Best TWAS P=4.5e-09 · Best GWAS P=2.81e-06 conditioned to 0.472
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | NCOA6 | 0.14 | 0.03 | enet | 13 | 0.05 | 1.6e-02 | -3.9 | 5.2 | 1.8e-07 | 0.75 | 0.04 | 0.37 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | NCOA6 | 0.13 | 0.00 | enet | 30 | 0.06 | 1.3e-02 | -3.8 | 5.2 | 2.5e-07 | 0.70 | 0.05 | 0.41 | FALSE |
| 3 | GTEx | Colon Transverse | NCOA6 | 0.10 | 0.06 | lasso | 8 | 0.04 | 4.1e-03 | 4.7 | 5.1 | 2.9e-07 | 0.96 | 0.04 | 0.82 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | NCOA6 | 0.24 | 0.07 | lasso | 4 | 0.08 | 5.9e-04 | 4.7 | 5.2 | 1.8e-07 | 0.88 | 0.04 | 0.77 | FALSE |
| 5 | GTEx | Esophagus Muscularis | NCOA6 | 0.14 | 0.10 | enet | 22 | 0.20 | 2.6e-12 | -3.8 | 5.4 | 6.5e-08 | 0.79 | 0.06 | 0.85 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | NCOA6 | 0.13 | 0.03 | enet | 12 | 0.03 | 1.5e-02 | 4.7 | 5.9 | 4.5e-09 | 0.71 | 0.04 | 0.70 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | NCOA6 | 0.03 | 0.01 | blup | 65 | 0.02 | 5.2e-03 | 4.7 | 5.1 | 3.0e-07 | 0.83 | 0.01 | 0.22 | FALSE |