Best TWAS P=2.95e-21 · Best GWAS P=5.03e-28 conditioned to 2.14e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Colon Transverse | REST | 0.26 | 0.04 | lasso | 9 | 0.10 | 1.9e-05 | 4.7 | 9.5 | 3.0e-21 | -0.65 | 0.02 | 0.94 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REST | 0.04 | 0.01 | lasso | 5 | 0.02 | 7.8e-04 | 4.7 | 9.0 | 3.1e-19 | -0.70 | 0.06 | 0.70 | FALSE |
| 1 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | -9.5 | 8.1 | 4.9e-16 | -0.46 | 0.35 | 0.24 | FALSE |
| 4 | GTEx | Muscle Skeletal | REST | 0.05 | 0.01 | enet | 9 | 0.02 | 3.9e-03 | 4.2 | 7.9 | 2.9e-15 | -0.43 | 0.29 | 0.58 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | 7.1 | 6.8 | 7.7e-12 | -0.37 | 0.24 | 0.20 | FALSE |
| 5 | METSIM | Adipose | RP11-738E22.3 | 0.07 | 0.04 | lasso | 6 | 0.05 | 7.7e-08 | 4.6 | -6.6 | 3.9e-11 | 0.46 | 0.85 | 0.15 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | REST | 0.13 | 0.04 | enet | 19 | 0.04 | 1.1e-03 | 5.1 | 5.2 | 2.5e-07 | -0.23 | 0.50 | 0.08 | FALSE |