TWAS hub - MAP4K4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1350	0.0520	0.0018	0.086	NA	0.078	NA	0.044	3.4e-05	NA	7.6e-05	NA	0.0026
2	TCGA	Breast Invasive Carcinoma	0.0174	0.0096	0.0032	0.005	0.01	0.003	NA	0.005	3.4e-02	0.0037	5.4e-02	NA	0.0310

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	9.0	69.3	102.0	10.1	6.0
Asthma	6.5	12.7	21.3	4.6	2.0
Asthma (self-reported)	5.6	11.1	18.5	4.3	1.9
Alzheimer’s Disease (in mother)	5.1	6.0	7.6	2.8	-2.1
Allergy	4.5	10.4	18.3	-4.3	-1.6
Prostate Cancer	3.6	5.1	9.9	-3.1	0.6
Serious illness, injury or assault to yourself	3.3	4.1	7.4	0.8	2.7
Frequency of tenseness / restlessness in last 2 weeks	3.3	5.1	8.2	-1.4	2.9
Average weekly champagne plus white wine intake	3.2	4.4	7.3	1.2	2.7
Number of incorrect matches in round	3.1	5.1	10.0	-0.4	-3.2
Chest pain or discomfort	3.1	4.5	5.0	2.2	2.0
Irritability	3.1	5.3	6.8	-2.6	1.9
Neuroticism (Nagel 2018)	3.0	7.2	10.7	-1.9	3.3
Alzheimer’s Disease (including proxy)	3.0	4.4	7.0	2.6	-1.3
Wheeze or whistling in the chest in last year	3.0	5.4	8.6	1.5	2.9
Depressed Affect (Nagel 2018)	2.9	6.1	9.0	-1.8	3.0
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	5.8	2.4	-0.6
Had other major operations	2.9	3.6	3.9	1.8	2.0
Medication: Seretide 50 evohaler	2.9	3.4	6.8	2.6	-0.1
Respiratory disease	2.8	6.3	7.0	2.6	2.4
Blood White Count	2.7	20.3	39.6	1.0	6.3
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	3.5	-1.6	1.9
Nervous feelings	2.7	5.0	9.5	-3.1	0.7
Exposure to tobacco smoke at home	2.7	3.1	5.3	0.9	2.3
Breast cancer (self-reported)	2.7	3.2	6.4	0.3	2.5
Breast Cancer	2.5	5.9	11.8	-0.2	-3.4
Diabetes (father)	2.5	3.1	4.6	-2.2	-1.3
Supplements: Glucosamine	2.5	3.2	6.4	0.1	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.6	3.5	1.9	1.3
Hayfever, allergic rhinitis or eczema	2.4	5.2	10.4	3.2	-0.0
Fed-up feelings	2.3	4.2	7.8	-0.8	2.8
Comparative body size at age 10	2.3	6.3	7.2	-2.7	-2.3
Risk taking	2.3	3.4	6.7	2.6	-0.2
Depression (Nagel 2018)	2.2	3.3	4.9	-1.3	2.2
Wears glasses or contact lenses	2.2	2.6	4.0	-2.0	-1.1
Number of operations (self-reported)	2.2	3.2	6.1	0.6	2.5
Medication: Cholesterol lowering	2.1	3.3	4.5	2.1	-1.4
Illnesses of mother	2.1	2.6	3.3	1.8	1.4
Medication: Ventolin 100micrograms inhaler	2.1	2.6	5.2	2.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	8.8	0.3	3.0
Loneliness, isolation	2.1	2.9	5.6	-2.4	0.5
Miserableness	2.1	3.6	6.7	-0.7	2.6
Pain type(s) experienced in last month: Hip pain	2.1	2.6	3.2	-1.4	1.8
Allergy or Eczema	2.0	5.4	8.8	3.0	1.4
Lung FEV1/FVC ratio	2.0	10.1	19.4	-4.4	0.9
Schizophrenia vs Biploar Disorder	1.9	2.6	4.0	-1.0	2.0
Type 2 Diabetes (T2D) (2018)	1.9	3.6	7.2	-0.1	-2.7
Medication: Atenolol	1.9	2.4	4.8	-2.2	-0.0
Financial difficulties in last 2 years	1.9	2.6	4.7	-0.6	2.2
Suffer from ‘nerves’	1.9	2.9	3.7	-1.4	1.9
Mood swings	1.9	3.4	3.8	-1.7	1.9
Mineral and other dietary supplements	1.9	2.5	2.6	-1.6	1.6
Supplements: Fish oil (including cod liver oil)	1.9	2.5	3.2	1.8	-1.3
Fractured/broken bones in last 5 years	1.9	2.5	3.5	1.2	1.9
Impedance of leg (right)	1.8	8.8	17.1	4.1	0.7
Hand grip strength (right)	1.8	4.8	7.0	1.6	2.6
Medication: Ramipril	1.8	2.3	4.1	-0.7	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	5.8	-0.4	2.4
Health satisfaction	1.8	2.3	3.3	-1.2	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.1	-0.7	2.0
Impedance of leg (left)	1.7	8.5	16.8	4.1	0.4
Medication: Simvastatin	1.7	2.5	3.6	1.2	-1.9
Neuroticism score	1.7	3.5	4.1	-1.7	2.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.9	0.7	2.0
Qualifications: College or University degree	1.7	5.2	5.4	-2.3	2.3
Diabetes diagnosed by doctor	1.7	2.8	5.5	-0.1	-2.4
Impedance of whole body	1.7	8.6	15.4	3.9	1.3
Blood Platelet Count	1.6	18.7	37.5	0.2	6.1
Blood clot in the leg (DVT)	1.6	2.1	4.0	-0.4	2.0
Chronic bronchitis/emphysema (mother)	1.6	1.9	2.0	-1.4	-1.4
Worry too long after embarrassment	1.6	2.7	4.6	-0.9	2.1
Medication: Paracetamol	1.6	2.5	4.9	-0.3	2.2
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.1	-0.3	2.0
Sensitivity / hurt feelings	1.5	2.6	4.4	-2.1	0.8
Medication for hormone replacement therapy	1.5	1.7	2.5	-1.6	0.9
High blood pressure	1.5	4.1	6.1	-1.4	-2.5
Mouth/teeth dental problems	1.5	2.3	3.9	-0.8	-2.0
Medication: Lansoprazole	1.5	1.8	1.9	-1.3	1.4
Length of working week for main job	1.5	1.6	3.2	-0.2	1.8
Hypertension (Self-reported)	1.5	4.1	5.8	-1.6	-2.4
Medication: Co-codamol	1.4	1.6	2.3	-1.5	-0.9
Maternal smoking around birth	1.4	2.0	2.8	-1.7	1.1
Forced vital capacity (FVC)	1.4	5.6	7.0	2.6	2.0
Happiness	1.4	1.7	3.2	-1.8	-0.4
Depression (self-reported)	1.4	1.6	1.8	-1.4	1.2
Lung cancer (father)	1.4	1.6	3.0	0.5	-1.7
Leg predicted mass (right)	1.4	7.2	8.5	-2.9	2.5
Commuting to job workplace: Public transport	1.4	1.7	1.8	-1.2	1.3
Worry (Nagel 2018)	1.3	2.7	4.6	-0.9	2.2
Neuroticism	1.3	3.2	6.2	-0.4	2.5
Leg predicted mass (left)	1.3	6.7	7.6	-2.8	2.4
Diabetes (self-reported)	1.3	1.9	3.2	-0.9	-1.8
Impedance of arm (left)	1.3	6.1	9.7	3.1	1.6
Forced vital capacity (FVC), Best measure	1.3	4.9	5.3	2.1	2.3
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.2	1.5	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.0	0.5	-1.7
Leg fat-free mass (right)	1.3	7.0	8.5	-2.9	2.4
Waist Hip Ratio (WHR)	1.2	5.3	8.2	1.6	2.9
Smoking Status	1.2	2.8	5.7	-0.1	2.4
Ever had hysterectomy (womb removed)	1.2	1.4	2.7	-0.3	1.7
Leg fat-free mass (left)	1.2	6.6	7.6	-2.8	2.4
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	1.9	-1.0	1.4
Sitting height	1.2	8.6	16.3	0.9	4.0
Impedance of arm (right)	1.2	5.8	10.4	3.2	1.1
Mean time to correctly identify matches	1.2	2.2	4.4	0.2	-2.1
Heart disease (mother)	1.2	1.4	2.8	-1.7	0.2
Number of self-reported non-cancer illnesses	1.2	2.1	3.6	1.9	-0.7
Myopia	1.2	1.7	1.8	-1.3	-1.3
Pain experienced in last month	1.2	1.9	3.5	-0.6	-1.9
Coronary Artery Disease (CAD)	1.1	1.3	1.5	1.1	1.2
Lung FVC	1.1	5.7	11.2	3.4	-0.3
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.6	1.6	0.5
Vitamin and mineral supplements	1.1	1.5	3.0	-0.2	1.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.4	-1.2	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.2	1.5	-0.6
Ever smoked	1.1	2.0	2.8	1.7	1.1
Bipolar Disorder (2018)	1.0	1.6	2.4	1.6	-0.9
Ulcerative Colitis (UC)	1.0	1.8	2.3	-1.1	-1.5
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.0	-1.4	0.6
Ulcerative Colitis	1.0	1.4	2.1	-0.8	-1.5
BMI	1.0	5.8	10.6	-3.3	-1.0
Standing height	1.0	9.9	19.0	0.8	4.4
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	2.9	-0.6	1.7
Emphysema/chronic bronchitis	1.0	1.1	2.0	-0.5	1.4
Comparative height size at age 10	1.0	5.6	10.9	0.6	3.3
Overall health rating	1.0	2.0	4.1	-2.0	0.1
Family relationship satisfaction	1.0	1.3	1.6	-1.3	1.0
Vascular/heart problems diagnosed by doctor	1.0	2.8	4.5	1.0	2.1
Pack years of smoking	1.0	1.5	3.0	0.1	-1.7
Pack years adult smoking proportion	0.9	1.4	2.8	0.1	-1.7
Current tobacco smoking	0.9	1.4	2.7	0.3	1.6
Average weekly fortified wine intake	0.9	1.0	2.0	-0.2	1.4
Stomach or abdominal pain in last month	0.9	1.1	2.0	0.5	1.4
Body mass index (BMI)	0.9	3.8	7.1	-2.7	-0.7
Alcohol usually taken with meals	0.9	1.5	2.1	0.9	-1.5
Arm fat-free mass (right)	0.9	4.8	5.5	-2.3	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.3	1.1	-0.9
Medication: Ibuprofen	0.9	1.1	1.3	-1.0	1.1
Arm predicted mass (right)	0.9	4.8	5.2	-2.3	2.1
Whole body fat-free mass	0.9	4.9	5.3	-2.3	2.1
Commuting to job workplace: Walk	0.9	1.0	1.4	0.8	-1.2
Osteoarthritis (self-reported)	0.9	1.1	1.9	1.4	0.6
Whole body water mass	0.9	5.0	5.2	-2.3	2.2
Hearing aid user	0.9	1.0	1.1	-0.9	-1.1
Financial situation satisfaction	0.9	1.1	1.9	1.4	0.6
Medication: Atorvastatin	0.9	1.1	1.8	-1.4	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.6	-1.3	-0.7
Unable to work because of sickness or disability	0.9	1.2	1.3	1.1	1.0
Fasting Glucose	0.8	1.0	1.9	0.2	-1.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.2	-0.2	1.5
Angina	0.8	1.0	1.9	0.2	1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	3.8	1.2	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	4.2	1.1	2.0
Medication: Paracetamol	0.8	1.3	2.6	0.1	1.6
Headache pain in last month	0.8	1.3	2.5	-0.5	1.6
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.9	-1.4	0.2
Medication for cholesterol	0.8	1.2	1.9	1.4	0.7
Mother’s age at death	0.8	1.0	2.0	-1.4	0.3
Medication: Lisinopril	0.8	1.0	2.0	1.4	0.1
Basal metabolic rate	0.8	4.7	5.2	-2.3	2.0
Height	0.7	13.6	25.5	1.3	5.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	-1.3	-0.1
Waist circumference	0.7	2.5	4.0	-2.0	0.9
Tense / ‘highly strung’	0.7	1.2	1.8	-0.8	1.3
Birth weight of first child	0.7	1.3	1.5	1.0	1.2
Pulse wave reflection index	0.7	0.9	1.3	0.7	1.1
Loud music exposure frequency	0.7	0.8	0.8	0.9	0.9
Gout (self-reported)	0.7	1.0	2.0	-0.0	-1.4
Medication: Blood pressure	0.7	1.3	2.6	-0.1	-1.6
Angina (self-reported)	0.7	0.9	1.7	0.3	1.3
Back pain experienced in last month	0.7	1.0	1.7	1.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.7	-1.7	0.5
High cholesterol (Self-reported)	0.7	1.2	1.8	1.4	-0.7
Basal cell carcinoma (self-reported)	0.7	0.8	1.5	-0.3	-1.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.4	-1.8	0.5
Hearing difficulty/problems: Yes	0.6	0.9	1.1	-0.8	1.0
Relative age of first facial hair	0.6	1.1	2.3	0.1	1.5
Trunk fat mass	0.6	2.4	2.5	-1.5	1.6
Weight	0.6	3.1	4.5	-2.1	1.2
Trunk fat-free mass	0.6	3.4	3.5	-1.8	1.9
Alcohol intake versus 10 years previously	0.6	0.8	1.5	-1.2	0.4
Worrier / anxious feelings	0.6	1.2	1.9	-0.6	1.4
Pulse rate	0.6	1.1	1.5	-0.8	1.2
Trunk predicted mass	0.6	3.4	3.7	-1.8	1.9
Breastfed as a baby	0.6	0.8	1.0	-0.8	-1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	0.8	0.8	-0.9
Supplements: Vitamin C	0.6	0.8	1.4	0.3	-1.2
Smoking status: Current	0.6	1.0	1.9	0.3	1.4
Arm fat mass (left)	0.6	2.3	3.7	-1.9	1.0
Ever taken oral contraceptive pill	0.6	0.7	1.3	-0.3	1.1
Medication: Blood pressure	0.6	1.1	1.3	-0.9	-1.2
Arm fat-free mass (left)	0.6	3.1	3.4	-1.9	1.7
Age started oral contraceptive pill	0.6	0.7	1.2	-0.5	1.1
Ever depressed for a whole week	0.6	0.8	1.5	1.2	0.2
Schizophrenia (2018)	0.5	1.1	2.2	-1.5	0.2
Irritable Bowel Disease (IBD)	0.5	1.1	2.2	0.2	-1.5
LDL Cholesterol	0.5	0.8	1.4	1.2	-0.3
Neuroticism (2016)	0.5	0.7	1.0	1.0	-0.7
Cardiovascular Disease	0.5	1.6	2.6	0.8	-1.6
Systolic blood pressure, automated reading	0.5	1.5	2.7	-0.6	-1.6
High blood pressure (mother)	0.5	0.8	1.5	-1.2	-0.3
Fluid intelligence score	0.5	1.1	2.0	-1.4	-0.5
Hip circumference	0.5	2.0	4.0	-2.0	0.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	-1.2	0.0
Prospective memory result	0.5	0.6	0.9	0.5	-0.9
Arm fat mass (right)	0.5	2.2	3.8	-1.9	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	0.9	-1.0	0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	1.1	0.2
Glaucoma (self-reported)	0.5	0.5	0.7	-0.7	0.8
Medication: Amlodipine	0.5	0.8	1.5	-0.2	-1.2
Whole body fat mass	0.5	2.0	2.9	-1.7	1.1
Pulse rate, automated reading	0.5	1.5	2.8	0.4	1.7
Long-standing illness, disability or infirmity	0.5	0.7	1.4	-0.1	1.2
Ever had bowel cancer screening	0.5	0.6	1.2	-0.1	-1.1
Eye problems/disorders: Cataract	0.5	0.6	0.7	0.8	0.7
Illnesses of father: High blood pressure	0.5	0.6	1.2	-1.1	-0.1
Alcohol drinker status: Never	0.5	0.6	0.8	-0.9	-0.6
Leg fat mass (left)	0.5	1.8	3.2	-1.8	0.6
Arm predicted mass (left)	0.5	2.6	3.1	-1.8	1.4
HbA1C	0.4	0.5	0.8	0.3	-0.9
HDL Cholesterol	0.4	0.6	1.2	0.3	-1.1
Heel T-Score	0.4	3.2	6.2	-0.4	-2.5
Hand grip strength (left)	0.4	1.0	1.2	0.9	1.1
Supplements: Zinc	0.4	0.4	0.8	-0.1	-0.9
Medication: Metformin	0.4	0.6	1.0	-0.5	-1.0
Age when periods started (menarche)	0.4	1.1	2.1	-0.1	1.5
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	-0.9	-0.6
Qualifications: None of the above	0.4	0.8	1.1	1.1	-0.7
Heart attack	0.4	0.6	1.1	1.0	-0.2
Pain all over the body in last month	0.4	0.4	0.8	0.2	-0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.1	1.1	-0.2
Mouth/teeth dental problems: Dentures	0.4	0.6	1.2	1.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.5	0.9
Number of children fathered	0.4	0.4	0.7	0.3	0.8
Leg fat mass (right)	0.4	1.5	2.6	-1.6	0.7
Alcohol intake frequency.	0.4	0.9	1.8	-1.4	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.6	0.8	-0.5
Knee pain experienced in last month	0.4	0.6	1.1	-0.3	1.1
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.9	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.4	0.9	0.1	0.9
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	-0.4	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	1.0	0.0
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.8	-0.2
Mean Putamen Volume	0.3	0.3	0.6	-0.8	-0.3
Lupus	0.3	0.5	1.0	-0.1	-1.0
Schizophrenia (2014)	0.3	0.7	1.3	-1.2	0.2
Systolic Blood Pressure	0.3	1.5	2.5	0.7	-1.6
Tanning	0.3	3.8	7.6	2.8	0.2
Number of treatments/medications taken	0.3	0.6	1.0	0.3	-1.0
Severe depression (siblings)	0.3	0.3	0.6	0.8	0.1
Trunk fat percentage	0.3	1.0	1.2	-0.9	1.1
Medication: Levothyroxine sodium	0.3	0.5	0.6	-0.8	0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	0.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.4	0.5	-0.6
Father’s age at death	0.3	0.4	0.7	-0.3	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.2	-1.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	-0.2	-1.0
Number of full brothers	0.3	0.4	0.6	0.3	0.8
Shortness of breath walking on level ground	0.3	0.3	0.5	0.7	0.3
Medication: Allopurinol	0.3	0.4	0.5	-0.7	-0.5
Age at last live birth	0.3	0.5	0.6	0.8	-0.7
Medication: Aspirin	0.3	0.4	0.7	0.8	0.0
Arm fat percentage (left)	0.3	1.3	2.1	-1.4	0.8
Average weekly red wine intake	0.3	0.5	0.9	1.0	-0.0
Friendships satisfaction	0.3	0.4	0.8	-0.9	-0.2
Qualifications: nursing, teaching	0.3	0.4	0.7	-0.3	0.8
Average weekly beer plus cider intake	0.3	0.4	0.6	0.5	0.8
Diastolic blood pressure, automated reading	0.3	1.0	1.8	-1.4	-0.3
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.4	-0.7	-0.5
Major Depression (MDD)	0.2	0.2	0.2	-0.4	0.4
Ovarian Cancer	0.2	0.2	0.3	0.6	-0.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	-0.5	-0.4
Rheumatoid Arthritis	0.2	0.3	0.6	0.8	0.3
Blood Red Count	0.2	1.9	3.7	-1.9	-0.2
Chronotype (morning person)	0.2	0.5	0.7	-0.6	0.9
Average weekly spirits intake	0.2	0.3	0.5	-0.4	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	-0.6	-0.4
Diabetes (mother)	0.2	0.2	0.3	0.3	0.6
Taking other prescription medications	0.2	0.3	0.4	0.4	0.6
Illnesses of siblings	0.2	0.3	0.4	-0.4	0.6
Arm fat percentage (right)	0.2	1.0	1.8	-1.3	0.4
Time employed in main current job	0.2	0.2	0.3	-0.6	0.3
Number of live births	0.2	0.2	0.4	0.6	-0.2
Noisy workplace	0.2	0.2	0.4	0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.0	-0.1	1.0
Body fat percentage	0.2	0.7	1.1	-1.0	0.6
Neck or shoulder pain in last month	0.2	0.3	0.3	0.5	0.6
Migraine (self-reported)	0.2	0.3	0.5	-0.7	-0.1
Medication: Omeprazole	0.2	0.2	0.4	0.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.7	-0.2
Osteoporosis (self-reported)	0.2	0.2	0.3	0.4	-0.5
Medication: Aspirin	0.2	0.2	0.3	0.6	0.3
Guilty feelings	0.2	0.3	0.6	-0.1	0.8
Leg fat percentage (left)	0.2	0.6	1.1	-1.0	-0.2
Supplements: Calcium	0.2	0.2	0.3	0.4	0.5
Alcohol drinker status: Previous	0.2	0.2	0.4	0.1	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	0.5
Crohns Disease (2017)	0.1	0.2	0.4	0.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.3	-0.5	0.5
Crohns Disease (2012)	0.1	0.2	0.2	0.5	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.1	-0.2	0.4
Triglycerides	0.1	0.1	0.1	-0.3	0.4
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.2	0.7
Hair Pigment	0.1	3.4	3.5	-1.8	1.9
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.2	0.3
Relative age voice broke	0.1	0.1	0.3	-0.5	0.2
Multivitamins +/- minerals	0.1	0.2	0.3	0.2	-0.5
Past tobacco smoking	0.1	0.2	0.3	-0.2	-0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.2	0.4	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.3	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.7	-0.0
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.1	0.7
Birth weight	0.1	0.2	0.3	-0.6	-0.3
High blood pressure (siblings)	0.1	0.1	0.3	-0.5	-0.1
Leg fat percentage (right)	0.1	0.2	0.5	-0.7	0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.0
Age at first live birth	0.1	0.3	0.5	-0.7	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.5	0.1
Number of full sisters	0.1	0.2	0.4	0.0	0.6
Had major operations	0.1	0.1	0.3	-0.5	-0.2
Leg pain on walking	0.1	0.1	0.2	-0.5	0.1
Illnesses of father: Heart disease	0.1	0.2	0.3	0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.3	-0.3
Cholesterol lowering medication	0.1	0.1	0.2	-0.0	-0.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.2	-0.4
Reaction Time	0.0	0.1	0.1	0.2	-0.3
Age at First Birth	0.0	0.0	0.0	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	-0.1	0.2
Qualifications: CSEs or equivalent	0.0	0.1	0.1	-0.2	0.2
Had menopause	0.0	0.1	0.1	-0.2	-0.2
Falls in the last year	0.0	0.0	0.0	-0.0	0.0
Pulse wave peak to peak time	0.0	0.0	0.1	0.3	-0.1
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.1	-0.1
Smoking status: Previous	0.0	0.0	0.0	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	-0.3	-0.2
Medication: Gliclazide	0.0	0.1	0.1	0.0	-0.3
Medication: Bendroflumethiazide	0.0	0.1	0.1	0.1	0.3
Heart disease (siblings)	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

MAP4K4

Models

Trait associations