Best TWAS P=6.6e-09 · Best GWAS P=1.17e-09 conditioned to 0.0373
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | TTC12 | 0.42 | 0.16 | enet | 33 | 0.38 | 7.7e-18 | 4.6 | 5.3 | 9.7e-08 | -0.35 | 0.85 | 0.14 | FALSE |
| 2 | METSIM | Adipose | ANKK1 | 0.16 | 0.11 | enet | 13 | 0.16 | 9.8e-23 | -3.8 | -5.8 | 6.6e-09 | 0.27 | 1.00 | 0.00 | TRUE |
| 3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ANKK1 | 0.04 | 0.02 | blup | 66 | 0.03 | 5.0e-04 | 4.6 | 5.3 | 9.5e-08 | -0.25 | 0.09 | 0.64 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANKK1 | 0.04 | 0.03 | blup | 67 | 0.04 | 6.3e-05 | 4.5 | -5.3 | 9.2e-08 | 0.36 | 0.26 | 0.60 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | DRD2 | 0.06 | 0.07 | lasso | 2 | 0.07 | 6.6e-09 | -5.7 | 5.8 | 8.4e-09 | -0.89 | 0.05 | 0.95 | TRUE |
| 6 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TTC12 | 0.07 | 0.06 | blup | 48 | 0.04 | 1.6e-02 | 4.0 | 5.2 | 2.2e-07 | -0.28 | 0.01 | 0.67 | FALSE |