Best TWAS P=5.14e-09 · Best GWAS P=1.08e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | DTD1 | 0.09 | 0.04 | lasso | 2 | 0.03 | 3.8e-03 | -5.5 | 5.6 | 2.6e-08 | -0.97 | 0.02 | 0.97 | FALSE |
2 | GTEx | Esophagus Mucosa | DTD1 | 0.19 | 0.15 | enet | 26 | 0.17 | 2.4e-11 | -5.4 | 5.3 | 1.0e-07 | -0.82 | 0.06 | 0.94 | FALSE |
3 | GTEx | Esophagus Muscularis | RBBP9 | 0.08 | 0.03 | lasso | 2 | 0.00 | 2.1e-01 | -5.2 | 5.1 | 2.8e-07 | -0.84 | 0.04 | 0.73 | FALSE |
4 | GTEx | Muscle Skeletal | DTD1 | 0.08 | 0.07 | lasso | 2 | 0.05 | 7.1e-06 | -5.2 | 5.2 | 2.4e-07 | -0.83 | 0.04 | 0.95 | FALSE |
5 | GTEx | Ovary | DTD1 | 0.27 | 0.20 | lasso | 2 | 0.18 | 3.3e-05 | -5.7 | 5.6 | 1.8e-08 | -0.99 | 0.02 | 0.92 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | DTD1 | 0.14 | 0.14 | lasso | 4 | 0.13 | 8.9e-08 | -5.6 | 5.8 | 5.1e-09 | -0.96 | 0.02 | 0.98 | TRUE |
7 | GTEx | Testis | LINC00493 | 0.11 | 0.05 | lasso | 5 | 0.03 | 1.3e-02 | -5.2 | 5.2 | 1.9e-07 | -0.88 | 0.04 | 0.89 | FALSE |
8 | The Cancer Genome Atlas | Glioblastoma Multiforme | LOC388789 | 0.25 | 0.11 | lasso | 2 | 0.07 | 3.4e-03 | -5.1 | 5.2 | 1.7e-07 | -0.84 | 0.02 | 0.40 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DTD1 | 0.03 | 0.01 | blup | 129 | 0.02 | 4.4e-03 | -5.2 | 5.2 | 1.7e-07 | -0.79 | 0.05 | 0.76 | FALSE |