	2.5	-2.3	-2.7	0.6	0.3	1.3	-0.7	-0.6	2.9
Arm fat mass (left)	0.9	3.6	8.6	1.8	1.4	-2.9	-2.6	1.7	1.1	1.9	0.8	1.5	2.2
Number of self-reported non-cancer illnesses	0.4	0.6	2.2	1.2	1.0	-0.7	-0.4	0.3	-0.5	1.5	-0.1	-0.3	0.5
Average weekly champagne plus white wine intake	2.4	3.2	7.3	-0.0	0.3	2.5	2.2	-2.7	-1.4	-0.1	-2.2	-2.5	-0.9
Miserableness	1.9	3.4	9.7	2.5	3.1	-2.0	-1.4	-0.8	1.6	0.4	-2.0	-0.3	2.0
Guilty feelings	0.8	1.2	2.6	-0.5	-1.0	-0.6	-1.1	1.2	1.6	-0.3	1.6	1.5	0.1
Wears glasses or contact lenses	0.7	0.8	2.4	-0.0	0.3	-1.5	-1.3	-0.4	1.2	-0.1	0.2	1.4	-0.2
Ever taken oral contraceptive pill	0.9	1.0	2.9	0.9	1.4	-0.6	-0.8	-0.7	0.6	-1.1	-1.7	-1.0	0.0
Hearing aid user	0.4	0.4	2.2	-0.4	-0.8	-0.3	-0.6	1.5	0.2	-0.1	0.6	0.7	0.1
Mother’s age at death	1.0	1.3	3.1	-1.7	-1.5	0.7	1.3	0.1	-0.2	-1.5	0.1	-0.0	-1.8
Financial situation satisfaction	0.5	0.6	2.0	1.1	0.9	-0.0	0.2	0.3	-0.3	1.4	-1.0	-0.3	1.0
Tinnitus: Yes, now most or all of the time	1.1	1.3	5.2	-1.2	-1.0	0.1	0.6	-0.3	0.2	-2.3	-0.7	-1.1	-1.9
Commuting to job workplace: Public transport	0.5	0.6	1.9	0.2	0.5	-1.3	-1.4	0.3	0.9	-0.7	0.3	-0.1	0.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	0.1	0.2	-0.5	-1.0	0.5	-0.1	1.0	0.9	0.1	0.8
Medication: Blood pressure	0.7	1.4	3.1	-1.2	-1.1	-1.0	-1.3	0.9	1.8	-0.4	1.2	1.6	-0.7
Pain type(s) experienced in last month: Hip pain	1.7	2.1	6.8	1.8	1.6	-1.5	-1.7	1.0	0.5	1.1	0.5	1.2	2.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	1.2	0.9	0.2	0.5	-1.0	-0.3	-0.2	-0.6	0.1	0.5
High cholesterol (Self-reported)	0.2	0.4	1.3	-0.7	-1.1	0.1	-0.1	0.6	-0.1	-0.8	0.8	0.4	-0.5
Medication: Bendroflumethiazide	0.7	1.1	4.7	-1.3	-1.2	-0.4	0.1	1.4	0.4	-2.2	-0.1	0.4	-0.7
Medication: Paracetamol	0.6	0.9	3.1	1.3	1.0	-0.8	-1.8	0.2	0.6	-0.3	-0.1	-0.6	1.3
Medication: Lisinopril	0.2	0.3	1.0	0.4	0.3	0.8	0.8	-0.6	-1.0	0.2	0.0	-0.0	-0.2
Medication: Atorvastatin	0.4	0.5	1.9	1.0	0.7	-1.0	-1.4	0.4	0.2	-0.5	0.3	-0.3	0.5
Illnesses of father: High blood pressure	1.8	2.2	6.6	0.5	0.7	-2.4	-1.9	1.1	2.6	-1.2	0.3	1.5	0.1
Alcohol drinker status: Never	1.6	2.0	4.8	-0.2	-0.1	-2.1	-2.0	1.4	2.2	0.4	1.2	1.5	0.6
Ever smoked	0.4	0.7	3.6	-0.2	-0.2	1.2	1.9	0.2	-1.4	0.3	-0.1	0.1	-0.3
Basal metabolic rate	0.5	2.6	7.0	2.6	1.9	-1.6	-2.2	0.5	-0.4	0.9	-0.4	-0.9	2.2
Leg fat percentage (left)	0.8	2.7	6.6	0.3	-0.1	-2.6	-2.3	2.2	1.5	1.1	1.8	1.9	0.5
Arm fat-free mass (left)	0.4	1.8	4.7	2.2	1.4	-1.3	-2.0	0.4	-0.8	0.6	-0.3	-1.1	1.7
Number of operations (self-reported)	0.5	0.7	4.3	0.7	0.6	-0.6	-0.7	0.3	0.5	2.1	0.0	0.4	0.7
Average weekly beer plus cider intake	0.3	0.5	1.7	1.0	0.1	-0.5	-0.8	1.3	-0.2	-0.2	0.1	-0.3	1.1
Irritability	2.8	4.7	11.6	-1.0	-1.1	-2.0	-1.9	2.6	2.7	0.2	3.4	3.4	0.2
Risk taking	0.2	0.2	0.6	0.6	0.0	0.7	0.4	0.8	-0.6	-0.0	-0.5	0.2	-0.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.7	-0.2	-0.2	-0.9	-0.4	0.5	1.1	-0.2	0.3	1.3	-0.2
Fractured/broken bones in last 5 years	1.9	2.4	6.4	2.5	2.5	-0.2	-0.1	-0.7	-0.6	2.0	-1.2	-0.5	2.2
Age started oral contraceptive pill	0.3	0.4	1.6	-0.2	-0.1	0.6	0.6	-1.3	-0.1	0.3	-0.6	0.0	-0.9
Diastolic blood pressure, automated reading	0.5	1.5	3.9	0.9	0.4	-2.0	-1.9	1.3	1.5	-0.1	0.8	1.2	0.7
Ever depressed for a whole week	1.2	1.4	3.1	-1.8	-1.6	1.5	1.3	0.2	-1.6	0.1	0.1	-0.7	-1.4
Unable to work because of sickness or disability	0.1	0.1	0.3	0.3	-0.0	-0.3	-0.1	0.5	0.1	0.4	0.4	0.5	0.2
Commuting to job workplace: Cycle	0.5	0.6	1.6	-1.0	-0.9	1.0	0.8	-0.7	0.2	-0.1	-0.1	-0.4	-1.3
Myopia	0.3	0.4	1.3	-0.3	0.2	-0.3	-0.4	-0.3	0.6	-0.9	-0.8	-1.1	-0.8
Vascular/heart problems diagnosed by doctor	1.2	3.2	6.4	1.4	1.8	1.6	1.6	-2.5	-1.6	0.5	-2.4	-2.5	0.9
Cholesterol lowering medication	0.7	1.1	2.8	-1.1	-0.8	-1.0	-1.0	1.0	1.2	-0.2	1.2	1.7	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.7	0.2	0.2	-1.6	-1.6	1.4	1.2	1.0	1.1	1.5	0.4
Pain experienced in last month	1.5	2.5	7.5	-2.1	-2.1	1.1	1.0	0.6	0.8	-2.7	0.5	0.0	-2.2
Supplements: Calcium	0.6	0.7	2.3	1.2	1.2	-0.6	-0.4	0.2	0.4	1.0	-0.2	0.0	1.5
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	-0.9	-0.8	0.7	0.5	0.7	-0.5	-0.6	0.6	0.5	-0.7
Heart attack/myocardial infarction (self-reported)	1.3	1.6	4.3	-0.1	0.1	1.7	1.4	-2.1	-1.7	0.7	-0.4	-1.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.3	0.3	0.2	-0.4	-0.6	0.9	0.5	1.1	1.2	1.5	1.1
Heart disease (siblings)	0.3	0.4	1.9	-0.5	-0.5	0.5	0.2	0.2	-0.2	-1.4	0.2	0.7	-0.7
Alcohol drinker status: Previous	0.3	0.3	1.1	-0.6	-0.5	0.2	0.2	0.1	1.0	0.5	0.6	0.5	-0.6
Pack years of smoking	0.7	1.0	2.6	-1.0	-0.9	-0.5	-0.3	1.3	0.4	-1.6	1.3	1.3	-0.6
Impedance of whole body	1.0	5.1	17.3	-0.3	0.2	3.1	4.2	-2.9	-2.3	-0.5	-2.2	-2.0	-1.3
Leg fat mass (left)	0.9	3.4	8.9	1.3	0.8	-3.0	-3.0	2.0	1.4	1.2	1.3	1.5	1.5
Arm predicted mass (left)	0.3	1.5	4.2	2.0	1.2	-1.1	-2.0	0.3	-0.6	0.4	-0.3	-1.2	1.4