Hub : Genes

MFSD2A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.304	0.082	1.7e-04	0.193	NA	0.209	NA	0.199	1.5e-09	NA	2.7e-10	NA	8.4e-10
2	GTEx	Esophagus Muscularis	0.101	0.041	2.4e-03	0.022	NA	0.019	NA	0.037	1.7e-02	NA	2.5e-02	NA	2.7e-03
3	TCGA	Thyroid Carcinoma	0.083	0.030	1.4e-06	0.016	0.059	0.062	NA	0.052	8.9e-03	2.2e-06	1.2e-06	NA	7.7e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.0	3.1	8.1	-2.9	1.1	-0.0
Bipolar Disorder or Schizophrenia	0.2	0.6	0.9	-1.0	-0.5	0.8
Depressed Affect (Nagel 2018)	0.3	0.5	1.2	-0.3	0.5	-1.1
Depression (Nagel 2018)	0.0	0.0	0.1	-0.0	0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.2	-0.9	0.6	-1.1
Neuroticism (Nagel 2018)	0.6	1.4	2.2	-1.5	0.8	-1.2
Schizophrenia (2018)	0.7	1.5	2.3	1.1	-1.5	1.1
Schizophrenia vs Biploar Disorder	1.4	1.8	2.5	1.6	-1.1	1.3
Worry (Nagel 2018)	1.1	2.3	5.3	-2.3	0.9	-0.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.0	0.9	-1.0	0.5
Alzheimer’s Disease (in father)	3.0	3.2	4.9	-0.7	2.2	-2.1
Alzheimer’s Disease (including proxy)	1.6	2.3	4.5	-0.1	1.6	-2.1
Crohns Disease (2017)	0.8	1.7	3.9	0.7	-2.0	0.7
Irritable Bowel Disease (IBD)	0.5	1.1	2.2	-0.1	-1.5	1.0
Ulcerative Colitis (UC)	0.3	0.6	1.0	-1.0	0.0	0.9
Major Depression (MDD)	4.0	4.8	9.1	-0.7	2.2	-3.0
Reaction Time	1.3	2.4	4.5	2.1	-1.6	-0.3
Verbal and Numeric Reasoning (VNR)	1.7	4.2	7.9	-1.3	1.8	-2.8
Breast Cancer	5.6	13.5	28.0	0.0	-3.5	5.3
Ovarian Cancer	3.2	4.2	11.5	3.4	0.4	-1.0
Prostate Cancer	0.5	0.7	1.9	-0.3	1.4	0.2
Age at First Birth	2.9	4.2	6.2	0.5	-2.5	2.5
Bipolar Disorder (2011)	3.4	3.3	5.4	-2.3	2.1	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	-0.3	-0.4	-0.2
Coronary Artery Disease (CAD)	0.4	0.5	0.7	0.6	-0.7	0.8
Crohns Disease (2012)	0.1	0.1	0.2	0.1	0.1	0.5
Mean Putamen Volume	1.4	1.6	2.4	0.2	-1.6	1.6
Fasting Glucose	1.9	2.3	3.2	1.0	-1.7	1.8
HbA1C	1.2	1.3	2.7	1.6	-0.3	1.0
HDL Cholesterol	1.1	1.8	5.0	2.2	0.6	-0.0
LDL Cholesterol	0.1	0.2	0.4	0.2	0.4	0.7
Lupus	0.1	0.2	0.4	-0.6	0.2	0.4
Neuroticism (2016)	0.3	0.5	1.1	-0.6	-0.2	-1.0
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.5	-0.2	0.3
Rheumatoid Arthritis	2.2	3.1	3.7	-1.6	1.8	-1.9
Schizophrenia (2014)	0.6	1.4	2.7	0.7	-0.9	1.6
Triglycerides	1.5	2.5	5.2	-1.3	0.8	-2.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	-0.0	-0.7	0.5
Ulcerative Colitis	0.5	0.8	1.7	-1.3	0.4	0.7
Blood Eosinophil Count	0.2	1.9	3.4	1.9	-1.1	1.0
Blood Platelet Count	7.9	91.9	136.9	-6.5	11.7	-9.9
Blood Red Count	1.6	15.7	30.8	2.7	-3.0	5.5
Blood White Count	3.2	23.8	30.4	-3.9	5.5	-5.1
Heel T-Score	0.5	3.6	5.9	2.4	-1.9	1.2
BMI	0.9	5.0	14.6	0.3	0.7	-3.8
Height	0.3	4.9	14.7	-0.2	3.8	-0.0
Waist Hip Ratio (WHR)	0.1	0.5	1.5	-1.2	-0.1	-0.1
Systolic Blood Pressure	0.9	4.7	6.9	-2.6	1.0	-2.4
Smoking Status	0.5	1.2	1.9	1.3	-1.4	0.3
Allergy or Eczema	0.4	1.1	2.9	0.5	-0.1	1.7
Cardiovascular Disease	0.4	1.4	3.1	-0.8	0.6	-1.8
Hypothyroidism (self reported)	1.9	4.5	5.2	-2.0	2.1	-2.3
Respiratory disease	0.1	0.1	0.3	0.5	-0.1	0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.6	2.7	1.0	1.1	-1.6
Lung FEV1/FVC ratio	2.3	11.9	19.0	4.0	-4.4	0.5
Lung FVC	0.5	2.5	4.2	1.1	1.4	-2.0
Neuroticism	0.3	0.8	1.2	-1.1	0.2	-1.0
Chronotype (morning person)	0.2	0.4	0.8	-0.2	-0.6	0.9
Hair Pigment	0.2	6.3	13.4	-1.5	1.8	-3.7
Tanning	0.0	0.2	0.5	0.3	-0.3	0.7
Hand grip strength (left)	0.5	1.4	2.9	1.7	1.1	0.2
Number of treatments/medications taken	0.3	0.6	1.1	0.8	-1.1	-0.1
Average weekly spirits intake	0.1	0.1	0.3	-0.6	-0.3	-0.1
Sensitivity / hurt feelings	0.2	0.4	0.9	0.6	-0.9	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.7	0.1	-0.8
Hearing difficulty/problems: Yes	0.2	0.4	1.0	0.2	1.0	-0.2
Relative age of first facial hair	0.3	0.5	1.2	-0.0	1.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.4	0.2	-0.7
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.2	-1.3	-1.3	1.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.3	0.5	0.6	-0.6
Systolic blood pressure, automated reading	1.1	3.2	7.2	-2.7	1.3	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.1	-0.9	0.1	-1.1
Angina	4.0	5.3	10.1	0.8	-3.2	2.3
Medication for hormone replacement therapy	3.6	4.1	5.9	1.4	-2.4	2.1
Vitamin and mineral supplements	0.2	0.3	0.6	0.5	0.3	-0.8
Supplements: Zinc	0.4	0.4	0.8	-0.1	0.7	-0.9
Medication: Co-codamol	0.1	0.1	0.2	-0.4	0.0	-0.4
Medication: Metformin	0.4	0.6	0.7	0.9	0.8	-0.6
Diabetes (father)	0.2	0.3	0.8	-0.9	-0.0	-0.0
Diabetes (mother)	0.4	0.5	1.5	0.3	-1.2	0.1
Severe depression (siblings)	3.2	3.6	7.8	-2.8	1.8	-0.0
Pack years adult smoking proportion	0.8	1.2	1.7	-1.3	1.3	-0.4
Impedance of leg (right)	0.3	1.6	3.8	-0.9	-0.3	2.0
Leg fat-free mass (left)	0.5	2.6	6.1	0.8	1.0	-2.5
Trunk fat percentage	0.9	3.8	7.8	-1.3	1.3	-2.8
Hand grip strength (right)	1.0	2.7	7.5	2.7	0.4	0.7
Townsend deprivation index at recruitment	0.0	0.1	0.1	-0.2	0.1	-0.4
Current tobacco smoking	0.9	1.5	2.7	0.5	-1.6	1.3
Average weekly fortified wine intake	0.7	0.9	1.6	-0.5	0.9	-1.3
Maternal smoking around birth	1.6	2.4	4.1	0.1	1.7	-2.0
Fed-up feelings	0.5	0.8	1.3	1.1	-1.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	-0.7	0.3	-1.1
Relative age voice broke	0.8	1.2	2.3	0.0	1.5	-1.2
Taking other prescription medications	0.2	0.4	0.6	-0.8	0.6	-0.3
Age when periods started (menarche)	0.3	0.6	1.9	0.0	1.4	-0.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	-0.4	-1.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.0	1.4	-0.2	-0.4
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.6	2.1	-0.0	-1.1
Qualifications: CSEs or equivalent	0.7	1.0	1.6	-0.2	1.3	-1.1
Serious illness, injury or assault to yourself	0.7	0.8	2.1	0.5	0.4	-1.4
High blood pressure	0.2	0.5	0.9	-0.5	0.6	-0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.0	1.0	-0.1	0.9
Multivitamins +/- minerals	0.1	0.2	0.2	0.5	-0.3	0.4
Stomach or abdominal pain in last month	1.1	1.4	3.0	-1.7	-0.4	0.9
Supplements: Glucosamine	0.8	1.1	2.1	0.3	1.4	-1.1
Diverticular disease/diverticulitis (self-reported)	3.6	4.3	8.6	0.8	-1.9	2.9
Medication: Atenolol	0.6	0.7	1.5	-1.2	0.3	-0.7
Medication: Levothyroxine sodium	0.9	1.4	2.2	-1.5	1.1	-1.0
Sitting height	0.2	1.6	4.2	0.6	2.0	-0.6
Chronic bronchitis/emphysema (father)	1.1	1.3	2.4	0.2	1.6	-1.2
High blood pressure (mother)	2.2	3.0	5.0	-2.2	1.9	-0.6
Body mass index (BMI)	0.8	3.5	10.4	-0.2	0.3	-3.2
Impedance of leg (left)	0.6	2.9	7.1	-1.2	-0.3	2.7
Leg predicted mass (left)	0.5	2.9	6.7	0.9	1.1	-2.6
Trunk fat mass	0.9	3.9	8.8	-0.8	1.5	-3.0
Waist circumference	0.7	2.7	6.7	-1.0	0.7	-2.6
Number of incorrect matches in round	2.0	3.3	5.6	2.4	-1.3	1.7
Past tobacco smoking	0.3	0.6	1.6	-1.3	0.3	0.4
Alcohol usually taken with meals	0.7	1.1	1.9	-1.1	1.4	-0.5
Nervous feelings	0.6	1.2	1.8	-1.2	-0.4	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.1	1.8	-1.0	0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.5	-0.5	0.8
Hair/balding pattern: Pattern 2	0.6	0.8	2.1	-1.4	0.2	-0.5
Had menopause	2.2	2.8	4.7	-0.7	-1.8	2.2
Had other major operations	0.7	0.9	2.3	0.1	1.5	-0.6
Forced vital capacity (FVC)	1.3	5.0	7.5	1.2	2.5	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.6	1.1	0.4	-1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.4	1.2	-0.9	-1.0
Qualifications: None of the above	1.0	2.2	4.0	-0.4	-1.6	2.0
Financial difficulties in last 2 years	0.5	0.6	1.7	-1.3	0.3	0.1
Mouth/teeth dental problems	4.0	6.1	10.0	2.3	-1.8	3.2
Heart attack	1.4	1.7	3.2	-0.9	-1.8	1.1
Allergy	0.6	1.4	3.4	-1.8	0.5	-0.8
Pain all over the body in last month	0.6	0.7	1.6	1.3	-0.4	-0.5
Diabetes (self-reported)	0.5	0.7	1.4	-0.1	1.2	-0.9
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	6.1	2.5	-1.1	0.8
Medication: Ramipril	0.5	0.6	0.9	0.9	-0.9	0.5
Medication: Simvastatin	0.8	1.2	2.8	0.5	0.8	-1.7
Fluid intelligence score	0.3	0.7	1.4	-0.8	0.4	-1.2
Illnesses of siblings	1.4	2.0	3.4	-1.8	0.8	1.4
Neuroticism score	0.3	0.7	1.0	-1.0	-1.0	0.2
Weight	0.7	3.6	8.9	-0.1	1.3	-3.0
Impedance of arm (right)	0.1	0.7	1.7	-0.5	1.3	0.3
Arm fat percentage (right)	1.4	5.5	13.7	-1.0	1.4	-3.7
Trunk fat-free mass	0.3	1.5	2.0	1.3	0.8	-1.4
Hip circumference	0.5	2.0	5.2	-0.3	0.9	-2.3
Time employed in main current job	0.9	1.1	1.6	-1.3	-0.2	1.3
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.5	0.7	0.6
Father’s age at death	1.4	1.9	3.6	-1.1	-0.9	1.9
Worrier / anxious feelings	0.4	0.8	1.9	-1.4	-0.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.9	0.3	0.2
Falls in the last year	1.5	2.0	5.4	-2.3	0.5	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	-0.6	0.4	-1.1
Number of live births	0.0	0.0	0.0	-0.2	-0.2	0.0
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	9.0	1.9	1.8	-3.0
Pulse rate	0.6	1.1	2.3	0.2	1.5	-0.9
Happiness	2.3	2.8	4.2	-2.0	2.0	-0.6
Noisy workplace	1.7	2.1	3.1	1.8	0.7	-1.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	0.9	-0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.4	-0.4	1.6	-1.1
Mouth/teeth dental problems: Dentures	1.5	2.5	6.7	-0.3	0.9	-2.6
Asthma	0.1	0.2	0.6	0.8	-0.2	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.9	1.4	-0.1	-1.0
Medication: Cholesterol lowering	1.3	1.9	3.6	-1.9	0.8	-1.2
Depression (self-reported)	1.5	1.8	2.3	-0.9	1.5	-1.5
Medication: Lansoprazole	2.2	2.5	4.1	0.2	-2.0	1.8
Prospective memory result	1.2	1.5	3.7	0.3	0.7	-1.9
Lung cancer (father)	0.9	1.0	1.2	-1.0	0.9	-1.1
Illnesses of mother	0.4	0.5	1.5	1.2	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.0	1.1	1.2	-1.4
Pulse wave Arterial Stiffness index	0.6	0.7	0.7	0.8	-0.9	0.8
Impedance of arm (left)	0.1	0.5	0.7	-0.5	0.8	0.8
Arm fat mass (right)	1.1	4.6	11.8	-0.8	1.2	-3.4
Trunk predicted mass	0.2	1.4	1.9	1.3	0.8	-1.4
Standing height	0.2	2.1	6.4	0.2	2.5	0.3
Length of working week for main job	1.4	1.6	4.5	-2.1	-0.2	0.5
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.3	0.0	-0.8
Breastfed as a baby	0.9	1.1	2.2	1.5	0.9	-0.5
Tense / ‘highly strung’	1.1	1.9	3.6	-1.9	1.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	-0.3	-0.6
Hair/balding pattern: Pattern 4	1.3	3.2	4.8	-0.6	2.1	-2.2
Birth weight of first child	1.8	3.2	6.5	2.5	0.7	1.6
Peak expiratory flow (PEF)	3.2	7.4	8.7	3.0	2.4	-2.8
Pulse wave reflection index	0.4	0.5	1.1	0.2	-1.0	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-1.1	-0.1	0.8
Loud music exposure frequency	0.3	0.3	0.6	0.2	-0.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.7	0.8	-0.2	0.8
Mouth/teeth dental problems: Bleeding gums	3.4	4.4	7.8	-2.8	2.1	-1.0
Blood clot in the leg (DVT)	0.5	0.6	1.6	1.3	-0.5	0.2
Medication: Paracetamol	0.7	1.1	2.1	-1.0	1.5	-0.4
Headache pain in last month	1.4	2.3	4.3	-2.1	1.5	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.3	0.3	0.5
Glaucoma (self-reported)	0.4	0.5	0.7	-0.3	-0.8	0.8
Gout (self-reported)	0.8	1.1	2.6	1.6	-0.9	-0.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	3.5	-1.9	1.7	-1.4
Medication: Amlodipine	0.8	1.1	2.8	1.7	-0.7	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.9	-0.6	0.1
Birth weight	1.2	2.6	6.9	-2.6	0.9	-0.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.1	0.8	-0.1
High blood pressure (siblings)	0.5	0.8	1.8	0.5	-0.5	-1.3
Forced vital capacity (FVC), Best measure	0.5	1.9	4.3	0.2	2.1	-1.2
Body fat percentage	0.9	3.5	8.0	-1.3	1.0	-2.8
Leg fat percentage (right)	0.9	3.2	9.2	-0.5	0.4	-3.0
Arm fat-free mass (right)	0.1	0.3	0.8	0.4	-0.1	-0.9
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.9	-0.3	-0.4
Comparative body size at age 10	0.6	1.6	4.4	0.1	-0.7	-2.1
Number of full brothers	0.4	0.5	1.3	0.3	-1.1	-0.1
Worry too long after embarrassment	0.3	0.4	0.9	-0.5	-1.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	5.1	-1.4	1.6	-2.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-0.3	-0.2	-1.0
Number of children fathered	0.4	0.4	1.0	1.0	-0.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.4	-0.5	1.5	-1.1
Age at first live birth	0.1	0.1	0.2	0.3	-0.4	-0.1
Pulse wave peak to peak time	0.6	0.7	0.9	-0.9	0.9	-0.5
Health satisfaction	0.4	0.5	1.1	0.3	0.7	-1.0
Shortness of breath walking on level ground	0.6	0.7	1.5	-0.7	0.1	-1.2
Qualifications: College or University degree	0.6	2.0	4.1	-0.6	1.2	-2.0
Eye problems/disorders: None of the above	1.5	1.7	2.3	1.5	-1.0	1.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.4	0.2	-0.5
Emphysema/chronic bronchitis	0.2	0.2	0.2	-0.4	-0.5	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.5	-0.2	0.4
Neck or shoulder pain in last month	0.5	0.7	0.9	-0.7	0.8	-1.0
Medication: Blood pressure	0.1	0.2	0.2	0.4	-0.4	-0.5
Angina (self-reported)	3.7	4.9	10.0	0.7	-3.2	2.1
Migraine (self-reported)	0.8	1.0	2.5	-0.4	1.6	-0.7
Medication: Ibuprofen	1.0	1.1	2.1	1.5	-0.8	-0.8
Medication: Allopurinol	0.6	0.8	1.6	0.7	0.3	-1.3
Medication: Omeprazole	0.8	0.9	2.2	0.7	-1.5	0.3
Medication: Seretide 50 evohaler	2.3	2.6	4.3	1.8	-2.1	-0.7
Mean time to correctly identify matches	0.5	1.0	1.7	1.3	-0.9	-0.7
Heart disease (mother)	1.3	1.5	3.0	0.8	-1.7	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.9	-1.1	0.0	-1.4
Whole body fat mass	0.9	3.6	8.3	-1.0	1.2	-2.9
Leg fat mass (right)	1.0	3.7	10.5	-0.3	0.7	-3.2
Arm predicted mass (right)	0.0	0.3	0.5	0.4	-0.2	-0.7
Pulse rate, automated reading	2.5	8.1	18.3	0.8	4.3	-2.3
Alcohol intake frequency.	0.7	1.6	2.6	-1.5	-0.3	1.6
Comparative height size at age 10	0.2	0.9	2.3	0.7	1.5	0.1
Number of full sisters	0.1	0.2	0.5	0.3	-0.7	-0.1
Suffer from ‘nerves’	1.9	2.9	7.7	-2.8	1.0	-0.3
Overall health rating	0.7	1.6	2.5	-1.6	0.5	-1.4
Chest pain or discomfort	0.4	0.6	0.8	-0.8	-0.5	-0.9
Had major operations	2.2	2.5	6.5	-2.5	0.8	-0.7
Age at last live birth	0.3	0.4	1.0	-1.0	-0.1	0.5
Family relationship satisfaction	3.0	3.7	7.0	0.6	1.9	-2.6
Leg pain on walking	0.2	0.3	0.6	-0.3	0.8	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.9	0.7	-0.2	-1.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.7	-0.6	0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	0.9	-0.2	-0.2
Medication: Aspirin	0.5	0.7	1.1	-0.7	1.1	-0.6
Supplements: Vitamin C	0.6	0.7	1.2	-1.1	-0.2	0.8
Knee pain experienced in last month	0.2	0.4	1.0	1.0	0.2	-0.3
Hypertension (Self-reported)	0.4	1.1	2.3	-0.3	0.9	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.9	-0.5	-1.4	0.1
Illnesses of father: Heart disease	0.7	0.9	1.7	0.4	-1.3	1.0
Illnesses of siblings: Diabetes	1.2	1.4	3.3	1.8	-0.7	0.7
Smoking status: Previous	0.3	0.4	0.8	0.6	-0.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.7	-0.4	-0.2	1.6
Whole body fat-free mass	0.3	1.6	3.1	1.1	0.7	-1.8
Leg fat-free mass (right)	0.4	2.0	4.5	0.7	1.1	-2.1
Arm fat percentage (left)	1.1	4.5	11.6	-0.9	1.0	-3.4
Average weekly red wine intake	2.7	4.0	6.2	-0.7	2.5	-2.3
Handedness (chirality/laterality): Left-handed	4.0	4.8	5.7	-2.1	2.1	-2.4
Mood swings	0.2	0.4	0.9	0.6	-1.0	-0.0
Loneliness, isolation	0.1	0.2	0.3	-0.5	0.5	0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.0	0.5	-0.4
Ever had bowel cancer screening	1.2	1.4	2.4	0.2	-1.3	1.5
Diabetes diagnosed by doctor	0.7	1.2	1.8	-0.6	1.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	3.9	-2.0	1.5	1.5
Friendships satisfaction	0.6	0.7	1.1	0.6	1.0	-0.9
Qualifications: nursing, teaching	0.2	0.3	0.4	-0.6	0.5	-0.7
Commuting to job workplace: Walk	0.7	0.8	1.8	0.2	1.3	-0.7
Eye problems/disorders: Cataract	1.5	1.8	2.9	-1.1	1.7	-1.1
Mouth/teeth dental problems: Mouth ulcers	2.8	4.4	7.3	-1.4	2.0	-2.7
Medication for cholesterol	0.0	0.1	0.1	-0.2	-0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.1	0.2	0.1
Back pain experienced in last month	0.5	0.8	2.3	-1.5	-0.3	-0.1
Mineral and other dietary supplements	0.7	0.9	1.7	-1.3	-0.8	0.7
Breast cancer (self-reported)	1.7	2.0	5.5	-2.3	0.4	0.6
Asthma (self-reported)	0.3	0.5	1.4	1.2	-0.2	-0.4
Osteoporosis (self-reported)	1.4	1.7	2.8	-1.5	0.3	-1.7
Osteoarthritis (self-reported)	0.5	0.7	1.8	0.4	-0.2	1.3
Medication: Aspirin	0.3	0.4	0.7	-0.4	0.8	-0.5
Medication: Gliclazide	0.6	0.7	1.2	-0.2	0.9	-1.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	0.2	-0.2	0.2
Smoking status: Current	0.7	1.1	1.6	0.9	-1.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.0	0.8	0.7	-2.0
Whole body water mass	0.3	1.5	3.0	0.9	0.8	-1.7
Leg predicted mass (right)	0.4	2.2	4.7	0.7	1.2	-2.2
Arm fat mass (left)	1.0	4.0	10.2	-0.7	1.2	-3.2
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	-0.2	0.0	0.4
Average weekly champagne plus white wine intake	0.6	0.9	2.0	0.6	-1.4	0.5
Miserableness	0.2	0.3	0.5	-0.7	-0.2	-0.7
Guilty feelings	0.2	0.3	0.7	-0.1	-0.8	0.5
Wears glasses or contact lenses	2.7	3.1	5.5	0.0	1.9	-2.4
Ever taken oral contraceptive pill	0.6	0.7	1.1	1.0	-0.6	-0.7
Hearing aid user	0.3	0.3	0.5	0.6	0.1	-0.7
Mother’s age at death	0.6	0.8	1.5	-0.4	-0.8	1.2
Financial situation satisfaction	0.2	0.2	0.6	-0.8	0.2	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	0.1	1.0	-0.9
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.7	-0.1	0.8
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	0.2	-0.3	0.6
Medication: Blood pressure	0.3	0.6	1.0	-0.3	0.8	-1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.5	-0.6	0.1	0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.2	1.7	1.3	0.6	-1.3
High cholesterol (Self-reported)	0.2	0.3	0.6	-0.8	0.3	-0.4
Medication: Bendroflumethiazide	0.6	0.9	1.3	1.1	0.5	-1.1
Medication: Paracetamol	0.9	1.4	1.8	-1.3	1.3	-0.8
Medication: Lisinopril	1.0	1.3	1.4	1.1	1.2	-1.2
Medication: Atorvastatin	2.3	2.9	6.8	-2.6	-0.6	1.2
Illnesses of father: High blood pressure	0.9	1.1	3.1	-0.3	0.3	-1.8
Alcohol drinker status: Never	0.3	0.4	0.6	0.6	-0.4	0.8
Ever smoked	0.4	0.7	2.0	1.4	-0.1	-0.2
Basal metabolic rate	0.4	2.0	4.5	0.7	1.0	-2.1
Leg fat percentage (left)	0.6	2.2	6.2	-0.6	0.2	-2.5
Arm fat-free mass (left)	0.2	0.9	2.4	0.3	0.5	-1.5
Number of operations (self-reported)	0.0	0.0	0.1	-0.1	0.3	-0.1
Average weekly beer plus cider intake	0.5	0.8	2.0	-1.4	0.5	-0.3
Irritability	0.3	0.5	1.1	0.5	-1.1	0.1
Risk taking	0.4	0.6	1.1	-0.7	1.0	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.0	0.5	0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.8	0.0	-0.9	-0.2
Age started oral contraceptive pill	1.5	1.9	5.2	-0.0	-0.7	2.3
Diastolic blood pressure, automated reading	0.5	1.6	2.9	-0.3	1.7	-1.4
Ever depressed for a whole week	0.3	0.3	0.7	0.5	0.2	-0.8
Unable to work because of sickness or disability	1.2	1.6	3.4	-1.8	-0.8	0.9
Commuting to job workplace: Cycle	2.8	3.3	3.6	1.9	-1.8	1.8
Myopia	1.5	2.2	3.5	1.9	-1.1	1.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.3	0.3	-0.4	1.2
Cholesterol lowering medication	0.3	0.4	0.9	0.4	0.5	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.8	0.5	-1.7	1.0
Pain experienced in last month	0.7	1.2	1.9	1.3	-1.4	0.4
Supplements: Calcium	0.7	0.8	1.2	-1.1	-0.4	1.1
Basal cell carcinoma (self-reported)	0.9	1.1	1.8	-1.4	0.5	-1.0
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.6	-0.9	-1.9	0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	1.3	-0.4	0.0
Heart disease (siblings)	2.1	2.6	6.2	2.5	-1.1	-0.6
Alcohol drinker status: Previous	0.0	0.0	0.1	0.3	0.0	-0.2
Pack years of smoking	1.0	1.5	2.2	-1.5	1.4	-0.6
Impedance of whole body	0.3	1.5	3.5	-0.9	0.2	1.9
Leg fat mass (left)	0.8	3.2	8.9	-0.5	0.6	-3.0
Arm predicted mass (left)	0.2	0.9	2.3	0.3	0.5	-1.5