Best TWAS P=6.8e-13 · Best GWAS P=1.69e-12 conditioned to 0.043
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ABCF3 | 0.05 | 0.00 | blup | 494 | 0.01 | 1.6e-02 | -3.6 | 6.4 | 1.3e-10 | 0.65 | 0.07 | 0.53 | FALSE |
| 2 | GTEx | Esophagus Mucosa | ABCC5 | 0.13 | 0.10 | lasso | 5 | 0.09 | 1.8e-06 | -5.5 | -5.5 | 4.0e-08 | -0.66 | 0.73 | 0.27 | FALSE |
| 3 | GTEx | Heart Left Ventricle | AP2M1 | 0.10 | 0.06 | enet | 15 | 0.03 | 9.7e-03 | -5.0 | -6.3 | 3.8e-10 | -0.30 | 0.41 | 0.39 | FALSE |
| 4 | GTEx | Whole Blood | ABCC5 | 0.10 | 0.08 | lasso | 4 | 0.08 | 9.9e-08 | 6.4 | -7.0 | 2.5e-12 | -0.89 | 0.03 | 0.97 | FALSE |
| 5 | NTR | Blood | ABCC5 | 0.08 | 0.11 | enet | 26 | 0.11 | 6.8e-33 | 6.4 | -7.2 | 6.8e-13 | -0.82 | 0.23 | 0.77 | TRUE |
| 6 | YFS | Blood | ABCC5 | 0.25 | 0.37 | enet | 48 | 0.42 | 8.9e-154 | 6.4 | -6.8 | 1.3e-11 | -0.90 | 0.23 | 0.77 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABCC5 | 0.04 | 0.03 | enet | 9 | 0.03 | 5.5e-04 | 5.6 | -6.2 | 5.6e-10 | -0.82 | 0.06 | 0.90 | FALSE |