TWAS hub - CITED4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.140	0.0510	3.1e-03	0.084	NA	0.090	NA	0.107	2.8e-06	NA	1.3e-06	NA	1.3e-07
2	GTEx	Pancreas	0.223	0.0840	3.1e-03	0.021	NA	0.045	NA	0.039	4.5e-02	NA	5.4e-03	NA	9.4e-03
3	GTEx	Whole Blood	0.170	0.0450	1.2e-05	0.125	NA	0.126	NA	0.118	1.3e-11	NA	1.2e-11	NA	5.5e-11
4	YFS	Blood	0.441	0.0374	0.0e+00	0.264	0.265	0.296	0.295	0.297	4.6e-86	1.7e-86	2.2e-98	4.1e-98	5.2e-99
5	TCGA	Prostate Adenocarcinoma	0.118	0.0337	6.9e-08	0.096	0.078	0.108	NA	0.111	3.3e-10	1.5e-08	2.1e-11	NA	1.2e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hair/balding pattern: Pattern 4	6.8	16.5	29.2	3.7	1.4	-5.4	-5.3	3.1
Ever depressed for a whole week	4.6	5.7	9.7	-3.0	-1.3	-2.3	-1.7	-3.1
Commuting to job workplace: Car/motor vehicle	3.9	4.5	8.0	-2.8	1.5	-2.1	0.2	-2.8
Illnesses of siblings: Diabetes	3.0	3.7	8.8	-2.8	0.1	1.0	0.8	-3.0
Irritable Bowel Disease (IBD)	2.5	6.0	15.0	-2.0	-3.9	2.6	1.6	-1.5
Commuting to job workplace: Walk	2.5	2.7	6.7	1.2	-1.8	2.6	0.5	1.4
Medication: Gliclazide	2.5	2.8	5.6	1.5	1.2	-1.8	-2.4	1.2
Qualifications: CSEs or equivalent	2.3	3.1	7.9	-0.1	0.2	2.8	2.7	0.1
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.7	-2.3	-1.6	-0.1	-0.2	-2.4
Hearing aid user	2.3	2.6	7.0	0.1	1.9	-2.6	-1.6	-0.2
Age started oral contraceptive pill	2.3	2.8	7.5	0.8	1.2	-2.7	-2.0	0.7
Commuting to job workplace: Public transport	2.1	2.5	3.6	1.9	-1.5	1.8	-0.4	1.7
Crohns Disease (2017)	2.0	4.5	13.3	-0.7	-3.6	2.6	1.2	-0.3
Ulcerative Colitis (UC)	2.0	3.7	6.8	-2.6	-1.9	1.5	1.2	-2.1
Illnesses of siblings	2.0	2.9	6.5	2.4	-0.2	-0.3	-1.4	2.5
Ovarian Cancer	1.9	2.5	5.1	2.0	0.4	-1.4	-1.1	2.3
Peak expiratory flow (PEF)	1.8	4.1	8.9	-0.7	-1.9	3.0	2.6	-0.6
Stomach or abdominal pain in last month	1.7	2.1	9.7	-0.2	-3.1	0.4	0.6	-0.7
Qualifications: O levels/GCSEs or equivalent	1.7	2.6	6.1	1.2	0.6	2.5	1.4	1.8
Illnesses of father: None of the above (group 1)	1.7	2.1	4.1	-1.1	2.0	0.7	2.0	-0.8
Heart disease (siblings)	1.7	2.0	4.2	-2.0	-0.5	0.2	1.2	-2.1
Blood White Count	1.6	12.0	29.7	1.8	2.4	-4.4	-5.5	1.2
Hayfever, allergic rhinitis or eczema	1.6	3.4	6.8	2.6	-2.1	1.0	1.3	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.0	-0.3	1.7	-2.0	-1.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.9	-1.6	-1.4	-1.2	-1.0	-1.7
Major Depression (MDD)	1.5	1.8	5.6	-2.4	-0.8	0.7	1.5	0.0
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.3	1.4	2.1	0.0	-0.2	1.5
Average weekly spirits intake	1.5	1.9	3.1	1.6	-0.4	-1.2	-1.4	1.8
Medication: Ramipril	1.5	1.9	4.8	-0.2	0.5	-2.2	-2.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.9	-1.2	0.5	1.5	1.7	-1.4
Shortness of breath walking on level ground	1.5	1.7	4.6	-1.1	-0.3	0.8	2.1	-1.4
Emphysema/chronic bronchitis	1.5	1.7	3.7	-0.9	0.6	-1.9	-1.3	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.5	0.6	-1.3	1.9	1.6	0.9
Osteoarthritis (self-reported)	1.5	2.0	4.4	-2.0	-1.0	-0.4	-0.6	-2.1
Lupus	1.4	2.1	6.7	-0.7	-1.2	2.6	1.4	-0.1
Frequency of depressed mood in last 2 weeks	1.4	2.0	4.7	-1.9	-0.7	0.2	1.2	-2.2
Pulse wave Arterial Stiffness index	1.4	1.6	2.6	1.4	-0.2	-1.5	-1.2	1.6
Exposure to tobacco smoke at home	1.4	1.6	4.9	0.3	-0.1	-2.2	-1.6	0.7
Pulse wave reflection index	1.4	1.8	3.6	0.2	1.5	-1.9	-1.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.3	0.8	-0.0	-2.1	-1.3	1.2
Migraine (self-reported)	1.4	1.7	5.1	-1.4	-0.1	2.3	0.6	-1.1
Medication: Ibuprofen	1.4	1.7	3.5	1.4	-0.1	1.9	0.6	1.7
Guilty feelings	1.4	2.1	4.7	-1.7	-1.8	0.2	0.1	-2.2
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.0	-1.9	0.2	-1.1	-0.3	-2.0
Depression (Nagel 2018)	1.3	1.9	4.4	-1.9	-1.2	-0.3	0.1	-2.1
Allergy or Eczema	1.3	3.4	7.2	2.7	-2.2	0.4	0.6	2.1
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.6	-1.7	-0.7	-0.5	-0.0	-2.1
Chronic bronchitis/emphysema (father)	1.3	1.5	3.6	1.0	-1.9	-1.2	-0.8	0.8
Heart attack	1.3	1.7	4.1	-1.9	0.0	-0.9	-0.1	-2.0
Allergy	1.3	3.1	6.2	-2.4	2.5	0.1	-0.5	-1.7
Medication: Lansoprazole	1.3	1.4	3.3	0.1	-1.8	-1.5	-1.0	-0.8
Headache pain in last month	1.3	2.2	5.2	-0.4	-1.4	2.3	2.0	-0.2
High blood pressure (siblings)	1.3	1.8	4.5	-2.1	0.1	0.3	0.9	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.5	1.6	0.9	1.0	0.4	1.6
Illnesses of father: High blood pressure	1.3	1.7	3.9	0.9	2.0	-0.4	-1.5	1.1
Risk taking	1.3	1.8	4.7	-0.5	1.3	1.5	2.2	-0.4
Hypothyroidism (self reported)	1.2	2.7	4.6	-1.2	2.1	-1.8	-1.6	-1.3
Medication: Co-codamol	1.2	1.3	2.6	-0.9	-0.0	-1.3	-1.6	-1.2
Serious illness, injury or assault to yourself	1.2	1.4	3.6	0.6	-0.1	-1.6	-1.9	0.7
Number of children fathered	1.2	1.4	2.7	-1.5	-0.2	1.3	1.7	-0.8
Had major operations	1.2	1.4	2.2	1.3	-0.7	-1.5	-1.5	0.8
Medication: Metformin	1.1	1.5	3.3	0.5	1.2	-1.8	-1.5	0.4
Hair/balding pattern: Pattern 3	1.1	1.6	4.7	1.1	0.3	-2.2	-1.0	1.0
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.6	-1.4	0.6	-1.3	-0.4	-1.6
Overall health rating	1.1	2.3	6.4	-0.6	-0.3	-2.5	-1.8	-1.2
Age at last live birth	1.1	1.6	3.6	1.8	-0.7	0.2	-0.7	1.9
Family relationship satisfaction	1.1	1.3	3.0	1.3	0.4	-0.9	-1.7	1.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.5	1.6	-1.0	-1.0	-0.9	1.2
Number of self-reported non-cancer illnesses	1.1	1.9	3.9	-1.3	-2.0	-0.8	-0.3	-1.8
Alzheimer’s Disease (in mother)	1.0	1.2	1.6	1.1	-1.0	0.9	1.3	1.1
Age at First Birth	1.0	1.5	2.9	1.7	1.7	0.3	0.2	1.3
Respiratory disease	1.0	2.2	9.0	-0.6	-3.0	0.2	1.0	-0.9
Ever had hysterectomy (womb removed)	1.0	1.2	3.1	0.1	1.0	-1.8	-1.2	0.4
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.9	0.9	1.0	2.1	0.1	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.1	1.0	-0.1	1.7	0.6	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.7	-1.5	-2.6	1.1	1.9	-1.3
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.3	-0.4	1.7	-1.8	-1.8	-0.3
Medication for pain relief, constipation, heartburn	1.0	1.7	2.4	1.6	1.5	-1.5	-0.3	1.2
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.8	0.2	-1.5	0.9	1.7	-0.1
Commuting to job workplace: Cycle	1.0	1.2	2.0	1.2	1.4	0.4	-0.5	1.4
Mean Putamen Volume	0.9	1.0	2.3	1.2	-1.5	-0.8	-0.4	0.7
Fasting Glucose	0.9	1.1	3.2	-0.9	1.8	-0.1	0.7	-0.9
Age when periods started (menarche)	0.9	2.1	4.9	2.0	0.4	0.7	-1.0	2.2
Medication: Atenolol	0.9	1.1	2.4	1.3	-1.6	0.1	-0.5	1.2
High blood pressure (mother)	0.9	1.2	2.6	-1.6	-0.9	0.9	0.2	-1.3
Alcohol intake versus 10 years previously	0.9	1.3	3.0	-1.0	1.7	-1.1	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	5.6	-0.6	-2.1	2.0	2.4	-0.5
Birth weight	0.9	2.0	3.9	-0.9	-2.0	1.1	1.4	-1.6
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.8	-0.8	0.5	-1.7	-1.0	-0.8
Comparative height size at age 10	0.9	4.9	8.2	2.9	-2.8	-1.7	-0.4	2.3
Chest pain or discomfort	0.9	1.3	2.4	-0.9	-1.5	0.8	1.1	-1.3
Average weekly red wine intake	0.9	1.4	3.5	1.7	-0.6	0.1	-0.3	1.9
Medication: Aspirin	0.9	1.1	3.4	-0.6	-1.8	0.9	0.6	-0.8
Medication: Paracetamol	0.9	1.4	3.0	-0.9	-0.8	1.7	1.5	-0.6
Supplements: Calcium	0.9	0.9	2.3	1.2	-0.5	-0.3	-0.7	1.5
Depressed Affect (Nagel 2018)	0.8	1.7	4.5	-2.0	-0.3	0.1	0.4	-2.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.8	-1.1	0.2	-1.1	-0.5	-1.4
Supplements: Zinc	0.8	0.9	1.3	1.1	0.8	-1.1	-0.7	1.0
Medication: Levothyroxine sodium	0.8	1.4	2.8	-1.7	0.4	-1.3	-0.8	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.7	0.0	0.2	-1.7	-1.9	0.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.6	-1.6	-0.5	0.3	0.5	-1.4
Mouth/teeth dental problems: Dentures	0.8	1.3	2.6	-1.5	1.2	-0.7	0.0	-1.6
Forced vital capacity (FVC), Best measure	0.8	3.0	7.8	-1.0	-2.8	1.0	1.9	-1.1
Pulse wave peak to peak time	0.8	0.9	1.5	-0.9	-0.1	1.2	1.0	-1.2
Number of full sisters	0.8	1.0	1.3	-1.0	0.6	1.0	1.2	-1.1
Knee pain experienced in last month	0.8	1.3	2.9	-1.5	-1.1	-0.2	-0.2	-1.7
Friendships satisfaction	0.8	1.0	1.8	1.0	0.0	-1.3	-1.2	0.7
Wears glasses or contact lenses	0.8	1.0	2.6	-1.4	-0.2	0.1	-0.3	-1.6
Neuroticism (Nagel 2018)	0.7	1.6	4.5	-1.8	-0.5	0.1	0.2	-2.1
Breast Cancer	0.7	1.8	4.2	-1.2	-2.0	1.0	0.7	-1.3
Coronary Artery Disease (CAD)	0.7	0.8	2.6	-1.0	0.4	-0.4	-0.3	-1.6
Crohns Disease (2012)	0.7	1.1	3.0	-0.6	-1.7	1.3	0.7	0.0
Number of incorrect matches in round	0.7	1.2	3.2	-1.5	-0.6	-0.3	0.3	-1.8
Forced vital capacity (FVC)	0.7	2.8	5.7	-0.4	-2.3	1.7	2.4	-0.4
Falls in the last year	0.7	0.9	1.7	0.8	-0.9	1.3	1.2	-0.1
Happiness	0.7	0.9	1.9	-0.1	-0.8	1.4	1.4	-0.3
Medication: Paracetamol	0.7	1.1	1.9	-1.4	-0.2	1.4	0.7	-1.1
Age at first live birth	0.7	1.3	3.1	1.8	-0.4	-0.1	-1.0	1.5
Qualifications: College or University degree	0.7	2.3	3.6	1.6	-1.9	0.4	-1.6	1.6
Medication: Aspirin	0.7	0.9	2.9	-0.6	-1.7	0.5	0.4	-0.8
Qualifications: nursing, teaching	0.7	1.1	3.6	0.1	-0.0	1.9	1.4	0.4
Ever taken oral contraceptive pill	0.7	0.7	2.1	-0.2	-1.4	0.6	0.3	-1.0
Mother’s age at death	0.7	0.9	2.4	0.7	0.1	1.0	1.5	0.8
Medication: Bendroflumethiazide	0.7	1.0	2.4	-1.2	-0.4	-0.4	0.9	-1.5
Unable to work because of sickness or disability	0.7	0.9	2.8	1.0	-0.6	-1.7	-0.4	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.6	-0.2	-1.1	1.3	1.2	-0.0
LDL Cholesterol	0.6	0.9	2.6	-1.6	0.2	-0.5	-0.1	-1.3
Height	0.6	11.8	32.8	4.0	-5.7	-1.3	0.6	2.8
Sensitivity / hurt feelings	0.6	1.1	3.1	-1.8	-0.1	0.1	0.5	-1.5
Systolic blood pressure, automated reading	0.6	1.8	3.6	1.9	0.3	-0.7	-1.1	1.9
Severe depression (siblings)	0.6	0.6	1.4	-0.4	-1.2	1.2	0.6	-0.2
Average weekly fortified wine intake	0.6	0.7	1.3	-0.9	0.6	0.8	0.3	-1.2
Maternal smoking around birth	0.6	0.9	1.4	-1.2	-1.0	-0.8	-0.4	-1.2
Relative age voice broke	0.6	0.9	2.5	1.3	0.4	0.3	-0.0	1.6
Multivitamins +/- minerals	0.6	0.7	3.0	-0.5	-1.7	-0.0	-0.1	-0.7
Had menopause	0.6	0.7	1.1	1.0	0.0	-1.0	-1.1	0.6
Fluid intelligence score	0.6	1.3	3.0	1.2	-0.5	1.7	0.1	1.3
Lung cancer (father)	0.6	0.7	1.9	-0.1	1.2	0.4	1.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.6	-1.1	-0.5	0.3	0.4	-1.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.1	0.2	0.0	-1.0	-1.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.1	-1.1	-1.8	-0.3	0.3	-1.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.5	-0.0	0.9	-1.6	-0.6	-0.2
Mood swings	0.6	1.1	2.7	-1.6	0.8	0.2	0.2	-1.5
Medication for cholesterol	0.6	0.9	2.4	0.8	0.1	1.5	0.8	0.9
Osteoporosis (self-reported)	0.6	0.8	1.5	-1.1	-1.2	-0.4	-0.6	-0.8
Average weekly champagne plus white wine intake	0.6	0.8	2.0	0.6	0.9	0.7	-0.2	1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	-1.1	0.5	-0.4	1.0	-1.1
Pain experienced in last month	0.6	1.0	3.3	0.4	-0.7	-1.8	-1.0	0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	2.3	0.2	0.2	-1.0	-1.5	0.2
Smoking Status	0.5	1.2	3.5	-0.6	0.7	-0.7	-1.9	-1.0
Hearing difficulty/problems: Yes	0.5	0.8	1.3	1.1	-0.2	-1.0	-0.7	1.0
Medication for hormone replacement therapy	0.5	0.6	1.0	-0.8	-1.0	-0.5	0.5	-0.8
Current tobacco smoking	0.5	0.8	1.8	-0.7	1.3	-0.6	-0.5	-1.0
Sitting height	0.5	3.2	8.2	1.0	-2.9	1.4	2.2	0.5
Alcohol usually taken with meals	0.5	0.9	2.1	0.4	-0.7	1.1	1.4	0.5
Medication: Simvastatin	0.5	0.8	1.5	-0.9	0.1	-1.2	-0.7	-1.1
Worrier / anxious feelings	0.5	0.9	2.1	-1.4	0.4	-0.1	0.3	-1.4
Pulse rate	0.5	0.8	2.5	0.4	-1.6	0.9	0.6	-0.2
Asthma	0.5	1.0	4.1	-0.3	-2.0	0.3	0.7	-0.5
Medication: Cholesterol lowering	0.5	0.7	1.4	0.0	-1.2	-0.8	-1.2	-0.4
Standing height	0.5	4.6	14.7	2.2	-3.8	-0.8	0.6	1.6
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.5	-0.7	-1.6	0.3	0.6	-0.4
Health satisfaction	0.5	0.6	1.8	0.1	-1.4	-0.9	0.6	-0.2
Medication: Blood pressure	0.5	0.8	1.5	-1.0	-1.2	-0.2	-0.6	-1.0
Medication: Seretide 50 evohaler	0.5	0.6	1.7	0.6	-1.3	-0.3	-0.9	-0.0
Mean time to correctly identify matches	0.5	0.9	1.6	1.3	0.4	-1.2	-0.0	1.2
Alcohol intake frequency.	0.5	1.2	5.2	-0.6	2.3	0.3	0.3	-0.5
Smoking status: Previous	0.5	0.8	1.5	0.4	-1.1	-0.9	-1.2	0.4
Loneliness, isolation	0.5	0.6	1.5	0.7	-0.2	-0.6	-1.2	0.8
Ever had bowel cancer screening	0.5	0.5	1.5	-0.3	-1.2	-0.1	-0.9	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	0.8	-1.4	0.5	1.0	0.7
Breast cancer (self-reported)	0.5	0.6	2.1	0.1	0.0	-1.4	-0.8	0.1
Miserableness	0.5	0.8	1.7	-0.3	-0.7	1.2	1.3	-0.5
Financial situation satisfaction	0.5	0.6	1.6	1.1	0.5	0.1	0.3	1.3
Number of operations (self-reported)	0.5	0.7	1.1	-0.5	-0.9	-1.1	-1.0	-0.6
Myopia	0.5	0.7	2.3	-0.1	-0.5	1.5	1.0	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	1.7	1.0	1.1	1.1	1.1	1.3
Alcohol drinker status: Previous	0.5	0.6	1.0	-0.6	1.0	-0.8	-0.7	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.4	-0.4	-1.0	2.1	0.3	-0.5
Schizophrenia (2018)	0.4	0.8	1.5	0.4	-1.0	0.9	1.2	0.5
Prostate Cancer	0.4	0.6	1.5	-0.8	1.2	-0.3	0.5	-0.7
HbA1C	0.4	0.5	1.0	-0.3	0.6	0.9	1.0	-0.1
Rheumatoid Arthritis	0.4	0.5	1.2	0.1	0.9	-1.1	-0.8	0.1
Blood Eosinophil Count	0.4	3.2	6.0	2.4	-2.4	-0.2	-0.8	1.9
Heel T-Score	0.4	2.8	8.2	0.0	2.1	2.9	1.0	0.6
Neuroticism	0.4	0.9	2.1	-1.3	-0.2	0.6	0.5	-1.4
Chronotype (morning person)	0.4	0.8	3.3	-0.4	-1.8	0.7	0.3	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	-0.8	0.7	-0.3	-0.6	-1.0
Angina	0.4	0.5	1.0	-0.5	-1.0	0.6	-0.3	-0.9
Vitamin and mineral supplements	0.4	0.6	2.1	0.5	1.4	0.4	-0.3	0.5
Townsend deprivation index at recruitment	0.4	0.6	1.0	0.9	0.9	-0.1	-1.0	0.7
Taking other prescription medications	0.4	0.6	1.2	-0.9	-0.2	-0.9	-0.5	-1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	-0.4	-1.1	0.7	-0.4	-0.1
Nervous feelings	0.4	0.8	1.2	-0.9	-0.8	0.9	1.1	-0.8
Financial difficulties in last 2 years	0.4	0.5	0.8	-0.9	-0.4	0.7	0.4	-0.8
Pain all over the body in last month	0.4	0.4	2.0	-0.1	1.4	-0.4	0.1	-0.1
Neuroticism score	0.4	0.8	1.7	-1.1	-0.9	0.3	0.4	-1.3
Prospective memory result	0.4	0.5	1.0	-0.5	0.0	-1.0	-1.0	-0.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	0.9	0.6	0.5	-0.1	1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.0	0.9	0.8	0.4	0.9	1.0
Worry too long after embarrassment	0.4	0.7	1.9	-0.9	-1.4	-0.1	-0.2	-0.9
Angina (self-reported)	0.4	0.5	1.5	-0.3	-1.2	0.5	-0.4	-0.6
Medication: Allopurinol	0.4	0.5	0.6	0.7	-0.8	-0.6	-0.7	0.6
Heart disease (mother)	0.4	0.5	1.1	-0.7	0.2	-0.9	-1.0	-0.3
Arm predicted mass (right)	0.4	1.9	3.0	1.6	-1.7	-1.5	0.3	1.3
Hypertension (Self-reported)	0.4	1.1	2.7	-0.2	-1.6	-0.8	-1.3	-0.4
Illnesses of father: Heart disease	0.4	0.5	1.4	-0.5	-1.2	0.5	-0.2	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	1.3	-0.9	-0.5	0.9	0.3	-1.1
Eye problems/disorders: Cataract	0.4	0.5	0.8	-0.5	-0.7	-0.8	-0.5	-0.9
Mineral and other dietary supplements	0.4	0.6	1.2	1.0	0.1	0.4	-0.6	1.1
Asthma (self-reported)	0.4	0.9	3.3	-0.4	-1.8	0.1	0.8	-0.5
Medication: Lisinopril	0.4	0.5	1.1	-0.1	0.4	-1.1	-1.0	0.2
Alcohol drinker status: Never	0.4	0.4	0.9	0.2	1.0	-0.6	-0.9	0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.2	-1.1	1.0	0.6	-0.3
Cholesterol lowering medication	0.4	0.7	2.8	-0.1	1.7	-0.7	0.0	-0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-1.0	-0.6	-0.0	0.5	-1.0
Arm predicted mass (left)	0.4	1.9	3.5	1.4	-1.8	-1.9	-0.1	0.9
Bipolar Disorder or Schizophrenia	0.3	0.8	1.6	0.1	-1.3	0.8	1.2	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.3	-0.8	0.9	0.6	0.2
Reaction Time	0.3	0.6	1.3	0.9	0.6	-0.5	0.5	1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.3	-0.2	-0.6	1.8	0.0	-0.3
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.7	-0.5	-0.9	0.3	0.0
Neuroticism (2016)	0.3	0.4	0.6	-0.6	0.1	-0.7	-0.7	-0.8
Ulcerative Colitis	0.3	0.4	1.0	-1.0	-0.6	-0.3	0.6	-0.6
Waist Hip Ratio (WHR)	0.3	1.2	3.7	1.9	0.1	0.1	-0.2	1.4
Systolic Blood Pressure	0.3	1.5	3.1	1.3	0.8	1.4	0.2	1.8
Lung FVC	0.3	1.6	3.3	-1.8	0.9	0.2	0.9	-1.8
Relative age of first facial hair	0.3	0.7	2.1	-0.4	1.4	0.8	0.5	-0.5
Leg fat-free mass (left)	0.3	1.4	5.9	0.8	-2.4	-0.6	0.5	0.2
Fed-up feelings	0.3	0.6	1.5	-1.0	-0.3	-0.5	-0.5	-1.2
High blood pressure	0.3	0.9	1.2	-0.8	-1.1	-0.9	-1.1	-1.0
Leg predicted mass (left)	0.3	1.4	5.8	0.8	-2.4	-0.6	0.5	0.3
Waist circumference	0.3	1.2	2.2	1.1	-1.1	-1.5	-1.2	0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.0	0.4	-0.7	-0.9	-1.0	0.3
Had other major operations	0.3	0.3	1.2	-0.5	-1.1	0.4	-0.2	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.4	0.2	0.9	-1.2	-0.1	0.1
Weight	0.3	1.4	4.5	0.7	-2.1	-1.3	-0.4	0.1
Trunk fat-free mass	0.3	1.6	5.5	0.7	-2.3	-1.4	0.4	0.3
Hip circumference	0.3	1.4	3.9	0.6	-2.0	-1.3	-1.0	0.2
Father’s age at death	0.3	0.4	1.6	-0.2	-1.3	0.5	-0.3	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	2.3	-0.2	-1.5	-0.3	0.4	-0.5
Depression (self-reported)	0.3	0.3	1.0	-0.2	-0.0	0.6	1.0	-0.5
Trunk predicted mass	0.3	1.5	5.0	0.7	-2.2	-1.4	0.5	0.3
Tense / ‘highly strung’	0.3	0.6	1.4	0.1	-1.2	1.0	0.7	-0.2
Glaucoma (self-reported)	0.3	0.3	0.8	0.6	-0.9	0.3	-0.4	0.6
Medication: Amlodipine	0.3	0.5	1.7	-0.5	-1.3	-0.2	-0.4	-0.3
Arm fat-free mass (right)	0.3	1.6	2.8	1.3	-1.7	-1.7	0.1	1.0
Comparative body size at age 10	0.3	0.9	3.4	0.1	-1.9	-0.7	-0.6	-0.4
Suffer from ‘nerves’	0.3	0.5	1.4	0.7	0.0	0.9	1.2	0.2
Supplements: Vitamin C	0.3	0.4	0.9	-0.3	-0.8	-0.9	0.5	-0.5
Whole body fat-free mass	0.3	1.7	5.5	1.0	-2.3	-1.4	0.3	0.5
Leg fat-free mass (right)	0.3	1.7	7.3	0.6	-2.7	-0.6	0.6	0.0
Back pain experienced in last month	0.3	0.5	0.8	0.9	-0.6	0.6	-0.0	0.9
Smoking status: Current	0.3	0.4	1.5	-0.2	1.2	-0.3	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	0.1	-0.9	1.2	0.6	0.6
Whole body water mass	0.3	1.8	5.8	1.0	-2.4	-1.4	0.3	0.5
Leg predicted mass (right)	0.3	1.7	7.5	0.7	-2.7	-0.6	0.6	0.1
Medication: Atorvastatin	0.3	0.4	0.9	0.8	-0.9	0.2	0.0	0.6
Ever smoked	0.3	0.6	1.3	1.1	0.4	-0.1	-0.1	1.1
Basal metabolic rate	0.3	1.6	5.7	0.9	-2.4	-1.2	0.3	0.4
Arm fat-free mass (left)	0.3	1.7	3.5	1.2	-1.9	-1.8	-0.2	0.8
Average weekly beer plus cider intake	0.3	0.5	0.8	-0.6	0.3	0.7	0.8	-0.9
Irritability	0.3	0.5	1.9	0.1	-0.5	0.7	1.4	-0.3
Diastolic blood pressure, automated reading	0.3	0.8	1.7	1.3	-0.1	0.0	-0.8	1.3
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.4	-0.7	0.1	0.5	-0.7
Worry (Nagel 2018)	0.2	0.5	0.8	-0.9	-0.3	0.5	0.7	-0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	-0.7	0.4	0.1	0.4
Schizophrenia (2014)	0.2	0.5	1.9	0.3	-1.4	0.3	0.5	0.2
Triglycerides	0.2	0.3	0.6	-0.4	-0.5	0.8	0.6	-0.4
Blood Red Count	0.2	2.1	4.0	-2.0	0.5	1.2	1.4	-1.7
Cardiovascular Disease	0.2	0.7	3.1	-0.0	-1.8	0.3	-0.6	-0.4
Number of treatments/medications taken	0.2	0.4	1.2	-0.8	-0.3	-0.4	-0.2	-1.1
Diabetes (father)	0.2	0.2	0.5	0.5	-0.2	0.3	0.4	0.7
Impedance of leg (right)	0.2	0.8	3.3	-0.1	1.8	0.8	0.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.4	-0.6	-0.1	0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.3	0.6	-0.4	-0.5	-0.5
Supplements: Glucosamine	0.2	0.3	0.8	0.9	-0.3	0.2	0.6	0.5
Trunk fat mass	0.2	0.7	1.2	1.1	-0.5	-1.1	-0.7	0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.5	-0.7	0.1	-0.8	0.2
Mouth/teeth dental problems	0.2	0.3	0.9	-0.6	0.2	0.9	0.6	-0.2
Diabetes (self-reported)	0.2	0.3	0.7	-0.1	-0.7	-0.7	-0.8	0.1
Time employed in main current job	0.2	0.2	0.4	0.5	-0.7	0.5	0.1	0.3
Noisy workplace	0.2	0.3	0.8	-0.6	-0.0	0.2	0.2	-0.9
Illnesses of mother	0.2	0.2	0.6	0.8	0.0	0.1	0.2	0.5
Impedance of arm (left)	0.2	0.9	3.7	-0.5	-0.4	1.9	0.5	-0.4
Length of working week for main job	0.2	0.2	0.4	0.5	0.5	-0.6	0.2	0.5
Breastfed as a baby	0.2	0.2	0.9	0.3	0.0	0.3	1.0	0.3
Birth weight of first child	0.2	0.4	1.3	0.8	-0.2	-0.1	0.0	1.1
Gout (self-reported)	0.2	0.3	0.7	-0.9	-0.3	-0.5	-0.2	-0.8
Leg fat percentage (right)	0.2	0.7	1.4	-0.1	1.2	-1.1	-0.9	-0.3
Exposure to tobacco smoke outside home	0.2	0.3	1.2	0.1	-1.1	-0.3	0.2	0.1
Number of full brothers	0.2	0.2	0.6	-0.8	0.2	-0.6	-0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.2	-0.5	0.1	0.5	-0.8
Medication: Omeprazole	0.2	0.3	0.6	0.2	0.0	0.7	0.8	0.3
Whole body fat mass	0.2	0.6	1.1	1.0	-0.7	-1.1	-0.6	0.5
Pulse rate, automated reading	0.2	0.6	1.7	-0.1	-0.1	-1.3	-1.1	-0.4
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.4	-0.2	-0.9	-0.8	-0.2
Medication: Blood pressure	0.2	0.4	0.9	-0.2	-0.7	-0.6	-1.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.3	-0.5	0.5	-0.4	0.7
Leg fat percentage (left)	0.2	0.6	1.4	-0.1	0.8	-1.2	-0.8	-0.4
Pack years of smoking	0.2	0.3	0.8	-0.3	0.9	-0.8	-0.3	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.4	-0.1	0.1	0.1	-0.5
HDL Cholesterol	0.1	0.1	0.2	-0.3	-0.4	0.2	0.4	-0.4
Blood Platelet Count	0.1	1.7	4.0	2.0	0.5	0.2	0.8	1.9
BMI	0.1	0.3	0.9	0.2	0.3	-0.9	-0.7	-0.4
Lung FEV1/FVC ratio	0.1	0.5	1.1	-1.1	0.3	-0.4	-0.7	-0.6
Tanning	0.1	1.7	3.5	0.6	-1.9	-1.9	-1.0	0.1
Hand grip strength (left)	0.1	0.2	0.5	0.3	0.7	-0.4	0.1	0.3
Diabetes (mother)	0.1	0.1	0.2	0.1	-0.1	0.4	0.2	0.4
Pack years adult smoking proportion	0.1	0.2	0.5	-0.4	0.7	-0.6	-0.1	0.1
Trunk fat percentage	0.1	0.4	0.8	0.9	-0.0	-0.8	-0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	0.4	0.6	0.8	-0.2	0.2
Body mass index (BMI)	0.1	0.4	1.2	-0.3	-0.3	-1.1	-0.6	-0.7
Impedance of leg (left)	0.1	0.5	2.2	-0.0	1.5	0.6	0.4	0.2
Past tobacco smoking	0.1	0.2	0.6	-0.2	0.8	0.4	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	0.3	0.4	1.0	0.0	0.1
Qualifications: None of the above	0.1	0.2	0.8	0.3	0.4	-0.9	0.0	0.1
Impedance of arm (right)	0.1	0.4	1.5	-0.4	0.0	1.2	-0.1	-0.5
Arm fat percentage (right)	0.1	0.2	0.4	-0.1	-0.4	-0.5	-0.7	-0.5
Number of live births	0.1	0.1	0.3	0.2	0.2	0.0	0.4	0.5
Arm fat mass (right)	0.1	0.5	1.2	0.1	-1.1	-1.0	-0.5	-0.3
Loud music exposure frequency	0.1	0.1	0.2	0.2	0.0	0.0	-0.5	-0.3
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.2	0.1	-0.7	-0.7	0.0
Body fat percentage	0.1	0.2	0.4	0.6	0.1	-0.6	-0.7	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.3	0.1	-0.8	-0.2	-0.5
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.1	0.6	0.2	0.0	0.4
Leg fat mass (right)	0.1	0.5	1.8	0.4	-0.0	-1.4	-0.7	0.1
Leg pain on walking	0.1	0.1	0.3	0.5	-0.1	-0.1	0.6	0.2
Arm fat mass (left)	0.1	0.4	1.1	-0.1	-1.1	-0.8	-0.4	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.4	-0.5
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.2	-0.2	-0.5	0.1	-0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.1	-0.2	-0.5	-0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.3	-0.0	-0.5	-0.4	0.1
Impedance of whole body	0.1	0.5	2.0	0.2	0.6	1.4	0.3	0.3
Leg fat mass (left)	0.1	0.6	2.0	0.5	-0.3	-1.4	-0.6	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.2
Hair Pigment	0.0	0.6	1.3	0.8	1.1	-0.4	-0.1	1.0
Hand grip strength (right)	0.0	0.0	0.1	-0.1	0.2	-0.3	0.3	0.1
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.1	0.3	-0.0	0.1	0.1
Arm fat percentage (left)	0.0	0.1	0.4	-0.3	-0.3	-0.1	-0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.0	-0.2	0.2	-0.1	0.0

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