Best TWAS P=4.28e-15 · Best GWAS P=1.36e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TIE1 | 0.04 | 0.05 | lasso | 3 | 0.05 | 2.1e-06 | 5.2 | -5.2 | 1.9e-07 | 0.05 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | TIE1 | 0.10 | 0.05 | lasso | 3 | 0.05 | 4.4e-05 | 5.2 | -5.2 | 2.0e-07 | 0.05 | 0.98 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | SLC2A1-AS1 | 0.35 | 0.27 | lasso | 4 | 0.27 | 4.5e-22 | -7.3 | -7.0 | 3.7e-12 | 0.99 | 0.00 | 1.00 | FALSE |
4 | GTEx | Adrenal Gland | SLC2A1-AS1 | 0.58 | 0.32 | enet | 29 | 0.29 | 5.1e-11 | -7.3 | -6.0 | 1.6e-09 | 0.86 | 0.00 | 1.00 | FALSE |
5 | GTEx | Artery Coronary | SLC2A1-AS1 | 0.48 | 0.41 | lasso | 5 | 0.41 | 3.4e-15 | -7.4 | -7.2 | 7.2e-13 | 0.99 | 0.00 | 1.00 | FALSE |
6 | GTEx | Artery Tibial | SLC2A1-AS1 | 0.51 | 0.25 | lasso | 7 | 0.37 | 5.4e-30 | -7.3 | -5.5 | 3.8e-08 | 0.89 | 0.00 | 1.00 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | SLC2A1-AS1 | 0.46 | 0.19 | enet | 18 | 0.24 | 6.3e-07 | -7.3 | -5.7 | 1.3e-08 | 0.82 | 0.00 | 0.99 | FALSE |
8 | GTEx | Brain Cerebellum | SLC2A1-AS1 | 0.39 | 0.12 | enet | 14 | 0.23 | 1.6e-07 | -2.1 | -5.3 | 1.4e-07 | 0.69 | 0.04 | 0.94 | FALSE |
9 | GTEx | Breast Mammary Tissue | TIE1 | 0.08 | 0.06 | lasso | 5 | 0.08 | 7.1e-05 | 5.3 | -5.4 | 6.1e-08 | 0.05 | 0.71 | 0.01 | FALSE |
10 | GTEx | Breast Mammary Tissue | SLC2A1-AS1 | 0.23 | 0.20 | lasso | 4 | 0.19 | 4.6e-10 | -7.3 | -7.6 | 3.6e-14 | 1.00 | 0.00 | 1.00 | FALSE |
11 | GTEx | Breast Mammary Tissue (Male) | SLC2A1-AS1 | 0.23 | 0.21 | lasso | 7 | 0.16 | 1.6e-04 | -7.4 | -7.3 | 3.7e-13 | 0.95 | 0.00 | 0.97 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | RP1-92O14.6 | 0.12 | 0.02 | lasso | 5 | 0.03 | 3.6e-03 | 5.1 | -5.2 | 1.7e-07 | 0.04 | 0.84 | 0.01 | FALSE |
13 | GTEx | Colon Sigmoid | SLC2A1-AS1 | 0.56 | 0.28 | lasso | 8 | 0.38 | 2.9e-14 | -2.1 | -5.8 | 5.3e-09 | 0.86 | 0.01 | 0.99 | FALSE |
14 | GTEx | Colon Transverse | SLC2A1-AS1 | 0.44 | 0.27 | lasso | 5 | 0.29 | 3.9e-14 | -7.3 | -6.1 | 1.2e-09 | 0.92 | 0.00 | 1.00 | FALSE |
15 | GTEx | Esophagus Gastroesophageal Junction | SLC2A1-AS1 | 0.46 | 0.25 | lasso | 5 | 0.34 | 3.5e-13 | -7.3 | -5.4 | 5.7e-08 | 0.88 | 0.00 | 1.00 | FALSE |
16 | GTEx | Esophagus Mucosa | LEPRE1 | 0.06 | 0.00 | enet | 24 | 0.00 | 5.5e-01 | 4.6 | 5.6 | 2.6e-08 | -0.18 | 0.11 | 0.04 | TRUE |
17 | GTEx | Esophagus Mucosa | SLC2A1-AS1 | 0.41 | 0.25 | enet | 20 | 0.24 | 1.7e-16 | -7.3 | -5.9 | 4.5e-09 | 0.93 | 0.00 | 1.00 | FALSE |
18 | GTEx | Esophagus Mucosa | RP1-92O14.6 | 0.12 | 0.11 | lasso | 3 | 0.09 | 8.3e-07 | 5.2 | -5.2 | 1.9e-07 | 0.05 | 0.99 | 0.00 | FALSE |
19 | GTEx | Heart Atrial Appendage | SLC2A1-AS1 | 0.32 | 0.23 | lasso | 3 | 0.22 | 2.2e-10 | -7.3 | -7.0 | 1.9e-12 | 0.99 | 0.00 | 1.00 | FALSE |
20 | GTEx | Heart Left Ventricle | SLC2A1-AS1 | 0.55 | 0.40 | lasso | 9 | 0.40 | 8.0e-23 | -7.3 | -7.2 | 5.5e-13 | 1.00 | 0.00 | 1.00 | FALSE |
21 | GTEx | Lung | SLC2A1-AS1 | 0.19 | 0.17 | lasso | 4 | 0.17 | 5.1e-13 | -7.4 | -7.1 | 1.5e-12 | 0.98 | 0.00 | 1.00 | FALSE |
22 | GTEx | Muscle Skeletal | TIE1 | 0.08 | 0.06 | lasso | 6 | 0.05 | 5.5e-06 | 5.1 | -5.5 | 4.0e-08 | 0.05 | 0.99 | 0.00 | FALSE |
23 | GTEx | Muscle Skeletal | MED8 | 0.23 | 0.37 | lasso | 1 | 0.37 | 7.7e-38 | 5.2 | -5.2 | 1.7e-07 | 0.05 | 1.00 | 0.00 | FALSE |
24 | GTEx | Muscle Skeletal | RP1-92O14.6 | 0.18 | 0.24 | lasso | 3 | 0.24 | 6.8e-23 | 5.2 | -5.3 | 1.1e-07 | 0.05 | 1.00 | 0.00 | FALSE |
25 | GTEx | Nerve Tibial | TIE1 | 0.20 | 0.09 | lasso | 6 | 0.13 | 2.6e-09 | 5.2 | -5.6 | 1.9e-08 | 0.06 | 0.99 | 0.00 | TRUE |
26 | GTEx | Nerve Tibial | MED8 | 0.13 | 0.07 | enet | 11 | 0.16 | 3.6e-11 | 4.8 | 5.3 | 1.3e-07 | -0.04 | 1.00 | 0.00 | FALSE |
27 | GTEx | Nerve Tibial | SLC2A1-AS1 | 0.61 | 0.43 | lasso | 12 | 0.44 | 9.7e-34 | -7.3 | -6.5 | 9.6e-11 | 0.98 | 0.00 | 1.00 | FALSE |
28 | GTEx | Prostate | SLC2A1-AS1 | 0.36 | 0.20 | enet | 7 | 0.29 | 4.3e-08 | -7.3 | -5.9 | 4.1e-09 | 0.87 | 0.00 | 0.99 | FALSE |
29 | GTEx | Skin Not Sun Exposed Suprapubic | SLC2A1-AS1 | 0.35 | 0.26 | lasso | 5 | 0.26 | 9.2e-15 | -7.3 | -6.9 | 4.3e-12 | 0.98 | 0.00 | 1.00 | FALSE |
30 | GTEx | Skin Sun Exposed Lower leg | SLC2A1-AS1 | 0.43 | 0.39 | lasso | 5 | 0.41 | 4.6e-36 | -7.3 | -7.0 | 3.1e-12 | 0.99 | 0.00 | 1.00 | FALSE |
31 | GTEx | Skin Sun Exposed Lower leg | RP1-92O14.6 | 0.13 | 0.07 | lasso | 5 | 0.07 | 1.6e-06 | 5.0 | -5.2 | 1.9e-07 | 0.04 | 1.00 | 0.00 | FALSE |
32 | GTEx | Spleen | SLC2A1-AS1 | 0.35 | 0.27 | lasso | 2 | 0.24 | 9.6e-07 | -7.4 | -7.4 | 1.7e-13 | 1.00 | 0.00 | 1.00 | FALSE |
33 | GTEx | Testis | SZT2 | 0.14 | 0.12 | lasso | 3 | 0.09 | 5.7e-05 | 5.0 | 5.2 | 1.8e-07 | -0.04 | 0.84 | 0.03 | FALSE |
34 | GTEx | Thyroid | MED8 | 0.08 | 0.07 | lasso | 3 | 0.06 | 2.0e-05 | 5.2 | 5.3 | 1.4e-07 | -0.05 | 0.96 | 0.00 | FALSE |
35 | GTEx | Uterus | RP5-994D16.9 | 0.37 | 0.20 | lasso | 6 | 0.14 | 7.5e-04 | 4.6 | -5.1 | 2.9e-07 | 0.22 | 0.23 | 0.08 | FALSE |
36 | GTEx | Whole Blood | SLC2A1-AS1 | 0.22 | 0.14 | lasso | 2 | 0.14 | 1.3e-12 | -7.3 | -6.9 | 5.6e-12 | 0.99 | 0.00 | 1.00 | FALSE |
37 | METSIM | Adipose | SLC2A1 | 0.07 | 0.05 | lasso | 10 | 0.04 | 2.3e-06 | -7.4 | -7.8 | 4.3e-15 | 0.99 | 0.00 | 1.00 | TRUE |
38 | METSIM | Adipose | SLC2A1-AS1 | 0.36 | 0.24 | lasso | 8 | 0.24 | 1.3e-35 | -7.4 | -7.1 | 1.0e-12 | 0.99 | 0.00 | 1.00 | FALSE |
39 | YFS | Blood | PPIH | 0.01 | 0.01 | lasso | 2 | 0.01 | 6.8e-05 | -5.0 | -5.5 | 2.9e-08 | 0.23 | 0.72 | 0.01 | FALSE |
40 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ELOVL1 | 0.06 | 0.04 | blup | 36 | 0.03 | 4.7e-03 | 5.2 | -5.4 | 5.5e-08 | 0.05 | 0.02 | 0.92 | FALSE |
41 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C1orf84 | 0.01 | 0.02 | blup | 45 | 0.02 | 3.0e-03 | 4.9 | -5.2 | 1.5e-07 | 0.04 | 0.03 | 0.75 | FALSE |
42 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1orf84 | 0.02 | 0.02 | blup | 45 | 0.02 | 1.3e-03 | 5.2 | -5.5 | 4.0e-08 | 0.05 | 0.02 | 0.87 | FALSE |
43 | The Cancer Genome Atlas | Lung Adenocarcinoma | CDC20 | 0.03 | 0.03 | blup | 34 | 0.03 | 8.8e-05 | 5.1 | -5.5 | 3.7e-08 | 0.07 | 0.02 | 0.95 | FALSE |
44 | The Cancer Genome Atlas | Lung Adenocarcinoma | MED8 | 0.02 | 0.02 | blup | 39 | 0.01 | 7.5e-03 | 5.0 | -5.6 | 2.5e-08 | 0.06 | 0.01 | 0.68 | FALSE |