TWAS
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Models
Genes
Traits
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Traits
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Blood White Count
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chr1:39,613,812-42,021,616
Best TWAS P=4.63e-09 · Best GWAS P=1.45e-10 conditioned to 0.0126
39.5M
40M
40.5M
41M
41.5M
42M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Cerebellar Hemisphere
TRIT1
0.35
0.30
enet
6
0.28
8.4e-08
5.8
5.9
4.6e-09
0.67
0.06
0.92
TRUE
4
YFS
Blood
CITED4
0.44
0.26
lasso
10
0.30
5.2e-99
-5.7
-5.5
5.1e-08
0.01
0.00
1.00
TRUE
5
The Cancer Genome Atlas
Testicular Germ Cell Tumors
PPT1
0.08
0.00
blup
57
0.04
1.7e-02
5.3
5.3
1.1e-07
0.13
0.02
0.51
TRUE
2
GTEx
Esophagus Muscularis
MFSD2A
0.10
0.02
lasso
5
0.04
2.7e-03
6.2
5.5
3.5e-08
0.52
0.04
0.78
FALSE
3
GTEx
Testis
PPT1
0.22
0.14
lasso
5
0.20
3.6e-09
4.3
5.1
2.8e-07
0.15
0.90
0.07
FALSE