Best TWAS P=6.61e-09 · Best GWAS P=3.78e-08 conditioned to 0.423
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Gastroesophageal Junction | ADCK3 | 0.23 | 0.12 | lasso | 9 | 0.09 | 3.6e-04 | -5.4 | -5.8 | 6.6e-09 | 0.88 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Spleen | PSEN2 | 0.32 | 0.35 | lasso | 5 | 0.34 | 1.6e-09 | -5.3 | -5.4 | 6.5e-08 | 0.98 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PSEN2 | 0.02 | 0.02 | blup | 51 | 0.02 | 1.6e-03 | -5.3 | 5.2 | 2.3e-07 | -0.93 | 0.01 | 0.86 | FALSE |