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chr3:195,734,915-197,161,849

Best TWAS P=7.41e-26 · Best GWAS P=1.01e-46 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	PAK2	0.03	0.00	blup	83	0.01	1.4e-02	10.38	-10.5	7.4e-26	0.72	0.05	0.37	TRUE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	C3orf34	0.03	0.00	blup	60	0.02	6.8e-06	-5.68	10.3	8.1e-25	-0.64	0.36	0.18	TRUE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PAK2	0.04	0.00	blup	82	0.00	1.1e-01	10.80	-8.4	5.8e-17	0.57	0.02	0.25	TRUE
46	The Cancer Genome Atlas	Thyroid Carcinoma	C3orf34	0.11	0.11	blup	59	0.12	1.4e-11	-5.59	7.5	6.6e-14	-0.40	1.00	0.00	TRUE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	C3orf34	0.04	0.04	enet	9	0.02	9.2e-03	7.45	6.5	1.1e-10	-0.35	0.03	0.21	TRUE
41	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C3orf34	0.12	0.06	blup	59	0.06	1.6e-03	0.87	6.4	1.9e-10	-0.33	0.04	0.06	TRUE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PIGX	0.16	0.00	lasso	8	0.04	6.3e-03	-6.60	6.0	2.1e-09	-0.27	0.02	0.05	TRUE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C3orf34	0.06	0.05	lasso	2	0.02	2.8e-02	-5.68	5.8	7.6e-09	-0.30	0.16	0.03	TRUE
11	GTEx	Brain Cerebellar Hemisphere	CEP19	0.33	0.00	enet	27	0.12	7.1e-04	-6.60	5.3	1.4e-07	-0.32	0.08	0.10	TRUE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	C3orf34	0.05	0.06	enet	10	0.05	2.8e-06	-6.41	9.6	7.3e-22	-0.57	0.85	0.06	FALSE
26	GTEx	Thyroid	CEP19	0.24	0.15	enet	24	0.19	1.4e-14	-6.59	8.7	2.3e-18	-0.45	0.99	0.01	FALSE
12	GTEx	Brain Frontal Cortex BA9	CEP19	0.36	0.07	enet	17	0.13	3.3e-04	-6.38	8.7	3.4e-18	-0.47	0.16	0.16	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CEP19	0.18	0.10	lasso	6	0.12	1.3e-14	-5.68	8.2	2.9e-16	-0.46	0.97	0.03	FALSE
15	GTEx	Esophagus Muscularis	CEP19	0.16	0.11	lasso	4	0.07	3.4e-05	-6.60	6.5	8.6e-11	-0.29	0.97	0.00	FALSE
10	GTEx	Brain Caudate basal ganglia	CEP19	0.31	0.18	lasso	5	0.18	8.0e-06	-6.59	6.5	1.1e-10	-0.29	0.60	0.02	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf34	0.05	0.07	lasso	1	0.06	1.1e-07	-6.41	6.4	1.4e-10	-0.30	1.00	0.00	FALSE
24	GTEx	Testis	CEP19	0.58	0.50	lasso	2	0.50	5.6e-25	-6.41	6.4	2.0e-10	-0.30	1.00	0.00	FALSE
17	GTEx	Lung	PIGX	0.21	0.08	enet	7	0.08	1.8e-06	-6.59	6.3	2.3e-10	-0.29	0.98	0.01	FALSE
25	GTEx	Thyroid	PIGX	0.12	0.05	lasso	3	0.04	2.3e-04	-6.60	6.3	3.1e-10	-0.28	0.82	0.04	FALSE
6	GTEx	Adrenal Gland	CEP19	0.24	0.17	lasso	3	0.15	4.8e-06	-5.68	6.2	5.1e-10	-0.31	0.72	0.02	FALSE
5	GTEx	Adrenal Gland	PIGX	0.24	0.01	lasso	6	0.04	1.1e-02	-5.58	6.2	5.8e-10	-0.30	0.47	0.04	FALSE
9	GTEx	Artery Tibial	CEP19	0.11	0.07	lasso	3	0.07	5.3e-06	-5.68	6.2	7.7e-10	-0.30	0.89	0.01	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C3orf34	0.08	0.14	lasso	5	0.15	2.3e-16	-5.85	6.1	8.4e-10	-0.28	1.00	0.00	FALSE
16	GTEx	Heart Atrial Appendage	CEP19	0.19	0.08	lasso	6	0.07	5.9e-04	-6.38	6.1	1.3e-09	-0.28	0.69	0.03	FALSE
18	GTEx	Muscle Skeletal	PIGX	0.24	0.23	lasso	3	0.25	1.1e-24	-5.52	6.0	1.5e-09	-0.35	1.00	0.00	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	PIGX	0.17	0.11	lasso	3	0.13	1.7e-07	-5.52	6.0	2.2e-09	-0.28	0.99	0.00	FALSE
23	GTEx	Stomach	PIGX	0.22	0.18	lasso	2	0.16	3.7e-08	-5.85	6.0	2.4e-09	-0.28	0.98	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	PIGX	0.16	0.05	lasso	5	0.08	2.3e-06	-5.52	5.9	2.9e-09	-0.32	0.97	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	CEP19	0.27	0.15	lasso	4	0.15	5.3e-08	-5.68	5.9	4.6e-09	-0.31	0.99	0.00	FALSE
7	GTEx	Artery Aorta	PIGX	0.19	0.12	lasso	3	0.12	3.6e-07	-5.52	5.8	5.6e-09	-0.29	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PIGX	0.08	0.08	lasso	4	0.08	4.5e-09	-5.57	5.8	5.6e-09	-0.30	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	PIGX	0.07	0.07	lasso	6	0.06	6.5e-08	-6.60	5.8	7.1e-09	-0.24	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C3orf34	0.20	0.21	lasso	5	0.23	1.5e-08	-6.60	5.8	7.9e-09	-0.22	0.96	0.00	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	C3orf34	0.07	0.09	lasso	2	0.09	1.2e-10	-5.50	5.7	1.1e-08	-0.28	1.00	0.00	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	CEP19	0.30	0.12	lasso	4	0.13	4.2e-05	-5.58	5.6	2.2e-08	-0.26	0.58	0.03	FALSE
27	GTEx	Whole Blood	CEP19	0.10	0.09	lasso	3	0.09	8.0e-09	-6.41	5.6	2.2e-08	-0.22	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	PIGX	0.11	0.05	lasso	2	0.04	3.4e-04	-5.58	5.6	2.4e-08	-0.28	0.67	0.19	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	PIGX	0.19	0.10	lasso	3	0.06	7.0e-03	5.10	5.5	4.5e-08	-0.43	0.02	0.07	FALSE
21	GTEx	Skin Sun Exposed Lower leg	PIGX	0.13	0.10	lasso	4	0.09	4.7e-08	-5.52	5.5	5.1e-08	-0.25	0.98	0.02	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C3orf34	0.04	0.04	lasso	2	0.04	2.0e-05	-6.41	5.4	5.4e-08	-0.26	0.75	0.01	FALSE
3	GTEx	Adipose Visceral Omentum	PIGX	0.25	0.08	lasso	4	0.08	7.5e-05	-5.85	5.4	5.5e-08	-0.28	0.84	0.01	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	C3orf34	0.05	0.05	enet	10	0.04	1.5e-05	-6.60	5.4	7.1e-08	-0.23	0.99	0.00	FALSE
19	GTEx	Nerve Tibial	CEP19	0.45	0.26	lasso	8	0.25	7.4e-18	-5.85	5.2	1.9e-07	-0.27	1.00	0.00	FALSE
8	GTEx	Artery Aorta	CEP19	0.17	0.09	lasso	2	0.05	8.5e-04	-5.85	5.2	2.1e-07	-0.22	0.67	0.04	FALSE
22	GTEx	Spleen	CEP19	0.51	0.20	lasso	6	0.17	3.2e-05	-5.85	5.2	2.2e-07	-0.29	0.62	0.02	FALSE
28	YFS	Blood	PIGX	0.07	0.04	bslmm	441	0.04	4.0e-14	-5.59	5.2	2.3e-07	-0.18	1.00	0.00	FALSE