Hub : Genes

PAK2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1913	0.0501	9.6e-05	0.129	NA	0.160	NA	0.163	1.3e-12	NA	1.9e-15	NA	8.6e-16
2	METSIM	Adipose	0.0425	0.0175	2.4e-03	0.020	0.008	0.027	0.010	0.020	4.1e-04	1.8e-02	4.6e-05	1.1e-02	4.5e-04
3	YFS	Blood	0.0244	0.0092	4.4e-04	0.009	0.012	0.013	0.013	0.010	5.4e-04	4.4e-05	2.7e-05	3.4e-05	1.6e-04
4	TCGA	Lung Squamous Cell Carcinoma	0.0353	0.0207	8.8e-03	0.002	0.004	0.000	NA	0.001	1.8e-01	1.1e-01	2.8e-01	NA	2.7e-01
5	TCGA	Prostate Adenocarcinoma	0.0303	0.0159	3.2e-03	0.003	0.013	0.000	NA	0.003	1.6e-01	1.4e-02	2.9e-01	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.4	1.0	0.7	-0.7	-0.5	-1.0	-0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	4.8	0.1	0.3	0.3	-2.2	-0.2
Depressed Affect (Nagel 2018)	0.5	1.1	2.7	-1.7	1.4	0.5	-0.0	-0.9
Depression (Nagel 2018)	1.0	1.5	5.3	0.4	-2.3	-1.3	-0.4	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.0	1.7	-0.8	0.7	-1.3	0.3
Neuroticism (Nagel 2018)	0.7	1.6	4.9	-1.3	0.7	0.2	-1.0	-2.2
Schizophrenia (2018)	0.6	1.3	3.9	-0.6	1.3	0.8	-2.0	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.7	0.0	0.7	0.2	0.0
Worry (Nagel 2018)	0.8	1.8	7.7	-0.9	0.4	0.4	-0.2	-2.8
Alzheimer’s Disease (in mother)	0.8	1.0	1.9	1.4	0.8	-1.3	0.4	-0.7
Alzheimer’s Disease (in father)	0.4	0.4	1.8	-1.3	-0.3	0.3	-0.1	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.4	0.8	0.1	-1.5	-0.3	-0.5
Crohns Disease (2017)	1.0	2.3	5.9	-2.3	0.1	2.4	-0.4	0.1
Irritable Bowel Disease (IBD)	0.9	2.2	4.8	-2.2	1.4	1.9	-1.0	0.2
Ulcerative Colitis (UC)	0.6	1.1	2.3	-1.2	1.5	0.9	-0.9	0.2
Major Depression (MDD)	0.5	0.6	2.2	-0.6	0.5	0.3	-0.1	-1.5
Reaction Time	0.7	1.4	3.6	-1.5	0.2	0.1	-1.9	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.3	0.9	-0.4	1.1	-0.6	0.1
Breast Cancer	0.6	1.5	4.5	0.1	-2.1	-0.1	-0.8	1.5
Ovarian Cancer	0.2	0.3	0.7	0.8	-0.5	0.3	-0.4	-0.3
Prostate Cancer	0.5	0.7	1.9	-0.3	0.2	1.0	1.4	0.7
Age at First Birth	0.8	1.2	5.5	-0.1	-0.6	-0.3	0.5	2.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.5	2.1	3.6	-1.1	1.7	1.9	-0.1	-1.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0
Crohns Disease (2012)	0.7	1.2	2.8	-1.7	-0.2	1.5	-0.9	0.2
Mean Putamen Volume	0.8	0.9	2.3	-1.1	-0.5	1.5	-0.8	0.3
Fasting Glucose	1.4	1.7	5.8	0.5	0.8	0.1	-2.4	1.3
HbA1C	1.4	1.6	5.0	-1.4	-0.1	0.8	-2.2	-0.4
HDL Cholesterol	1.3	2.2	6.5	1.2	-0.5	-1.4	-0.9	-2.5
LDL Cholesterol	0.4	0.6	2.2	-0.4	0.6	0.6	0.3	-1.5
Lupus	0.3	0.5	1.0	-1.0	-0.6	-0.3	-0.6	-0.7
Neuroticism (2016)	1.7	2.5	6.2	-0.3	-2.5	-1.8	-1.0	-1.4
Primary Biliary Cirrhosis	0.6	0.8	3.0	-0.7	1.7	0.0	0.2	-0.7
Rheumatoid Arthritis	0.4	0.6	2.1	-0.6	-0.1	-0.1	-0.6	-1.5
Schizophrenia (2014)	0.3	0.8	2.8	0.6	0.7	0.2	-1.7	-0.2
Triglycerides	1.0	1.6	3.5	-1.3	0.3	1.5	1.9	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.8	0.0	-0.3	0.5	-0.3
Ulcerative Colitis	0.5	0.8	2.6	-1.6	0.8	0.1	-0.7	0.5
Blood Eosinophil Count	1.6	12.3	29.3	-2.7	2.2	4.3	1.1	-5.4
Blood Platelet Count	1.3	15.0	32.7	-1.1	-0.8	3.5	-5.3	-5.7
Blood Red Count	0.1	1.2	5.1	0.5	0.9	0.1	0.1	-2.2
Blood White Count	5.1	37.6	110.2	-0.6	-2.2	1.6	-8.4	-10.5
Heel T-Score	0.3	2.4	9.7	-0.5	-0.5	-1.0	-0.9	-3.1
BMI	0.1	0.3	0.9	-0.1	0.7	0.4	-0.9	0.2
Height	0.0	0.3	0.9	-0.2	-0.6	0.0	-0.5	0.9
Waist Hip Ratio (WHR)	0.9	4.2	8.0	2.8	-1.6	-2.8	1.5	-0.5
Systolic Blood Pressure	0.7	3.3	7.8	-2.2	1.6	2.8	-0.6	1.0
Smoking Status	1.1	2.7	5.0	0.7	-2.2	-1.9	1.7	1.2
Allergy or Eczema	1.6	4.2	17.4	1.0	0.1	-0.5	1.5	-4.2
Cardiovascular Disease	0.2	0.6	1.1	-0.6	-1.0	1.0	-0.5	0.4
Hypothyroidism (self reported)	0.9	2.1	8.0	1.6	-0.4	-0.2	0.0	-2.8
Respiratory disease	0.6	1.3	5.2	-0.4	0.6	0.4	-0.6	-2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.6	0.6	0.6	0.6	-0.2	1.6
Lung FEV1/FVC ratio	0.4	2.2	5.4	-1.8	0.9	0.3	2.3	1.3
Lung FVC	0.9	4.7	8.8	2.3	-3.0	-1.6	-2.3	-1.2
Neuroticism	1.0	2.4	5.7	-2.4	-0.5	0.7	-0.6	-2.3
Chronotype (morning person)	0.5	1.2	3.0	1.7	0.5	-1.3	-0.4	1.0
Hair Pigment	0.1	2.3	7.7	-0.4	0.5	0.2	2.8	1.9
Tanning	0.1	0.9	2.7	1.2	-1.6	0.4	-0.6	-0.2
Hand grip strength (left)	0.3	0.9	2.6	1.0	-0.5	-0.2	0.8	1.6
Number of treatments/medications taken	0.4	0.7	1.5	-0.7	1.2	0.5	-0.6	-1.1
Average weekly spirits intake	0.3	0.3	1.0	-1.0	0.5	-0.2	0.3	0.6
Sensitivity / hurt feelings	0.3	0.4	1.4	-0.5	0.0	-0.6	-0.5	-1.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.0	0.5	-1.7	-1.2	-0.5	-0.5
Hearing difficulty/problems: Yes	0.8	1.2	4.9	-0.5	0.8	0.2	0.1	-2.2
Relative age of first facial hair	1.7	3.4	7.5	-1.3	0.9	1.0	2.5	2.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.6	-0.1	0.5	-0.5	-1.9	-0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	-0.5	1.0	0.3	0.1	-0.6
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	-0.0	1.1	-0.5	0.9	-0.1
Systolic blood pressure, automated reading	1.3	3.8	8.7	-2.9	1.1	2.8	-1.0	0.6
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	11.3	1.1	0.9	-0.3	0.9	3.4
Angina	1.4	1.8	4.3	-2.1	1.4	1.4	0.3	1.0
Medication for hormone replacement therapy	0.3	0.3	0.7	0.0	0.7	0.5	-0.1	-0.8
Vitamin and mineral supplements	0.5	0.7	1.6	-0.2	-1.2	-0.2	-1.3	-0.5
Supplements: Zinc	2.0	2.2	5.2	2.3	-0.4	-2.1	0.8	0.7
Medication: Co-codamol	1.1	1.3	4.3	0.6	-0.4	-1.2	-0.5	-2.1
Medication: Metformin	0.3	0.5	0.9	1.0	-0.4	-0.1	-0.7	0.8
Diabetes (father)	0.6	0.7	2.9	1.7	-0.4	-0.7	-0.3	0.0
Diabetes (mother)	1.6	2.1	4.4	-2.1	0.1	1.1	0.8	2.0
Severe depression (siblings)	0.4	0.4	0.9	0.7	-0.4	-0.8	-0.9	0.2
Pack years adult smoking proportion	0.6	0.8	2.9	-1.7	-0.9	-0.2	-0.0	-0.8
Impedance of leg (right)	0.2	1.1	5.1	-0.4	0.1	-0.5	-0.1	-2.2
Leg fat-free mass (left)	0.1	0.8	1.9	0.9	0.1	-0.2	-1.4	1.1
Trunk fat percentage	0.4	1.5	3.1	-0.9	1.5	-0.0	-1.8	-1.1
Hand grip strength (right)	0.5	1.5	3.5	1.9	-1.1	-0.8	0.5	1.4
Townsend deprivation index at recruitment	0.2	0.3	1.3	0.6	-1.1	0.2	-0.0	-0.0
Current tobacco smoking	1.9	3.1	8.8	1.3	-3.0	-1.9	0.7	-1.1
Average weekly fortified wine intake	0.7	0.8	1.9	-0.7	-0.1	1.4	-1.1	-0.6
Maternal smoking around birth	0.3	0.4	0.9	-0.3	-0.6	-0.9	-0.3	0.9
Fed-up feelings	0.3	0.5	0.9	-0.4	-0.9	-0.9	-0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	4.9	-0.3	-2.2	-0.5	-0.7	-1.0
Relative age voice broke	0.8	1.3	2.9	-1.7	0.1	1.6	0.9	-0.4
Taking other prescription medications	0.3	0.5	2.3	0.5	1.5	-0.2	0.0	-0.4
Age when periods started (menarche)	0.1	0.2	0.5	0.1	0.7	0.1	0.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.0	-1.0	0.7	0.6	0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.9	-0.4	-0.2	-0.7	-0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.0	0.6	-1.4	-1.1	-0.2	0.4
Qualifications: CSEs or equivalent	0.6	0.8	2.4	-0.6	-0.6	-1.0	0.2	1.5
Serious illness, injury or assault to yourself	0.3	0.3	1.0	0.3	-0.1	0.6	-1.0	0.2
High blood pressure	0.1	0.2	0.6	-0.5	-0.8	0.3	-0.2	0.3
Hayfever, allergic rhinitis or eczema	1.7	3.6	7.9	1.6	0.0	-1.6	2.2	-2.8
Multivitamins +/- minerals	0.3	0.4	1.0	-0.2	1.0	0.0	0.5	0.9
Stomach or abdominal pain in last month	0.4	0.5	0.7	0.8	0.7	-0.9	-0.5	0.7
Supplements: Glucosamine	0.6	0.8	2.4	-0.8	0.0	0.3	1.5	-0.8
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.0	-2.2	0.5	1.9	0.2	-1.9
Medication: Atenolol	1.0	1.2	2.5	-1.6	1.4	0.8	-0.1	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.6	1.3	0.2	0.7	0.6	-0.1
Sitting height	0.3	1.8	2.6	-0.5	1.6	1.6	1.2	1.4
Chronic bronchitis/emphysema (father)	0.5	0.5	1.9	1.4	-0.2	-0.4	0.3	0.7
High blood pressure (mother)	0.5	0.7	2.7	-0.0	0.1	0.1	-1.6	-0.9
Body mass index (BMI)	0.2	0.8	3.1	-0.6	0.5	0.0	-1.8	-0.6
Impedance of leg (left)	0.2	1.1	4.6	-0.4	0.3	-0.8	-0.4	-2.1
Leg predicted mass (left)	0.2	0.8	2.1	1.0	0.0	-0.3	-1.4	1.0
Trunk fat mass	0.3	1.2	2.9	-0.7	1.5	0.1	-1.7	-0.5
Waist circumference	0.1	0.5	0.9	0.1	0.5	-0.7	-1.0	-0.9
Number of incorrect matches in round	0.7	1.2	2.4	1.3	-0.6	-1.6	-0.3	-1.2
Past tobacco smoking	0.8	1.5	3.5	0.4	-0.8	0.2	-1.9	-1.8
Alcohol usually taken with meals	1.2	1.9	3.7	1.5	-1.9	-1.9	0.1	0.2
Nervous feelings	1.3	2.5	6.8	0.9	-2.1	-0.6	-0.4	-2.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	0.2	-1.1	-0.8	-0.5	-0.3
Hearing difficulty/problems with background noise	0.4	0.6	1.1	1.0	-0.0	-1.1	-0.3	-0.8
Hair/balding pattern: Pattern 2	0.7	0.9	2.9	-0.7	1.7	0.3	0.7	0.7
Had menopause	0.7	0.9	1.9	1.4	-0.7	-0.5	1.3	0.5
Had other major operations	1.0	1.2	2.6	1.6	-1.2	-1.3	-0.4	0.1
Forced vital capacity (FVC)	0.1	0.4	0.8	0.3	0.9	0.5	-0.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	4.1	-2.0	0.0	0.9	-0.2	-1.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.1	0.4	-0.5	-0.5	0.1
Qualifications: None of the above	0.5	1.0	2.4	-1.3	0.9	0.3	-0.3	1.6
Financial difficulties in last 2 years	0.2	0.2	0.4	0.1	0.0	-0.6	-0.7	0.4
Mouth/teeth dental problems	1.1	1.7	3.4	-1.4	1.2	1.8	1.0	0.9
Heart attack	0.3	0.3	1.1	-0.1	0.7	-0.3	-1.1	0.1
Allergy	1.5	3.4	10.1	-1.2	0.6	1.8	-1.4	3.2
Pain all over the body in last month	0.8	0.8	2.0	-0.7	-0.2	1.2	-1.4	0.2
Diabetes (self-reported)	0.8	1.2	5.3	0.3	0.1	0.6	0.2	2.3
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.7	2.2	-0.6	-1.9	0.2	-1.2
Medication: Ramipril	0.1	0.1	0.3	-0.0	-0.4	-0.4	0.1	-0.5
Medication: Simvastatin	0.6	0.9	4.2	-0.0	-0.1	0.0	-2.1	-0.1
Fluid intelligence score	0.7	1.4	2.8	1.6	-0.9	-0.4	-1.7	-0.7
Illnesses of siblings	0.3	0.4	1.2	-0.0	-0.2	-0.0	0.8	1.1
Neuroticism score	0.7	1.5	4.2	-1.3	-0.7	-0.1	-1.0	-2.1
Weight	0.1	0.7	2.7	-0.2	0.7	0.1	-1.6	-0.1
Impedance of arm (right)	0.2	1.0	2.0	-1.0	1.4	0.2	1.4	0.2
Arm fat percentage (right)	0.3	1.2	2.4	-1.1	1.5	0.3	-1.4	-0.4
Trunk fat-free mass	0.1	0.8	2.4	0.9	-0.5	-0.1	-1.5	0.7
Hip circumference	0.5	2.1	7.8	-1.0	0.6	0.0	-2.8	-1.2
Time employed in main current job	0.4	0.5	0.8	0.8	0.6	-0.9	0.6	0.5
Alcohol intake versus 10 years previously	1.5	2.2	5.8	-1.3	2.4	1.9	0.2	0.3
Father’s age at death	0.7	0.9	1.7	1.0	-0.6	-0.4	1.2	-1.3
Worrier / anxious feelings	0.2	0.4	1.1	0.2	0.0	-0.6	0.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.2	-0.2	0.6	0.2	-2.0	-0.8
Falls in the last year	0.7	0.9	3.5	-0.3	0.1	-0.9	-0.5	-1.9
Hair/balding pattern: Pattern 3	1.0	1.5	3.0	-0.7	-1.2	1.2	-1.1	-1.7
Number of live births	0.5	0.7	1.4	-0.3	-0.7	-0.6	-1.2	1.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.4	-0.1	1.2	0.5	0.1	0.7
Pulse rate	1.0	1.7	3.5	1.9	-1.5	-0.2	-1.5	-0.5
Happiness	0.2	0.2	0.4	-0.3	0.5	0.6	-0.3	-0.7
Noisy workplace	1.4	1.7	4.4	-2.1	1.4	1.3	0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.6	1.2	1.1	-0.4	0.9	-0.5	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.5	0.5	-0.5	0.1	-0.3
Mouth/teeth dental problems: Dentures	1.6	2.7	7.7	1.5	-0.3	-2.8	-0.4	-1.8
Asthma	0.3	0.6	3.1	-0.0	0.3	0.1	-0.3	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.6	-0.3	1.3	0.7	0.9	0.2
Medication: Cholesterol lowering	0.3	0.5	1.7	0.6	-0.3	-0.6	-1.3	0.0
Depression (self-reported)	0.6	0.7	1.5	1.0	0.3	-1.2	0.5	-0.8
Medication: Lansoprazole	2.6	3.0	6.0	-2.4	2.3	1.5	0.5	-0.9
Prospective memory result	1.6	1.9	7.3	0.4	0.8	-0.1	1.3	2.7
Lung cancer (father)	1.0	1.2	3.1	-1.0	0.3	0.9	1.8	1.0
Illnesses of mother	2.2	2.7	6.8	-0.8	0.6	-0.6	2.3	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.4	-0.3	1.6	0.6	0.6	0.1
Pulse wave Arterial Stiffness index	1.0	1.1	2.9	1.6	0.2	0.1	-0.4	1.7
Impedance of arm (left)	0.2	0.8	1.9	-0.8	1.1	-0.0	1.4	-0.3
Arm fat mass (right)	0.3	1.1	3.1	-0.8	1.2	0.4	-1.8	-0.3
Trunk predicted mass	0.1	0.8	2.6	0.9	-0.6	-0.2	-1.6	0.6
Standing height	0.0	0.2	0.6	0.7	0.3	0.1	-0.0	0.8
Length of working week for main job	2.0	2.2	6.2	2.5	-0.5	-1.5	-1.4	0.6
Exposure to tobacco smoke at home	0.4	0.4	1.3	0.1	-0.4	0.1	-1.1	-0.8
Breastfed as a baby	1.4	1.7	4.8	1.3	-1.1	-1.0	-0.2	-2.2
Tense / ‘highly strung’	0.7	1.1	1.3	-1.0	1.1	1.1	1.1	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.7	0.0	0.8	-0.7	1.3	-1.2
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	0.7	-0.4	-1.0	0.3	1.5
Birth weight of first child	0.4	0.7	2.2	0.8	0.3	-0.8	-1.5	-0.3
Peak expiratory flow (PEF)	0.4	0.8	2.0	-0.3	1.4	1.0	0.0	1.1
Pulse wave reflection index	0.4	0.5	1.6	0.5	0.4	0.4	0.2	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.2	0.7	0.0	-0.5	-0.3	1.1
Loud music exposure frequency	0.4	0.4	1.1	0.4	0.8	0.4	-1.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.8	0.2	-0.8	-0.9	1.3	-1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.5	0.4	-1.6	0.6	0.9	0.5
Blood clot in the leg (DVT)	1.0	1.2	3.7	-1.3	0.2	-0.2	0.8	1.9
Medication: Paracetamol	0.9	1.4	2.2	-1.5	1.0	1.2	0.9	1.3
Headache pain in last month	0.9	1.5	4.2	1.0	-1.0	-1.1	-0.5	2.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	-0.4	1.0	0.8	1.4	-0.3
Glaucoma (self-reported)	1.5	1.7	3.9	0.6	-0.4	-2.0	-1.7	-1.2
Gout (self-reported)	0.3	0.4	0.9	0.9	0.4	0.6	-0.8	-0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.8	1.7	-0.2	0.4	0.4	-1.4
Medication: Amlodipine	1.2	1.7	3.7	-1.6	0.5	1.9	-1.3	-0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	-0.0	-0.8	0.1	-0.9	-0.8
Birth weight	1.0	2.1	6.5	0.1	-1.1	-0.4	1.6	2.5
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.6	2.1	-0.4	-0.5	-0.6	-0.9
High blood pressure (siblings)	0.4	0.6	1.5	-0.1	-0.5	1.0	-1.2	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	-0.0	1.0	0.9	0.2	-0.0
Body fat percentage	0.4	1.6	3.0	-0.8	1.5	-0.1	-1.7	-1.3
Leg fat percentage (right)	0.4	1.4	3.3	-0.5	0.7	-0.4	-1.8	-1.7
Arm fat-free mass (right)	0.2	1.0	4.0	0.9	-0.5	-0.1	-2.0	0.1
Exposure to tobacco smoke outside home	0.9	1.2	4.3	-2.1	1.1	0.7	0.0	-0.1
Comparative body size at age 10	0.5	1.3	3.0	1.4	-1.7	-0.7	-0.9	0.1
Number of full brothers	0.4	0.6	1.9	-0.5	0.1	1.4	0.7	0.4
Worry too long after embarrassment	1.0	1.7	3.3	0.7	-1.6	-1.3	-1.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.3	2.1	-1.9	-1.5	0.4	-0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.6	-0.3	0.0	-0.8	-0.7	-1.3
Number of children fathered	0.7	0.8	2.1	1.4	-0.1	-0.8	1.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	-0.5	1.2	0.6	-0.7	-1.2
Age at first live birth	0.2	0.3	0.8	-0.0	0.7	0.2	-0.3	0.9
Pulse wave peak to peak time	0.9	1.1	2.8	-1.6	-0.1	-0.2	0.3	-1.7
Health satisfaction	0.4	0.5	1.1	-0.7	0.7	1.1	0.5	0.1
Shortness of breath walking on level ground	1.0	1.2	3.3	0.7	-0.0	-1.0	1.8	1.2
Qualifications: College or University degree	1.1	3.5	9.1	3.0	-2.4	0.3	-1.5	-0.5
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.0	-0.9	0.8	-0.3	-0.2
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.7	0.9	-1.6	-0.8	-1.9	-0.4
Emphysema/chronic bronchitis	1.1	1.3	2.3	0.8	-0.9	-1.4	-1.5	-0.8
Medication for pain relief, constipation, heartburn	0.9	1.5	3.7	1.3	-1.9	-0.3	-1.1	-1.0
Neck or shoulder pain in last month	0.2	0.3	0.5	0.7	-0.5	-0.4	-0.4	0.4
Medication: Blood pressure	0.4	0.7	1.5	-0.0	-0.0	-0.8	-1.2	1.2
Angina (self-reported)	2.0	2.6	6.5	-2.5	1.4	1.7	0.3	1.1
Migraine (self-reported)	0.3	0.4	1.0	0.4	-0.6	-0.6	-0.5	1.0
Medication: Ibuprofen	0.6	0.8	1.7	-0.9	1.3	0.8	0.8	0.2
Medication: Allopurinol	0.3	0.4	0.7	0.8	0.3	0.4	-0.9	-0.7
Medication: Omeprazole	0.4	0.4	0.7	-0.6	0.7	-0.7	0.2	-0.9
Medication: Seretide 50 evohaler	0.6	0.7	1.6	0.7	-1.3	-0.1	-0.9	-0.7
Mean time to correctly identify matches	0.7	1.3	4.0	-2.0	0.1	0.8	-1.1	-0.6
Heart disease (mother)	0.9	1.1	2.9	0.2	-0.5	0.8	-1.3	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.7	-0.8	1.1	-0.4	-0.6	-1.6
Whole body fat mass	0.3	1.2	3.5	-0.6	1.3	-0.1	-1.9	-0.5
Leg fat mass (right)	0.2	0.9	3.1	-0.2	1.1	-0.2	-1.8	-0.5
Arm predicted mass (right)	0.2	1.0	3.9	1.0	-0.4	-0.4	-2.0	0.0
Pulse rate, automated reading	1.0	3.1	6.0	2.4	-2.0	-1.5	-1.5	-1.0
Alcohol intake frequency.	0.3	0.7	1.7	0.8	1.0	0.3	-0.5	1.3
Comparative height size at age 10	0.4	2.0	7.6	0.8	-0.3	-0.1	-2.8	-1.4
Number of full sisters	0.3	0.3	1.1	-1.0	0.4	0.1	0.1	-0.7
Suffer from ‘nerves’	2.6	4.0	12.9	0.1	-1.5	-1.0	-1.9	-3.6
Overall health rating	0.3	0.6	1.7	0.2	-0.3	-0.5	-1.1	-1.3
Chest pain or discomfort	1.1	1.6	3.4	1.3	-0.4	-1.1	-1.2	-1.8
Had major operations	0.4	0.5	1.4	-0.5	1.2	-0.1	1.0	0.1
Age at last live birth	0.3	0.5	0.8	-0.2	-0.1	0.9	-0.9	0.8
Family relationship satisfaction	0.2	0.2	0.7	0.3	0.6	-0.1	-0.3	-0.8
Leg pain on walking	0.7	0.9	2.6	-0.0	-1.0	-1.0	1.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.9	-0.2	2.0	0.0	1.2	1.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.1	0.2	0.4	-1.1	-0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	0.0	-0.0	0.6	1.0	0.5
Medication: Aspirin	0.1	0.2	0.5	0.3	0.7	-0.6	0.1	0.1
Supplements: Vitamin C	1.1	1.2	3.6	1.9	-0.4	0.0	1.0	1.2
Knee pain experienced in last month	1.0	1.6	2.4	-1.5	1.3	0.9	0.9	-1.6
Hypertension (Self-reported)	0.1	0.3	0.6	-0.4	-0.7	0.6	-0.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.9	-2.0	1.9	0.1	-0.4	0.1
Illnesses of father: Heart disease	0.6	0.8	1.8	0.9	-1.3	0.2	-1.2	0.1
Illnesses of siblings: Diabetes	0.4	0.5	2.7	-0.2	0.1	0.1	-0.0	1.6
Smoking status: Previous	1.5	2.2	3.6	-1.2	1.7	0.3	1.7	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.4	0.1	1.2	0.6	-0.4	0.4
Whole body fat-free mass	0.2	1.0	2.8	1.1	-0.4	-0.2	-1.7	0.8
Leg fat-free mass (right)	0.2	0.9	2.1	1.1	0.1	-0.3	-1.4	1.1
Arm fat percentage (left)	0.3	1.2	2.6	-1.1	1.6	0.3	-1.2	-0.6
Average weekly red wine intake	1.1	1.6	4.7	1.4	-0.8	0.3	-0.8	-2.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.8	0.2	-1.7	0.2	-0.2	-1.4
Mood swings	0.6	1.0	3.2	-1.8	-0.3	0.4	-1.1	-0.6
Loneliness, isolation	0.5	0.8	2.0	-0.4	1.4	0.9	0.8	-0.2
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.1	0.3	0.6	-0.4	-1.0
Ever had bowel cancer screening	0.1	0.1	0.2	0.1	0.3	-0.1	-0.5	0.2
Diabetes diagnosed by doctor	0.4	0.7	2.7	0.5	0.3	0.3	-0.6	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.6	0.3	-1.2	-0.5	-0.6	-0.2
Friendships satisfaction	0.9	1.1	2.9	-1.7	1.3	0.9	-0.3	0.0
Qualifications: nursing, teaching	0.3	0.5	1.8	0.1	1.4	0.6	0.3	-0.5
Commuting to job workplace: Walk	0.1	0.2	0.4	-0.2	-0.1	-0.3	0.5	0.6
Eye problems/disorders: Cataract	0.6	0.7	2.3	-0.2	-0.2	0.6	-0.8	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.6	1.6	-0.9	-1.6	-1.1	0.0
Medication for cholesterol	1.3	2.0	3.3	1.5	-1.7	-1.8	-0.7	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	0.6	-0.1	-1.3	0.2	-1.0
Back pain experienced in last month	0.3	0.5	1.4	-1.2	0.5	0.7	0.2	-0.2
Mineral and other dietary supplements	1.0	1.4	4.8	0.1	-2.2	-0.3	-1.3	-0.6
Breast cancer (self-reported)	0.3	0.3	0.7	-0.6	0.7	0.9	-0.1	-0.1
Asthma (self-reported)	0.3	0.6	2.7	-0.2	0.4	0.1	0.1	-1.6
Osteoporosis (self-reported)	0.4	0.5	1.3	0.2	0.7	0.1	-0.9	-1.1
Osteoarthritis (self-reported)	0.7	0.8	2.3	-1.2	1.5	0.4	0.0	0.6
Medication: Aspirin	0.2	0.3	0.6	0.7	0.8	-0.7	0.1	0.1
Medication: Gliclazide	0.6	0.7	1.7	1.3	-0.1	-0.5	0.2	1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-0.6	-0.2	0.6	1.4	0.2
Smoking status: Current	2.0	3.1	9.5	1.3	-3.1	-1.8	0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.7	-1.3	0.7	0.9	0.3	-1.2
Whole body water mass	0.2	0.9	2.8	0.9	-0.3	-0.1	-1.7	0.9
Leg predicted mass (right)	0.2	0.8	1.9	1.0	0.1	-0.2	-1.4	1.1
Arm fat mass (left)	0.3	1.1	3.1	-0.8	1.2	0.3	-1.8	-0.5
Number of self-reported non-cancer illnesses	0.6	1.0	2.8	0.7	-1.0	-1.7	-0.9	-0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.3	0.0	0.3	0.6	0.2
Miserableness	0.8	1.4	3.9	-2.0	0.5	1.1	0.3	-1.3
Guilty feelings	0.8	1.3	3.4	0.1	-1.9	-0.4	-1.4	-0.9
Wears glasses or contact lenses	0.8	1.0	3.5	0.6	-1.9	-0.8	-0.1	0.6
Ever taken oral contraceptive pill	0.7	0.8	3.0	1.7	-0.3	-0.1	-0.9	0.4
Hearing aid user	0.7	0.8	1.4	-0.9	1.2	-0.7	-0.8	-0.9
Mother’s age at death	0.5	0.6	1.0	-1.0	1.0	0.8	0.6	0.1
Financial situation satisfaction	0.2	0.3	0.6	-0.8	0.0	0.2	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	5.6	-0.4	-0.2	-0.2	2.4	0.5
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.3	0.2	0.4	-0.1
Eye problems/disorders: Glaucoma	0.8	1.0	3.7	-0.1	0.3	-1.9	-1.0	-0.3
Medication: Blood pressure	0.8	1.5	2.6	-1.4	1.1	1.6	1.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	-0.3	0.6	0.1	0.5	-1.1
Supplements: Fish oil (including cod liver oil)	1.0	1.2	5.4	0.4	2.3	-0.8	0.2	-0.2
High cholesterol (Self-reported)	0.3	0.6	1.4	0.5	0.1	-0.8	-0.9	-1.2
Medication: Bendroflumethiazide	0.8	1.2	2.3	-1.5	0.8	1.5	-0.1	0.9
Medication: Paracetamol	0.8	1.2	2.9	-1.7	0.9	1.2	0.2	0.8
Medication: Lisinopril	0.5	0.7	2.3	-0.4	0.1	0.7	-1.5	0.6
Medication: Atorvastatin	0.5	0.7	2.1	0.5	1.5	0.7	-0.4	0.6
Illnesses of father: High blood pressure	0.7	0.9	3.8	-0.2	2.0	0.4	-0.3	0.6
Alcohol drinker status: Never	0.7	0.9	2.1	-0.9	0.4	0.8	0.7	1.4
Ever smoked	0.2	0.4	1.9	0.0	0.1	-0.1	1.4	0.5
Basal metabolic rate	0.2	0.8	3.3	0.8	0.0	-0.1	-1.8	0.5
Leg fat percentage (left)	0.4	1.4	3.3	-0.5	0.8	-0.7	-1.8	-1.5
Arm fat-free mass (left)	0.1	0.7	3.2	0.5	-0.2	0.1	-1.8	0.2
Number of operations (self-reported)	0.3	0.5	1.3	-0.3	0.7	-1.1	-0.4	0.6
Average weekly beer plus cider intake	0.5	0.8	2.5	-1.6	1.0	0.3	0.1	0.5
Irritability	0.4	0.7	2.6	-1.6	0.5	0.8	0.2	-0.0
Risk taking	0.3	0.4	0.9	0.7	-0.7	0.9	0.2	0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.6	-0.2	-0.6	0.0	0.4
Fractured/broken bones in last 5 years	0.7	0.9	1.8	1.4	-0.6	-1.3	-0.5	0.6
Age started oral contraceptive pill	0.3	0.4	1.3	0.5	-0.4	0.2	1.1	-0.3
Diastolic blood pressure, automated reading	1.1	3.5	7.9	-2.4	1.0	2.8	-1.8	-0.2
Ever depressed for a whole week	0.6	0.7	1.2	1.0	0.5	-1.1	-0.2	-1.0
Unable to work because of sickness or disability	1.0	1.3	2.6	1.4	-1.2	-1.6	-0.5	-0.3
Commuting to job workplace: Cycle	1.8	2.1	4.0	2.0	-2.0	-1.0	0.0	-1.3
Myopia	0.5	0.7	2.8	1.7	-0.3	0.5	0.1	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	0.8	0.6	-0.6	0.3	-0.4
Cholesterol lowering medication	0.5	0.7	2.5	0.4	-0.1	-0.4	-0.7	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.2	-1.8	1.5	-0.0	0.0	-1.0
Pain experienced in last month	0.1	0.2	0.9	-0.1	0.2	0.2	0.9	0.5
Supplements: Calcium	0.8	0.8	2.7	-0.2	1.6	-0.4	0.8	0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.1	0.6	0.6	0.2	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	-0.2	0.8	-0.2	-1.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.3	-1.2	-0.2	-0.3	0.4	1.5
Heart disease (siblings)	0.6	0.8	2.4	0.9	0.3	-1.6	-0.4	-0.7
Alcohol drinker status: Previous	1.6	1.8	5.6	2.4	-0.9	-0.9	-0.1	1.4
Pack years of smoking	0.7	1.0	4.3	-2.1	-0.4	-0.2	0.1	-0.5
Impedance of whole body	0.1	0.6	1.7	-0.6	0.6	-0.5	0.6	-1.3
Leg fat mass (left)	0.3	1.0	3.3	-0.3	1.1	-0.3	-1.8	-0.5
Arm predicted mass (left)	0.1	0.7	3.1	0.6	-0.3	0.1	-1.8	0.1