Hub : Genes

MFSD2A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.304 0.082 1.7e-04 0.193 NA 0.209 NA 0.199 1.5e-09 NA 2.7e-10 NA 8.4e-10
2 GTEx Esophagus Muscularis 0.101 0.041 2.4e-03 0.022 NA 0.019 NA 0.037 1.7e-02 NA 2.5e-02 NA 2.7e-03
3 TCGA Thyroid Carcinoma 0.083 0.030 1.4e-06 0.016 0.059 0.062 NA 0.052 8.9e-03 2.2e-06 1.2e-06 NA 7.7e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.0 3.1 8.1 -2.9 1.1 -0.0
Bipolar Disorder or Schizophrenia 0.2 0.6 0.9 -1.0 -0.5 0.8
Depressed Affect (Nagel 2018) 0.3 0.5 1.2 -0.3 0.5 -1.1
Depression (Nagel 2018) 0.0 0.0 0.1 -0.0 0.2 -0.1
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.2 -0.9 0.6 -1.1
Neuroticism (Nagel 2018) 0.6 1.4 2.2 -1.5 0.8 -1.2
Schizophrenia (2018) 0.7 1.5 2.3 1.1 -1.5 1.1
Schizophrenia vs Biploar Disorder 1.4 1.8 2.5 1.6 -1.1 1.3
Worry (Nagel 2018) 1.1 2.3 5.3 -2.3 0.9 -0.9
Alzheimer’s Disease (in mother) 0.6 0.7 1.0 0.9 -1.0 0.5
Alzheimer’s Disease (in father) 3.0 3.2 4.9 -0.7 2.2 -2.1
Alzheimer’s Disease (including proxy) 1.6 2.3 4.5 -0.1 1.6 -2.1
Crohns Disease (2017) 0.8 1.7 3.9 0.7 -2.0 0.7
Irritable Bowel Disease (IBD) 0.5 1.1 2.2 -0.1 -1.5 1.0
Ulcerative Colitis (UC) 0.3 0.6 1.0 -1.0 0.0 0.9
Major Depression (MDD) 4.0 4.8 9.1 -0.7 2.2 -3.0
Reaction Time 1.3 2.4 4.5 2.1 -1.6 -0.3
Verbal and Numeric Reasoning (VNR) 1.7 4.2 7.9 -1.3 1.8 -2.8
Breast Cancer 5.6 13.5 28.0 0.0 -3.5 5.3
Ovarian Cancer 3.2 4.2 11.5 3.4 0.4 -1.0
Prostate Cancer 0.5 0.7 1.9 -0.3 1.4 0.2
Age at First Birth 2.9 4.2 6.2 0.5 -2.5 2.5
Bipolar Disorder (2011) 3.4 3.3 5.4 -2.3 2.1 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 -0.3 -0.4 -0.2
Coronary Artery Disease (CAD) 0.4 0.5 0.7 0.6 -0.7 0.8
Crohns Disease (2012) 0.1 0.1 0.2 0.1 0.1 0.5
Mean Putamen Volume 1.4 1.6 2.4 0.2 -1.6 1.6
Fasting Glucose 1.9 2.3 3.2 1.0 -1.7 1.8
HbA1C 1.2 1.3 2.7 1.6 -0.3 1.0
HDL Cholesterol 1.1 1.8 5.0 2.2 0.6 -0.0
LDL Cholesterol 0.1 0.2 0.4 0.2 0.4 0.7
Lupus 0.1 0.2 0.4 -0.6 0.2 0.4
Neuroticism (2016) 0.3 0.5 1.1 -0.6 -0.2 -1.0
Primary Biliary Cirrhosis 0.1 0.2 0.3 0.5 -0.2 0.3
Rheumatoid Arthritis 2.2 3.1 3.7 -1.6 1.8 -1.9
Schizophrenia (2014) 0.6 1.4 2.7 0.7 -0.9 1.6
Triglycerides 1.5 2.5 5.2 -1.3 0.8 -2.3
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.6 -0.0 -0.7 0.5
Ulcerative Colitis 0.5 0.8 1.7 -1.3 0.4 0.7
Blood Eosinophil Count 0.2 1.9 3.4 1.9 -1.1 1.0
Blood Platelet Count 7.9 91.9 136.9 -6.5 11.7 -9.9
Blood Red Count 1.6 15.7 30.8 2.7 -3.0 5.5
Blood White Count 3.2 23.8 30.4 -3.9 5.5 -5.1
Heel T-Score 0.5 3.6 5.9 2.4 -1.9 1.2
BMI 0.9 5.0 14.6 0.3 0.7 -3.8
Height 0.3 4.9 14.7 -0.2 3.8 -0.0
Waist Hip Ratio (WHR) 0.1 0.5 1.5 -1.2 -0.1 -0.1
Systolic Blood Pressure 0.9 4.7 6.9 -2.6 1.0 -2.4
Smoking Status 0.5 1.2 1.9 1.3 -1.4 0.3
Allergy or Eczema 0.4 1.1 2.9 0.5 -0.1 1.7
Cardiovascular Disease 0.4 1.4 3.1 -0.8 0.6 -1.8
Hypothyroidism (self reported) 1.9 4.5 5.2 -2.0 2.1 -2.3
Respiratory disease 0.1 0.1 0.3 0.5 -0.1 0.3
Type 2 Diabetes (T2D) (2018) 0.9 1.6 2.7 1.0 1.1 -1.6
Lung FEV1/FVC ratio 2.3 11.9 19.0 4.0 -4.4 0.5
Lung FVC 0.5 2.5 4.2 1.1 1.4 -2.0
Neuroticism 0.3 0.8 1.2 -1.1 0.2 -1.0
Chronotype (morning person) 0.2 0.4 0.8 -0.2 -0.6 0.9
Hair Pigment 0.2 6.3 13.4 -1.5 1.8 -3.7
Tanning 0.0 0.2 0.5 0.3 -0.3 0.7
Hand grip strength (left) 0.5 1.4 2.9 1.7 1.1 0.2
Number of treatments/medications taken 0.3 0.6 1.1 0.8 -1.1 -0.1
Average weekly spirits intake 0.1 0.1 0.3 -0.6 -0.3 -0.1
Sensitivity / hurt feelings 0.2 0.4 0.9 0.6 -0.9 -0.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.7 0.7 0.1 -0.8
Hearing difficulty/problems: Yes 0.2 0.4 1.0 0.2 1.0 -0.2
Relative age of first facial hair 0.3 0.5 1.2 -0.0 1.1 -0.6
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.4 -0.4 0.2 -0.7
Ever used hormone-replacement therapy (HRT) 1.4 1.8 2.2 -1.3 -1.3 1.5
Ever had hysterectomy (womb removed) 0.3 0.3 0.3 0.5 0.6 -0.6
Systolic blood pressure, automated reading 1.1 3.2 7.2 -2.7 1.3 -0.9
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.1 -0.9 0.1 -1.1
Angina 4.0 5.3 10.1 0.8 -3.2 2.3
Medication for hormone replacement therapy 3.6 4.1 5.9 1.4 -2.4 2.1
Vitamin and mineral supplements 0.2 0.3 0.6 0.5 0.3 -0.8
Supplements: Zinc 0.4 0.4 0.8 -0.1 0.7 -0.9
Medication: Co-codamol 0.1 0.1 0.2 -0.4 0.0 -0.4
Medication: Metformin 0.4 0.6 0.7 0.9 0.8 -0.6
Diabetes (father) 0.2 0.3 0.8 -0.9 -0.0 -0.0
Diabetes (mother) 0.4 0.5 1.5 0.3 -1.2 0.1
Severe depression (siblings) 3.2 3.6 7.8 -2.8 1.8 -0.0
Pack years adult smoking proportion 0.8 1.2 1.7 -1.3 1.3 -0.4
Impedance of leg (right) 0.3 1.6 3.8 -0.9 -0.3 2.0
Leg fat-free mass (left) 0.5 2.6 6.1 0.8 1.0 -2.5
Trunk fat percentage 0.9 3.8 7.8 -1.3 1.3 -2.8
Hand grip strength (right) 1.0 2.7 7.5 2.7 0.4 0.7
Townsend deprivation index at recruitment 0.0 0.1 0.1 -0.2 0.1 -0.4
Current tobacco smoking 0.9 1.5 2.7 0.5 -1.6 1.3
Average weekly fortified wine intake 0.7 0.9 1.6 -0.5 0.9 -1.3
Maternal smoking around birth 1.6 2.4 4.1 0.1 1.7 -2.0
Fed-up feelings 0.5 0.8 1.3 1.1 -1.1 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.3 -0.7 0.3 -1.1
Relative age voice broke 0.8 1.2 2.3 0.0 1.5 -1.2
Taking other prescription medications 0.2 0.4 0.6 -0.8 0.6 -0.3
Age when periods started (menarche) 0.3 0.6 1.9 0.0 1.4 -0.0
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 -0.4 -1.5 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.0 1.4 -0.2 -0.4
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 4.6 2.1 -0.0 -1.1
Qualifications: CSEs or equivalent 0.7 1.0 1.6 -0.2 1.3 -1.1
Serious illness, injury or assault to yourself 0.7 0.8 2.1 0.5 0.4 -1.4
High blood pressure 0.2 0.5 0.9 -0.5 0.6 -0.9
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.0 1.0 -0.1 0.9
Multivitamins +/- minerals 0.1 0.2 0.2 0.5 -0.3 0.4
Stomach or abdominal pain in last month 1.1 1.4 3.0 -1.7 -0.4 0.9
Supplements: Glucosamine 0.8 1.1 2.1 0.3 1.4 -1.1
Diverticular disease/diverticulitis (self-reported) 3.6 4.3 8.6 0.8 -1.9 2.9
Medication: Atenolol 0.6 0.7 1.5 -1.2 0.3 -0.7
Medication: Levothyroxine sodium 0.9 1.4 2.2 -1.5 1.1 -1.0
Sitting height 0.2 1.6 4.2 0.6 2.0 -0.6
Chronic bronchitis/emphysema (father) 1.1 1.3 2.4 0.2 1.6 -1.2
High blood pressure (mother) 2.2 3.0 5.0 -2.2 1.9 -0.6
Body mass index (BMI) 0.8 3.5 10.4 -0.2 0.3 -3.2
Impedance of leg (left) 0.6 2.9 7.1 -1.2 -0.3 2.7
Leg predicted mass (left) 0.5 2.9 6.7 0.9 1.1 -2.6
Trunk fat mass 0.9 3.9 8.8 -0.8 1.5 -3.0
Waist circumference 0.7 2.7 6.7 -1.0 0.7 -2.6
Number of incorrect matches in round 2.0 3.3 5.6 2.4 -1.3 1.7
Past tobacco smoking 0.3 0.6 1.6 -1.3 0.3 0.4
Alcohol usually taken with meals 0.7 1.1 1.9 -1.1 1.4 -0.5
Nervous feelings 0.6 1.2 1.8 -1.2 -0.4 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.1 1.8 -1.0 0.1
Hearing difficulty/problems with background noise 0.2 0.3 0.6 0.5 -0.5 0.8
Hair/balding pattern: Pattern 2 0.6 0.8 2.1 -1.4 0.2 -0.5
Had menopause 2.2 2.8 4.7 -0.7 -1.8 2.2
Had other major operations 0.7 0.9 2.3 0.1 1.5 -0.6
Forced vital capacity (FVC) 1.3 5.0 7.5 1.2 2.5 -2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.6 1.1 0.4 -1.6
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.4 1.2 -0.9 -1.0
Qualifications: None of the above 1.0 2.2 4.0 -0.4 -1.6 2.0
Financial difficulties in last 2 years 0.5 0.6 1.7 -1.3 0.3 0.1
Mouth/teeth dental problems 4.0 6.1 10.0 2.3 -1.8 3.2
Heart attack 1.4 1.7 3.2 -0.9 -1.8 1.1
Allergy 0.6 1.4 3.4 -1.8 0.5 -0.8
Pain all over the body in last month 0.6 0.7 1.6 1.3 -0.4 -0.5
Diabetes (self-reported) 0.5 0.7 1.4 -0.1 1.2 -0.9
Hayfever/allergic rhinitis (self-reported) 2.0 2.6 6.1 2.5 -1.1 0.8
Medication: Ramipril 0.5 0.6 0.9 0.9 -0.9 0.5
Medication: Simvastatin 0.8 1.2 2.8 0.5 0.8 -1.7
Fluid intelligence score 0.3 0.7 1.4 -0.8 0.4 -1.2
Illnesses of siblings 1.4 2.0 3.4 -1.8 0.8 1.4
Neuroticism score 0.3 0.7 1.0 -1.0 -1.0 0.2
Weight 0.7 3.6 8.9 -0.1 1.3 -3.0
Impedance of arm (right) 0.1 0.7 1.7 -0.5 1.3 0.3
Arm fat percentage (right) 1.4 5.5 13.7 -1.0 1.4 -3.7
Trunk fat-free mass 0.3 1.5 2.0 1.3 0.8 -1.4
Hip circumference 0.5 2.0 5.2 -0.3 0.9 -2.3
Time employed in main current job 0.9 1.1 1.6 -1.3 -0.2 1.3
Alcohol intake versus 10 years previously 0.2 0.3 0.5 -0.5 0.7 0.6
Father’s age at death 1.4 1.9 3.6 -1.1 -0.9 1.9
Worrier / anxious feelings 0.4 0.8 1.9 -1.4 -0.6 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.8 -0.9 0.3 0.2
Falls in the last year 1.5 2.0 5.4 -2.3 0.5 -0.6
Hair/balding pattern: Pattern 3 0.4 0.6 1.3 -0.6 0.4 -1.1
Number of live births 0.0 0.0 0.0 -0.2 -0.2 0.0
Forced expiratory volume in 1-second (FEV1) 1.6 5.4 9.0 1.9 1.8 -3.0
Pulse rate 0.6 1.1 2.3 0.2 1.5 -0.9
Happiness 2.3 2.8 4.2 -2.0 2.0 -0.6
Noisy workplace 1.7 2.1 3.1 1.8 0.7 -1.6
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.8 0.9 -0.5 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.4 -0.4 1.6 -1.1
Mouth/teeth dental problems: Dentures 1.5 2.5 6.7 -0.3 0.9 -2.6
Asthma 0.1 0.2 0.6 0.8 -0.2 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.9 1.4 -0.1 -1.0
Medication: Cholesterol lowering 1.3 1.9 3.6 -1.9 0.8 -1.2
Depression (self-reported) 1.5 1.8 2.3 -0.9 1.5 -1.5
Medication: Lansoprazole 2.2 2.5 4.1 0.2 -2.0 1.8
Prospective memory result 1.2 1.5 3.7 0.3 0.7 -1.9
Lung cancer (father) 0.9 1.0 1.2 -1.0 0.9 -1.1
Illnesses of mother 0.4 0.5 1.5 1.2 -0.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 2.0 1.1 1.2 -1.4
Pulse wave Arterial Stiffness index 0.6 0.7 0.7 0.8 -0.9 0.8
Impedance of arm (left) 0.1 0.5 0.7 -0.5 0.8 0.8
Arm fat mass (right) 1.1 4.6 11.8 -0.8 1.2 -3.4
Trunk predicted mass 0.2 1.4 1.9 1.3 0.8 -1.4
Standing height 0.2 2.1 6.4 0.2 2.5 0.3
Length of working week for main job 1.4 1.6 4.5 -2.1 -0.2 0.5
Exposure to tobacco smoke at home 0.2 0.2 0.6 0.3 0.0 -0.8
Breastfed as a baby 0.9 1.1 2.2 1.5 0.9 -0.5
Tense / ‘highly strung’ 1.1 1.9 3.6 -1.9 1.3 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.5 -0.3 -0.6
Hair/balding pattern: Pattern 4 1.3 3.2 4.8 -0.6 2.1 -2.2
Birth weight of first child 1.8 3.2 6.5 2.5 0.7 1.6
Peak expiratory flow (PEF) 3.2 7.4 8.7 3.0 2.4 -2.8
Pulse wave reflection index 0.4 0.5 1.1 0.2 -1.0 0.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.2 -1.1 -0.1 0.8
Loud music exposure frequency 0.3 0.3 0.6 0.2 -0.5 0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.7 0.8 -0.2 0.8
Mouth/teeth dental problems: Bleeding gums 3.4 4.4 7.8 -2.8 2.1 -1.0
Blood clot in the leg (DVT) 0.5 0.6 1.6 1.3 -0.5 0.2
Medication: Paracetamol 0.7 1.1 2.1 -1.0 1.5 -0.4
Headache pain in last month 1.4 2.3 4.3 -2.1 1.5 -0.6
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 0.3 0.3 0.5
Glaucoma (self-reported) 0.4 0.5 0.7 -0.3 -0.8 0.8
Gout (self-reported) 0.8 1.1 2.6 1.6 -0.9 -0.0
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 3.5 -1.9 1.7 -1.4
Medication: Amlodipine 0.8 1.1 2.8 1.7 -0.7 0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.9 -0.6 0.1
Birth weight 1.2 2.6 6.9 -2.6 0.9 -0.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.7 -0.1 0.8 -0.1
High blood pressure (siblings) 0.5 0.8 1.8 0.5 -0.5 -1.3
Forced vital capacity (FVC), Best measure 0.5 1.9 4.3 0.2 2.1 -1.2
Body fat percentage 0.9 3.5 8.0 -1.3 1.0 -2.8
Leg fat percentage (right) 0.9 3.2 9.2 -0.5 0.4 -3.0
Arm fat-free mass (right) 0.1 0.3 0.8 0.4 -0.1 -0.9
Exposure to tobacco smoke outside home 0.3 0.4 0.9 -0.9 -0.3 -0.4
Comparative body size at age 10 0.6 1.6 4.4 0.1 -0.7 -2.1
Number of full brothers 0.4 0.5 1.3 0.3 -1.1 -0.1
Worry too long after embarrassment 0.3 0.4 0.9 -0.5 -1.0 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.2 5.1 -1.4 1.6 -2.2
Wheeze or whistling in the chest in last year 0.2 0.3 0.9 -0.3 -0.2 -1.0
Number of children fathered 0.4 0.4 1.0 1.0 -0.2 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.4 -0.5 1.5 -1.1
Age at first live birth 0.1 0.1 0.2 0.3 -0.4 -0.1
Pulse wave peak to peak time 0.6 0.7 0.9 -0.9 0.9 -0.5
Health satisfaction 0.4 0.5 1.1 0.3 0.7 -1.0
Shortness of breath walking on level ground 0.6 0.7 1.5 -0.7 0.1 -1.2
Qualifications: College or University degree 0.6 2.0 4.1 -0.6 1.2 -2.0
Eye problems/disorders: None of the above 1.5 1.7 2.3 1.5 -1.0 1.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 0.4 0.2 -0.5
Emphysema/chronic bronchitis 0.2 0.2 0.2 -0.4 -0.5 0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 -0.5 -0.2 0.4
Neck or shoulder pain in last month 0.5 0.7 0.9 -0.7 0.8 -1.0
Medication: Blood pressure 0.1 0.2 0.2 0.4 -0.4 -0.5
Angina (self-reported) 3.7 4.9 10.0 0.7 -3.2 2.1
Migraine (self-reported) 0.8 1.0 2.5 -0.4 1.6 -0.7
Medication: Ibuprofen 1.0 1.1 2.1 1.5 -0.8 -0.8
Medication: Allopurinol 0.6 0.8 1.6 0.7 0.3 -1.3
Medication: Omeprazole 0.8 0.9 2.2 0.7 -1.5 0.3
Medication: Seretide 50 evohaler 2.3 2.6 4.3 1.8 -2.1 -0.7
Mean time to correctly identify matches 0.5 1.0 1.7 1.3 -0.9 -0.7
Heart disease (mother) 1.3 1.5 3.0 0.8 -1.7 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.9 -1.1 0.0 -1.4
Whole body fat mass 0.9 3.6 8.3 -1.0 1.2 -2.9
Leg fat mass (right) 1.0 3.7 10.5 -0.3 0.7 -3.2
Arm predicted mass (right) 0.0 0.3 0.5 0.4 -0.2 -0.7
Pulse rate, automated reading 2.5 8.1 18.3 0.8 4.3 -2.3
Alcohol intake frequency. 0.7 1.6 2.6 -1.5 -0.3 1.6
Comparative height size at age 10 0.2 0.9 2.3 0.7 1.5 0.1
Number of full sisters 0.1 0.2 0.5 0.3 -0.7 -0.1
Suffer from ‘nerves’ 1.9 2.9 7.7 -2.8 1.0 -0.3
Overall health rating 0.7 1.6 2.5 -1.6 0.5 -1.4
Chest pain or discomfort 0.4 0.6 0.8 -0.8 -0.5 -0.9
Had major operations 2.2 2.5 6.5 -2.5 0.8 -0.7
Age at last live birth 0.3 0.4 1.0 -1.0 -0.1 0.5
Family relationship satisfaction 3.0 3.7 7.0 0.6 1.9 -2.6
Leg pain on walking 0.2 0.3 0.6 -0.3 0.8 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.9 0.7 -0.2 -1.7
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.5 -0.7 -0.6 0.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.9 0.9 -0.2 -0.2
Medication: Aspirin 0.5 0.7 1.1 -0.7 1.1 -0.6
Supplements: Vitamin C 0.6 0.7 1.2 -1.1 -0.2 0.8
Knee pain experienced in last month 0.2 0.4 1.0 1.0 0.2 -0.3
Hypertension (Self-reported) 0.4 1.1 2.3 -0.3 0.9 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.9 -0.5 -1.4 0.1
Illnesses of father: Heart disease 0.7 0.9 1.7 0.4 -1.3 1.0
Illnesses of siblings: Diabetes 1.2 1.4 3.3 1.8 -0.7 0.7
Smoking status: Previous 0.3 0.4 0.8 0.6 -0.3 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 2.7 -0.4 -0.2 1.6
Whole body fat-free mass 0.3 1.6 3.1 1.1 0.7 -1.8
Leg fat-free mass (right) 0.4 2.0 4.5 0.7 1.1 -2.1
Arm fat percentage (left) 1.1 4.5 11.6 -0.9 1.0 -3.4
Average weekly red wine intake 2.7 4.0 6.2 -0.7 2.5 -2.3
Handedness (chirality/laterality): Left-handed 4.0 4.8 5.7 -2.1 2.1 -2.4
Mood swings 0.2 0.4 0.9 0.6 -1.0 -0.0
Loneliness, isolation 0.1 0.2 0.3 -0.5 0.5 0.1
Long-standing illness, disability or infirmity 0.1 0.1 0.2 0.0 0.5 -0.4
Ever had bowel cancer screening 1.2 1.4 2.4 0.2 -1.3 1.5
Diabetes diagnosed by doctor 0.7 1.2 1.8 -0.6 1.4 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 2.6 2.8 3.9 -2.0 1.5 1.5
Friendships satisfaction 0.6 0.7 1.1 0.6 1.0 -0.9
Qualifications: nursing, teaching 0.2 0.3 0.4 -0.6 0.5 -0.7
Commuting to job workplace: Walk 0.7 0.8 1.8 0.2 1.3 -0.7
Eye problems/disorders: Cataract 1.5 1.8 2.9 -1.1 1.7 -1.1
Mouth/teeth dental problems: Mouth ulcers 2.8 4.4 7.3 -1.4 2.0 -2.7
Medication for cholesterol 0.0 0.1 0.1 -0.2 -0.1 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.0 -0.1 0.2 0.1
Back pain experienced in last month 0.5 0.8 2.3 -1.5 -0.3 -0.1
Mineral and other dietary supplements 0.7 0.9 1.7 -1.3 -0.8 0.7
Breast cancer (self-reported) 1.7 2.0 5.5 -2.3 0.4 0.6
Asthma (self-reported) 0.3 0.5 1.4 1.2 -0.2 -0.4
Osteoporosis (self-reported) 1.4 1.7 2.8 -1.5 0.3 -1.7
Osteoarthritis (self-reported) 0.5 0.7 1.8 0.4 -0.2 1.3
Medication: Aspirin 0.3 0.4 0.7 -0.4 0.8 -0.5
Medication: Gliclazide 0.6 0.7 1.2 -0.2 0.9 -1.1
Illnesses of father: None of the above (group 1) 0.0 0.0 0.0 0.2 -0.2 0.2
Smoking status: Current 0.7 1.1 1.6 0.9 -1.3 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 4.0 0.8 0.7 -2.0
Whole body water mass 0.3 1.5 3.0 0.9 0.8 -1.7
Leg predicted mass (right) 0.4 2.2 4.7 0.7 1.2 -2.2
Arm fat mass (left) 1.0 4.0 10.2 -0.7 1.2 -3.2
Number of self-reported non-cancer illnesses 0.0 0.1 0.2 -0.2 0.0 0.4
Average weekly champagne plus white wine intake 0.6 0.9 2.0 0.6 -1.4 0.5
Miserableness 0.2 0.3 0.5 -0.7 -0.2 -0.7
Guilty feelings 0.2 0.3 0.7 -0.1 -0.8 0.5
Wears glasses or contact lenses 2.7 3.1 5.5 0.0 1.9 -2.4
Ever taken oral contraceptive pill 0.6 0.7 1.1 1.0 -0.6 -0.7
Hearing aid user 0.3 0.3 0.5 0.6 0.1 -0.7
Mother’s age at death 0.6 0.8 1.5 -0.4 -0.8 1.2
Financial situation satisfaction 0.2 0.2 0.6 -0.8 0.2 0.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.9 0.1 1.0 -0.9
Commuting to job workplace: Public transport 0.3 0.4 0.7 -0.7 -0.1 0.8
Eye problems/disorders: Glaucoma 0.1 0.2 0.3 0.2 -0.3 0.6
Medication: Blood pressure 0.3 0.6 1.0 -0.3 0.8 -1.0
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.5 -0.6 0.1 0.7
Supplements: Fish oil (including cod liver oil) 1.0 1.2 1.7 1.3 0.6 -1.3
High cholesterol (Self-reported) 0.2 0.3 0.6 -0.8 0.3 -0.4
Medication: Bendroflumethiazide 0.6 0.9 1.3 1.1 0.5 -1.1
Medication: Paracetamol 0.9 1.4 1.8 -1.3 1.3 -0.8
Medication: Lisinopril 1.0 1.3 1.4 1.1 1.2 -1.2
Medication: Atorvastatin 2.3 2.9 6.8 -2.6 -0.6 1.2
Illnesses of father: High blood pressure 0.9 1.1 3.1 -0.3 0.3 -1.8
Alcohol drinker status: Never 0.3 0.4 0.6 0.6 -0.4 0.8
Ever smoked 0.4 0.7 2.0 1.4 -0.1 -0.2
Basal metabolic rate 0.4 2.0 4.5 0.7 1.0 -2.1
Leg fat percentage (left) 0.6 2.2 6.2 -0.6 0.2 -2.5
Arm fat-free mass (left) 0.2 0.9 2.4 0.3 0.5 -1.5
Number of operations (self-reported) 0.0 0.0 0.1 -0.1 0.3 -0.1
Average weekly beer plus cider intake 0.5 0.8 2.0 -1.4 0.5 -0.3
Irritability 0.3 0.5 1.1 0.5 -1.1 0.1
Risk taking 0.4 0.6 1.1 -0.7 1.0 -0.4
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 -0.0 0.5 0.1
Fractured/broken bones in last 5 years 0.2 0.3 0.8 0.0 -0.9 -0.2
Age started oral contraceptive pill 1.5 1.9 5.2 -0.0 -0.7 2.3
Diastolic blood pressure, automated reading 0.5 1.6 2.9 -0.3 1.7 -1.4
Ever depressed for a whole week 0.3 0.3 0.7 0.5 0.2 -0.8
Unable to work because of sickness or disability 1.2 1.6 3.4 -1.8 -0.8 0.9
Commuting to job workplace: Cycle 2.8 3.3 3.6 1.9 -1.8 1.8
Myopia 1.5 2.2 3.5 1.9 -1.1 1.4
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.3 0.3 -0.4 1.2
Cholesterol lowering medication 0.3 0.4 0.9 0.4 0.5 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.8 0.5 -1.7 1.0
Pain experienced in last month 0.7 1.2 1.9 1.3 -1.4 0.4
Supplements: Calcium 0.7 0.8 1.2 -1.1 -0.4 1.1
Basal cell carcinoma (self-reported) 0.9 1.1 1.8 -1.4 0.5 -1.0
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.6 -0.9 -1.9 0.9
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.7 1.3 -0.4 0.0
Heart disease (siblings) 2.1 2.6 6.2 2.5 -1.1 -0.6
Alcohol drinker status: Previous 0.0 0.0 0.1 0.3 0.0 -0.2
Pack years of smoking 1.0 1.5 2.2 -1.5 1.4 -0.6
Impedance of whole body 0.3 1.5 3.5 -0.9 0.2 1.9
Leg fat mass (left) 0.8 3.2 8.9 -0.5 0.6 -3.0
Arm predicted mass (left) 0.2 0.9 2.3 0.3 0.5 -1.5